[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurologic-findings\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurologic-findings":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100515583","pharmacological-reversal-of-neuromuscular-blockade-in-critically-ill-patients-100515583",false,"NCT05993390","Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients","Effect of Neuromuscular Reversal Agents on Time for Neurological Assessment After Endotracheal Intubation in Critically Ill Patients","Inclusion Criteria:\n\n* Adult patients 19 years of age or older who were intubated after admission to the intensive care unit.\n\nExclusion Criteria:\n\n* Patients younger than 19 years of age\n* Patients who are not neurologically evaluable or have concomitant neurologic dysfunction\n* Patients with neuromuscular disorder\n* Patients with a history of drug allergic reactions to sugammadex or neostigmine\n* Patients taking or planning to take toremifene, fusidic acid, or hormonal contraceptives","ALL","19 Years","90 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare the effect of use of reversal agents for neuromuscular blockade in critically ill patients on time for neurological assessment after endotracheal intubation\n\nThe main questions it aims to answer are:\n\n* The use of reversal agents for neuromuscular blockade after endotracheal intubation may reduce the time for neurological assessment.\n* The types of reversal agents for neuromuscular blockade may affect the time for neurological assessment.\n\nParticipants will receive different reversal agents or no medications based on the assigned groups. Thirty minutes after intubation using rocuronium, medication is administered, and the time of initial confirmation of eye opening and movement is recorded.\n\nResearchers will compare 3 groups (sugammadex, neostigmine and control(no medication) to see the difference of time for neurological assessment after endotracheal intubation.",[27,28,29],"Neuromuscular Blockade","Critical Illness","Neurologic Findings",[31,32,33,34],"Reversal of neuromuscular blockade","Neurologic assessment","Endotracheal intubation","Critically ill patient","RECRUITING","2026-05-30",{"date":38,"type":39},"2026-06-02","ACTUAL",{"date":41,"type":39},"2024-01-11",{"date":43,"type":21},"2028-04-30",{"name":45,"class":46},"Seoul National University Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":47},"100610149","handheld-point-of-care-electro-diagnostic-device-100610149","NCT07223827","Handheld Point of Care Electro-Diagnostic Device","Inclusion Criteria:\n\n* Patients 18 years old or above\n* Seen inpatient or in outpatient service at IU Health facilities - Methodist Hospital, and the Neuroscience Center, by a Neurology and\u002For Neurosurgery consultant as part of their SOC.\n* The participant has capacity to sign consent or has an assigned LAR (Legally Authorized Representative - Spouse, parent, sibling, etc.) able to consent on their behalf.\n\nExclusion Criteria:\n\n* Pregnant woman\n* PI unblinded by participant or LAR regarding indication or clinical data\n* Burns or extensive skin lesions\n* Implanted stimulation devices (any)\n* Participant without standard imaging and, or other paraclinical SOC investigations to be comparable to the POC investigational device acquired data.\n* Significant acute or chronic medical, neurologic, or other illness in the patient that, in the judgment of the PI, could compromise subject safety, limit the ability to complete the study, and\u002For compromise the objectives of the study.","18 Years",{"count":20,"type":21},[24],"There are currently several products offering POC EEG, intended to be deployed on each patient individually and continuously. The investigators propose studying a different approach by using a migrating POC electrodiagnostic device that is deployed directly by the onsite provider and is actively used, like other POC devices, to acquire real-time diagnostic insight and facilitate immediate medical decision making. This can significantly shorten time to treatment which in several neurological and neurosurgical conditions, and thus, can significantly improve patient outcome.\n\nThe investigational POC investigational device is based on a handheld limited electrode array, complemented by various stimulation modalities such as SSEP, VEP and BAEP, and potentially other sensors. For this study, the investigators intend to use readily available industry standard stimulators and only use the proposed POC investigational device to acquire and analyze the data. The POC investigational electrodiagnostic prototype was assembled using OpenBCI8 electronic board and electrodes, based on ADS 129X chip by Texas Instruments, that was shown to provide an adequate low-cost solution for electrodiagnostic data acquisition.",[29],"2026-02-05",{"date":61,"type":39},"2026-02-09",{"date":63,"type":39},"2026-01-10",{"date":65,"type":21},"2026-12",{"name":67,"class":46},"Indiana University"]