[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurophysiology\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurophysiology":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,54],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100641517","investigating-the-transcutaneous-vs-transcranial-mechanisms-of-trigeminal-nerve-stimulation-etns-using-fmri-100641517",false,"NCT07657260","Investigating the Transcutaneous vs. Transcranial Mechanisms of Trigeminal Nerve Stimulation (eTNS) Using fMRI","Differentiating the Transcutaneous and Transcranial Mechanisms of Direct Current Trigeminal Nerve Stimulation on Brainstem and Autonomic Function: A Randomized, Sham-Controlled, Crossover fMRI Study With Local Anesthesia","Inclusion Criteria:\n\n1. Healthy volunteers, aged 18 to 40 years old.\n2. Right-handed.\n3. Generally healthy with no history of neurological, psychiatric, or severe cardiovascular diseases.\n4. Normal physical and neurological examinations.\n5. Capable of understanding the study procedures and voluntarily signing the written informed consent form.\n\nExclusion Criteria:\n\n1. Known allergy, hypersensitivity, or adverse reactions to Lidocaine or other amide-type local anesthetics. (Crucial for this specific study design)\n2. Contraindications to MRI scanning (e.g., claustrophobia, cardiac pacemakers, artificial cochlea, metallic braces, or any other ferromagnetic implants).\n3. Female participants who are pregnant, lactating, or suspect they might be pregnant.\n4. Contraindications to transcranial or transcutaneous electrical stimulation (e.g., personal or family history of epilepsy\u002Fseizures, implanted brain stimulators).\n5. Any active skin disease, inflammation, lesions, cuts, or abrasions on the forehead (specifically over the supraorbital area), which could alter electrical impedance or anesthetic absorption.\n6. History of trigeminal neuralgia, facial nerve palsy, or chronic facial pain. Current or recent (within the past month) use of any medications known to affect the central nervous system, autonomic nervous system, or pain perception (e.g., analgesics, antidepressants, beta-blockers, or sedatives).\n7. History of substance abuse, heavy smoking, or excessive daily consumption of alcohol or caffeine.\n8. Irregular sleep patterns, shift work, or severe sleep deprivation within 24 hours prior to the scanning sessions.",true,"ALL","18 Years","35 Years",{"count":21,"type":22},25,"ESTIMATED","INTERVENTIONAL",[25],"NA","Transcutaneous Trigeminal Nerve Stimulation (eTNS) is a non-invasive technique that modulates brain activity by applying electrical currents to the forehead. However, it remains unclear whether its effects are primarily driven by activating peripheral nerves in the skin (the transcutaneous pathway) or by the electrical current passing directly through the skull into the brain (the transcranial pathway).\n\nThis study aims to differentiate these two mechanisms in healthy volunteers. Participants will complete two separate MRI scanning sessions. In one session, a local anesthetic (lidocaine) will be applied to numb the skin over the forehead (specifically the supraorbital nerve branch) to temporarily block the peripheral nerve signals. In the other session, no anesthesia will be used. During both sessions, participants will receive active direct current eTNS (DC-eTNS) and a sham (inactive) stimulation while inside a 3T MRI scanner.\n\nResearchers will simultaneously measure brain activity (fMRI) and physiological signals (breathing and heart rate). By comparing the brain and bodily responses between the anesthetized and non-anesthetized conditions, the study seeks to determine exactly how eTNS signals travel to and affect the brainstem, cortex, and autonomic nervous system.",[28,29,30],"Healthy Volunteers","Neurophysiology","fMRI Research",[32,33,34,35,36,37,38,39,40],"Direct Current Trigeminal Nerve Stimulation","DC-eTNS","Lidocaine","Transcutaneous Mechanism","Transcranial Mechanism","Trigeminal Nerve","Functional Magnetic Resonance Imaging \u002F fMRI","Central-Autonomic Coupling","Amplitude of Low-Frequency Fluctuations \u002F ALFF","RECRUITING","2026-06-15",{"date":44,"type":45},"2026-06-18","ACTUAL",{"date":47,"type":22},"2026-06-21",{"date":49,"type":22},"2026-07-05",{"name":51,"class":52},"Xidian University","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":53},"100412627","multi-level-approach-of-brain-activity-using-intracranial-electrodes-in-epileptic-patients-100412627","NCT04653012","Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients","EpiMicro","Inclusion Criteria:\n\n* Patients with focal drug-resistant epilepsy\n* Patients who undergo a presurgical evaluation with intracranial electrodes in the videoEEG unit of the Neurology department at the Pitié-Salpêtrière hospital.\n* Patients who have been informed and provided written informed consent to take part in the study\n\nExclusion Criteria:\n\n* Contraindication for an intracranial investigation (with macro-electrodes) : intercurrent infectious syndrome, decompensated associated pathology (cardiac, pulmonary, renal, hepatic), patient with increased risk of infection (ex: under immunosuppressive therapy)\n* Pregnant or parturient woman\n* Breastfeeding woman\n* Minor person or legally protected adult (tutelage, legal guardianship, maintenance of justice)",{"count":62,"type":22},50,[25],"The main goal of this project is to study the mechanisms of epileptic activities using intracranial macro and micro electrodes in epileptic patients undergoing pre-surgical investigation.\n\nThe recordings will also be used to study physiological mechanisms like sleep and different cognitive functions.",[66,67,68,29],"Focal Epilepsy","Electrodes, Implanted","Cognitive Function",[70,71,72],"Microelectrodes","Seizures","EEG","2025-09-02",{"date":75,"type":45},"2025-09-08",{"date":77,"type":45},"2021-02-28",{"date":79,"type":22},"2031-02-27",{"name":81,"class":82},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV"]