[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurophysiological-assessment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurophysiological-assessment":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,53],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":5},"100623769","brain-stimulation-combined-with-watching-hand-movements-to-improve-hand-recovery-in-chronic-stroke-100623769",false,"NCT07400939","Brain Stimulation Combined With Watching Hand Movements to Improve Hand Recovery in Chronic Stroke","Investigating The Neurophysiological Mechanisms Of Transcranial Direct Current Stimulation Combined With Action Observation Therapy On Hand Muscle Neuroplasticity in Chronic Stroke","Inclusion Criteria:\n\n* Adults aged 18 to 59 years\n* Single episode of unilateral stroke and weakness in hand muscles 6 to 24 months post-stroke\n* No excessive spasticity of the upper limb, defined as grade two or less on Modified Ashworth Scale\n\nExclusion Criteria:\n\n* Patients diagnosed with posterior circulation infarction\n* Unable to follow commands due to poor cognitive function\n* Unilateral neglect\n* Homonymous hemianopia\n* Other existing neurological disorders that lead to poor hand function\n* Grade four or five hand muscle strength.","ALL","18 Years","59 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study investigates the neurophysiological mechanisms underlying the combined use of transcranial direct current stimulation (tDCS) and action observation therapy (AOT) for hand motor recovery in individuals with stroke. Background: While both tDCS and AOT have shown promise individually for stroke rehabilitation, the neural mechanisms of their combined effects remain unclear. Understanding these mechanisms could optimise rehabilitation protocols and improve functional outcomes. Intervention: Participants will receive 10 sessions of anodal tDCS over the ipsilesional motor cortex combined with AOT over two weeks in a clinical setting, followed by 8 weeks of home-based AOT practice. Control groups will receive tDCS alone or AOT alone. Neurophysiological changes will be assessed using motor evoked potentials (MEPs) to evaluate corticospinal excitability. Clinical hand function will be assessed using standardised outcome measures. Measurements: Assessments will be conducted at baseline, during intervention (week 2), and after the home practice phase (week 10) to evaluate neuroplastic changes. Significance: This study will provide mechanistic insights into how neuromodulation and observational learning interact to promote motor recovery, informing evidence-based rehabilitation strategies for stroke survivors in Malaysia and globally. Study Design: Randomised controlled trial with three parallel arms, recruiting 60 participants with chronic stroke from Sabah, Malaysia.",[27,28,29,30,31,32,33,34],"Stroke","tDCS","Action Observation Therapy","Hand","Motor Evoked Potential","EMG","Neuroplasticity","Neurophysiological Assessment",[36,37,38,39,40],"stroke rehabilitation","transcranial direct current stimulation","action observation therapy","neuroplasticity","neurophysiological","RECRUITING","2026-05-07",{"date":44,"type":45},"2026-05-12","ACTUAL",{"date":47,"type":45},"2026-04-01",{"date":49,"type":21},"2028-01-20",{"name":51,"class":52},"Universiti Malaysia Sabah","OTHER",{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100570454","postoperative-clinical-and-neurophysiological-assessment-of-patients-after-open-heart-surgery-100570454","NCT06707454","Postoperative Clinical and Neurophysiological Assessment of Patients After Open Heart Surgery","Inclusion Criteria:\n\n* Patient ≥ 60 years.\n* Both sexes.\n* Patients who are scheduled for on-pump open heart surgery either isolated coronary artery bypass grafting (CABG) or combined CABG and valve surgery.\n\nExclusion Criteria:\n\n* Patients with a past history of CNS disease (e.g. Epilepsy, brain tumors, or Dementia).\n* Patients with metabolic disturbance.\n* Illiterate patient.\n* Patient with sever cognitive impairment on Mini-mental state Examination (MMSE) and\u002For Montreal Cognitive Assessment (MoCA)\n* Patients who cannot undergo DEEG recordings (eg, uncooperative).\n* Patients with abnormal brain images except for small vessel disease.","60 Years",{"count":61,"type":21},80,"OBSERVATIONAL","This study aims to investigate postoperative clinical, cognitive and neurophysiological assessment of patients after open heart surgery among sample of Egyptian patients.",[65,66,34,67],"Postoperative","Clinical","Open Heart Surgery","2024-11-24",{"date":70,"type":45},"2024-11-27",{"date":72,"type":45},"2023-06-01",{"date":74,"type":21},"2025-05-01",{"name":76,"class":52},"Ain Shams University",1]