[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neuroplasticity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neuroplasticity":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,54,91,127],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100623769","brain-stimulation-combined-with-watching-hand-movements-to-improve-hand-recovery-in-chronic-stroke-100623769",false,"NCT07400939","Brain Stimulation Combined With Watching Hand Movements to Improve Hand Recovery in Chronic Stroke","Investigating The Neurophysiological Mechanisms Of Transcranial Direct Current Stimulation Combined With Action Observation Therapy On Hand Muscle Neuroplasticity in Chronic Stroke","Inclusion Criteria:\n\n* Adults aged 18 to 59 years\n* Single episode of unilateral stroke and weakness in hand muscles 6 to 24 months post-stroke\n* No excessive spasticity of the upper limb, defined as grade two or less on Modified Ashworth Scale\n\nExclusion Criteria:\n\n* Patients diagnosed with posterior circulation infarction\n* Unable to follow commands due to poor cognitive function\n* Unilateral neglect\n* Homonymous hemianopia\n* Other existing neurological disorders that lead to poor hand function\n* Grade four or five hand muscle strength.","ALL","18 Years","59 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study investigates the neurophysiological mechanisms underlying the combined use of transcranial direct current stimulation (tDCS) and action observation therapy (AOT) for hand motor recovery in individuals with stroke. Background: While both tDCS and AOT have shown promise individually for stroke rehabilitation, the neural mechanisms of their combined effects remain unclear. Understanding these mechanisms could optimise rehabilitation protocols and improve functional outcomes. Intervention: Participants will receive 10 sessions of anodal tDCS over the ipsilesional motor cortex combined with AOT over two weeks in a clinical setting, followed by 8 weeks of home-based AOT practice. Control groups will receive tDCS alone or AOT alone. Neurophysiological changes will be assessed using motor evoked potentials (MEPs) to evaluate corticospinal excitability. Clinical hand function will be assessed using standardised outcome measures. Measurements: Assessments will be conducted at baseline, during intervention (week 2), and after the home practice phase (week 10) to evaluate neuroplastic changes. Significance: This study will provide mechanistic insights into how neuromodulation and observational learning interact to promote motor recovery, informing evidence-based rehabilitation strategies for stroke survivors in Malaysia and globally. Study Design: Randomised controlled trial with three parallel arms, recruiting 60 participants with chronic stroke from Sabah, Malaysia.",[27,28,29,30,31,32,33,34],"Stroke","tDCS","Action Observation Therapy","Hand","Motor Evoked Potential","EMG","Neuroplasticity","Neurophysiological Assessment",[36,37,38,39,40],"stroke rehabilitation","transcranial direct current stimulation","action observation therapy","neuroplasticity","neurophysiological","RECRUITING","2026-05-07",{"date":44,"type":45},"2026-05-12","ACTUAL",{"date":47,"type":45},"2026-04-01",{"date":49,"type":21},"2028-01-20",{"name":51,"class":52},"Universiti Malaysia Sabah","OTHER",2,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":16,"minAge":17,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":72,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":90},"100589103","amplifi-adaptive-modulation-of-plasticity-through-lactate-and-fitness-interventions-100589103","NCT06950060","AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions","AMPLIFI","Inclusion Criteria:\n\nFor All Participants:\n\n* Able to provide informed consent\n* Right-handed (for TMS consistency)\n* English-speaking\n* Clearance for moderate-intensity aerobic exercise\n* Able to safely sit and pedal a stationary cycle ergometer\n* No contraindications to TMS (e.g., no metal in skull, pacemakers, or seizure history)\n\nYounger Adults (18-35):\n\n* No history of neurological or psychiatric conditions\n* Not currently on medications that affect the central nervous system\n\nOlder Adults (60-85):\n\n* No diagnosis of dementia\n* Independent in activities of daily living\n* No stroke history\n\nStroke Survivors (40-85):\n\n* At least 6 months post-stroke (chronic phase)\n* Medically stable and cleared for aerobic exercise\n* Able to engage in motor learning task (with or without hemiparetic adaptations)\n\nExclusion Criteria:\n\n* History of epilepsy or seizures\n* Current substance abuse or uncontrolled psychiatric disorder\n* Severe cardiovascular disease or unstable medical condition\n* Pregnancy\n* Contraindications to TMS or exercise testing (e.g., implanted neurostimulators, severe hypertension)\n* Participation in another interventional trial within the past 30 days",true,"85 Years",{"count":64,"type":21},48,[24],"The AMPLIFI study (Adaptive Modulation of Plasticity through Lactate and Fitness Interventions) investigates how short-term aerobic exercise influences brain plasticity and learning in older adults and stroke survivors. The study compares three groups: one performing aerobic cycling at an intensity that elevates lactate levels, one performing low-intensity exercise, and one receiving health education without exercise.\n\nAll participants will complete motor learning tasks and undergo brain-stimulation testing using transcranial magnetic stimulation (TMS) to assess how well the brain responds to training. The goal is to understand whether different types of exercise can improve brain function, movement, and memory, and how the body's response to exercise (like lactate levels) might support brain health.\n\nThis research may help identify low-cost, non-invasive interventions-such as targeted exercise-that improve motor and cognitive outcomes in aging and stroke recovery.",[68,69,70,71,33],"Stroke, Chronic","Aging","Cognitive Decline","Motor Dysfunction",[73,74,33,75,76,69,77,78,79],"Transcranial Magnetic Stimulation (TMS)","Cortical Inhibition","Aerobic Exercise","Motor Learning","Stroke Rehabilitation","Cortical Excitability","GABAergic Inhibition","NOT_YET_RECRUITING","2026-04-16",{"date":83,"type":45},"2026-04-17",{"date":85,"type":21},"2026-05-14",{"date":87,"type":21},"2030-01-01",{"name":89,"class":52},"University of Alabama at Birmingham",1,{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":102,"conditions":103,"keywords":114,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":90},"100420789","neurorehabilitation-through-hippotherapy-of-a-brain-stroke-100420789","NCT04759326","Neurorehabilitation Through Hippotherapy of a Brain Stroke","Neurorehabilitation Through Hippotherapy on Neurofunctional Sequels of Brain Stroke: (i) Effect on Patient's Functional Independence, Sensorimotor and Cognitive Capacities and Quality of Life (ii) Effect on Caregivers' Quality of Life","HippoPostCVA","Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Ischemic or haemorrhagic stroke according to ICD 10 I61-I69 (30)\n* Inclusion \\> 3 months post-stroke\n* Deficit still existing (Rankin score ≥ 3 and ≤ 4 at inclusion)\n* Existing declaration of informed consent\n* Affiliation of the patient to a social security scheme\n* Minimal abduction of the hip of 25 degrees bilateral with no history of hip dislocation and\u002For dysplasia\n* Certificate of non-contraindication issued by the referring physician\n\nExclusion Criteria:\n\n* Major cognitive impairment affecting comprehension (Mini Mental State Examination test \\\u003C 24 points)\n* Global or sensory aphasia\n* Neurological or psychiatric co-morbidity (other than mild-to-moderate post-stroke depression)\n* Evidence of an uncontrolled seizure disorder\n* Substance abuse\n* History of uncontrolled pain\n* History of allergic reactions to dust and\u002For horsehair, or severe asthma\n* Overweight (≥ 110 kg)\n* Contraindications to physical activity\n* Inability or medical contraindication to travel to the Equiphoria Institute by personal car or taxi\n* History of horse riding or hippotherapy care during the last 6 months\n* Pregnant or lactating women\n* Patients participating in other biomedical research or in a period of exclusion",{"count":100,"type":21},52,[24],"Cerebrovascular accident \\[CVA\\] (medical term for stroke) is a high burden worldwide disorder and the second leading cause of disability. As illustrated by the number of survivors that remain disabled after a CVA (2 out of 3 according to the US National Stroke Association), recovery is limited, and novel neurorehabilitation approaches are urgently needed. Hippotherapy is an emerging specialized rehabilitation approach, performed by accredited health professionals on a specially trained horse via its movement. A body of scientific evidence has gradually emerged in recent years, showing robust benefits of hippotherapy in various massive neurological disabling conditions including brain stroke.\n\nThe aim of the study is to analyze the effect of a hippotherapy program of several cycles delivered during 22 weeks in total, on the functional and global evolution of post-stroke patients (with a score of Rankin ≥ 3 at inclusion) during the outpatient rehabilitation phase. A second purpose is to measure the impact of the intervention on the quality of life of their close caregivers.\n\nA prospective clinical trial on the effectiveness of hippotherapy versus conventional outpatient rehabilitation alone will be carried out. The 22-weeks program includes three cycles of hippotherapy as follows: an initial 2-weeks cycle, an intermediate 1-week cycle and a final 1-week cycle. One-hour daily sessions will be conducted during each cycle exclusive additional rehabilitation care. After each cycle, the patients will have a 9-weeks rest period where they will continue their conventional therapy. A battery of clinical tests will measure both functional and psychological outcome. The primary end point will be the functional independence of the patient. The secondary end points will consider the patient's sensorimotor and cognitive function, the severity of stroke and the quality of life, as well as the caregivers' burden and quality of life.\n\nProgram evaluation is important in neurorehabilitation to ensure that patients are achieving meaningful outcomes from the care. A primary question is how do stroke patients clinically evolve after being discharged from the hospital and how stable is the achieved rehabilitation outcome. Hippotherapy optimizes brain plasticity and has a strong impact on the global rehabilitation process and functional outcome of these patients. A remaining question concerns the improvement of the caregivers' quality of life.",[104,105,33,106,107,108,109,110,111,112,113],"Cerebrovascular Accident","Neurorehabilitation","Hippotherapy","Silent Neurofunctional Barriers","Functional Deficit","Cognitive Deficit","Psychological Trauma","Autonomy","Quality of Life","Caregiver Burnout",[115,116,117],"NeuroRehabilitation through hippotherapy","Brain plasticity","Functional recovery","2024-07-30",{"date":120,"type":45},"2024-07-31",{"date":122,"type":45},"2022-04-27",{"date":124,"type":21},"2026-03",{"name":126,"class":52},"Alliance Equiphoria",{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":16,"minAge":134,"maxAge":135,"enrollmentInfo":136,"targetDuration":138,"studyType":139,"phases":4,"briefSummary":140,"conditions":141,"keywords":150,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":90},"100544681","tornado-omics-techniques-and-neural-networks-for-the-development-of-predictive-risk-models-100544681","NCT06372054","TORNADO-Omics Techniques and Neural Networks for the Development of Predictive Risk Models","Integration of Omics-based Technologies and Artificial Intelligence to Identify Predictive Risk Models in a Air Force's Pilot Cohort for the Maintenance of Safety, Well-being, Health, and Performance to be Translated to Civil Population","Inclusion Criteria:\n\n* Being part of the Italian Air Force, as in active flight service or ground staff\n* Age between 26 and 38 years\n* Consent to collect biological samples and use the wearable device to monitor exposure parameters\n\nExclusion Criteria:\n\n* Age \\\u003C 25 years and \\> 39 years\n* no signature on informed consent","26 Years","38 Years",{"count":137,"type":21},200,"3 Years","OBSERVATIONAL","The goal of this observational study is to define a personalized risk model in the super healthy and homogeneous population of Italian Air Force high-performance pilots. This peculiar cohort conducts dynamic activities in an extreme environment, compared to a population of military people not involved in flight activity. The study integrates the analyses of biological samples (urine, blood, and saliva), clinical records, and occupational data collected at different time points and analyzed by omic-based approaches supported by Artificial Intelligence. Data resulting from the study will clarify many etiopathological mechanisms of diseases, allowing the creation of a model of analyses that can be extended to the civilian population and patient cohorts for the potentiation of precision and preventive medicine.",[142,143,144,145,146,147,148,33,149],"Oxidative Injury","Stress Physiological","Discogenic Pain","Cardiovascular Risk Factor","Space Maintenance","Epigenetic Changes","LONGEVITY 1","NGS",[151,152,153,154],"pilots","air force","epigenetic change","environmental exposure","2024-04-16",{"date":157,"type":45},"2024-04-17",{"date":159,"type":45},"2024-02-05",{"date":161,"type":21},"2027-02-05",{"name":163,"class":52},"Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico"]