[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neuropathic-pain-nociceptive-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neuropathic-pain-nociceptive-pain":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100643903","phase-2-functional-brain-mri-to-understand-pain-phenotypes-in-knee-osteoarthritis-100643903",false,"NCT07668674","Functional Brain MRI to Understand Pain Phenotypes in Knee Osteoarthritis","Functional Brain MRI to Understand Pain Phenotypes in Knee Osteoarthritis: a Multicenter Comparative Pilot Study","INDIGO","Inclusion Criteria:\n\n* Women aged 40 or older (only women will be included to ensure consistency in the analyses, given the higher prevalence of osteoarthritis in women and the influence of sex\u002Fgender on the experience of pain)\n* Diagnosis of femorotibial osteoarthritis of the knee according to the 1986 American College of Rheumatology criteria\n* Presence of knee pain with an intensity of ≥ 4\u002F10 on a numerical rating scale (NRS)\n* Chronic knee pain, i.e., lasting at least 6 months with at least 15 days of pain in the past 30 days\n* Completion of the PainDETECT questionnaire, which will allow the patient to be assigned to one of two groups prior to the enrollment visit (those with nociceptive pain \\[score ≤ 12\\] and those with neuropathic pain \\[score \\> 13\\])\n* Patients have read and understood the information letter\n* Patients have signed the informed consent form\n* Patients are enrolled in a social security program\n\nExclusion Criteria:\n\n* Other joint diseases affecting the knees (gout, chondrocalcinosis, rheumatoid arthritis, spondyloarthritis, psoriatic arthritis)\n* Conditions that, in the investigator's opinion, interfere with the assessment of osteoarthritic pain, such as conditions causing neuropathic pain in the lower extremities (e.g., peripheral neuropathy, chronic radiculopathy) or fibromyalgia\n* Kellgren-Lawrence radiographic stage IV in one or both knees\n* Patients with one or more knee prostheses\n* Claustrophobia making MRI impossible\n* Contraindication to MRI\n* Pregnant or breastfeeding women\n* Patients under guardianship, conservatorship, deprived of liberty, or under judicial protection\n* Patients who have participated in an interventional clinical trial within the last 6 months that could impact the primary endpoint","FEMALE","40 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","Some people with knee osteoarthritis (gonarthrosis) experience pain differently. In some, the pain is described as \"nociceptive\" (directly related to the joint), while in others it has \"neuropathic\" characteristics (related to nerve function).\n\nThe goal of this multicenter, cross-sectional and comparative study is to compare resting brain activity in a brain region called the anterior insula among female patients with painful knee osteoarthritis who experience nociceptive pain compared to those with neuropathic pain.\n\nResearchers will compare brain activity at rest between these two types of pain in women over 40 with painful knee osteoarthritis. A better understanding could help improve pain management in the future.\n\nParticipants will be asked to :\n\n* complete questionnaires during the inclusion visit and on the day of the scan,\n* undergo a clinical examination and a blood test at the inclusion visit,\n* undergo a functional MRI (fMRI), an imaging test that allows observation of brain activity at rest.\n\nPaticipants in the study does not involve any additional treatment. the fMRI scan is non-invasive and does not require any injections.",[27,28],"Gonarthrosis","Neuropathic Pain, Nociceptive Pain",[27,30,31,32,33,34,15],"Neuropathic pain","Nociceptive Pain","Functional MRI","Anterior insula","Brain activity in the anterior insula at rest","NOT_YET_RECRUITING","2026-06-23",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":21},"2026-07",{"date":43,"type":21},"2028-08",{"name":45,"class":46},"University Hospital, Clermont-Ferrand","OTHER",3,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100604351","accelerated-intermittent-theta-burst-stimulation-aitbson-neuropathic-pain-100604351","NCT07148388","Accelerated Intermittent Theta Burst Stimulation (AiTBS)on Neuropathic Pain","Effects and Mechanism of Accelerated Intermittent Theta Burst Stimulation on Neuropathic Pain","AiTBS","Inclusion Criteria:\n\n* IASP diagnosis of peripheral neuropathic pain;\n* At least three months after the onset of pain;\n* At least moderate pain intensity (≥ 3 assessed by VAS or NRS);\n* 18 years or older;\n* Stable medical treatment from 2 weeks before allocation to the end of the trial;\n* Willing to receive TMS treatment and capable of fulfilling clinical assessments.\n\nExclusion Criteria:\n\n* Contradictions to TMS treatment, such as metal implants or seizure;\n* Serious psychiatric disorder (Hamilton Depression Rating Scale score ≥ 35 or Hamilton Anxiety Rating Scale score ≥ 29);\n* Aphasia or cognitive disorders (Mini mental state examination ≤ 24);\n* Severe clinical disorders caused by tumor or other conditions;\n* Severe cardiopulmonary dysfunction or extreme weakness;\n* History of substance abuse (alcohol, drugs).","ALL","18 Years",{"count":59,"type":21},120,[61],"NA","The present study was designed to be the first to evaluate the efficacy of the AiTBS protocol to relieve neuropathic pain in a therapeutic setting, i.e. with repeated stimulation sessions. The investigator directly compared the analgesic efficacy of AiTBS versus conventional 10-Hz rTMS delivered to the left M1. In addition to pain experiences, The investigator examined the effects of intervention on corticospinal excitability that assessed by TMS-EEG. The working hypothesis was that AiTBS would result in larger analgesic and significant cortical excitability changes compared to 10-Hz rTMS.\n\nEligible patients were randomly assigned to receive either 5 days of AiTBS within 10 days (6 sessions per day) or 10 consecutive days of classic 10Hz rTMS intervention. Clinical and neurophysiological assessments were performed at baseline and after the last sessions.",[28],[65],"AiTBS, rTMS, Neuropathic pain","RECRUITING","2026-01-22",{"date":69,"type":39},"2026-01-26",{"date":71,"type":39},"2025-09-12",{"date":73,"type":21},"2027-12-31",{"name":75,"class":46},"Second Affiliated Hospital, School of Medicine, Zhejiang University",1]