[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neuromuscular-adaptations\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neuromuscular-adaptations":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,81,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100642043","squat-jump-performance-and-chiropractic-ankle-manipulation-100642043",false,"NCT07641621","Squat Jump Performance and Chiropractic Ankle Manipulation","The Effects of Chiropractic Ankle Manipulation on Athletic Performance of College-Aged Recreational Athletes: Randomized Controlled Trial","Inclusion Criteria\n\n* age range from 18 to 35 years old; and\n* participating in recreational exercise, three times a week for at least 30 minutes. Recreational exercise includes ball sports (e.g. soccer, basketball, volleyball, etc.), racket sports (e.g. tennis, pickle ball, racket ball, etc.), strength\u002Fcombat sports (e.g. weight lifting, boxing, martial arts, kickboxing, etc.), endurance sports (running, cycling, rock climbing, etc.), snow\u002Fice sports (downhill or cross-county skiing, snow shoeing, hockey, etc.), interval training (e.g., high-intensity interval training), sprint interval training, repeated sprint training etc.) or moderate-intensity aerobic activities (step classes, dance classes, hiking, etc.)\n\nExclusion Criteria\n\n* professional or amateur ranked athlete;\n* participation in water sports (swimming, water aerobics, kayaking, water skiing, etc.) to meet the recreational exercise inclusion criteria\n* acute or chronic musculoskeletal injury \u002F condition of the feet, ankles, knees, and\u002For hips;\n* acute or chronic musculoskeletal injury \u002F condition of the spine;\n* pregnancy or there is a possibility of pregnancy.\n* any diagnosed medical condition; and\n* any prescribed medications with the exceptions of birth control, anxiety, or attention-deficit\u002Fhyperactivity disorder (ADHD) medications.",true,"ALL","18 Years","35 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn if chiropractic ankle manipulation can improve squat jump performance. It will also learn about the relationship among chiropractic ankle manipulation, ankle range of motion, and squat jump performance. The main questions it aims to answer are:\n\n* Does chiropractic ankle manipulation increase squat jump height?\n* Is there a relationship among chiropractic ankle manipulation, ankle range of motion, and squat jump performance?\n\nResearchers will compare squat jump performance between subjects who receive chiropractic ankle manipulations with control subjects to see if ankle chiropractic manipulation works to improve squat jump performance.\n\nParticipants will:\n\n* Visit the research laboratory for one testing session to measure ankle range of motion and squat jump performance, before and after their randomly assigned intervention arm\n* Receive either a chiropractic ankle manipulations or rest quietly as the control condition during the testing session.",[28,29,30,31],"Athletic Performance","Neuromuscular Adaptations","Lower Limb","Chiropractic Manipulation",[33,34,35,36,37],"chiropractic","manipulation","ankle","squat jump","athletic performance","RECRUITING","2026-06-14",{"date":41,"type":42},"2026-06-16","ACTUAL",{"date":44,"type":22},"2026-06",{"date":46,"type":22},"2027-05",{"name":48,"class":49},"Northeast College of Health Sciences","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":58,"minAge":18,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":50},"100638371","postpartum-exercise-intervention-100638371","NCT07613333","Postpartum Exercise Intervention","Influence of a Supervised Postpartum Exercise Program on Maternal Physical Activity Levels and Musculoskeletal Health","Inclusion Criteria:\n\n* 18 years of age or older\n* gave birth in the 24 months prior to study enrollment\n\nExclusion Criteria:\n\n* less than 6 weeks postpartum or not medically appropriate to engage in exercise regardless of time since childbirth (will be screened using the Get Active Questionnaire for Postpartum)\n* prescription anti-inflammatory\u002Fpain medications that are taken daily;\n* significant orthopedic conditions that would contraindicate performance of the fatigue task and participation in the exercise intervention (such as fractures, severe scoliosis, etc)\n* moderate to severe cardiovascular \\&\u002For pulmonary disease that contraindicates participation in exercise\n* neuromuscular health conditions (such as diabetes, neuropathy, multiple sclerosis, stroke, seizures, etc);\n* smoking\u002Fvaping or use of other tobacco or nicotine products (chewing tobacco, nicotine patches, nicotine gum, etc.)\n* use of any illegal drugs","FEMALE",{"count":60,"type":22},50,[25],"The postpartum period is associated with decreases in physical activity levels, muscular strength, muscular endurance, and pelvic floor muscle function, but little scientific evidence exists on how best to initiate and progress exercise in the postpartum period. This proposal aims to improve habitual physical activity levels, neuromuscular health (i.e., strength, fatigability, symptom burden) and overall wellbeing (i.e., decreased fear of movement, improved sleep quality, improved perception of quality of life) through participation in a weekly exercise program. This study will help to inform postpartum exercise recommendations and is novel as it allows participants to incorporate their children into the exercise routine, thus removing a primary barrier to physical activity\u002Fexercise.",[64,29,65,66,67],"Postpartum","Abdominal Muscles","Pelvic Floor Dysfunctions","Physical Activity",[69,70,71],"postpartum physical activity","postpartum neuromuscular function","postpartum exercise","2026-05-21",{"date":74,"type":42},"2026-05-29",{"date":76,"type":42},"2026-02-19",{"date":78,"type":22},"2028-08",{"name":80,"class":49},"Carroll University",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":97,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":50},"100631043","comparison-of-the-effects-of-free-weight-and-machine-based-exercises-on-muscular-parameters-100631043","NCT07495540","Comparison of the Effects of Free Weight and Machine-Based Exercises on Muscular Parameters","Comparison of Free Weight and Machine-Based Exercise Effects on Muscular Parameters","Inclusion Criteria:\n\n* Being an individual between the ages of 18-30 years\n* Being physically inactive according to the International Physical Activity Questionnaire short form (\\\u003C600 MET-min\u002Fweek)\n* Residing in Istanbul\n* Voluntary participation in the study.\n\nExclusion Criteria:\n\n* Having a neurological or cardiopulmonary system problem that prevents exercise.\n* Having mental dysfunction.\n* Having an acute musculoskeletal injury which limits exercise participant\n* Being pregnant.\n* Having answered \"YES\" to any question on the Exercise Readiness Questionnaire.","30 Years",{"count":90,"type":22},26,[25],"The aim of our study is to compare and investigate the effects of resistance exercises performed with free weights and those performed using machine systems on muscular parameters and neuromuscular control.",[94,29,95,96],"Resistance Exercise","Muscle","Adult","NOT_YET_RECRUITING","2026-03-21",{"date":100,"type":42},"2026-03-27",{"date":102,"type":22},"2026-03-23",{"date":104,"type":22},"2026-06-01",{"name":106,"class":49},"Biruni University",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":16,"sex":114,"minAge":18,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":123,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":50},"100586199","effects-of-strength-training-on-the-plantar-flexors-properties-after-achilles-tendon-rupture-100586199","NCT06912269","Effects of Strength Training on the Plantar Flexors' Properties After Achilles Tendon Rupture","Effects of Strength Training at Different Intensities on the Plantar Flexors' Functional, Neuromuscular, and Tendon Properties After Achilles Tendon Rupture","Inclusion Criteria:\n\n* Men aged 18 to 64 who have ruptured their Achilles tendon unilaterally no more than 5 years ago;\n* Who are not performing systematic and regular calf strength training.\n\nExclusion Criteria:\n\n* Non-surgical treatment for Achilles tendon rupture;\n* History of postsurgical complications (infection or re-rupture);\n* Presence of any type of ankle injury in the last six month;\n* Participation in a strength training program for plantar flexors in the last six months prior to participation in the study;\n* Having heart failure; autoimmune diseases; and\u002For diabetes;\n* Systematic use of antibiotics or steroids within the last 12 months;\n* Presence of any other clinical contraindication for performing maximum strength tests.","MALE","64 Years",{"count":117,"type":22},67,[25],"Among the injuries that affect the Achilles tendon, rupture is one of the most frequent. This injury can generate functional, neuromuscular, and tendon deficits that can last for long periods or even be permanent. In the long term (i.e., more than a year after the injury), individuals present functional impairments related to the lower limb, deficits in the capacity to produce muscle force, as well as higher levels of muscle activation (as a compensatory response). Such changes may be due to injury adaptations in the plantar flexor muscles' architecture, which may have shorter, more pennate fibers, leading to reduced muscle thickness. Furthermore, the Achilles tendon may be elongated, with a greater cross-sectional area, presenting lower stiffness and quality (i.e., lower Young's modulus). Strength training can play an important role in recovering from Achilles tendon ruptures, as it promotes functional, neuromuscular, and tendon adaptations that can minimize deficits caused by the injury. However, there is a gap in the literature regarding strength training, as well as the dose vs response relationship, regarding functional, neuromuscular, and tendon adaptations after Achilles tendon rupture. Thus, the aim of the present study is to compare the effects of a strength training program of different intensities on plantar flexors' functional, neuromuscular, and tendon outcomes after Achilles tendon rupture. Men aged between 20 and 50 years old who suffered a total unilateral rupture of the Achilles tendon between one and five years after the rupture will be included in the study, as well as healthy men who did not suffer the rupture (control group). Participants who have suffered an Achilles tendon rupture will undergo a progressive lower limb strength training program twice a week for a total duration of 12 weeks, which will be randomized between two groups: low intensity (G55 - 55% of 1-RM) and moderate intensity (G70 - 70% of 1-RM). The following outcomes will be evaluated: a) Achilles tendon's morphological (length and cross-sectional area), mechanical (force-elongation relationship and stiffness) and material (stress-strain relationship and Young's modulus) properties; b) triceps surae muscles' morphological (architecture \\[fascicle length, pennation angle and thickness\\] and quality \\[measured by echointensity and specific tension\\]) properties; c) ankle functionality (maximum height in the heel raise test); d) the plantar flexors' force production capacity (peak and rate of torque development in different joint positions); e) the plantar flexors' muscle voluntary activation; and f) triceps suraes' neuromuscular capacity (i.e., recruitment curves). Assessments will be performed at two times (pre-training; and after 12 weeks of training \\[post-12\\]) through functional tests, ultrasound techniques, isokinetic dynamometry, electromyography, and percutaneous electrical stimulation. An intraclass correlation coefficient will be used to verify the test-retest reproducibility of ultrasound measurements. The Chi-Square test will be used to compare the level of physical activity (pre-training) between the groups. The results of the intervention will be expressed using descriptive statistics (mean, standard deviation, and standard error). The normality and sphericity of the data will be tested using the Shapiro-Wilk and Mauchly tests, respectively. A generalized estimating equation, followed by Bonferroni post-hoc, will be used to compare the effects of groups (G55 and G70) and times (pre-training, Post-6, and Post-12). A one-way ANOVA, followed by a Bonferroni post-hoc, will be used to compare the control group participants' limbs with the healthy and injured limbs from both intervention groups (G55 and G70) in the Pre and Post-12 times. The effect size will be estimated for each outcome. All statistical analyzes will be performed using SPSS software.",[121,122,29],"Achilles Tendon Rupture","Strength Training Adaptations",[124,125,126,127,128],"Neuromuscular plasticity","Stiffness","Functionality","Triceps surae","Calcaneal tendon rupture","2026-01-28",{"date":131,"type":42},"2026-01-30",{"date":133,"type":42},"2024-10-10",{"date":135,"type":22},"2026-08-30",{"name":137,"class":49},"Federal University of Rio Grande do Sul"]