[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neuropathy-diabetic\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neuropathy-diabetic":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100481218","characterization-and-prediction-of-early-onset-diabetic-peripheral-neuropathy-100481218",false,"NCT05546138","Characterization and Prediction of Early Onset Diabetic Peripheral Neuropathy","Characterization and Prediction of Early Onset Diabetic Peripheral Neuropathy (NeuroPredict)","NeuroPredict","Inclusion Criteria:\n\n* Men and women aged 18-80 years\n* Diagnosed with diabetes (of any type)\n* No clinically established diabetic peripheral neuropathy at inclusion\n\nExclusion Criteria:\n\n* Alcohol or drug abuse within the last year (prior to inclusion)\n* Chemotherapy (prior or within study period) or experimental medicine\n* Severe vitamin deficiencies\n* Inability to understand or comply with the examinations\n* Planned or likely discontinuation of care at Aalborg University Hospital\n* Known hematologic disorders resulting in a markedly reduced ability to stop small bleedings\n* Severe limb ischemia\n* Active diabetic foot ulcers\n* Previous amputations\n* Severe skin diseases or diseases known to cause neural damage\n* Pregnancy at inclusion","ALL","18 Years","60 Years",{"count":21,"type":22},200,"ESTIMATED","OBSERVATIONAL","Predicting early onset neuropathy in people with type 1 diabetes",[26,27,28],"Neuropathy, Diabetic","Small Nerve Fiber Neuropathy","Type 1 Diabetes",[30],"Diabetic neuropathy, Early detection, Clinical Endpoints, Prediction, Risk stratification","RECRUITING","2024-06-27",{"date":34,"type":35},"2024-06-28","ACTUAL",{"date":37,"type":35},"2023-10-01",{"date":39,"type":22},"2029-12-31",{"name":41,"class":42},"Aalborg University Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":43},"100552317","neuroprosthetic-device-for-improving-issues-caused-by-diabetic-neuropathy-with-specifically-designed-neural-stimulation-100552317","NCT06471517","Neuroprosthetic Device for Improving Issues Caused by Diabetic Neuropathy With Specifically Designed Neural Stimulation","DiabeticStim","Inclusion Criteria:\n\n* Diagnosed polyneuropathy\n* Ability to stand and walk unassisted.\n* Sensory loss in the feet\n\nExclusion Criteria:\n\n* Open ulcers on the feet\n* Pregnancy\n* History of or current psychological diseases that include schizophrenia and major depression\n* Hypersensitivity to electrical stimulation",{"count":52,"type":22},20,"INTERVENTIONAL",[55],"NA","Neuropathy refers to a condition that results from damage to the peripheral nerves.The most common cause of it is diabetes mellitus, metabolic disorder that affects more than 422 million individuals worldwide, putting a huge strain on the healthcare system and up to 50% of these individuals will develop neuropathy. Peripheral neuropathy is characterized by sensory nerve abnormalities such as an impaired sense of touch. Sensory loss in feet can lead to functional deficits during gait, low balance, and increased risk of falls and is considered the strongest risk factor for diabetic foot ulceration. Moreover, these patients usually also suffer from neuropathic pain, which is believed to be associated with aberrant sensory input.\n\nWith this in mind, the study aims to understand the effects of restoring sensation lost to neuropathy using transcutaneous electrical stimulation. Additionally, the investigators aim to understand if electrical stimulation of the damaged nerves can reduce health consequences such as chronic pain.\n\nTo achieve this, the investigators have developed a wearable sensory restoration system that can restore lost sensation with non-invasive, precisely controlled electrical stimulation through electrodes integrated into the sock garment. A system is composed of a system controller that communicates via Bluetooth with force-sensitive insoles placed in the shoes and neurostimulators directly connected to electrode array socks. Based on the insole recordings the stimulation parameters are defined in real-time, making it a closed-loop system for restoring somatotopic sensory feedback.",[58,26,59],"Neuropathy;Peripheral","Neuropathy, Painful","2024-06-18",{"date":62,"type":35},"2024-06-24",{"date":64,"type":35},"2024-06-13",{"date":66,"type":22},"2025-07-31",{"name":68,"class":42},"Institute Mihajlo Pupin"]