[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neuromuscular-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neuromuscular-function":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,82,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":35,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100633108","acute-power-training-effects-in-older-adults-100633108",false,"NCT07522398","Acute Power Training Effects in Older Adults","Acute Neuromuscular and Physiological Responses to Different Velocity Loss Thresholds During Power Training in Older Adults","APTE-OA","Inclusion criteria:\n\nParticipants must:\n\n* Be 65 to 85 years old.\n* Be able to live independently and perform everyday activities without help.\n* Not have regularly done resistance or strength training in the past year.\n* Be able to understand study instructions and communicate in the study language.\n* Have a recent statement from their treating physician confirming that their heart and blood vessels are healthy enough to safely take part in this study.\n\nExclusion criteria\n\nParticipants will not be eligible if they have any of the following:\n\n* Unstable heart disease, neurological disease, acute infection, or fever.\n* Use of non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, in the 5 days before the study.\n* Use of whey protein, casein, or amino acid supplements in the month before the study.\n* Acute or chronic injuries to the legs or lower body muscles.\n* Any injury or condition that prevents safe leg extension exercises.\n* Recent lower-limb joint replacement (less than 6 months ago).\n* Dependence on walking aids.\n* Current participation in another interventional trial.",true,"ALL","65 Years","85 Years",{"count":22,"type":23},42,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this clinical trial is to learn how older adults respond to power training when the level of fatigue during exercise is different. Power training means performing fast movements with moderate loads to improve strength, power and mobility.\n\nThe main questions the study aims to answer are:\n\n* How does the level of fatigue during power training acutely affect strength, movement, and muscle function?\n* How does it affect recovery, muscle soreness, and how hard the exercise feels?\n\nResearchers will compare three power-training sessions with different fatigue levels to see which approach may be safest and most effective for older adults.\n\nParticipants will be healthy older adults aged 65 to 85 years. Each participant will complete three supervised exercise sessions on a leg press machine. The sessions will take place about one week apart.\n\nDuring the study, participants will:\n\n* Perform power training on a pneumatic leg press machine\n* Complete strength and mobility tests before and after exercise\n* Provide small blood samples to measure body responses to exercise\n* Rate how hard the exercise feels\n* Report muscle soreness for up to two days after exercise\n\nThe results may help researchers design safer and more effective power-training programs to improve strength, mobility, and recovery in older adults.",[29,30,31,32,33,34],"Muscle Power","Functional Performance","Older Adults (65 Years and Older)","Neuromuscular Function","Physiological Responses","Healthy Older Adults",[36,37,38,29,39,40,32,30,33,41],"Power Training","Older Adults","Aging","Velocity Loss","Resistance Training","Exercise Fatigue","RECRUITING","2026-04-03",{"date":45,"type":46},"2026-04-13","ACTUAL",{"date":48,"type":23},"2026-04-20",{"date":50,"type":23},"2027-01",{"name":52,"class":53},"Hasselt University","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":18,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":24,"phases":67,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":54},"100567036","exercise-with-audible-cues-on-motor-unit-behavior-in-athletes-with-anterior-cruciate-ligament-reconstruction-100567036","NCT06662955","Exercise With Audible Cues on Motor Unit Behavior in Athletes With Anterior Cruciate Ligament Reconstruction","Terminal Knee Extension Exercise Synchronize With Audible Cues on Motor Unit Behavior of Vastus Medialis Muscle in Athletes With Anterior Cruciate Ligament Reconstruction","ACLR","Inclusion Criteria:\n\n* Male or female participants who receive primary ACL reconstruction within 2 weeks with or without meniscus repair\n* No or mild resting pain (Numeric rating scale ≤ 3)\n* Reconstruction procedures using autograft including hamstrings or bone-patella bone grafts\n* Age range 18-35 years (33).\n* BMI of 18.5-25 kg\u002Fm² (34).\n* Tegner activity scale ≥ level 4\n\nExclusion Criteria:\n\n* Non-weight bearing within 2 weeks after the operation (prescription from surgeon)\n* Hearing problem, such as being unable to hear the metronome sound or being unable to synchronize exercises with the metronome correctly\n* Limitations in knee extension range caused by joint stiffness evaluated by using passive knee range of motion\n* Unable to perform active and passive ≥ 30º knee flexion on the operative side\n* History of serious injury or operation of lower back and lower extremities such as fracture\n* Lower back or lower extremities pain within 6 months before the study\n* On the pain killer medication","18 Years","35 Years",{"count":66,"type":23},40,[26],"The closed kinetic chain (CKC) of terminal knee extension exercise (TKE) is designed to activate VM activity for knee injury training. This CKC exercise is effective for highest recruiting muscle activity, especially safe for post-operative knee surgery. The study of ACL reconstruction rehabilitation guideline suggests that exercises can be applied within the early phase of rehabilitation to prevent knee laxity and less knee pain compared to open chain exercise. Therefore, it is interesting to investigate the effects of TKE exercise synchronized with metronome pace on change of VM motor unit behavior in post operative ACL reconstruction. This study focuses on the immediate effect of 1-seesion TKE and expects that adding metronome during TKE will enhance neuromuscular control of VM and may change motor unit behavior.",[70,71,32],"Therapeutic Exercise","Physical Therapy Techniques",[61],"2025-12-11",{"date":75,"type":46},"2025-12-12",{"date":77,"type":46},"2024-10-20",{"date":79,"type":23},"2026-12-30",{"name":81,"class":53},"Mahidol University",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":17,"sex":18,"minAge":63,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":24,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":104,"leadSponsor":106,"locationsCount":54},"100560177","effect-of-12-week-milk-fat-globule-membrane-supplementation-on-the-human-muscle-function-of-healthy-recreationally-active-adults-100560177","NCT06573749","Effect of 12-week Milk Fat Globule Membrane Supplementation on the Human Muscle Function of Healthy, Recreationally Active Adults","Effect of 12-week Bioactive Whey Protein Concentrate Supplementation on the Neuromuscular System of Healthy, Recreationally Active Adults","Inclusion Criteria:\n\n* 18-30 or 60-75 years old\n* Male or female\n* Healthy with no contraindications to exercise\n* Classified as recreationally active (meet the government's guidelines for weekly physical activity - 150 minutes of moderate physical activity or 75 minutes of vigorous physical activity)\n\nExclusion Criteria:\n\n* Any injury, medical condition or symptom precluding the ability to complete strenuous exercise as identified by the health screen questionnaire and physical activity readiness questionnaire\n* Uncontrolled hypertension (blood pressure of 140\u002F90 mmHg or higher) as identified by recording resting blood pressure\n* Neuromuscular or musculoskeletal disease\n* Occurrence of a severe injury to the lower limbs or back within the previous 6 months (time loss of \\> 21 days of normal activity)\n* Occurrence of a minor injury to the lower limbs or back within the previous month (time loss of \\>1 day of normal activity)\n* Do not meet the government guidelines of minimum weekly physical activity as revealed by the IPAQ-SF\n* Allergic to dairy or pea, or lactose intolerant\n* Complete greater than 6 hours structured exercise per week as revealed by the exercise and physical activity form\n* Consumption of supplements that may confound the results of the present study within the previous 3 months (includes any form of protein supplement, creatine, pre-workout supplements, any form of testosterone supplement, amino acids, beta-alanine, beta- hydroxy-beta-methylbutyrate (HMB), fish or krill oil, collagen supplements, any choline- containing supplement, or any phospholipid-containing supplement) as highlighted by the health screen questionnaire\n* Taking anticoagulants or antiplatelet drugs\n* Use of antidepressant\u002Fanti-anxiety medication\n* Having a blood borne virus, or a partner who has a blood-borne virus\n* Extreme diet classified as identified by the food-frequency questionnaire","75 Years",{"count":91,"type":23},96,[26],"The main aim of this study is to understand if chronic supplementation (12 weeks) of a milk fat globule membrane containing supplement, called bioactive whey protein concentrate, improves human muscle function greater than a placebo supplement within a cohort of healthy, recreationally active adults. Furthermore, we aim to investigate whether any potential benefits of milk fat globule membrane are influenced by age through the assessment of 2 distinct age subgroups (young and older). We hypothesise that neuromuscular function (strength and power) will increase from pre to post within the group that consumes bioactive whey protein concentrate but not the placebo group, with a greater increase in the older group compared to the young group.",[95,32],"Ageing Well",[97,98,99],"Nutrition","Neuromuscular","Milk fat globule membrane","2025-03-28",{"date":102,"type":46},"2025-04-02",{"date":100,"type":46},{"date":105,"type":23},"2026-01",{"name":107,"class":53},"Loughborough University",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":17,"sex":116,"minAge":63,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":24,"phases":119,"briefSummary":120,"conditions":121,"keywords":129,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":54},"100568305","impact-of-menstrual-cycle-based-resistance-training-on-neuromuscular-performance-in-female-athletes-100568305","NCT06679491","Impact of Menstrual Cycle-Based Resistance Training on Neuromuscular Performance in Female Athletes","Effects of Menstrual Cycle-based Undulating Periodized Resistance Training in Women's Neuromuscular Abilities","MENSES","Inclusion Criteria:\n\n* Female athletes with natural menstrual cycles (eumenorrheic): Participants must have regular menstrual cycles lasting between 21 and 35 days, with at least 9 cycles per year.\n* Women using a low-dose monophasic estrogen-progestin oral contraceptive.\n* Age 18 or older: Participants must be legal adults.\n* Body Mass Index (BMI) between 18 and 30 kg\u002Fm².\n* No medical contraindications to high-level physical training or exercise.\n* Physically active: Engages in at least 3 hours of physical activity per week.\n* Informed consent: Provides written, informed consent to participate in the study.\n* Affiliation with a social security system (if applicable by local regulations).\n\nExclusion Criteria:\n\n\\-","FEMALE",{"count":118,"type":23},60,[26],"The goal of this clinical trial is to assess the impact of menstrual cycle-based resistance training on neuromuscular function in female athletes.\n\nThe primary questions it aims to answer are :\n\n* Does varying resistance training intensity according to menstrual phases improve maximal knee extensor strength?\n* How do different training protocols affect voluntary activation, rate of force development, muscle stiffness, and vertical jump height?\n\nResearchers will compare natural menstrual cycle groups with an oral contraceptive control group to determine if menstrual phase-specific training influences neuromuscular adaptations.\n\nParticipants will:\n\n* Undergo 2 weekly resistance training sessions over 13 weeks with intensity adjustments based on menstrual phase\n* Complete periodic neuromuscular assessments across three menstrual phases: early follicular, late follicular, and mid-luteal before and after resistance training intervention",[122,40,32,123,124,125,126,127,128],"Menstrual Cycle","Female Athlete","Women Health","Oral Contraceptive Pill","Muscle Strenght","Hormones","Periodized Training",[122,130,131,132,133,127,134,135],"Resistance training","Periodized training","neuromuscular function","Female athlete","oral contraceptive pill","women health","2024-11-05",{"date":138,"type":46},"2024-11-07",{"date":140,"type":23},"2024-11-01",{"date":142,"type":23},"2027-12-31",{"name":144,"class":53},"Universite de La Reunion"]