[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurogenic-bowel\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurogenic-bowel":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,76,100],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100622953","bowel-continence-across-the-lifespan-in-people-with-spina-bifida-100622953",false,"NCT07390318","Bowel Continence Across the Lifespan in People With Spina Bifida","Comparing Antegrade Versus Retrograde Enemas To Improve Bowel Continence Across the Lifespan in People With Spina Bifida","BCALS","Inclusion Criteria:\n\n* Minimum age 5 years old\n* Myelomeningocele diagnosis\n* Starting a retrograde or antegrade enema program (or switching from one enema program to the other)\n* English or Spanish speaking\u002Fliterate\n\nExclusion Criteria:\n\n\\- Other types of spinal dysraphism (e.g., lipomyelomeningocele, fatty filum)","ALL","5 Years",{"count":20,"type":21},943,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn how different enema programs affect bowel control in children and adults with spina bifida. An enema program involves putting liquid into the large intestine (colon) to help someone poop. The main questions it aims to answer are:\n\n1. How well do different enema programs prevent bowel accidents?\n2. How do these enema programs affect independence, bowel symptoms, and quality of life?\n\nResearchers will compare two types of enema programs to see which works better and is easier for participants to manage.\n\nParticipants starting a new enema program will answer online survey questions at 3 different timepoints over the course of 1 year.",[25,26,27],"Spina Bifida","Neurogenic Bowel","Bowel Incontinence",[29,30,31,32,33,34],"retrograde enema","antegrade enema","bowel management program","bowel continence program","self-management","quality of life","RECRUITING","2026-04-17",{"date":38,"type":39},"2026-04-21","ACTUAL",{"date":41,"type":39},"2026-04-01",{"date":43,"type":21},"2030-05-01",{"name":45,"class":46},"David Chu","OTHER",24,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100542662","abdominal-functional-electrical-stimulation-to-improve-bowel-function-in-spinal-cord-injury-100542662","NCT06345781","Abdominal Functional Electrical Stimulation to Improve Bowel Function in Spinal Cord Injury","Inclusion Criteria:\n\n1. Chronic SCI (\\> 12 months since injury) above the level of T11\n2. \\> 18 years of age\n3. a measurable and consistent start and end event is determinable for the bowel routine\n\n   * Start events include: 1) enema insertion, 2) digital stimulation, 3) hot drink or initiation of the gastrocolic reflex, 3) abdominal massage, or 4) other, as determined by the participant and research team.\n   * Ending events include: 1) final digital stimulation, 2) when evacuation has ceased, or 3) other, as determined by the participant and research team.\n4. Portable smart device with video capabilities and internet access\n5. Willingness to access and\u002For download Zoom (videoconferencing software)\n\nExclusion Criteria:\n\n1. American Spinal Injuries Association (ASIA) Impairment Scale (AIS) E\n2. Self-reported bowel management time (BMT) of \\\u003C30 minutes\n3. Current bowel conditions such as gastro-esophageal reflux, bowel obstruction, Crohn's disease, or diverticulitis\n4. Physical obstacles that prevent AFES (e.g., pregnancy, abdominal trauma, cardiac pacemaker, or other implanted electromedical devices)\n5. Stoma or colostomy\n6. No response to AFES (e.g., lower motor neuron impairment)\n7. History of gastrointestinal surgery within the past 3 months\n8. Severely obese participants (\\>40 BMI)\n9. Primary language other than English\n10. Previous history of uncontrolled, recurrent episodes of AD\n11. Resting systolic blood pressure (BP) reported as \\>140 mmHg","18 Years",{"count":56,"type":21},15,"INTERVENTIONAL",[59],"NA","The primary objective of this study is to gather information about the effectiveness of abdominal FES to improve bowel management time (BMT) for people with chronic SCI. This study will also evaluate whether abdominal FES can improve: 1) bowel-related quality of life, 2) participant-reported bowel function, 3) bowel management strategy, 4) bladder symptoms, and 5) unplanned hospital admissions. In addition, we will also explore participant perspectives and experiences about the stimulation sessions and use of the device.",[62,26],"Spinal Cord Injuries",[64,65,26],"Spinal Cord Injury","Functional Electrical Stimulation (FES)","2026-03-26",{"date":68,"type":39},"2026-03-31",{"date":70,"type":39},"2025-04-30",{"date":72,"type":21},"2026-05",{"name":74,"class":46},"Craig Hospital",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":57,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":75},"100555679","improving-pelvic-rehabilitation-using-epidural-stimulation-after-spinal-cord-injury-100555679","NCT06515223","Improving Pelvic Rehabilitation Using Epidural Stimulation After Spinal Cord Injury","ImPRESS","Inclusion Criteria:\n\n* Spinal Cord Injury (supra-sacral)\n* AIS A-D\n* \\>18 years;\n* SCI sustained \\>12 months ago;\n* Neurogenic detrusor overactivity (NDO) confirmed on urodynamics;\n* Responsive to dorsal genital nerve stimulation\n* Willing and able to provide informed consent\n* Stable medical, physical and psychological condition as considered by the investigators\n* Able to understand and interact with the study team in English\n* Sufficient upper limb function to operate the device\n* Suitably optimised bladder and bowel routine\n\nExclusion Criteria:\n\n* Transected cord or SCI related to a neurodegenerative disease\n* Any device or metal work in situ that would exclude the patient from having eSCS implanted\n* Intra-detrusor botulinum toxin injections within the last 6 months\n* Previous surgical intervention on bladder sphincters\n* Any diseases and conditions that would exclude the patient from eSCS and\u002For surgery, for example, degenerative spinal pathology, syrinx and\u002For tumor.\n* Recurrent urinary tract infection refractory to antibiotics\n* Women who are pregnant or intending to become pregnant (pregnancy test obligatory for woman of childbearing potential) or breast feeding, or lack of safe contraception for women of childbearing capacity.\n* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders or dementia of the participant\n* Participation in another study with investigational drug within the 30 days preceding and during the present study\n* Enrolment of the investigator, his\u002Fher family members, employees, and other dependent persons.",{"count":84,"type":21},20,[59],"The investigators will recruit up to 20 volunteers with chronic, supra-sacral SCI. Following screening, eligible participants will enter 'Phase I', they will complete baseline outcome measures and then have the epidural spinal cord stimulator (eSCS) implanted with either percutaneous or paddle electrodes. Preoperative and intraoperative testing will determine exact location of electrodes.\n\nMapping and optimisation of stimulation parameters will be performed simultaneously with urodynamic investigations of bladder function, and anorectal physiology investigations of bowel function. The acute effects of eSCS to suppress bladder overactivity, facilitate voiding, prevent unwanted reflex sphincter activity, and pelvic floor function will guide development of eSCS programmes for use at home.\n\nIn 'Phase II', participants will use eSCS at home for 12-weeks. Participants will also be taught how to perform bladder and pelvic floor muscle training (PFMT) in combination with eSCS.\n\nOutcome measures assessing bladder, bowel, sexual function, quality of life, motor function and spasticity will be captured prior to and following the 12-week intervention, and at 3 and 6 month follow up.",[62,88,89,26,90],"Neuromodulation","Neurogenic Bladder","Neurogenic Detrusor Overactivity","2025-03-13",{"date":93,"type":39},"2025-03-14",{"date":95,"type":39},"2024-10-14",{"date":97,"type":21},"2027-11-01",{"name":99,"class":46},"University College, London",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":17,"minAge":107,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":57,"phases":110,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":117,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":4},"100577679","transcutaneous-spinal-cord-stimulation-for-bowel-management-in-individuals-with-motor-complete-spinal-cord-injury-100577679","NCT06801431","Transcutaneous Spinal Cord Stimulation for Bowel Management in Individuals with Motor Complete Spinal Cord Injury","A Pilot Study on the Tolerance, Feasibility, and Impact of Transcutaneous Spinal Cord Stimulation on Bowel Management in Individuals with Motor Complete Spinal Cord Injury Receiving Inpatient Care","Inclusion Criteria:\n\n1. Individual must have a T10 and above AIS A-B traumatic spinal cord injury\n2. Individual must be 16 years or older\n3. They must be willing to comply with the study procedure and be medically stable\n4. They must be at least 3 months since their injury, to minimize the chances that they are in spinal shock, which may influence the impact of TSCS as the peripheral nerves may be less excitable)\n5. There must not be any changes to their bowel medications or bowel regimen in the week leading up to the intervention, to minimize any confounding effect on bowel habits\n6. They must have bowel care either daily or q2 days\n\nExclusion Criteria:\n\n1. Individuals with a pacemarker, cochlear implant, baclofen pump or other implantable device that may be affected by electrical stimulation.\n2. Individuals with epilepsy\n3. Individuals with open wounds at stimulation sites\n4. Individuals with implanted metal in the trunk and spinal cord at the cathode pad application sites (i.e. T10 to L2)\n5. Individuals with a severe acute medical issue that is felt to affect participation at the discretion of the research team, including individuals with uncontrolled autonomic dysreflexia\n6. Individuals who are pregnant or planning to become pregnant, and who may be breastfeeding.","16 Years",{"count":109,"type":21},5,[59],"The primary goals of this pilot trial are to understand the feasibility and safety of thoracolumbar transcutaneous spinal cord stimulation for neurogenic bowel management in individuals with new onset, traumatic, cervicothoracic spinal cord injury admitted to inpatient rehabilitation.\n\nThe secondary goal is to understand the clinical impact of thoracolumbar spinal cord stimulation on bowel function.\n\nStudy participants will receive a 10-day course of transcutaneous spinal cord stimulation at T10-T11 and T12-L1. Each daily treatment will consist of 30 minutes of stimulation.\n\nFeasibility will be evaluated by documenting how many stimulation sessions were attended per participant, and the average duration of stimulation provided per session (with a maximum value of 30 minutes). It is believed that transcutaneous spinal cord stimulation will be feasible to deliver for participants receiving inpatient rehabilitation.\n\nSafety will be evaluated by documenting hemodynamic parameters (heart and blood pressure) and pain levels during each stimulation session. The skin will be evaluated after treatment to ensure no pressure injuries. Participants will be asked to document bladder continence before and after the two-week stimulation protocol, to understand if there are any changes on bladder function, given similar nerve root innervation as bowel function. Investigators expect that transcutaneous spinal cord stimulation will be safe, with minimal adverse effects on heart, blood pressure, skin integrity, pain levels and bladder continence.\n\nThe impact on bowel function will be evaluated by completing a bowel diary documenting the time spent on bowel care per day per participant. Participants will also rate their satisfaction with bowel care before, immediately after and two weeks after the 10-day stimulation protocol. Peak cough flow will be collected before, immediately after and two weeks after the 10-day stimulation protocol, as surrogate measures of abdominal strength, which is important for timely bowel evacuation. It is believed that transcutaneous spinal cord stimulation will reduce time spent on bowel care and improve participant-reported satisfaction with bowel care, and it will be associated with improvements in peak cough flow.",[26,113],"Spinal Cord Injuries (SCI)",[115,116],"neurogenic bowel","transcutaneous spinal stimulation","NOT_YET_RECRUITING","2025-01-24",{"date":120,"type":39},"2025-01-30",{"date":122,"type":21},"2025-09-01",{"date":124,"type":21},"2028-04-01",{"name":126,"class":46},"Nova Scotia Health Authority"]