[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neuromuscular-electrical-stimulation-nmes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neuromuscular-electrical-stimulation-nmes":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,80,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100607422","neuromuscular-electrical-stimulation-in-a-patient-on-invasive-mechanical-ventilation-movcare-100607422",false,"NCT07188350","Neuromuscular Electrical Stimulation in a Patient on Invasive Mechanical Ventilation (MOVCARE)","Neuromuscular Electrical Stimulation of Lower Limbs in Patients Undergoing Invasive Mechanical Ventilation: Randomized Clinical Trial","MOVCARE","Inclusion Criteria:\n\n* Patients will be eligible if they are 18 years or older, are under invasive mechanical ventilation (IMV), and are expected to require IMV for more than 48 hours.\n\nExclusion Criteria:\n\n* Body mass index (BMI) greater than or equal to 35 kg\u002Fm²;\n* Length of ICU stay longer than 7 ICU-free days or more than 3 continuous days of invasive mechanical ventilation (IMV) before enrollment;\n* Known intracranial process (e.g., stroke, intracranial hypertension);\n* Neuromuscular disease (e.g., Guillain-Barré syndrome, myasthenia gravis) at ICU admission;\n* Inability to speak Portuguese or pre-existing cognitive impairment prior to ICU admission;\n* Any condition that prevents neuromuscular electrical stimulation (NMES) treatment or assessment of the primary outcome in both legs (e.g., skin lesions, fractures, or amputation);\n* inability to transfer from bed to chair with or without assistance prior to hospital admission;\n* Cardiac arrest as the cause of ICU admission or cardiac arrest before screening;\n* Deep vein thrombosis (DVT) or pulmonary embolism (PE) treated for less than 48 hours;\n* Pregnant patients;\n* Known or suspected malignancy in the legs;\n* Any care limitation including a do-not-resuscitate order.","ALL","18 Years",{"count":20,"type":21},150,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical study aims to compare the effects of conventional physical therapy alone versus conventional physical therapy combined with neuromuscular electrical stimulation (NMES) in patients admitted to the ICU and undergoing invasive mechanical ventilation. Participants will be randomly assigned to receive either conventional physical therapy or the same therapy plus NMES applied to the lower limbs. The protocol includes muscle-specific stimulation parameters and safety criteria to postpone sessions in cases of clinical instability. The primary goal is to assess whether NMES improves muscle function and recovery in critically ill patients.",[27,28,29,30,31],"Mechanical Ventilation","Critical Illness","Intensive Care Unit Patients","Muscle Weakness Condition","Neuromuscular Electrical Stimulation (NMES)",[33,34,27,35,36,28],"Neuromuscular Electrical Stimulation","Physiotherapy","Muscle Strength","Randomized Controlled Trial","RECRUITING","2026-03-22",{"date":40,"type":41},"2026-03-25","ACTUAL",{"date":43,"type":41},"2025-09-04",{"date":45,"type":21},"2027-03",{"name":47,"class":48},"Hospital Moinhos de Vento","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":49},"100600592","reduced-functionality-and-kinesiophobia-in-patients-with-heart-failure-use-of-alternative-therapeutic-strategies-100600592","NCT07099495","REDUCED FUNCTIONALITY AND KINESIOPHOBIA IN PATIENTS WITH HEART FAILURE: USE OF ALTERNATIVE THERAPEUTIC STRATEGIES","Reduced Functionality and Kinesiophobia in Patients With Heart Failure: Use of Neuromuscular Electrical Stimulation as an Alternative Therapeutic Strategy","Inclusion Criteria:\n\n* Individuals of both sexes;\n* Age ≥ 18 years;\n* Diagnosis of chronic HF;\n* Symptoms compatible with Functional Class (FC) III-IV of the New York Heart Association (NYHA);\n* Stable condition on pharmacological therapy;\n* Absence of Acute Myocardial Infarction in the last three months prior to participant recruitment;\n* Absence of an automatic internal cardioverter defibrillator (ICD) or cardiac pacemaker;\n\nExclusion Criteria:\n\n* Individuals with hemodynamic instability, unstable angina, acute myocardial infarction during the period of application of the protocol and diagnosis of hypertrophic cardiomyopathy during the period of application of the protocol;\n* Individuals with recent muscle or tendon injuries, muscular dystrophies, myopathies, unstable fractures, infections or deep vein thrombosis (DVT);\n* Chronic need for oxygen therapy;\n* Absence in reassessments;\n* Refusal to participate in the research after its beginning.",{"count":58,"type":21},54,[24],"Introduction: Heart failure (HF) is a clinical syndrome that has advanced on a large scale concomitant with population aging and other factors. Thus, the search for alternatives that minimize the losses resulting from its structural and functional damage are important to optimize its treatments, with the primary objective of enabling the participation of these individuals in the most diverse daily tasks. Low-frequency (LF) or medium-frequency (MF) neuromuscular electrical stimulation (NMES) can be considered a resource to enable the improvement of vital and functional parameters of the population with HF intolerant to physical exercise, and it is also important to identify within these modalities which is most effective. In addition to these factors, kinesiophobia can be found in this population, and NMES can also be adopted as a strategy for kinesiophobia in these patients, with the objective of enabling the progression of behaviors. Objective: To evaluate and compare the effectiveness of LF and MF NMES on the indices of kinesiophobia and functionality in patients with HF. Methods: The research will be divided into two types of study: a double-blind randomized clinical trial (RCT) to evaluate NMES protocols, and a qualitative study with subsequent development and validation of a questionnaire to measure kinesiophobia in individuals with HF. The population included in the RCT will have their assessments (personal, socioeconomic, demographic data, Sit-to-Stand Test, kinesiological ultrasound and surface electromyography of the quadriceps muscles) conducted before their discharge from Hospital Nova Esperança (HNE), and after completion of the protocols at the same institution, in the city of João Pessoa - Paraíba. The application of NMES protocols will be carried out in the home environment (30 min\u002Fday, 3 times a week, for a total of 8 consecutive weeks). The population for the qualitative study and for the development of the questionnaire will consist of individuals diagnosed with HF of any etiology, compensated and able to perform kinesiotherapy activities, admitted to the HNE wards, between 24-48 hours before hospital discharge. An in-depth semi-structured interview will be conducted with these individuals, followed by the application of questionnaires developed based on the interviews, and the entire study will be conducted while the patients are hospitalized. Expected results: Regarding the first study, it is expected that patients treated with NMES will show improvements in clinical and functional variables, and these improvements may be more pronounced depending on the frequency applied. On the other hand, the qualitative study may reveal whether patients have fear of movement, even if they are clinically stable. The developed questionnaire will be well understood and have adequate psychometric qualities. Finally, it is expected that this knowledge can serve as a basis for optimizing the care of this patient population.",[62,63,64,31,65],"Heart Failure","Heart Failure NYHA Class III","Heart Failure NYHA Class IV","Kinesiophobia",[67,68,69],"heart failure","neuromuscular electrical stimulation","kinesiophobia","NOT_YET_RECRUITING","2025-07-24",{"date":73,"type":41},"2025-08-01",{"date":75,"type":21},"2025-08-18",{"date":77,"type":21},"2027-12-30",{"name":79,"class":48},"Universidade Federal do Rio Grande do Norte",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":49},"100589278","the-impact-of-respiratory-neuromuscular-stimulation-on-patients-with-invasive-mechanical-ventilation-100589278","NCT06952335","The Impact Of Respiratory Neuromuscular Stimulation On Patients With Invasive Mechanical Ventilation","The Impact Of Respiratory Neuromuscular Stimulation On Patients With Invasive Mechanical Ventilation: A Prospective Randomized Crossover Physiological Study","Inclusion Criteria:\n\n1. Aged between 18 and 80 years;\n2. Mechanical ventilation duration \\> 48 hours;\n3. Hemodynamically stable;\n4. RASS score ranging from 1 to -2.\n\nExclusion Criteria:\n\n1. Having a pacemaker implanted;\n2. Unhealed surgical wounds in the chest or abdomen;\n3. Pregnant women and lactating women;\n4. History of recent airway surgery or trauma;\n5. Surgery in the neck, chest, or upper abdomen;\n6. Intracranial hypertension;\n7. Contraindications for esophageal pressure catheter placement;\n8. Withdrawal of life support.","80 Years",{"count":89,"type":21},12,[24],"Mechanical ventilation (MV) is an important treatment measure for critically ill patients in the intensive care unit (ICU). MV is widely used in the treatment of respiratory failure and is also one of the important means of life support for critically ill patients after surgery. Although the use of MV has significantly reduced the mortality rate of critically ill patients, MV is also a double-edged sword. A large amount of evidence shows that it can lead to complications such as ventilator-induced diaphragmatic dysfunction (VIDD) . In a retrospective study, it was first found and proposed that long-term MV can lead to diaphragmatic atrophy. Later, a prospective clinical study conducted by Le Bourdelles et al. provided direct evidence to support this conjecture. Continuous use of mechanical ventilation for 48 hours can cause diaphragmatic atrophy and contractile dysfunction. Therefore, effectively preventing diaphragmatic atrophy is of great significance for the outcome of patients with mechanical ventilation.\n\nRespiratory NMES has been used in clinical practice for decades. Previous studies have shown that electrical stimulation of a certain intensity applied to the respiratory neuromuscular can increase the excitability of the phrenic nerve, enhance diaphragmatic contraction, increase the range of diaphragmatic movement, and improve lung ventilation. In addition to the diaphragm, the abdominal muscles are also an important part of the respiratory muscles and an important supplement to the inspiratory muscles. Studies have shown that electrical stimulation of the abdominal muscles can retrain the expiratory muscles, increase muscle strength, induce expiratory muscle contraction through repeated afferent stimulation of the abdominal muscles, increase intra-abdominal pressure, facilitate the upward movement of the diaphragm, reduce thoracic pressure and lung volume, and thus improve the ability of expiration and expectoration. Electrical stimulation of the abdominal muscles has received increasing attention as a supplement to inspiratory muscle training, and many foreign literatures have reported on the improvement of respiratory function by abdominal muscle stimulation. At present, some domestic scholars have also reported that simultaneous stimulation of the phrenic nerve and abdominal muscles can improve the quality of life and prognosis of patients. However, there are few studies on how simultaneous stimulation of the diaphragm and abdominal muscles can improve the physiological effect indicators of the respiratory system, especially the impact on respiratory drive and inspiratory effort. Animal model studies have shown that electrical stimulation of the phrenic nerve in rabbits can significantly reduce the central drive of the diaphragm and the conduction function of the phrenic nerve after diaphragmatic fatigue, and the reduction of central drive may be a self-protective mechanism of the body. An observational study abroad suggested that percutaneous diaphragmatic electrical stimulation can control WOB within four-fifths of the normal range 96.8% of the time. This study is dedicated to applying respiratory NMES to study the impact on the physiological parameters of patients with invasive mechanical ventilation, providing a theoretical basis for its clinical application in critically ill patients.",[27,31],"2025-04-28",{"date":95,"type":41},"2025-04-30",{"date":97,"type":21},"2025-05-01",{"date":99,"type":21},"2025-09-01",{"name":101,"class":48},"Capital Medical University",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":109,"sex":17,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":49},"100572890","the-enhancement-effect-of-low-level-laser-therapy-for-muscle-training-with-combined-nmes-and-bfr-100572890","NCT06739148","The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined NMES and BFR","The Enhancement Effect of Low-Level Laser Therapy for Muscle Training with Combined Neuromuscular Electrical Stimulation and Blood Flow Restriction","Inclusion Criteria:\n\n1. Healthy adults aged 20-40, without a diagnosis of cardiovascular or neuromusculoskeletal diseases.\n2. Normal vision range after visual correction.\n\nExclusion Criteria:\n\n1. Exclude students who have a teacher-student relationship with the principal investigator to ensure the participants\\' autonomy.\n2. History of brain injury, stroke, spinal cord injury, or other neuromuscular-related conditions.\n3. Contraindications for laser therapy: pregnancy, malignant tumor tissues, bleeding areas, and photosensitive skin regions.\n4. Presence of any contraindications for blood flow restriction training, such as a history of injury or strain in the non-dominant arm\\'s biceps, deep vein thrombosis or venous occlusion in the non-dominant arm, acute unstable fractures in the non-dominant arm, acute regional infections in the non-dominant arm, severe peripheral arterial occlusive disease in the non-dominant arm, complete lymphatic obstruction in the non-dominant arm, and edema due to acute pulmonary edema or congestive heart failure in the non-dominant arm.",true,"20 Years","40 Years",{"count":113,"type":21},44,[24],"Blood flow restriction training (BFR) with neuromuscular stimulation (NMES) is employed for individuals with limited mobility and joint issues. However, this approach is highly susceptible to muscle fatigue, despite its potential beneficial effects on muscle strength. Recently, there has been growing interest in using low-level laser therapy (LLLT) to address muscle fatigue. LLLT, known for improving microcirculation and mitochondrial function, shows promise in alleviating enhanced muscle fatigue associated with combined BFR and NMES training. Despite these positive effects, there is limited knowledge about the short-term training impact of combined BFR and NMES with LLLT preconditioning. This project aims to investigate whether the photobiomodulation effects of LLLT could further enhance the training benefits of combined BFR and NMES. The study will employ an integrated analysis of decomposition surface EMG, EEG, and mechanomyogram to explore the behavior and neuromuscular mechanisms underlying the training benefits. If additional benefits are identified, LLLT pre-conditioning is recommended to enhance the use of combined BFR and NMES.",[117,31,118,35],"Blood Flow Restriction Therapy","Laser Therapy, Low-Level",[120,121,122,123,124],"Muscle strength","Training","Low-level laser Therapy","Blood flow restriction","Neuromuscular electrical stimulation","2024-12-16",{"date":127,"type":41},"2024-12-18",{"date":129,"type":41},"2024-10-01",{"date":131,"type":21},"2025-07-31",{"name":133,"class":48},"National Cheng-Kung University Hospital"]