[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neuromuscular-blockade\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neuromuscular-blockade":30},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,49,80,104,129,150,173,197,223,245,268,289,310,333,355,387,408,431,450,471,488,508,530,556,577],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100639092","low-dose-rocuronium-maintenance-during-spine-surgery-with-intraoperative-neurophysiological-monitoring-100639092",false,"NCT07627750","Low-Dose Rocuronium Maintenance During Spine Surgery With Intraoperative Neurophysiological Monitoring","A Randomized Controlled Trial Comparing Low-Dose Rocuronium Maintenance Versus Discontinuation After Induction on Motor Evoked Potential Quality During Spine Surgery With Intraoperative Neurophysiological Monitoring","ROC-IONM","Inclusion Criteria:\n\n\\- 1. Patients aged 18 years or older. 2. Patients scheduled for spine surgery under general anesthesia. 3. Patients undergoing spine surgery with intraoperative neurophysiological monitoring, including motor evoked potentials and\u002For somatosensory evoked potentials.\n\n4\\. Patients who agree to participate in the study and provide written informed consent.\n\nExclusion Criteria:\n\n* 1\\. Pre-existing central or peripheral neurological disease that may affect intraoperative neurophysiological monitoring, such as quadriplegia, persistent sensory disorder, sequelae of stroke, or polyneuropathy.\n\n  2\\. History of epilepsy or electroencephalographic disorder. 3. Use of neuropsychiatric drugs, strong sedatives, or drugs affecting neuromuscular or neurological conduction within 48 hours before surgery.\n\n  4\\. Decompensated cardiovascular disease or severe respiratory disease that may affect emergence or anesthetic drug metabolism.\n\n  5\\. Contraindication to intraoperative neurophysiological monitoring. 6. Contraindication to rocuronium. 7. Refusal to participate or withdrawal of consent at any time..","ALL","18 Years",{"count":21,"type":22},62,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled trial will compare two strategies for rocuronium use during general anesthesia for spine surgery with intraoperative neurophysiological monitoring. Participants undergoing spine surgery under general anesthesia with motor evoked potential and\u002For somatosensory evoked potential monitoring will be randomized to either low-dose rocuronium maintenance targeting a train-of-four ratio of 0.60 to less than 0.90, or no rocuronium maintenance after induction.\n\nThe main objective is to compare the effects of these two strategies on the quality of intraoperative neurophysiological monitoring, especially motor evoked potential signals. Secondary objectives include comparing surgical field conditions, unwanted patient movement, emergence and extubation times, early respiratory events, and new postoperative neurological deficits.\n\nThe study will be conducted at the Center for Anesthesia and Surgical Intensive Care, Bach Mai Hospital, Hanoi, Vietnam. The planned sample size is 62 participants, with 31 participants in each group.",[28,29,30],"Spine Surgery","Intraoperative Neurophysiological Monitoring","Neuromuscular Blockade",[32,33,34,35,28,29,36],"Rocuronium","Motor Evoked Potentials","Somatosensory Evoked Potentials","Train-of-Four Ratio","Total Intravenous Anesthesia","NOT_YET_RECRUITING","2026-05-30",{"date":40,"type":41},"2026-06-04","ACTUAL",{"date":43,"type":22},"2026-06",{"date":45,"type":22},"2028-12",{"name":47,"class":48},"Bach Mai Hospital","OTHER",{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":79},"100515583","pharmacological-reversal-of-neuromuscular-blockade-in-critically-ill-patients-100515583","NCT05993390","Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients","Effect of Neuromuscular Reversal Agents on Time for Neurological Assessment After Endotracheal Intubation in Critically Ill Patients","Inclusion Criteria:\n\n* Adult patients 19 years of age or older who were intubated after admission to the intensive care unit.\n\nExclusion Criteria:\n\n* Patients younger than 19 years of age\n* Patients who are not neurologically evaluable or have concomitant neurologic dysfunction\n* Patients with neuromuscular disorder\n* Patients with a history of drug allergic reactions to sugammadex or neostigmine\n* Patients taking or planning to take toremifene, fusidic acid, or hormonal contraceptives","19 Years","90 Years",{"count":59,"type":22},30,[25],"The goal of this clinical trial is to compare the effect of use of reversal agents for neuromuscular blockade in critically ill patients on time for neurological assessment after endotracheal intubation\n\nThe main questions it aims to answer are:\n\n* The use of reversal agents for neuromuscular blockade after endotracheal intubation may reduce the time for neurological assessment.\n* The types of reversal agents for neuromuscular blockade may affect the time for neurological assessment.\n\nParticipants will receive different reversal agents or no medications based on the assigned groups. Thirty minutes after intubation using rocuronium, medication is administered, and the time of initial confirmation of eye opening and movement is recorded.\n\nResearchers will compare 3 groups (sugammadex, neostigmine and control(no medication) to see the difference of time for neurological assessment after endotracheal intubation.",[30,63,64],"Critical Illness","Neurologic Findings",[66,67,68,69],"Reversal of neuromuscular blockade","Neurologic assessment","Endotracheal intubation","Critically ill patient","RECRUITING",{"date":72,"type":41},"2026-06-02",{"date":74,"type":41},"2024-01-11",{"date":76,"type":22},"2028-04-30",{"name":78,"class":48},"Seoul National University Hospital",1,{"id":81,"slug":82,"hasResults":12,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":12,"sex":18,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":100,"leadSponsor":102,"locationsCount":79},"100638839","effect-of-sarcopenia-and-frailty-on-rocuronium-pharmacodynamics-in-geriatric-patients-100638839","NCT07580144","Effect of Sarcopenia and Frailty on Rocuronium Pharmacodynamics in Geriatric Patients","Inclusion Criteria:\n\n* Scheduled to undergo elective surgery under general anesthesia requiring endotracheal intubation\n* Planned use of rocuronium for neuromuscular blockade\n* Quantitative neuromuscular monitoring planned during anesthesia\n* American Society of Anesthesiologists physical status I-III\n* Ability to provide written informed consent\n* Completion of preoperative frailty and sarcopenia assessment\n\nExclusion Criteria:\n\n* Emergency surgery\n* Known neuromuscular disease\n* History of allergy or contraindication to rocuronium, sugammadex\n* Severe hepatic insufficiency\n* Severe renal insufficiency\n* Use of drugs known to significantly affect neuromuscular transmission\n* Preoperative mechanical ventilation or intensive care unit admission\n* Inability to perform a frailty or sarcopenia assessment\n* Patients in whom quantitative neuromuscular monitoring cannot be properly performed\n* Refusal to participate in the study","65 Years","80 Years",{"count":89,"type":22},100,"OBSERVATIONAL","This prospective observational study aims to evaluate whether sarcopenia and frailty affect the pharmacodynamic profile of rocuronium in geriatric patients undergoing elective surgery under general anesthesia.",[93,94,30,32,95],"Sarcopenia","Frailty","Pharmacodynamics","2026-05-13",{"date":98,"type":41},"2026-05-15",{"date":96,"type":41},{"date":101,"type":22},"2026-08-05",{"name":103,"class":48},"Konya Meram State Hospital",{"id":105,"slug":106,"hasResults":12,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":128},"100627259","phase-2-safety-and-efficacy-of-hrs-9190-compared-to-cisatracurium-for-continuous-intravenous-infusion-in-adults-100627259","NCT07446309","Safety and Efficacy of HRS-9190 Compared to Cisatracurium for Continuous Intravenous Infusion in Adults","A Phase II, Multicenter, Randomized, Double-Blind, Active-Controlled Study to Evaluate the Efficacy and Safety of Continuous Intravenous Infusion of HRS-9190 Versus Cisatracurium for Maintaining Neuromuscular Blockade During General Anesthesia in Adults Undergoing Elective Surgery.","Inclusion Criteria:\n\n1. Able and willing to provide a written informed consent\n2. Subjects requiring elective general anesthesia surgery\n3. Meet specified age and body mass index (BMI) criteria\n4. Conform to the ASA Physical Status Classification\n5. Use of highly effective contraception for a specified period if applicable\n\nExclusion Criteria:\n\n1. Scheduled for specific high-risk surgical procedures\n2. History of significant neuromuscular, cardiovascular, respiratory, or neurological disorders\n3. History of conditions affecting drug metabolism or anesthesia risk\n4. Abnormal laboratory values indicating significant clinical abnormalities\n5. Positive serology for specified infectious diseases\n6. Known hypersensitivity to related medications\n7. Recent use of medications interfering with neuromuscular function\n8. History of mental illness, cognitive impairment, or epilepsy\n9. Participation in another clinical trial within a specified period\n10. Any other condition deemed unsuitable by the investigator\n11. Pregnant or nursing women\n12. Unwilling to use birth control during the specified period","75 Years",{"count":113,"type":22},60,[115],"PHASE2","The study will enroll adult patients scheduled for elective surgery requiring general anesthesia. Participants will be randomly assigned to receive either HRS-9190 for Injection or Cisatracurium. The primary objective is to measure the duration from cessation of the study drug infusion until the recovery of neuromuscular function to a specific level (TOFr ≥ 90%). Secondary objectives include onset time, duration of action, total time of adequate muscle relaxation during surgery, and neuromuscular recovery pattern.. Safety assessments will include monitoring of adverse events, vital signs, laboratory parameters, and other safety indicators throughout the study period. The hypothesis of this study is that HRS-9190 for Injection could provide effective neuromuscular relaxation, with a satisfied safety profile in the target patient population.",[30],"2026-04-22",{"date":120,"type":41},"2026-04-27",{"date":122,"type":22},"2026-04-10",{"date":124,"type":22},"2026-07",{"name":126,"class":127},"Jiangsu HengRui Medicine Co., Ltd.","INDUSTRY",2,{"id":130,"slug":131,"hasResults":12,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":57,"enrollmentInfo":136,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":137,"conditions":138,"keywords":139,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":128},"100487823","comparison-of-an-acceleromyography--and-electromyography-based-neuromuscular-monitor-with-tof-watch--monitor-100487823","NCT05632107","Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor","Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor：a Pilot Study","Inclusion Criteria:\n\n* Age less than 18 yr\n* American Society of Anesthesiologists Physical Status I to III\n* Elective surgery requiring muscle relaxation\n* Patients participated voluntarily and signed informed consent\n\nExclusion Criteria:\n\n* Patients with known neuromuscular disorder\n* Stroke\n* Patients with a history of allergic reaction toneuromuscular blocking agents\n* Use of medications that might interfere with neuromuscular transmission\n* Any previous injury to the examined arm that might influence nerve conduction parameters\n* Pacemaker",{"count":89,"type":22},"A quantitative neuromuscular monitoring device is desirable to titrate the depth of neuromuscular block (NMB) during a procedure, and to prevent residual effects after removal of the endotracheal tube. Unfortunately, the most widely used monitoring technique acceleromyography (AMG) typically implies a series of cumbersome installation and calibration procedures that frequently precludes correct use of these devices in clinical practice. Electromyography (EMG) has recently attracted a lot of attention as an alternative strategy to compensate for the deficiency of AMG-based neuromuscular monitors. Nowadays, a new technology that allows for the simultaneous acquisition of EMG and AMG signals is commercially available. Although its reliability has been rapidly accepted in Physical Medicine and Rehabilitation, the use of the technique in neuromuscular monitoring has never been reported. The aim of the present study is to assess the validity of the new device for estimating the neuromuscular block by comparing with TOF Watch®-SX, which is the most widely accepted AMG-based neuromuscular monitor that has been practiced in the clinical arena for decades.",[30],[140],"neuromuscular blocking agents; residual neuromuscular blockade; neuromuscular monitoring; acceleromyography; electromyography","2026-03-30",{"date":143,"type":41},"2026-04-03",{"date":145,"type":41},"2023-03-01",{"date":147,"type":22},"2027-12",{"name":149,"class":48},"Huazhong University of Science and Technology",{"id":151,"slug":152,"hasResults":12,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":12,"sex":18,"minAge":157,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":23,"phases":160,"briefSummary":161,"conditions":162,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":4},"100626450","tetragraph-to-evaluate-onset-and-recovery-times-of-rocuronium-100626450","NCT07435792","TetraGraph to Evaluate Onset and Recovery Times of Rocuronium","Train-of-four Monitoring Using the TetraGraph Electromyographic Neuromuscular Transmission Monitor to Evaluate Onset and Recovery Times of a Single Bolus Dose of Rocuronium","Inclusion Criteria:\n\n* consenting American Society of Anesthesiologists (ASA) Physical Status 1-4 patients\n* undergoing a surgical procedure with general anesthesia and requiring the administration of rocuronium\n\nExclusion Criteria:\n\n* Patients with history of a progressive or degenerative peripheral neurologic or neuropathic disorder\n* Patients undergoing a surgical procedure in which neuromuscular blockade is not required\n* Edematous patients","1 Month",{"count":159,"type":22},130,[25],"In most clinical instances, direct laryngoscopy and endotracheal intubation is performed after a set time (generally 60 seconds) following the administration of a neuromuscular (NM) blocking agent, rocuronium. Although the average onset time is 60 seconds, clinical studies show a standard deviation around the mean onset time of 10-20 seconds, meaning that a significant number of patients do not achieve complete NM blockade by 60 seconds. Given the above noted variability, complete NM blockade may not be achieved in 60 seconds in a significant percentage of patients, resulting in more problematic direct laryngoscopy and endotracheal intubation. Various studies have shown a higher incidence of perioperative respiratory events and postoperative concerns (sore throat, vocal cord injury) when NM blockade is not complete prior to endotracheal intubation.\n\nThis study aims to use the TetraGraph monitor to clearly identify onset times of rocuronium. Additionally, whenever feasible based on the clinical needs of the case, recovery times after the single dose of rocuronium will be recorded.",[163,30],"Surgery","2026-02-25",{"date":166,"type":41},"2026-02-27",{"date":168,"type":22},"2026-06-01",{"date":170,"type":22},"2029-05-31",{"name":172,"class":48},"Nationwide Children's Hospital",{"id":174,"slug":175,"hasResults":12,"nctId":176,"briefTitle":177,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":179,"sex":18,"minAge":19,"maxAge":87,"enrollmentInfo":180,"targetDuration":4,"studyType":23,"phases":182,"briefSummary":184,"conditions":185,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":79},"100608571","phase-4-risk-of-acute-complications-with-rocuronium-vs-cisatracurium-in-patients-with-chronic-kidney-disease-100608571","NCT07203287","Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease","Inclusion Criteria:\n\n* The subject is able and willing to provide and sign informed consent\n* The subject must be between 18 and 80 years of age\n* The subject should have chronic kidney disease as defined by glomerular filtration rate\n* The surgery must require general anesthesia with endotracheal intubation and neuromuscular blockade\n\nExclusion Criteria:\n\n* Any patient under the age of 18\n* Any patient over the age of 80\n* Any patient with end stage renal disease\n* Any patient requiring dialysis\n* Patients presenting for Renal Transplantation\n* Pregnant Female\n* Any patient in the correctional system\n* Urgent or Emergent procedure\n* The surgery requires intubation post-operatively\n* Documented allergy to Rocuronium, Sugammadex, Cisatracurium or Neostigmine",true,{"count":181,"type":22},490,[183],"PHASE4","The purpose of the study is to determine which combination of neuromuscular blocking agent and reversal agent is safer to use during anesthesia for patients with chronic kidney disease. The main question it aims to answer is\n\n\"The use of Cisatracurium with neostigmine leads to less post-operative pulmonary complications than Rocuronium with sugammadex.\"",[186,30,187],"Post Operative Pulmonary Complications","General Anesthesia","2026-02-19",{"date":190,"type":41},"2026-02-23",{"date":192,"type":41},"2025-08-26",{"date":194,"type":22},"2027-08-26",{"name":196,"class":48},"The University of Texas Medical Branch, Galveston",{"id":198,"slug":199,"hasResults":12,"nctId":200,"briefTitle":201,"officialTitle":202,"acronym":4,"eligibilityCriteria":203,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":86,"enrollmentInfo":204,"targetDuration":206,"studyType":90,"phases":4,"briefSummary":207,"conditions":208,"keywords":210,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":221,"locationsCount":79},"100533001","comparison-of-the-performances-of-the-ctofr-and-the-mtofr-during-reversal-of-deep-neuromuscular-blockade-with-sugammadex-100533001","NCT06220136","Comparison of the Performances of the cTOFR and the mTOFR During Reversal of Deep Neuromuscular Blockade With Sugammadex","Comparison of the Performances of the Train-of-Four Ratio and the Modified Train-of-Four Ratio During Reversal of Deep Neuromuscular Blockade With Sugammadex","Inclusion Criteria:\n\n* Age: 18 - 65 (not including 65)\n* BMI: 18.5-24.9\n\nExclusion Criteria:\n\n* Liver and kidney disease\n* Non-consenting\n* Emergency surgeries\n* Muscle disease\n* Allergy to rocuronium and sugammadex\n* Patients predicted to have difficult mask ventilation or difficult intubation\n* Pregnant and breastfeeding women",{"count":205,"type":22},199,"6 Months","It is known that deep neuromuscular block improves surgical conditions, especially during laparoscopic abdominal surgery. Based on this, in the Perioperative Neuromuscular Blockade Management guide published by the ESAIC association in 2022, it is recommended to deepen the level of neuromuscular blockade in cases where surgical conditions need to be improved. Sugammadex should be used to quickly and reliably reverse deep neuromuscular blockade. TOFScan, a 3-dimensional acceleromyograph for neuromuscular monitoring, has become widely used in recent years. With this monitor, it has been shown that in addition to the classical train-of-four ratio (cTOFR), the modified train-of-four ratio (mTOFR) can be used during the spontaneous recovery of nondepolarizing neuromuscular blockade. In a study conducted by Schmartz et al. in 2021, it was shown that mTOFR, which is the ratio of T4 to the reference stimulus, was compiled later than cTOFR. Therefore, it is suggested that the mTOFR value is a better determinant for safe extubation.",[30,209],"Anesthesia, General",[211,212,213,214],"neuromuscular blockade","neuromuscular junction monitoring","TOFscan","modified TOF ratio","2026-02-11",{"date":217,"type":41},"2026-02-12",{"date":219,"type":41},"2024-06-01",{"date":168,"type":22},{"name":222,"class":48},"Ankara University",{"id":224,"slug":225,"hasResults":12,"nctId":226,"briefTitle":227,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":111,"enrollmentInfo":229,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":231,"conditions":232,"keywords":233,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":79},"100558593","median-versus-ulnar-nerve-quantitative-electromyography-neuromuscular-blockade-monitoring-comparison-100558593","NCT06553131","Median Versus Ulnar Nerve Quantitative Electromyography Neuromuscular Blockade Monitoring Comparison","Inclusion Criteria:\n\n* Adults 18 - 75 years of age who are able to provide consent\n* Scheduled for elective surgery requiring muscle relaxation, in a supine position under general anesthesia, with an anticipated duration of at least 1.5 hours\n\nExclusion Criteria:\n\n* Contraindication to rocuronium use\n* Comorbidities that may prolong the duration of neuromuscular blockade or alter pharmacodynamics and\u002For pharmacokinetics, such as:\n* Neuromuscular disease\n* Expected or known difficult airway\n* Rocuronium allergy\n* BMI \\\u003C 18.5 or \\> 40\n* History of adhesive allergy\n* Upper extremity weakness, limb deformity, or absence of all or part of an upper limb\n* Patients undergoing surgical procedures requiring cardiopulmonary bypass",{"count":230,"type":22},32,"Medications used to relax the muscles are used during surgery. The amount of muscle relaxation can monitored with devices that stimulate a specific nerve and evaluate the muscle response. The response to, and recovery from, medications that relax the muscles are best described for a nerve in the arm called the ulnar nerve. The investigators believe that other nerves in the arm, such as the median nerve, could be used to monitor the amount of muscle relaxation. The purpose of this study is to compare the muscle response at two different nerve sites after giving medications to relax the muscles.\n\nThis study is going to measure the depth of muscle relaxation during surgery at two different sites. The muscle response to stimulation of the ulnar nerve (located in the arm) will be compared to the muscle response to stimulation of the median nerve (also located in the arm).",[30],[234,30,235],"Median Nerve","Ulnar Nerve","2026-01-28",{"date":238,"type":41},"2026-01-30",{"date":240,"type":41},"2024-12-26",{"date":242,"type":22},"2026-12",{"name":244,"class":48},"Loma Linda University",{"id":246,"slug":247,"hasResults":12,"nctId":248,"briefTitle":249,"officialTitle":249,"acronym":250,"eligibilityCriteria":251,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":252,"targetDuration":4,"studyType":23,"phases":254,"briefSummary":255,"conditions":256,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":79},"100402770","partial-neuromuscular-blockade-in-acute-hypoxemic-respiratory-failure-100402770","NCT04524585","Partial Neuromuscular Blockade in Acute Hypoxemic Respiratory Failure","PNEUMA","Inclusion Criteria:\n\nPatients supported on invasive mechanical ventilation for moderate to severe AHRF (PaO2\u002FFiO2 \\\u003C 150 mm Hg or FiO2 ≥ 60% with an SpO2 ≤ 97% or receiving venovenous extracorporeal membrane oxygenation)\n\nExclusion Criteria:\n\n1. Contraindication to neuromuscular blockade (allergy, history of malignant hyperthermia)\n2. Contraindication to ulnar nerve stimulation (bilateral peripheral neuropathy, skin burns on both wrists)\n3. Previous history of a formally diagnosed neuromuscular disorder",{"count":253,"type":22},23,[25],"PNEUMA is a preliminary safety and feasibility trial of a novel approach to the titration of neuromuscular blockade (NMB) to safe spontaneous breathing in patients with moderate to severe acute hypoxemic respiratory failure (AHRF) supported with invasive mechanical ventilation.",[257,30,258],"Respiratory Insufficiency","Mechanical Ventilation","2025-12-30",{"date":261,"type":41},"2026-01-06",{"date":263,"type":41},"2020-10-01",{"date":265,"type":22},"2027-03-01",{"name":267,"class":48},"University Health Network, Toronto",{"id":269,"slug":270,"hasResults":12,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":179,"sex":18,"minAge":206,"maxAge":275,"enrollmentInfo":276,"targetDuration":4,"studyType":23,"phases":278,"briefSummary":279,"conditions":280,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":79},"100547537","neuromuscular-monitoring-in-children-6-months---2-years-with-electromyography-and-acceleromyography-100547537","NCT06409260","Neuromuscular Monitoring in Children (6 Months - 2 Years) With Electromyography and Acceleromyography","Objective Neuromuscular Monitoring in Children (6 Months - 2 Years) With Electromyography and Acceleromyography: A Randomized Study","Inclusion Criteria:\n\n* Patients 6 months - 2 years of age\n* Scheduled for elective surgery under general anaesthesia with intubation and use of rocuronium\n* American Society of Anesthesiologists (ASA) physical status classification I to III\n\nExclusion Criteria:\n\n* Known allergy to rocuronium\n* Neuromuscular disease that may interfere with neuromuscular data\n* Indication for rapid sequence induction\n* Prone position","2 Years",{"count":277,"type":22},120,[25],"The aim of this study is to compare AMG and EMG (Philips IntelliVue NMT module and Senzime TetraGraph) in the objective monitoring of neuromuscular blocking in children between the age of 6 months and 2 years.The monitoring will be done bilaterally either on n.ulnaris or n. tibialis. The hypothesis of the study is that AMG will indicate faster recovery time (time to return to TOF 90%) from neuromuscular block than EMG.",[30],"2025-08-19",{"date":192,"type":41},{"date":284,"type":41},"2024-07-01",{"date":286,"type":22},"2025-10-01",{"name":288,"class":48},"Matias Vested",{"id":290,"slug":291,"hasResults":12,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":296,"enrollmentInfo":297,"targetDuration":4,"studyType":23,"phases":298,"briefSummary":299,"conditions":300,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":308,"locationsCount":4},"100424595","lia-vs-lia--acb-ipack-block-for-total-knee-arthroplasty-100424595","NCT04808947","LIA vs. LIA + ACB-iPACK Block for Total Knee Arthroplasty","The Ideal Analgesic Technique for Total Knee Arthroplasty: A Randomized Comparison Between Local Infiltration Analgesia Alone or Combined With Adductor Canal and iPACK Blocks","Inclusion Criteria:\n\n1. ASA classification I-III\n2. BMI \\\u003C 35 kg\u002Fm2\n3. Having elective unilateral total knee arthroplasty\n\nExclusion Criteria:\n\n1. Bilateral knee surgery.\n2. Pre-existing neurological deficit or peripheral neuropathy in the lower the lower limbs\n3. Severe, poorly controlled cardiac conditions, significant arrhythmias, severe valvular heart diseases\n4. Severe, poorly controlled respiratory conditions (severe COPD, severe interstitial lung disease, severe \u002F poorly controlled asthma)\n5. Contraindication to regional anesthesia (e.g. bleeding diathesis, coagulopathy, sepsis, infection at the site of potential needle puncture on the posterior chest)\n6. Patient refusal\n7. Chronic pain disorder\n8. Chronic opioid use (≥30 mg oxycodone \u002F day)\n9. Contraindication (or allergy) to a component of multi-modal analgesia protocol\n10. Allergy to amide local anesthetics used in nerve blocks\n11. Contraindications to spinal anesthesia\n12. Significant psychiatric disorder that would preclude objective study assessment\n13. Pregnancy\n14. Inability to provide informed consent","85 Years",{"count":113,"type":22},[25],"LIA is the mainstay of postoperative analgesia in patients having knee arthroplasty. The combination of ACB-iPACK blocks has also been proposed as an effective analgesic modality for total knee arthroplasty. However, whether combining these two modalities yields any important incremental analgesic benefit remains unclear. The investigators hypothesized that the addition of ACB and iPACK blocks to LIA will yield clinically important analgesic benefits compared to LIA alone in patients having total knee arthroplasty.",[301,30],"Nerve Block","2025-07-14",{"date":304,"type":41},"2025-07-16",{"date":306,"type":22},"2027-01",{"date":45,"type":22},{"name":309,"class":48},"Women's College Hospital",{"id":311,"slug":312,"hasResults":12,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":4,"eligibilityCriteria":316,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":86,"enrollmentInfo":317,"targetDuration":4,"studyType":23,"phases":318,"briefSummary":319,"conditions":320,"keywords":323,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":328,"startDateStruct":329,"completionDateStruct":330,"leadSponsor":332,"locationsCount":79},"100360872","erector-spinae-block-vs-placebo-block-study-100360872","NCT03978780","Erector Spinae Block vs. Placebo Block Study","Quality of Recovery Scores Following Erector Spinae Block vs. Sham Block in Ambulatory Breast Cancer Surgery: A Randomised Controlled Trial","Inclusion Criteria:\n\n* ASA classification: I-III\n* BMI \\\u003C 35 kg\u002Fm2\n* Day surgery procedure\n\nExclusion Criteria:\n\n* Prior ipsilateral breast surgery, excluding lumpectomy\n* Pre-existing neurological deficit or peripheral neuropathy involving the ipsilateral chest\n* Severe, poorly controlled cardiac conditions, significant arrhythmias, severe valvular heart diseases\n* Severe, poorly controlled respiratory conditions (severe COPD, severe interstitial lung disease, severe \u002F poorly controlled asthma)\n* Contraindication to regional anaesthesia (e.g. bleeding diathesis, coagulopathy, sepsis, infection at the site of potential needle puncture on the posterior chest)\n* Patient refusal\n* Chronic pain disorder\n* Chronic opioid use (≥30 mg oxycodone \u002F day)\n* Contraindication (or allergy) to a component of multi-modal analgesia protocol\n* Allergy to amide local anaesthetics used in nerve blocks\n* Contraindications to any of the components of the standardized general anaesthesia\n* Significant psychiatric disorder that would preclude objective study assessment\n* Pregnancy\u002F women with nursing infants\n* Unable to provide informed consent\n* Unable to speak and read English",{"count":113,"type":22},[25],"Regional anaesthesia combined with general anaesthesia has become common in the perioperative management of breast cancer surgery patients. Regional techniques have been recognised to provide excellent post-operative analgesia. It enhances multi-modal analgesia regimes while being opioid sparing, reducing incidence of post-operative nausea and vomiting and allowing earlier mobilisation\u002Fdischarge and improving treatment success. Therefore identifying the correct regional anaesthetic technique for this group of patients is important in providing optimum peri-operative care.",[321,301,322,30],"Breast Cancer","Regional Anesthesia",[324,325,326,327],"Spinae fascial plane block","Breast surgery","interfascial plane block","erector spinae block",{"date":304,"type":41},{"date":43,"type":22},{"date":331,"type":22},"2028-01",{"name":309,"class":48},{"id":334,"slug":335,"hasResults":12,"nctId":336,"briefTitle":337,"officialTitle":338,"acronym":4,"eligibilityCriteria":339,"healthyVolunteers":12,"sex":18,"minAge":340,"maxAge":341,"enrollmentInfo":342,"targetDuration":4,"studyType":23,"phases":344,"briefSummary":345,"conditions":346,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":350,"completionDateStruct":352,"leadSponsor":354,"locationsCount":79},"100568311","deep-neuromuscular-blockade-on-postoperative-pain-100568311","NCT06679569","Deep Neuromuscular Blockade on Postoperative Pain","Effect of Deep Neuromuscular Blockade on Postoperative Pain in Pediatric Patients Undergoing Laparoscopic Surgery: a Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Pediatric patients aged over 2 months to under 7 years scheduled for laparoscopic surgery under general anesthesia.\n* American Society of Anesthesiologists (ASA) Physical Status Classification I, II, or III.\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery.\n* Patients with chronic pain or currently taking analgesics for chronic pain.\n* Known hypersensitivity to general anesthetic agents or analgesics.\n* Patients with underlying cardiovascular disease.\n* Patients with neuromuscular disorders.\n* Any other condition that, in the investigator's judgment, would make the patient unsuitable for participation in the study.","2 Months","7 Years",{"count":343,"type":22},106,[25],"This study aims to investigate the impact of varying degrees of neuromuscular blockade on postoperative pain in pediatric patients aged over 2 months to under 7 years undergoing laparoscopic surgery under general anesthesia.",[30],"2025-05-11",{"date":349,"type":41},"2025-05-13",{"date":351,"type":41},"2024-11-06",{"date":353,"type":22},"2026-11-07",{"name":78,"class":48},{"id":356,"slug":357,"hasResults":12,"nctId":358,"briefTitle":359,"officialTitle":360,"acronym":361,"eligibilityCriteria":362,"healthyVolunteers":12,"sex":363,"minAge":19,"maxAge":4,"enrollmentInfo":364,"targetDuration":4,"studyType":23,"phases":366,"briefSummary":367,"conditions":368,"keywords":372,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":385,"locationsCount":79},"100532684","incidence-of-residual-neuromuscular-blockade-in-fraility-in-oncogynae-surgery-100532684","NCT06216002","Incidence of Residual Neuromuscular Blockade in Fraility in OncoGynae Surgery","Incidence of Residual Neuromuscular Blockade in Patients With Frailty Undergoing Gynecologic Cancer Surgery","FIGO","Inclusion Criteria:\n\n* Age \\>,= 18 years\n* Patients undergoing elective gynecologic-oncology surgery\n\nExclusion Criteria:\n\n* Unable to communicate Thai\n* Unable to understand the questionnaire\n* Preexisting neuromuscular disease\n* Preexisting disease involved wrist that may affect the nerve stimulator examination","FEMALE",{"count":365,"type":22},622,[25],"Frailty among patients undergoing surgery is strongly associated with an elevated risk of adverse perioperative outcomes, heightened incidence of postoperative complications, increased mortality rates, and prolonged hospital length of stay. Our focus centers on investigating the frailty index in the context of complications experienced by patients undergoing oncologic gynecology surgery. The principal objective of this research is to elucidate the extent to which residual neuromuscular blocking agents are linked to frailty.",[94,30,369,370,371],"General Anesthetic Drug Adverse Reaction","Gynecologic Cancer","Surgical Complication",[373,374,375,376,377],"neuromuscular blocking agents","frailty","gynecologic oncology","surgery","anesthetic complications","2025-05-07",{"date":380,"type":41},"2025-05-08",{"date":382,"type":41},"2024-01-02",{"date":384,"type":22},"2025-12-31",{"name":386,"class":48},"Mahidol University",{"id":388,"slug":389,"hasResults":12,"nctId":390,"briefTitle":391,"officialTitle":392,"acronym":4,"eligibilityCriteria":393,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":111,"enrollmentInfo":394,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":396,"conditions":397,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":404,"leadSponsor":406,"locationsCount":4},"100580244","evaluation-of-neuromuscular-blockade-responses-in-statin-using-and-non-using-patients-100580244","NCT06834776","Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients","Evaluation of Neuromuscular Blockade Responses in Statin-Using and Non-Using Patients Undergoing Elective Surgery Under General Anesthesia, Monitored by Train-of-Four (TOF)","Inclusion Criteria:\n\n* Age 18-75 years\n* ASA classification I, II, III\n* BMI 18-30\n* Statin use for at least 3 months or no prior statin use\n* Elective surgery requiring general anesthesia with endotracheal intubation\n* Signed informed consent for participation in the study\n\nExclusion Criteria:\n\n* ASA classification IV or higher\n* BMI \\\u003C18 or \\>30\n* History of liver or renal insufficiency (creatinine \\>1.6, liver function tests \\>2x normal)\n* Neuromuscular, psychiatric, or neurological disorders\n* Pregnancy\n* Use of drugs affecting neuromuscular function (e.g., anticonvulsants, aminoglycosides)\n* History of malignant hyperthermia\n* Respiratory disorders, including sleep apnea\n* Allergy to anesthetic drugs used in the study",{"count":395,"type":22},104,"This study aims to compare the neuromuscular blockade responses in patients undergoing elective surgery under general anesthesia, with a focus on the use of statins. The study will assess the depth of neuromuscular blockade, recovery time, and postoperative residual curarization using Train-of-Four (TOF) monitoring, with the primary goal of determining whether statin use alters the neuromuscular blockade management.",[30,398,399],"Statin-Associated Myopathy","Neuromuscular Monitoring","2025-02-15",{"date":402,"type":41},"2025-02-19",{"date":400,"type":22},{"date":405,"type":22},"2025-12-15",{"name":407,"class":48},"Ankara City Hospital Bilkent",{"id":409,"slug":410,"hasResults":12,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":4,"eligibilityCriteria":414,"healthyVolunteers":179,"sex":18,"minAge":56,"maxAge":111,"enrollmentInfo":415,"targetDuration":4,"studyType":23,"phases":417,"briefSummary":418,"conditions":419,"keywords":420,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":424,"lastUpdatePostDateStruct":425,"startDateStruct":427,"completionDateStruct":428,"leadSponsor":429,"locationsCount":79},"100541799","the-clinical-effect-of-sugammadex-sodium-domestic-for-antagonizing-neuromuscular-blockade-after-thoracic-surgery-100541799","NCT06334562","The Clinical Effect of Sugammadex Sodium (Domestic) for Antagonizing Neuromuscular Blockade After Thoracic Surgery","An Observational Study on the Clinical Effect of Sugammadex Sodium (Domestic) for Antagonizing Neuromuscular Blockade After Thoracic Surgery","Inclusion Criteria:\n\n1. Patients who undergo elective lung surgery under general anesthesia and require endotracheal intubation;\n2. Age\\>18 years old, gender not limited;\n3. American Society of Anesthesiologists ASA Level I-III;\n4. Use rocuronium bromide for neuromuscular blockade;\n5. The patient voluntarily participated in the trial.\n\nExclusion Criteria:\n\n1. The patient explicitly refused to participate in this trial;\n2. Family history of malignant hyperthermia, patients with allergies to sodium sulbactam, neostigmine ingredients and their excipients, and patients with allergies to drugs used during general anesthesia;\n3. Patients with tracheal malformations or suspected difficult airways, coagulation dysfunction, severe liver and kidney dysfunction, and severe lung disease;\n4. Patients who are not extubated and sent to the ward or ICU after surgery;\n5. The researchers believe that patients with any other unfavorable factors to participate in this trial.",{"count":416,"type":22},80,[25],"This study aims to compare the use of sugammadex (domestic) and neostigmine for antagonism after thoracic surgery, and observe the effect of sugammadex (domestic) on neuromuscular blockade antagonism after thoracic surgery, in order to provide a basis for optimizing the use of muscle relaxants and their antagonists during anesthesia.",[30],[421,422,423],"Sugammadex Sodium","Postoperative Neuromuscular Block Antagonism","thoracic surgery","2025-02-14",{"date":426,"type":41},"2025-02-17",{"date":219,"type":41},{"date":384,"type":22},{"name":430,"class":48},"The Fourth Affiliated Hospital of Zhejiang University School of Medicine",{"id":432,"slug":433,"hasResults":12,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":12,"sex":18,"minAge":87,"maxAge":4,"enrollmentInfo":438,"targetDuration":4,"studyType":23,"phases":439,"briefSummary":440,"conditions":441,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":442,"lastUpdatePostDateStruct":443,"startDateStruct":445,"completionDateStruct":447,"leadSponsor":449,"locationsCount":128},"100568471","phase-4-ephedrine-for-reducing-onset-time-of-rocurinium-in-elderly-patients-100568471","NCT06681662","Ephedrine for Reducing Onset Time of Rocurinium in Elderly Patients","A Blinded Randomized Study of Ephedrine 0.15 Mg\u002Fkg for Reducing Onset Time of Rocuronium 0.6 Mg\u002Fkg in Elderly Patients (≥ 80 Years)","Inclusion Criteria:\n\n* Age ≥ 80\n* Scheduled for elective operations under general anesthesia with intubation\n* American Society of Anesthesiologists physical status classification (ASA) I to III\n* Informed consent\n* Read and understand Danish\n\nExclusion Criteria:\n\n* Known allergy to rocuronium or ephedrine\n* Neuromuscular disease that may interfere with neuromuscular data\n* Indication for rapid sequence induction\n* Daily use of beta-blocking agents\n* Known cardiac arrythmia (atrial fibrillation, supraventricular or ventricular)",{"count":416,"type":22},[183],"The aim of this study is to determine the onset time of rocuronium after administration of ephedrine 0.15 mg\u002Fkg in patients with age ≥ 80 years. The hypothesis of this study is that ephedrine 0.15 mg\u002Fkg provides a shorter onset time compared to placebo (saline).",[30],"2025-01-15",{"date":444,"type":41},"2025-01-17",{"date":446,"type":41},"2025-01-13",{"date":448,"type":22},"2025-12",{"name":288,"class":48},{"id":451,"slug":452,"hasResults":12,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":4,"eligibilityCriteria":456,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":87,"enrollmentInfo":457,"targetDuration":459,"studyType":90,"phases":4,"briefSummary":460,"conditions":461,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":462,"lastUpdatePostDateStruct":463,"startDateStruct":465,"completionDateStruct":467,"leadSponsor":469,"locationsCount":79},"100575257","abdominal-muscle-volume-and-a-neuromuscular-blocking-agent-100575257","NCT06769932","Abdominal Muscle Volume and a Neuromuscular Blocking Agent","Relationship Between Muscle Mass in Preoperative Computed Tomography and a Neuromuscular Blocking Agent Dose Required for Maintaining Deep Neuromuscular Blockage: a Prospective Observational Study.","Inclusion Criteria:\n\n* Those who voluntarily agreed and signed the written consent form before participating in the study\n* American Society of Anesthesiologists physical class (ASA class) 1-3\n* Patients scheduled for elective colon surgery under general anesthesia\n* Patients undergoing abdominal computed tomography for routine preoperative preparation\n\nExclusion Criteria:\n\n* Pregnant women\n* Decreased renal function (GFR\\\u003C60mL\u002Fmin\u002F1.73m2).\n* Patients taking drugs that affect deep neuromuscular blockade\n* Patients with a history of neuromuscular and muscle disorders",{"count":458,"type":22},90,"1 Day","With the recent development of image analysis and artificial intelligence, it has become possible to measure the muscle volume from preoperative computed tomography (CT) images. Therefore, in this study, the investigators quantify the muscle volume from preoperative CT images and analyze the correlation with the dose of neuromuscular blocking agent, rocuronium, required for maintaining deep neuromuscular blockade.",[30],"2025-01-06",{"date":464,"type":41},"2025-01-10",{"date":466,"type":22},"2025-01-07",{"date":468,"type":22},"2027-01-07",{"name":470,"class":48},"Seoul National University Bundang Hospital",{"id":472,"slug":473,"hasResults":12,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":4,"eligibilityCriteria":456,"healthyVolunteers":12,"sex":18,"minAge":56,"maxAge":87,"enrollmentInfo":477,"targetDuration":459,"studyType":90,"phases":4,"briefSummary":478,"conditions":479,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":480,"lastUpdatePostDateStruct":481,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":487,"locationsCount":4},"100573023","skeletal-muscle-index-and-a-neuromuscular-blocking-agent-100573023","NCT06740877","Skeletal Muscle Index and a Neuromuscular Blocking Agent","Relationship Between Skeletal Muscle Index in Preoperative Computed Tomography and a Neuromuscular Blocking Agent Dose Required for Maintaining Deep Neuromuscular Blockage: a Prospective Observational Study.",{"count":458,"type":22},"With the recent development of image analysis, it has become possible to measure the skeletal muscle index representing the subject's muscle mass from preoperative computed tomography (CT) images. Therefore, in this study, the investigators quantify the skeletal muscle index from preoperative CT images and analyze the correlation with the dose of neuromuscular blocking agent, rocuronium, required for maintaining deep neuromuscular blockade.",[30],"2024-12-13",{"date":482,"type":41},"2024-12-18",{"date":484,"type":22},"2024-12-25",{"date":486,"type":22},"2026-12-25",{"name":470,"class":48},{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":4,"eligibilityCriteria":494,"healthyVolunteers":179,"sex":18,"minAge":275,"maxAge":19,"enrollmentInfo":495,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":497,"conditions":498,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":507,"locationsCount":79},"100502326","high-dimensional-analysis-of-immune-cells-in-pediatric-patients-100502326","NCT05820802","High Dimensional Analysis of Immune Cells in Pediatric Patients","High Dimensional Analysis of Immune Cells Using scRNA-seq in Pediatric Patients With Allergic Reactions to Neuromuscular Blockers","Inclusion Criteria:\n\n* Pediatric patients between the ages of 2 and 18 undergoing general anesthesia and surgery using the neuromuscular blocker, rocuronium.\n\nExclusion Criteria:\n\n* Patients who have received immunomodulators, immunosuppressants, etc.\n* Patients with autoimmune diseases (rheumatoid arthritis, lupus, Behcet's disease, etc.)\n* Patients who regularly take, or have taken within 4 weeks, medications that may affect the immune system (oral steroids, anti-inflammatories, etc.)\n* Other cases where the Principal Investigator determines that it is difficult to conduct the study.",{"count":496,"type":22},294,"The purpose of this study is to characterize immune cells using single-cell transcriptomic analysis in pediatric patients aged 2 to 18 years undergoing general anesthesia who are expected to receive Rocuronium, a non-depolarizing neuromuscular blocking agent, in the event of an allergic reaction.",[499,30],"Drug Allergy","2024-11-26",{"date":502,"type":41},"2024-11-29",{"date":504,"type":41},"2023-04-27",{"date":506,"type":22},"2026-12-01",{"name":78,"class":48},{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":512,"acronym":4,"eligibilityCriteria":513,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":514,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":516,"conditions":517,"keywords":519,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":521,"lastUpdatePostDateStruct":522,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":528,"locationsCount":128},"100569204","comparison-of-adductor-pollicis-and-abductor-digiti-minimi-muscles-thumb-vs-fifth-digit-as-sites-for-neuromuscular-monitoring-with-electromyography-100569204","NCT06691204","Comparison of Adductor Pollicis and Abductor Digiti Minimi Muscles (Thumb Vs. Fifth Digit) As Sites for Neuromuscular Monitoring with Electromyography","Inclusion Criteria:\n\n* Age \\> or = 18 years old\n* Patients willing to participate and provide an informed consent\n* Patients undergoing elective surgical procedures that require use of NMBA agents (rocuronium) administered intraoperatively.\n\nExclusion Criteria:\n\n* Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury.\n* Patients with systemic neuromuscular diseases such as myasthenia gravis.\n* Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents, i.e., severe renal impairment or end-stage liver disease.\n* Patients having surgery that would involve prepping the arm into the sterile field.\n* Patients receiving a rapid sequence induction.\n* Patients allergic to rocuronium or sugammadex.",{"count":515,"type":22},46,"This study aims to evaluate the performance of the TetraGraph on two muscle groups: the adductor pollicis and the abductor digiti minimi. Theese muscles are located on the arms. Key time points for assessment will include the onset of neuromuscular blockade and the recovery from rocuronium blockade using sugammadex.",[518,30],"Postoperative Residual Curarization",[520],"Electromyography","2024-11-13",{"date":523,"type":41},"2024-11-15",{"date":525,"type":41},"2024-10-18",{"date":527,"type":22},"2026-05-31",{"name":529,"class":48},"Tamas Vegh, MD",{"id":531,"slug":532,"hasResults":12,"nctId":533,"briefTitle":534,"officialTitle":535,"acronym":4,"eligibilityCriteria":536,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":537,"enrollmentInfo":538,"targetDuration":4,"studyType":23,"phases":540,"briefSummary":541,"conditions":542,"keywords":543,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":547,"lastUpdatePostDateStruct":548,"startDateStruct":550,"completionDateStruct":552,"leadSponsor":554,"locationsCount":79},"100560276","phase-2-sugammadex-dose-finding-under-two-years-old-100560276","NCT06575036","Sugammadex Dose Finding Under Two Years Old","Reversal of Rocuronium-induced Neuromuscular Blockade by Sugammadex in Children Younger Than 2 Years Old: a Prospective Dose Finding Study","Inclusion Criteria:\n\n* Childern younger than 2 years old who are scheduled to undergo surgery under general anesthesia\n* American Society of Anesthesiologists Physical Status 1 or 2\n\nExclusion Criteria:\n\n* History of hypersensitivity to rocuronium or any anesthetics\n* Presence of cardiovascular or genitourinary disease\n* Presence of severe renal dysfunction or in need of dialysis\n* Presence of severe hepatic dysfunction or coagualtion disorder\n* Current state of administration of neuromuscular blocking agent on admission to operating room\n* Concurrent use of any medications that affect the activity of neuromuscular blocking agents\n* History of malignant hyperthermia\n* Refusal to enroll in the study by one or more parents\n* Presence of any other reasons that investigator regards inappropriate to enroll in the study.","23 Months",{"count":539,"type":22},33,[115],"This is a prospective dose-finding study of sugammadex for conventional reversal of rocuronium-induced neuromuscular blockade in children under two years of age. This study will explore 50% effective dose and 95% effective dose of sugammadex for reversal of neuromuscular blockade in less than two minutes under biased coin up-and-down method.",[30],[544,545,546],"Sugammadex","Children","Dose-finding study","2024-08-27",{"date":549,"type":41},"2024-08-29",{"date":551,"type":22},"2024-09-15",{"date":553,"type":22},"2025-05-31",{"name":555,"class":48},"Sang-Hwan Ji",{"id":557,"slug":558,"hasResults":12,"nctId":559,"briefTitle":560,"officialTitle":561,"acronym":4,"eligibilityCriteria":562,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":86,"enrollmentInfo":563,"targetDuration":4,"studyType":23,"phases":565,"briefSummary":566,"conditions":567,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":568,"lastUpdatePostDateStruct":569,"startDateStruct":571,"completionDateStruct":573,"leadSponsor":575,"locationsCount":4},"100558588","deep-versus-moderate-neuromuscular-blockade-in-bariatric-surgery-100558588","NCT06553066","Deep Versus Moderate Neuromuscular Blockade in Bariatric Surgery","Deep Versus Moderate Neuromuscular Blockade in Bariatric Surgery:","Inclusion Criteria:\n\n* Patients aged ≥18 years ASA II-III who are to undergo planned laparoscopic bariatric surgery\n\nExclusion Criteria:\n\n* ASA 4 patients\n* Maternal population\n* Patients who are not scheduled to receive general anesthesia, but some other type of anesthesia.\n* Contraindicated patients: administration of neuromuscular blockade, suppression of spontaneous respiration, and those with an indication for awake intubation or surgical airway.\n* Patients with neuromuscular diseases\n* Patients who refuse to participate in the study.",{"count":564,"type":22},50,[25],"The aim of this study is to investigate the effect of depth of neuromuscular blockade on the surgical field, patient postoperative pain, intestinal motility, the incidence of postoperative nausea and vomiting and the effect of deep versus moderate neuromuscular blockade on postoperative atelectasis quantitatively using chest computed tomography.This is a prospective, randomized, controlled clinical-controlled study in patients ≥18 years old scheduled to undergo elective bariatric surgery.",[30],"2024-08-10",{"date":570,"type":41},"2024-08-14",{"date":572,"type":22},"2024-08",{"date":574,"type":22},"2026-08",{"name":576,"class":48},"University Hospital of Patras",{"id":578,"slug":579,"hasResults":12,"nctId":580,"briefTitle":581,"officialTitle":582,"acronym":4,"eligibilityCriteria":583,"healthyVolunteers":12,"sex":363,"minAge":19,"maxAge":86,"enrollmentInfo":584,"targetDuration":4,"studyType":23,"phases":586,"briefSummary":587,"conditions":588,"keywords":590,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":594,"lastUpdatePostDateStruct":595,"startDateStruct":597,"completionDateStruct":599,"leadSponsor":601,"locationsCount":79},"100552190","deep-neuromuscular-block-affect-the-quality-of-recovery-after-laparoscopic-hysterectomy-100552190","NCT06469866","Deep Neuromuscular Block Affect the Quality of Recovery After Laparoscopic Hysterectomy","Effect of Deep Neuromuscular Block on the Quality of Recovery After Laparoscopic Hysterectomy","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status Ⅰ- Ⅲ\n* Scheduled for elective laparoscopic hysterectomy\n\nExclusion Criteria:\n\n* Inability to give informed consent\n* BMI \\>35\n* Renal or hepatic insufficiency\n* History of preoperative psychiatric\n* Previous surgery at procedure site\n* Neuromuscular disease, pregnancy, and contraindications to study medications.",{"count":585,"type":22},72,[25],"BACKGROUND: Some studies have revealed that deep neuromuscular block (NMB) improve surgical conditions and alleviated postoperative pain compared with moderate NMB. The present study investigated deep NMB could improve the quality of recovery after laparoscopic hysterectomy\n\nMETHODS: seventy-two women with elective laparoscopic hysterectomy were randomly divided into 2 groups: Patients in group A received low-pressure pneumoperitoneum (LPP), which was set at 8-10 mmHg with deep NMB. Patients in group B received standard-pressure pneumoperitoneum (SPP), which was set at 12-14 mmHg with moderate NMB. Primary outcome was the quality of recovery (QoR-15) at 1 day after sugery. The secondary outcomes included postoperative pain, surgical condition, incidence of shoulder pain, the incidence of rescue analgesic drug use, cumulative dose of analgesics, time of first flatus, post-operative nausea and vomiting, time of tracheal tube removal.",[30,589],"Laparoscopy",[591,592,593],"Neuromuscular block","Recovery","Laparoscopic hysterectomy","2024-06-19",{"date":596,"type":41},"2024-06-24",{"date":598,"type":22},"2024-06-25",{"date":600,"type":22},"2024-11-25",{"name":602,"class":48},"Anqing Municipal Hospital"]