[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurogimaging\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurogimaging":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":5},"100586234","pediatric-neuroimaging-100586234",false,"NCT06912724","Pediatric Neuroimaging","A Cross-Sectional Observational Feasibility Pilot Study in Pediatric Neuroimaging: Quantifying White Matter Microstructural Changes in Adolescents With Multidimensional Assessment of Pubertal Stage","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Stated willingness to comply with all study procedures and availability for the duration of the study.\n* Male or female, 9 to 14 years of age.\n* In good general health\n* Ability of parent\u002Fguardian to understand and the willingness to sign a written informed consent document.\n* Ability of participant to participate in the assent process and willingness to sign a written informed assent document.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n* Any known brain abnormalities (e.g. tumor, periventricular leukomalacia, microcephaly) or history of medical conditions known to affect cerebral micro or macro-structural integrity (e.g., epilepsy, history of stroke, head injury with a loss of consciousness of one hour or more).\n* History neurodevelopmental delay or disorder, learning disability, intellectual disability (formerly referred to as mental retardation), autism spectrum disorders, and attention deficit\u002Fhyperactivity disorder (ADHD)), as evaluated history, physical and by the SDQ, and if indicated, the KSADS\n* History of psychiatric disorder as evaluated by history and the SDQ, and if indicated, the KSADS.\n* History of prematurity (\\\u003C 32 weeks gestational age).\n* History of endocrine abnormalities, including diagnosed disorders of thyroid, growth, and precocious or delayed puberty\n* History of major medical conditions or chronic medical conditions. Examples include neurological disorders, medical or genetic conditions with associated neurological manifestations, malnutrition, conditions raising risk of micronutrient or macronutrient deficiencies (e.g. inflammatory bowel disease), untreated chronic anemia, cardiovascular disease, significant lung disease (e.g. bronchiectasis), significant liver disease, significant kidney disease, significant autoimmune condition, and chronic infections (e.g. HIV, hepatitis B).\n* Pregnancy.\n* Not eligible to have an MRI as per the MRI eligibility form and the safety standards of the NIA 3T MRI center.\n* Presence of hardware (e.g. orthodontic braces) that may interfere with MRI data quality.\n* Any other condition which in the investigator s opinion may adversely affect the subject s ability to complete the study or its measures or which may pose significant risk to the subject.",true,"ALL","9 Years","14 Years",{"count":21,"type":22},80,"ESTIMATED","OBSERVATIONAL","Background:\n\nPuberty is a normal part of life. Many big changes occur in all parts of the body as a child matures into an adult. Researchers in this study want to find out more about how the brain changes during puberty.\n\nObjective:\n\nTo study changes that occur in the brain before, during, and after puberty.\n\nEligibility:\n\nHealthy children aged 9 to 14 years.\n\nDesign:\n\nParticipants will have 2 clinic visits. Each visit will last up to 4 hours.\n\nIn the first visit, participants will be screened:\n\nThey will have a physical exam with blood tests.\n\nThey will complete a mental health questionnaire on a computer.\n\nThey will undergo a mock magnetic resonance imaging (MRI) scan. Participants will be made comfortable as they lie on the table and slide into the big tube. They will learn what it feels and sounds like to lie still inside a real MRI.\n\nAt the second visit, participants will have more tests:\n\nThey will have a physical exam with blood tests. This time the doctor will check for their stage of puberty. The doctor will look at and touch their genitals and breasts.\n\nThey will have a real MRI exam.\n\nAn x-ray will be taken of their hand and wrist. This will show how their bones are maturing.\n\nThey will have a DEXA scan. They will lie on a table while a machine uses x-rays to measure the makeup of their bodies, including bone, muscle, and fat.\n\nThey will have a 3D body scan. They will wear tight clothes and a shower cap. They will stand on a platform while sensors take pictures of their body.",[26],"Neurogimaging",[28],"Pediatric Neuroimaging Pubertal Adolescents","RECRUITING","2026-05-14",{"date":32,"type":33},"2026-05-15","ACTUAL",{"date":35,"type":33},"2025-04-21",{"date":37,"type":22},"2027-05-01",{"name":39,"class":40},"National Institute on Aging (NIA)","NIH"]