[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neuroma-of-lower-limb\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neuroma-of-lower-limb":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":33,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":51,"leadSponsor":53,"locationsCount":5},"100640278","botulinum-toxin-type-a-versus-local-anesthetic-injection-for-chronic-neuroma-pain-after-combat-related-amputation-100640278",false,"NCT07626983","Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation","Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation: A Multicenter Randomized Double-Blind Trial","NEUROQUIET","Inclusion Criteria:\n\n* Age ≥18 years\n* Combat-related limb amputation\n* Persistent neuroma pain lasting ≥3 months\n* Ultrasound-confirmed neuroma\n* Positive Tinel sign over the neuroma\n* Average pain intensity ≥4\u002F10 on the Numeric Rating Scale (NRS)\n* Stable analgesic regimen for at least 14 days before enrollment\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Active infection at the injection site\n* Previous botulinum toxin injection within 6 months\n* Previous neuroma surgery within 3 months\n* Severe uncontrolled psychiatric disorder\n* Coagulopathy or anticoagulant therapy contraindicating injection\n* Known allergy to botulinum toxin or local anesthetics\n* Severe uncontrolled systemic disease\n* Inability to complete study follow-up or questionnaires","ALL","18 Years","60 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"NA","Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life. Current treatment options often provide only temporary relief. This study aims to compare two ultrasound-guided injection approaches for chronic neuroma pain after combat-related amputation: botulinum toxin type A and local anesthetic injection.\n\nParticipants will be randomly assigned to receive one of the two treatments. Pain intensity, neuropathic pain symptoms, phantom limb pain, prosthesis tolerance, and functional outcomes will be evaluated during follow-up visits over a 24-week period.\n\nThe goal of the study is to determine whether botulinum toxin type A provides longer-lasting pain reduction and improved functional recovery compared with local anesthetic injection in patients with chronic neuroma pain after combat-related amputation.",[28,29,30,31,32],"Chronic Pain Due to Injury","Neuroma of Lower Limb","Neural Injury","Neuroma of Upper Limb","Combat Related Symptoms",[34,35,36,37,38,39,40,41,42,43,44],"Neuroma pain","Combat-related amputation","Botulinum toxin type A","Local anesthetic injection","Ultrasound-guided injection","Phantom limb pain","Residual limb pain","Neuropathic pain","Military trauma","Chronic post-amputation pain","Ultrasound-guided pain intervention","NOT_YET_RECRUITING","2026-05-30",{"date":48,"type":49},"2026-06-04","ACTUAL",{"date":46,"type":22},{"date":52,"type":22},"2026-12-15",{"name":54,"class":55},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":67,"conditions":68,"keywords":69,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100574106","does-rpni-reduce-incidence-of-neuroma-formation-following-sural-nerve-biopsy-100574106","NCT06754969","Does RPNI Reduce Incidence of Neuroma Formation Following Sural Nerve Biopsy","Does RPNI Reduce Incidence of Neuroma Formation Following Sural Nerve Biopsy: a Pilot Study","NBxPilot","Inclusion Criteria:\n\n* Patient 18 years old and older who are referred for sural nerve and muscle biopsy to the University of British Columbia Division of Plastic Surgery from January 2025 onwards for diagnostic or prognostic clarification of a medical condition.\n\nExclusion Criteria:\n\n* Patients with previous nerve trauma (traumatic injury, surgery, or repeat biopsy) of biopsied nerve.",{"count":65,"type":22},20,[25],"The purpose of our project is to determine if incorporating preventative surgical techniques such as regenerative peripheral nerve interfaces (RPNI) into sural nerve biopsy can reduce the incidence of symptomatic neuroma formation. Findings from this study will inform best practice guidelines and can dramatically impact patient care, improve patient quality of life, and reduce the number of required repeat operations.",[29],[70,71,72],"Sural Nerve Biopsy","Regenerative Peripheral Nerve Biopsy","RPNI","2024-12-23",{"date":75,"type":49},"2025-01-01",{"date":77,"type":22},"2025-03",{"date":79,"type":22},"2026-12",{"name":81,"class":55},"University of British Columbia",3]