[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neurorehabilitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neurorehabilitation":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,46,81,113,139,168,190,215,241],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":4},"100640039","effects-of-functional-electrical-stimulation-on-spasticity-quadriceps-muscle-strength-and-functional-mobility-in-individuals-with-paraplegia-100640039",false,"NCT07583576","Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia","Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia: A Randomized Controlled Trial","FES-PAR-RCT","Inclusion Criteria:\n\n* Participants will be included in the study if they meet all of the following criteria:\n* Aged between 18 and 65 years\n* Diagnosed with spinal cord injury resulting in paraplegia (traumatic or non-traumatic etiology)\n* Classified as ASIA Impairment Scale C or D\n* Medically stable condition\n* Presence of lower extremity spasticity (Modified Ashworth Scale ≥ 1)\n* Ability to understand and follow simple instructions\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Participants will be excluded if they present any of the following conditions:\n* Presence of cardiac pacemaker or implanted electrical device\n* Severe cognitive impairment or communication difficulties preventing participation\n* Active infection or systemic inflammatory condition\n* Severe lower extremity contractures or deformities limiting movement\n* Dermatological conditions or open wounds preventing FES application\n* History of severe autonomic dysreflexia triggered by electrical stimulation\n* Uncontrolled medical conditions that may interfere with participation or safety","ALL","18 Years","65 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","Spinal cord injury (SCI)-related paraplegia is a complex neurological condition characterized by motor impairment, increased spasticity, and significant functional limitations in daily activities. Spasticity is one of the most common secondary complications after upper motor neuron lesions and can negatively affect rehabilitation outcomes, gait ability, and functional independence.\n\nThis randomized controlled study aims to investigate the effects of Functional Electrical Stimulation (FES) applied to the quadriceps muscle in individuals with paraplegia. Participants will be randomly assigned to either a control group receiving conventional neurorehabilitation or an intervention group receiving additional FES treatment.\n\nThe primary outcomes include changes in spasticity level, quadriceps muscle strength, and functional mobility. Spasticity will be assessed using the Modified Ashworth Scale (MAS), muscle strength will be evaluated with Manual Muscle Testing (MMT), and functional mobility will be measured using the Spinal Cord Independence Measure (SCIM), Timed Up and Go Test (TUG), and 6-Minute Walk Test (6MWT).\n\nThe intervention period will last 8 weeks, with standardized rehabilitation programs applied to both groups. The FES group will additionally receive quadriceps stimulation with specific neuromuscular electrical stimulation parameters.\n\nThe findings of this study are expected to provide evidence regarding the effectiveness of FES as an adjunct to conventional rehabilitation in improving motor function and functional independence in individuals with paraplegia.",[28,29,30,31],"Spinal Cord Injury","Paraplegia","Spasticity","Neurorehabilitation",[28,33,31,30,29],"Paraplegia Rehabilitation","NOT_YET_RECRUITING","2026-05-15",{"date":37,"type":38},"2026-05-19","ACTUAL",{"date":40,"type":22},"2026-05-10",{"date":42,"type":22},"2026-07-10",{"name":44,"class":45},"Istanbul Medipol University Hospital","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100626725","multifocal-theta-burst-stimulation-to-enhance-upper-limb-motor-recovery-after-stroke-inspire-100626725","NCT07439367","Multifocal Theta-Burst Stimulation to Enhance Upper Limb Motor Recovery After Stroke (INSPIRE)","Advancing Stroke Rehabilitation Through Multifocal Network-based Theta-burst Stimulation and Assistive Technology: Enhancing Upper Limb Motor Learning: A Single-center, Randomized, Sham-controlled Study With Parallel Groups.","INSPIRE","Inclusion Criteria:\n\nFor Stroke Participants:\n\n* Age ≥ 18 years\n* First-ever ischemic or hemorrhagic stroke\n* Time since stroke ≥ 6 months\n* Unilateral upper limb hemiparesis\n* Fugl-Meyer Assessment Upper Extremity (FMA-UE) score between 29 and 57\n* Modified Ashworth Scale score \\\u003C 2 at elbow, wrist, or finger flexors\n* Manual muscle testing ≥ 3\u002F5 in proximal upper limb muscles (deltoid, biceps, triceps, wrist pronators\u002Fsupinators)\n* Ability to understand and follow study procedures\n* Provided written informed consent\n\nFor Healthy Participants:\n\n* Age ≥ 18 years\n* No history of neurological disease\n* Ability to understand and follow study procedures\n* Provided written informed consent\n\nExclusion Criteria:\n\nFor Stroke Participants:\n\n* Second stroke occurring during the study period\n* Botulinum toxin injection within 3 months prior to study start\n* History of one or more epileptic seizures\n* Metallic object near the stimulation site\n* Implanted electronic or metallic devices (e.g., pacemaker, neurostimulator) incompatible with TMS\n* Severe comorbid conditions affecting the upper limb (traumatic, rheumatologic, osteoarticular, or neurodegenerative disorders)\n* Pregnancy\n* Delirium or impaired vigilance\n* Inability to participate in one-hour treatment sessions\n* Inability to comply with study procedures (e.g., language barrier, psychological disorder, dementia)\n* Current or past substance abuse, including excessive alcohol consumption\n* Participation in another interventional clinical trial within 30 days prior to enrollment\n\nFor Healthy Participants:\n\n* Severe musculoskeletal or neurological condition affecting the non-dominant upper limb\n* Pregnancy\n* Delirium or impaired vigilance\n* Inability to participate in one-hour treatment sessions\n* Inability to comply with study procedures\n* Current or past substance abuse, including excessive alcohol consumption\n* Participation in another interventional clinical trial within 30 days prior to enrollment",true,{"count":56,"type":22},46,[25],"Stroke is one of the leading causes of long-term disability worldwide. Many individuals who survive a stroke continue to experience weakness and reduced control of one arm, even months or years after the event. These motor impairments significantly affect independence, daily activities, and quality of life. Despite rehabilitation efforts, recovery of upper limb function remains incomplete for many patients.\n\nMotor recovery after stroke depends on the brain's ability to reorganize itself, a process known as neuroplasticity. Recent research suggests that motor learning and brain recovery are influenced not only by activity in the primary motor cortex (M1), but also by its functional connectivity with other brain regions, particularly the parietal cortex (PC). Strengthening communication between these regions may enhance motor recovery.\n\nThis study aims to investigate a novel, non-invasive brain stimulation approach called intermittent theta-burst stimulation (iTBS). Unlike traditional stimulation methods that target a single brain region, this study uses a multifocal stimulation protocol targeting both the primary motor cortex and the parietal cortex. The stimulation is combined with structured motor training using an interactive tablet-based rehabilitation device (REAtouch®Lite 2), designed to improve arm movement through goal-directed reaching tasks.\n\nThe study is a single-center, randomized, sham-controlled, triple-blind clinical trial with parallel groups. Thirty-six individuals with chronic stroke-related upper limb impairment will be randomly assigned to receive either active multifocal iTBS or sham (placebo) stimulation. Both groups will complete identical motor training sessions. In addition, ten healthy participants will complete the same motor training protocol (without brain stimulation) to provide reference data.\n\nParticipants will attend six visits over approximately 10 days. Assessments will include motor performance tests using the interactive tablet, a standardized clinical motor scale (Fugl-Meyer Assessment for Upper Extremity), and resting-state electroencephalography (EEG) to measure brain connectivity changes.\n\nThe primary outcome is improvement in motor performance between baseline and one week after the intervention. Secondary outcomes include short-term motor improvements, retention of learning, changes in movement quality, and changes in brain functional connectivity.\n\nThis study seeks to determine whether combining multifocal brain stimulation with targeted motor training can enhance motor learning and promote better recovery of arm function after stroke. If effective, this approach could contribute to the development of more precise, network-based neurorehabilitation strategies.",[60,61,31,62],"Chronic Stroke Patient","Motor Impairment","Theta Burst Stimulation",[64,65,66,67,68,69],"Chronic Stroke","Upper Limb Rehabilitation","Intermittent Theta Burst Stimulation","Tablet-Based Rehabilitation","Neuroplasticity","Motor Learning","RECRUITING","2026-02-23",{"date":73,"type":38},"2026-02-27",{"date":75,"type":38},"2025-09-05",{"date":77,"type":22},"2026-08-31",{"name":79,"class":45},"School of Health Sciences Geneva",1,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":80},"100617295","eccentric-cycling-in-multiple-sclerosis-rehabilitation-100617295","NCT07316764","Eccentric Cycling in Multiple Sclerosis Rehabilitation","Eccentric Cycling : a New Training Modality in Multiple Sclerosis Rehabilitation","Inclusion Criteria:\n\n* Diagnosis of multiple sclerosis\n* Multiple sclerosis: EDSS score \\\u003C 7\n* Age under 75 years\n* Stable disease state\n* Written medical clearance authorizing participation\n* Legal adult status\n* Written informed consent, with demonstrated understanding of the consent form (via a few specific questions)\n* Ability to mobilize independently (e.g., transfers, walking)\n\nExclusion Criteria:\n\n* One or more contraindications to physical activity\n* Significant comorbidities\n* Current hospitalization or undergoing changes in medication\n* Active flare-up","75 Years",{"count":90,"type":22},60,[25],"The project aims to optimise functional rehabilitation programmes for people with multiple sclerosis.\n\nInvestigators are proposing eccentric cycling as a new exercise modality for treating these patients.\n\nBased on previous results in healthy subjects, investigators will attempt to define the optimal parameters of this new modality (in terms of duration, intensity, frequency, etc.).\n\nInvestigators also aim to demonstrate the effectiveness of this training (compared to conventional training) in improving muscle function, functional capacity, perception of chronic fatigue, quality of life, physical condition, and neurological and cognitive function.",[94,95,96,31],"Multiple Sclerosis","Rehabilitation","Neuro-Degenerative Disease",[98,99,100,101,102,103],"eccentric cycling","multiple sclerosis","eccentric training","neurorehabilitation","physical therapy","neuro-degenerative disease","2025-12-23",{"date":106,"type":38},"2026-01-05",{"date":108,"type":22},"2026-01",{"date":110,"type":22},"2026-12",{"name":112,"class":45},"University of Liege",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":23,"phases":122,"briefSummary":123,"conditions":124,"keywords":127,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":80},"100611154","towards-restoring-complex-movement-after-paralysis-algorithm-development-with-healthy-participants-100611154","NCT07236892","Towards Restoring Complex Movement After Paralysis: Algorithm Development With Healthy Participants","Restoring Complex Movement and Locomotion After Paralysis Through Collaborative Copilots: Algorithm Development With Healthy Participants","Inclusion Criteria:\n\n* Fluent in the English language\n\nExclusion Criteria:\n\n* Neurological injury or disease that results in functional paralysis",{"count":121,"type":22},50,[25],"Participants will perform experiments with non-invasive activity recordings. The study will record from multiple non-invasive signal sources that reflect motor intent that may include: electroencephalography (EEG), electromyography (EMG), functional near infrared spectroscopy (fNIRS), inertial measurement units (IMUs), eye movements, pupil size, and speech. Participants will wear all or a subset of these sensors and be asked to perform, imagine, or attempt movements or speech. The recorded sensor signals will be decoded to help guide an end effector, which may be a computer, robotic arm, wheelchair, or other assistive device.\n\nThese experiments present minimal risk and participants may withdraw participation at any time for any reason. Participants may return for additional experiments if desired and to perform additional comparisons. If a participant withdraws during a comparison, another participant will be recruited to complete collection of data for that comparison.",[125,31,126],"Movement Disorders","Non-invasive Activity Recording",[128,129],"Machine Learning","Algorithm Development","2025-12-22",{"date":132,"type":38},"2025-12-24",{"date":134,"type":38},"2025-11-26",{"date":136,"type":22},"2029-12-01",{"name":138,"class":45},"University of California, Los Angeles",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":88,"enrollmentInfo":146,"targetDuration":4,"studyType":23,"phases":148,"briefSummary":149,"conditions":150,"keywords":152,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":80},"100612059","comprehensive-therapeutic-program-for-people-with-multiple-sclerosis-100612059","NCT07248657","Comprehensive Therapeutic Program For People With Multiple Sclerosis","BIB_MS","Inclusion criteria:\n\n* Confirmed clinical diagnosis of MS\n* Age ≤ 75 years\n* Predominantly motor impairment\n* EDSS 2-8\n* Ability and motivation to attend outpatient physiotherapy regularly\n\nExclusion criteria:\n\n• Contraindications such as severe orthopedic or cardiovascular dysfunction, or presence of another neurological disorder",{"count":147,"type":22},26,[25],"This study investigates the effectiveness of an intensive multidisciplinary rehabilitation program for people with multiple sclerosis (PwMS). The program integrates intensive outpatient physiotherapy, psychotherapeutic consultations, and nutritional counseling to enhance motor and cognitive functions, promote neuroplasticity, and improve overall well-being as well as physical performance in PwMS. Through clinical assessments and standardized questionnaires, the study aims to provide scientific evidence on the benefits of comprehensive, non-pharmacological therapy as a core element in MS treatment.",[94,31,95,151],"Rehabilitation Exercise",[99,153,154,155,156,157,101,158],"rehabilitation","physiotherapy","psychotherapy","psychological support","exercise","facilitation and inhibition","2025-11-24",{"date":161,"type":38},"2025-12-01",{"date":163,"type":22},"2025-12-05",{"date":165,"type":22},"2026-12-31",{"name":167,"class":45},"Charles University, Czech Republic",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":23,"phases":177,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":4},"100599627","early-phase-1-neurorehabilitation-of-cognitive-deficits-in-multiple-sclerosis-using-an-adaptive-cognitive-exergame---randomized-controlled-multi-center-clinical-trial-100599627","NCT07086950","Neurorehabilitation of Cognitive Deficits in Multiple Sclerosis Using an Adaptive Cognitive Exergame - Randomized, Controlled, Multi-center Clinical Trial","REALISE-MS","Inclusion Criteria:\n\n1. Informed Consent signed by the participant,\n2. Adults 18+ years,\n3. Patients with a diagnosis of relapsing multiple sclerosis according to the most recent internationally recognized criteria, as evaluated by their treating physicians (Thompson et al., 2018) or secondary progressive MS (diagnosis ≤ 30 months),\n4. Presence of cognitive complaint,\n5. Z-Score ≤ -0.5 in the Symbol Digit Modalities Test (SDMT)\n\nExclusion criteria:\n\n1. Clinically or radiologically confirmed MS relapses within 3 months prior to enrollment,\n2. Change in disease modifying treatments (DMT), antidepressant or anxiolytic medication within 1 month prior to enrollment,\n3. High risk of falls based on a completion time of more than 15 seconds in the Four Square Step Test (FSST) (Dite \\& Temple, 2002),\n4. Assisted locomotion or falls in the past 3 months as evaluated in the enrollment interview (Hopkins Falls Grading Scale (Grade \\> 1)),\n5. Major psychiatric and\u002For neurocognitive disorders according to the DSM-5 (APA, 2013),\n6. Incapacity to discriminate colors (Ishihara test; (Clark, 1924)),\n7. Insufficient language knowledge to understand instructions or questionnaires,\n8. High-risk pregnancy as evaluated by the appointed gynecologist.\n9. Z-Score ≤ -3.5 in the Symbol Digit Modalities Test (SDMT).",{"count":176,"type":22},190,[178],"EARLY_PHASE1","Approximately 2.8 million people worldwide suffer from multiple sclerosis (MS). In 40 to 70% of cases, individuals with MS experience cognitive impairments that significantly interfere with their personal lives, careers, and quality of life. Current pharmacological and neurorehabilitation treatment options do not adequately reduce cognitive deficits. The absence of standards of care in Switzerland or internationally regarding cognitive neurorehabilitation in MS highlights the need for effective interventions with lasting effects.\n\nTo address this need, we are exploring different approaches to support and improve cognitive impairments through training exercises using computerized tools. Traditionally, these exercises are in paper-and-pencil format, consisting of tests, puzzles, and memory tasks. While this approach is useful, computerized tools now allow us to offer more playful, interactive, and engaging approaches.\n\nIn this study, we are examining the effect of serious video games (a medical device) on cognitive deficits related to MS. The serious video games we are testing have already been evaluated at CHUV in individuals with MS and cognitive impairments. This recent study demonstrated the feasibility and safety of using these games in people with MS. With the current study, we aim to test these tools on a larger scale in order to better understand their effects on cognitive functions. More specifically, we seek to determine which of the two proposed interventions provides the greatest cognitive benefits.",[94,31],"2025-07-18",{"date":183,"type":38},"2025-07-25",{"date":185,"type":22},"2025-09-01",{"date":187,"type":22},"2028-06-30",{"name":189,"class":45},"Prof. Arseny Sokolov, MD, PhD",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":197,"targetDuration":4,"studyType":23,"phases":198,"briefSummary":199,"conditions":200,"keywords":203,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":80},"100590220","cognitive-rehabilitation-of-deficits-in-patients-with-multiple-sclerosis-100590220","NCT06964581","Cognitive Rehabilitation of Deficits in Patients With Multiple Sclerosis","Cognitive Rehabilitation of Deficits in Patients With Multiple Sclerosis: Proposal for an Integrated Cognitive Treatment in a Telematic Format","Inclusion Criteria:\n\n* Diagnosis of relapsing-remitting multiple sclerosis (RRMS), or primary progressive (PPMS) or secondary progressive (SPMS), defined by at least 3-6 months.\n* Age between 18 and 65 years.\n* Expanded Disability Status Scale (EDSS) between 3 and 5 to include patients with overall neurological disability from mild to moderate.\n* Presence of one or more of the following cognitive disorders (reported by the patient and subsequently confirmed through the Oxford Cognitive Screen-OCS):\n* Memory disorders\n* Attention disorders\n* Executive function disorders\n* Availability of internet at the patient's home necessary for the tele-rehabilitation procedures.\n* Adequate visual and auditory abilities to use the rehabilitation device.\n\nExclusion Criteria:\n\n* Presence of other neurological conditions;\n* Psychiatric disorders in medical history;\n* Alcohol and\u002For drug abuse;\n* Presence of uncorrected severe visual deficits.",{"count":90,"type":22},[25],"Non-Inferiority Study, Post-Market Clinical Investigation with a Device, Single-Blind Randomized Controlled Trial in a Cohort of Patients Diagnosed with Multiple Sclerosis (MS).\n\nThe aim of the study is to assess whether a computer-based cognitive treatment delivered via telerehabilitation produces effects from T0 to T1 that are not inferior to those of an in-person treatment on sustained attention in a cohort of patients with MS.\n\nThe secondary objective is to evaluate the effects of telerehabilitation compared to the same treatment delivered in person on attentional shifting, memory, executive functions, and daily functioning (including cognitive fatigue, quality of life, and mood) in patients with MS.",[201,94,202,31],"Telerehabilitation","Cognitive Disorders",[204,99,205],"telerehabilitation","cognitive disorders","2025-04-30",{"date":208,"type":38},"2025-05-09",{"date":210,"type":38},"2023-02-08",{"date":212,"type":22},"2025-09-30",{"name":214,"class":45},"Universita di Verona",{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":17,"minAge":221,"maxAge":4,"enrollmentInfo":222,"targetDuration":4,"studyType":23,"phases":224,"briefSummary":225,"conditions":226,"keywords":230,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":239,"locationsCount":80},"100589156","effects-of-robotic-gloves-along-with-task-oriented-mirror-therapy-on-motor-functions-of-hands-in-sub-acute-stroke-patients-100589156","NCT06950749","Effects of Robotic Gloves Along With Task-oriented Mirror Therapy on Motor Functions of Hands in Sub-acute Stroke Patients","Inclusion Criteria:\n\n* 40 years and above.\n* Ischemic (MCA) stroke.\n* Male and females both.\n* Montreal Cognitive Assessment (MoCA score \\>24 points).\n* Motor power of proximal upper Extremity at least 3 with ability to reach out.\n* FMA score for upper Extremity below 47\n* Modified Ashworth spasticity score \\\u003C2 in hands and finger joints.\n* Ability to sit for at least 60 minutes\n\nExclusion Criteria:\n\n* Musculoskeletal problems such as severe pain in any joints of the paretic upper extremity.\n* Contractures in shoulder, elbow, hand or finger joints.\n* Severe Visual impairments.","40 Years",{"count":223,"type":22},30,[25],"This study is randomized control trial and purpose of this study is to find effects of robotic gloves assisted task-oriented mirror therapy in comparison with task-oriented mirror therapy on motor functions of hand in sub-acute stroke patients.",[227,228,229,31],"Stroke","Mirror Therapy","Robotics",[231,232,233,101],"stroke","mirror therapy","robotics","2025-04-27",{"date":206,"type":38},{"date":237,"type":38},"2024-10-12",{"date":206,"type":22},{"name":240,"class":45},"Foundation University Islamabad",{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":23,"phases":251,"briefSummary":252,"conditions":253,"keywords":263,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":80},"100420789","neurorehabilitation-through-hippotherapy-of-a-brain-stroke-100420789","NCT04759326","Neurorehabilitation Through Hippotherapy of a Brain Stroke","Neurorehabilitation Through Hippotherapy on Neurofunctional Sequels of Brain Stroke: (i) Effect on Patient's Functional Independence, Sensorimotor and Cognitive Capacities and Quality of Life (ii) Effect on Caregivers' Quality of Life","HippoPostCVA","Inclusion Criteria:\n\n* Age ≥ 18 years old\n* Ischemic or haemorrhagic stroke according to ICD 10 I61-I69 (30)\n* Inclusion \\> 3 months post-stroke\n* Deficit still existing (Rankin score ≥ 3 and ≤ 4 at inclusion)\n* Existing declaration of informed consent\n* Affiliation of the patient to a social security scheme\n* Minimal abduction of the hip of 25 degrees bilateral with no history of hip dislocation and\u002For dysplasia\n* Certificate of non-contraindication issued by the referring physician\n\nExclusion Criteria:\n\n* Major cognitive impairment affecting comprehension (Mini Mental State Examination test \\\u003C 24 points)\n* Global or sensory aphasia\n* Neurological or psychiatric co-morbidity (other than mild-to-moderate post-stroke depression)\n* Evidence of an uncontrolled seizure disorder\n* Substance abuse\n* History of uncontrolled pain\n* History of allergic reactions to dust and\u002For horsehair, or severe asthma\n* Overweight (≥ 110 kg)\n* Contraindications to physical activity\n* Inability or medical contraindication to travel to the Equiphoria Institute by personal car or taxi\n* History of horse riding or hippotherapy care during the last 6 months\n* Pregnant or lactating women\n* Patients participating in other biomedical research or in a period of exclusion",{"count":250,"type":22},52,[25],"Cerebrovascular accident \\[CVA\\] (medical term for stroke) is a high burden worldwide disorder and the second leading cause of disability. As illustrated by the number of survivors that remain disabled after a CVA (2 out of 3 according to the US National Stroke Association), recovery is limited, and novel neurorehabilitation approaches are urgently needed. Hippotherapy is an emerging specialized rehabilitation approach, performed by accredited health professionals on a specially trained horse via its movement. A body of scientific evidence has gradually emerged in recent years, showing robust benefits of hippotherapy in various massive neurological disabling conditions including brain stroke.\n\nThe aim of the study is to analyze the effect of a hippotherapy program of several cycles delivered during 22 weeks in total, on the functional and global evolution of post-stroke patients (with a score of Rankin ≥ 3 at inclusion) during the outpatient rehabilitation phase. A second purpose is to measure the impact of the intervention on the quality of life of their close caregivers.\n\nA prospective clinical trial on the effectiveness of hippotherapy versus conventional outpatient rehabilitation alone will be carried out. The 22-weeks program includes three cycles of hippotherapy as follows: an initial 2-weeks cycle, an intermediate 1-week cycle and a final 1-week cycle. One-hour daily sessions will be conducted during each cycle exclusive additional rehabilitation care. After each cycle, the patients will have a 9-weeks rest period where they will continue their conventional therapy. A battery of clinical tests will measure both functional and psychological outcome. The primary end point will be the functional independence of the patient. The secondary end points will consider the patient's sensorimotor and cognitive function, the severity of stroke and the quality of life, as well as the caregivers' burden and quality of life.\n\nProgram evaluation is important in neurorehabilitation to ensure that patients are achieving meaningful outcomes from the care. A primary question is how do stroke patients clinically evolve after being discharged from the hospital and how stable is the achieved rehabilitation outcome. Hippotherapy optimizes brain plasticity and has a strong impact on the global rehabilitation process and functional outcome of these patients. A remaining question concerns the improvement of the caregivers' quality of life.",[254,31,68,255,256,257,258,259,260,261,262],"Cerebrovascular Accident","Hippotherapy","Silent Neurofunctional Barriers","Functional Deficit","Cognitive Deficit","Psychological Trauma","Autonomy","Quality of Life","Caregiver Burnout",[264,265,266],"NeuroRehabilitation through hippotherapy","Brain plasticity","Functional recovery","2024-07-30",{"date":269,"type":38},"2024-07-31",{"date":271,"type":38},"2022-04-27",{"date":273,"type":22},"2026-03",{"name":275,"class":45},"Alliance Equiphoria"]