[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurological-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurological-injury":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,77,101],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100420510","early-phase-1-chronic-transcutaneous-stimulation-to-promote-motor-function-and-recovery-in-individuals-with-paralysis-or-paresis-100420510",false,"NCT04755699","Chronic Transcutaneous Stimulation to Promote Motor Function and Recovery in Individuals With Paralysis or Paresis","Healthy Volunteer Inclusion Criteria:\n\n* Individuals between 18 and 75 years of age\n* Individuals without physical disabilities or conditions\u002Fdiseases that may make them incapable of completing the physical study tasks or otherwise places them at a greater risk of harm\n* Individuals that are considered English Proficient due to the study requirements to follow verbal commands during sessions\n* Individuals that are able to comprehend the study goals and procedures, and are able to provide informed consent for participation\n* Individuals that are willing and able to visit the study center for study procedures, which may be up to 5 sessions a week for up to 1 year (at least 2 months) at up to 4 hours per session\n\nStroke and Spinal Cord Injury Participant Inclusion Criteria:\n\n* Individuals between 18 and 75 years of age\n* Individuals with a limited ability to use at least one hand due to a spinal cord injury or stroke\n* Individuals that are at least six months from their initial stroke or one year from their initial spinal cord injury\n* Individuals that are considered English Proficient due to the study requirements to follow verbal commands during testing sessions\n* Individuals that are able to comprehend the study goals and procedures, and are able to provide informed consent for participation\n* Individuals that are willing and able to visit the study center for study procedures, which may be up to 5 sessions a week for up to 1 year (at least 2 months) at up to 4 hours per session\n\nBrain or Nerve Injury Participant Inclusion Criteria:\n\n* Individuals between 18 and 75 years of age\n* Individuals with a limited ability or no ability to use at least one limb due to a brain or nerve injury such as a traumatic brain injury, brachial plexus injury, peripheral nerve damage, or Parkinson's Disease.\n* Individuals that are considered English Proficient due to the study requirements to follow verbal commands during testing sessions\n* Individuals that are able to comprehend the study goals and procedures, and are able to provide informed consent for participation\n* Individuals that are willing and able to visit the study center for study procedures, which may be up to 5 sessions a week for up to 1 year (at least 2 months) at up to 4 hours per session\n\nExclusion Criteria for All Study Participants:\n\n* Individuals participating in another study that may affect the conduct or results of this study\n* Individuals having or exhibiting any of the following, as specified by self-report:\n\n  * Stage III-IV pressure ulcers that adversely interfere with study involvement (i.e., pressure ulcer on the extremity of interest or prohibits extended bouts of sitting)\n  * History of epilepsy\n  * Chronically-implanted electronic medical device (e.g. deep brain stimulator, epidural stimulator, cardiac pacemaker, vagus nerve stimulator, or other)\n  * Abnormalities of the arms\u002Fhands, legs\u002Ffeet, or spinal column that would prevent electrical stimulation\n  * Ventilator dependence\n  * History of serious mood or thought disorder\n  * Uncontrolled autonomic dysreflexia\n  * Severe spasticity in extremities of interest that are uncontrolled by pharmacological methods or prevents electrical stimulation\n  * Botulinum toxin injections to the extremity of interest within 3 months\n  * Presence of active cancer at or near the areas of transcutaneous stimulation\n  * History of heart or kidney disease\n  * History of additional neurologic diseases (e.g., multiple strokes, multiple sclerosis, etc.)\n  * Presence of other serious infections, diseases, or disorders that could affect ability to participate in this study (e.g., uncontrolled hypertension, uncontrolled diabetes, rheumatic disease, peripheral neuropathy, HIV or AIDS, etc.)\n* Individuals with a substance abuse (alcoholism or other) problem\n* Pregnant women\n* Prisoners",true,"ALL","18 Years","75 Years",{"count":20,"type":21},64,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","This is an early feasibility trial to determine whether transcutaneous neuromuscular electrical stimulation, with or without transcutaneous spinal cord stimulation, using an investigational neurostimulation device improves functional arm\u002Fhand movements in individuals with paralysis or paresis due to a spinal cord injury or stroke and improves functional arm\u002Fhand or leg\u002Ffoot movements in individuals with paralysis or paresis due to other brain or nerve injuries.\n\nIn this study, eligible individuals that agree to participate will be asked to attend up to 5 study sessions a week for 1 year (depending on participant availability), with each session lasting up to 4 hours. At the first study session, participants will have their demographic information collected, vital signs assessed, and have measurements performed of their limbs and torso, as appropriate. They will also undergo clinical evaluations and tests to assess their current functional movement and sensation capabilities.\n\nDuring subsequent study sessions, participants will undergo many tasks designed to improve functional movements in paralyzed limbs. Specifically, participants will receive neuromuscular electrical stimulation to the limb(s) and\u002For electrical stimulation to the spinal cord to evoke specified movements. The stimulation parameters and locations on the spinal column and\u002For limb(s) that evoke specific movements will be noted. The movements will be assessed with visual inspection, electromyography, and\u002For sensors.\n\nThe clinical evaluations and tests to assess functional movement and sensation capabilities will be repeated throughout the study and at the last study session to assess for functional improvements compared to the first study session. Upon completion of these study sessions, the individual's participation in the study is considered complete.",[27,28,29,30,31,32],"Healthy Volunteers","Spinal Cord Injury","Stroke","Paralysis","Paresis","Neurological Injury",[34,35,36],"Neuromuscular Stimulation","Spinal Cord Stimulation","Physical Medicine and Rehabilitation","RECRUITING","2026-03-09",{"date":40,"type":41},"2026-03-11","ACTUAL",{"date":43,"type":41},"2020-12-02",{"date":45,"type":21},"2028-06-30",{"name":47,"class":48},"Northwell Health","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":49},"100477071","neuropathic-pain-and-operant-conditioning-of-cutaneous-reflexes-after-sci-100477071","NCT05492188","Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI","Targeted Spinal Cord Plasticity for Alleviating SCI-related Neuropathic Pain","Inclusion Criteria:\n\n1. neurologically stable (\\>1 year post SCI)\n2. medical clearance to participate\n3. ability to stand with or without an assistive device for at least 3 minutes at a time\n4. expectation that current medication will be maintained without change for at least 3 months (stable use of anti-spasticity medication is accepted)\n5. For participants with neuropathic pain, the area of neuropathic pain must include lower leg.\n\nExclusion Criteria:\n\n1. motoneuron injury\n2. known cardiac condition\n3. medically unstable condition (incl. pregnancy)\n4. cognitive impairment\n5. uncontrolled peripheral neuropathy\n6. frequent use of electrical spinal stimulation (either transcutaneous or epidural) for pain treatment\n7. daily use of electrical stimulation to the leg\n8. complete lack of cutaneous sensation around foot.",{"count":58,"type":21},15,[60],"NA","The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).",[63,64,32,65],"Spinal Cord Injuries","Neuropathic Pain","Pain",[67],"Neuroplasticity","2025-10-08",{"date":70,"type":41},"2025-10-10",{"date":72,"type":41},"2023-03-27",{"date":74,"type":21},"2026-10-01",{"name":76,"class":48},"Medical University of South Carolina",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},"100446509","operant-conditioning-of-spinal-reflexes-training-system--reflex-operant-down-conditioning-100446509","NCT05094362","Operant Conditioning of Spinal Reflexes Training System--Reflex Operant Down Conditioning","Operant Conditioning of Spinal Reflexes to Enhance Motor Function Recovery After Spinal Cord Injury","Inclusion Criteria:\n\n1. a clinically stable spinal cord injury (above T11) that occurred at least one year previously\n2. the ability to ambulate at least 10 m with or without an assistive device (i.e., walker, crutches, or cane, not parallel bars) within 100 sec (those with 10-meter walking time \\>100 sec are excluded because it is unlikely that they are able to participate in and complete our planned locomotion evaluation procedures)\n3. clinical signs of spasticity in the plantarflexor muscles at least unilaterally (i.e., hyperreactivity to Achilles tendon tap, and increased muscle tone, score \\>1 on Modified Ashworth scale)\n4. spastic hyperreflexia reflected in exaggerated H-reflex\n5. functionally and medically stable for at least 3 months\n6. medical clearance to participate\n7. reasonable expectation that current medications (including antispasticity medication such as baclofen, diazepam, and tizanidine) will not change over the conditioning period. Each participant's medication and dosage will be monitored and recorded throughout the study. Once enrolled, the subject will remain enrolled even if medication changes. (Because only neurologically stable subjects will enter this study, medication changes will be unlikely.)\n\nExclusion Criteria:\n\n1. motoneuron injury;\n2. a cardiac condition (history of myocardial infarct, pacemaker use, etc.)\n3. an unstable medical condition\n4. a pre-existing or confounding neurological condition (e.g., history of Multiple Sclerosis (MS), Traumatic Brain Injury (TBI), Stroke, Parkinson's disease)\n5. a condition that prevents lower extremity mobility testing or weight bearing (e.g. fracture, severe sprain\u002Fstrain, botox muscular injection) (orthotic knee hyperextension is not excluded; in severe cases of knee hyperextension, the brace can be worn during the study sessions)\n6. a cognitive impairment that precludes giving informed consent (e.g., severe intellectual disability)\n7. use of a functional electrical stimulation (FES) foot-drop stimulator or an FES bicycle on a daily basis (FES applied to the arm is acceptable)\n8. deep vein thrombosis within the past 6 months\n9. depression (due to potential interference of anti-depressant medication with the intervention and possible reduced participation reliability)\n10. pregnancy (due to expected changes in weight and posture and potentially unstable medical condition).",{"count":85,"type":21},25,[60],"The purpose of this study is to validate the capacity of a reflex training system to change the size of the targeted reflex. For this, the researchers are recruiting 25 individuals with chronic incomplete SCI who have spasticity in the leg to participate in the reflex training procedure. The study involves approximately 45 visits with a total study duration of about 6 months.",[63,32,30,89],"Spasticity, Muscle",[67,91],"Spinal Reflex","2025-09-05",{"date":94,"type":41},"2025-09-09",{"date":96,"type":41},"2023-08-23",{"date":98,"type":21},"2026-12-31",{"name":76,"class":48},2,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":110,"phases":4,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":120,"locationsCount":49},"100456031","nfl-dynamics-as-a-predictor-factor-in-patients-with-out-of-hospital-cardiac-arrest-100456031","NCT05218278","NFL Dynamics as a Predictor Factor in Patients With Out of Hospital Cardiac Arrest","Dynamics of Light Chain of NFL as a Predictor Factor of Neurological Outcome in Patients With Out of Hospital Cardiac Arrest","Inclusion Criteria:\n\n* out-of-hospital cardiac arrest successfully resuscitated and admitted to the ICU\n\nExclusion Criteria:\n\n* trauma, drowning, electrocution, less than 18 years of age,",{"count":109,"type":21},60,"OBSERVATIONAL","To investigate the pharmacodynamics of light chain of NFL in patients with out-of hospital cardiac arrest after successful resuscitation and determine the difference in the serum levels of NFL in patients with favorable neurological outcome compared to those with non-favorable neurological outcome.",[113,32],"Out-Of-Hospital Cardiac Arrest","2025-03-25",{"date":116,"type":41},"2025-03-30",{"date":118,"type":41},"2022-01-01",{"date":98,"type":21},{"name":121,"class":48},"University Medical Centre Maribor"]