[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neuromuscular-blocking-agents\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neuromuscular-blocking-agents":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,72,99],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100633305","antagonism-of-neostigmine-in-continuous-infusion-of-mivacurium-100633305",false,"NCT07524959","Antagonism of Neostigmine in Continuous Infusion of Mivacurium","Antagonism of Neostigmine in Continuous Infusion of Mivacurium: a Randomised Controlled Trial","Inclusion Criteria:\n\n* 18 - 65 years old;\n* American Society of Anesthesiologists (ASA) physical stastus classification system: I-II;\n* Body mass index (BMI) 18.5 - 30 kg\u002Fm2\n* Patients with normal cholinesterase levels before the operation\n\nExclusion Criteria:\n\n* Refusal to participate in the study;\n* ASA classification of grade III or above;\n* Severe organ dysfunction, difficult airway or neurological muscle disorders;\n* Taking drugs that affect neuromuscular monitoring or neuromuscular conduction function;\n* Allergic to the test drug or having other contraindications;\n* Pregnant and lactating women","ALL","18 Years","65 Years",{"count":20,"type":21},120,"ESTIMATED","INTERVENTIONAL",[24],"NA","In this study, the antagonism of neostigmine, a cholinesterase inhibitor, on continuous infusion of mivacurium during foot and ankle surgery under general anesthesia was investigated, and the appropriate time point of antagonism was explored.",[27],"Neuromuscular Blocking Agents",[29,30,31,27],"Neuromuscular Monitoring","Mivacurium","Neostigmine","NOT_YET_RECRUITING","2026-04-06",{"date":35,"type":36},"2026-04-13","ACTUAL",{"date":38,"type":21},"2026-05-01",{"date":40,"type":21},"2026-07-29",{"name":42,"class":43},"Beijing Tongren Hospital","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":44},"100596341","phase-4-reversal-of-pipecuronium-induced-neuromuscular-blockade-with-sugammadex-during-sevoflurane-anesthesia-100596341","NCT07044193","Reversal of Pipecuronium-induced Neuromuscular Blockade With Sugammadex During Sevoflurane Anesthesia","Reversal of Pipecuronium-induced Neuromuscular Blockade With Sugammadex During Sevoflurane Anesthesia: a Drug Safety Randomised Controlled Trial","RPINMBWS","Inclusion Criteria:\n\n* 80 adult general surgery and neurosurgical patients are enrolled in the study after giving an informed written consent regarding their participation.\n* Age: between 18-65 years;\n* ASA score: 1-3;\n* BMI 18.5-25 (normal body weight);\n* Males and females were recruited in an equal ratio;\n* Minimal surgical time of at least ≥ 40 minutes;\n* Procedures requiring endotracheal intubation;\n\nExclusion Criteria:\n\n* Diseases affecting neuromuscular function (myopathies, severe liver and kidney failure);\n\n  * Drugs affecting neuromuscular function (magnesium, aminoglycosides);\n  * Difficult airway, or anticipated difficult intubation;\n  * Pregnancy (a pregnancy test is performed in women of childbearing age to rule out pregnancy);\n  * Breast-feeding;\n  * Acute surgery;\n  * COPD\n  * Glaucoma\n  * History of previous allergic\u002Fanaphylactic reactions",{"count":54,"type":21},80,[56],"PHASE4","Safety during modern practice of anaesthesia is of great concern. Patients admitted daily for surgical procedures undergoing general anaesthesia for different types of operations are exposed to different risks, starting from the anaesthesia and ending with the surgical intervention. Aim of the study is to provide a comprehensive and evidence based data regarding the safety of the neuromuscular blocking agents used in modern anaesthesia practice, precisely Rocuronium and Pipecuronium, as well as the reversal agents such as Sugammadex, which is the sole agent in use in practice nowadays. A routine anaesthetic practice will be performed during the whole period of our study after strict patient selection criteria. Intraoperative standard monitoring as per local and international guidelines will be applied, this includes Spo2, ECG, NIBP\u002FIBP, etCO2, BIS and Tetragaph for neuromuscular blockade monitoring. After induction of anaesthesia and prior to the administration of the muscle relaxant agent, a TOFC (Train of Four Count) will be registered as the starting point. Throughout the anaesthetic time, there will be continuous TOF monitoring. The anaesthesia will be maintained by sevoflurane. Also, the recruited samples will be divided according to the neuromuscular blockade agents administered, either Rocuronium or Pipecuronium. At the end of the surgical procedure, the time lapse between the administration of the reversal agent Sugammadex and a TOF ratio of 0.9 is registered as our primary end point. TOF measures will be performed in the postoperative period, to make sure there is no residual neuromuscular blockade in the early postoperative phase. The study will not only monitor the safety of the neuromuscular blocking agents in use, but will also monitor any signs of anaphylaxis due to their administration both intra and postoperatively.",[27,59,60],"Residual Neuromuscular Block","Reversal of Neuromuscular Blockade",[62],"reversal of neuromuscular blockade","2025-06-27",{"date":65,"type":36},"2025-06-29",{"date":67,"type":21},"2025-06-26",{"date":69,"type":21},"2028-12-31",{"name":71,"class":43},"Tamas Vegh, MD",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":79,"targetDuration":81,"studyType":82,"phases":4,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100593367","study-of-the-relationship-between-curarization-and-pneumoperitoneum-in-laparoscopic-surgery-100593367","NCT07005518","Study of the Relationship Between Curarization and Pneumoperitoneum in Laparoscopic Surgery","PneumandTOF","Major patient, operated on by robot-assisted laparoscopic surgery, by two surgeons targeted for their similar working surgical technique.",{"count":80,"type":21},200,"3 Months","OBSERVATIONAL","The number of surgical procedures is increasing worldwide (1). Laparoscopic surgery is one of the surgical techniques that has become indispensable. Laparoscopic surgery is less invasive than laparotomy. Laparoscopic surgery is performed in several stages, one of which involves the creation of a peritoneal detachment. This detachment is achieved by the addition of a gas (CO2), which requires total relaxation of the abdominal muscle fibers. To achieve this, it is advisable to administer a muscle relaxant called curare (2). Curare-induced neuromuscular block, its depth and its release must be monitored during surgery. Curares act as acetylcholine antagonists, inducing neuromuscular block by competing with this neurotransmitter. In France, only one type of device, called an accelerometer, is used to monitor curarization. This device couples electrical stimulation of a nerve with an accelerometer. Curarization can be said to be deep, moderate, residual or absent. Despite curarization appearing deep to the accelerometer, operating conditions do not always seem ideal for abdominal contraction. Indeed, the muscles tested with this device do not concern the muscles involved in laparoscopic surgery.\n\nA currently unexploited surgical parameter, variation in insufflation pressure, could change our approach to intraoperative curarization.",[85,27,86],"Laparoscopic Surgery","Pneumoperitoneum",[88,89],"pneumoperitoneum pressure","curarization","2025-06-17",{"date":92,"type":36},"2025-06-18",{"date":94,"type":21},"2025-07-01",{"date":96,"type":21},"2027-11-01",{"name":98,"class":43},"Poitiers University Hospital",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":44},"100577142","phase-1-recovery-times-of-half-dose-sugammadex-and-neostigmine-for-rocuronium-induced-neuromuscular-blockade-100577142","NCT06794450","Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade","Comparison of Recovery Times Between 1 mg\u002Fkg Sugammadex and 60 mcg\u002Fkg Neostigmine for Moderate Neuromuscular Blockade Induced by Rocuronium in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients who underwent laparoscopic cholecystectomy under general anesthesia\n* Using muscle relaxant rocuronium\n* Aged 18-59 years\n* American Society of Anesthesiologists (ASA) physical status classification of 1 or 2.\n\nExclusion Criteria:\n\n* History of drug allergies to the agents used\n* Renal dysfunction\n* Musculoskeletal disorders\n* Central nervous system disorders\n* Difficult airways requiring intubation without the use of muscle relaxants.","59 Years",{"count":108,"type":21},60,[110,111],"PHASE1","PHASE2","In operating procedure with general anesthesia muscle relaxant is usually used to increase success rate of the operation and to give better outcome. The use of reversal drugs aims to reduce the risk of post-operative complications due to muscle relaxants. Neostigmine is commonly used as a reversal drug, but its indirect mechanism of action results in a long and unpredictable recovery time. Sugammadex directly bind and inactivate rocuronium, in which resulting in a faster and predictable recovery time. However, the high price limits the use of sugammadex.\n\nThis study aims to compare the effect of half dose sugammadex and neostigmine against the moderate neuromuscular blockade of rocuronium.\n\nThe main questions it aims to answer are:\n\nDoes half dose sugammadex gives faster recovery time? Researchers will compare sugammadex to neostigmine to see if sugammadex gives faster recovery time.\n\nParticipants will:\n\nBe given sugammadex or neostigmine as a reversal drug after the operation done",[27,60,114],"Recovery Time",[116,31,117],"Sugammadex","recovery time from neuromuscular blockade","RECRUITING","2025-01-25",{"date":121,"type":36},"2025-01-28",{"date":123,"type":36},"2024-11-05",{"date":125,"type":21},"2025-02",{"name":127,"class":43},"Universitas Padjadjaran"]