[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"neutrophil-to-lymphocyte-ratio\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:neutrophil-to-lymphocyte-ratio":55},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100620093","preoperative-neutrophil-to-lymphocyte-ratio-and-early-postoperative-pain-after-septorhinoplasty-100620093",false,"NCT07353138","Preoperative Neutrophil-to-Lymphocyte Ratio and Early Postoperative Pain After Septorhinoplasty","The Relationship Between Preoperative Neutrophil-to-Lymphocyte Ratio and Hemogram Parameters and Early Postoperative Pain Scores in Patients Undergoing Septorhinoplasty","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* Patients undergoing elective septorhinoplasty\n* Surgery performed under general anesthesia\n* Complete recording of early postoperative VAS pain scores, Aldrete scores, NUDES scores, and vital signs in the Post-Anesthesia Care Unit (PACU)\n* Preoperative complete blood count (hemogram) performed within 30 days prior to surgery\n* Clinical records and hospital information system data that are complete, accessible, and adequate for analysis\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery\n* Septorhinoplasty combined with additional major surgical procedures (e.g., advanced ENT or maxillofacial surgery)\n* Presence of known hematological disease, active infection, immunosuppressive therapy, or advanced liver or renal failure\n* Chronic opioid use or regular analgesic medication use in the preoperative period\n* History of significant clinical events between the preoperative hemogram and surgery that could alter inflammatory status (e.g., infection, hospitalization, additional surgery)\n* Incomplete or missing data regarding preoperative hemogram parameters or PACU pain scores","ALL","18 Years","65 Years",{"count":20,"type":21},110,"ESTIMATED","OBSERVATIONAL","This prospective, observational study investigates the relationship between early oxygen exposure and oxidative stress in adult intensive care unit patients with sepsis or septic shock. Fraction of inspired oxygen (FiO₂) administered during the first 24 hours of ICU admission will be recorded and analyzed in relation to changes in the uric acid\u002Falbumin ratio (UAR), a biomarker reflecting oxidative burden and inflammation. Serum uric acid and albumin levels will be measured at baseline and at 24 hours, and the percentage change in UAR will be calculated. Secondary analyses will examine associations between UAR changes, oxygenation indices, and 28-day mortality. The study aims to determine whether higher FiO₂ exposure is associated with increased oxidative stress and to evaluate the potential role of UAR as a clinically accessible marker of oxygen-related oxidative injury in septic ICU patients.",[25,26],"Neutrophil-to-Lymphocyte Ratio","Septorhinoplasty","NOT_YET_RECRUITING","2026-01-15",{"date":30,"type":31},"2026-01-20","ACTUAL",{"date":33,"type":21},"2026-01-01",{"date":35,"type":21},"2026-03-31",{"name":37,"class":38},"Istinye University","OTHER",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100525917","phase-1-the-relationship-between-nlr-and-ponv-and-espb-100525917","NCT06127966","The Relationship Between NLR and PONV and ESPB","The Relationship Between the Preoperative Neutrophil-to-lymphocyte Ratio (NLR) and Postoperative Nausea and Vomiting (PONV) in Lumbar Spine Surgery Patients, as Well as the Impact of Erector Spinae Plane Block on NLR and PONV","Inclusion Criteria:\n\n1. Patients undergoing elective posterior lumbar spine surgery in a prone position under general anesthesia.\n2. ASA classification grades I to II.\n3. Age between 18 and 80 years old.\n4. Signed the informed consent for this study.\n\nExclusion Criteria:\n\n1. Preoperative blood transfusion.\n2. Uncontrolled systemic diseases.\n3. Patients with known uncontrolled systemic inflammatory diseases (e.g., rheumatoid arthritis, lupus, or active infections).\n4. Gastrointestinal system disorders.\n5. History of antiemetic and anticholinergic drug use.\n6. History of adverse reactions related to surgery, deformity correction surgeries, defined as procedures involving instrumentation across three or more levels or aimed at correcting scoliosis or kyphosis.\n7. Severe spinal deformities.\n8. Infection at the puncture site.\n9. Coagulation disorders.\n10. Long-term use of sedatives and analgesic drugs before surgery.\n11. Patients with mental illness or communication barriers.\n12. Allergic to ropivacaine.\n13. Participants involved in other clinical studies within the past 3 months.\n14. History of previous lumbar surgeries.\n15. Subjective unwillingness to participate in this study.","80 Years",{"count":48,"type":21},220,"INTERVENTIONAL",[51],"PHASE1","This study aims to investigate whether preoperative NLR (Neutrophil-to-Lymphocyte Ratio) serves as a biomarker for PONV (Postoperative Nausea and Vomiting). It also examines the impact of erector spinae plane block on NLR and PONV. Furthermore, the research explores the effect of erector spinae plane block on postoperative pain relief in spinal surgery and its influence on the usage of opioid medications.",[54,55],"Erector Spinae Plane Block","Neutrophil to Lymphocyte Ratio",[55,57,58,59,60],"Postoperative Nausea and Vomiting","erector spinae plane block","Postoperative analgesia","lumbosacral spine surgery","2025-07-24",{"date":63,"type":31},"2025-07-29",{"date":65,"type":21},"2025-08-01",{"date":67,"type":21},"2026-09-01",{"name":69,"class":38},"Qianfoshan Hospital",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":96},"100573530","neutrophil-to-lymphocyte-ratio-and-ca-199-as-predictors-of-perineural-invasion-in-pancreatic-cancer-100573530","NCT06747481","Neutrophil-to-lymphocyte Ratio and CA 19.9 as Predictors of Perineural Invasion in Pancreatic Cancer","Inclusion Criteria:\n\n* Patient with a histopathological diagnosis of adenocarcinoma.\n* Surgical resection of the neoplasm.\n* Preoperative blood count allowing calculation of the neutrophil-to-lymphocyte ratio and preoperative CA 19.9, both before and after neoadjuvant therapy.\n\nExclusion Criteria:\n\n* Patients with a diagnosis of another histological type.\n* Patients with incomplete data.\n* Patients who were not operated on.",{"count":77,"type":21},323,"Pancreatic cancer has an incidence of 1,401,450 new cases diagnosed annually worldwide and is the third leading cause of cancer-related death in Spain. This disease is associated with a poor prognosis, reflected by a 5-year survival rate of less than 5% when all stages are grouped together.\n\nSeveral prognostic factors for pancreatic cancer have been identified. The most relevant include preoperative levels of carbohydrate antigen 19-9 (CA 19.9), surgical margins after resection, venous and\u002For arterial vascular involvement, and histopathological features such as affected locoregional lymph nodes, or perineural and lymphovascular invasion. Among all these factors, perineural invasion may be the primary independent factor affecting prognosis, particularly in patients with relatively favorable pathological features.\n\nThe identification of perineural invasion before surgery could influence the clinical management of these patients. It may facilitate risk stratification, allowing the identification of patients who would benefit most from neoadjuvant treatments or more aggressive surgical procedures, such as vascular resections. However, perineural involvement is very difficult to detect preoperatively.\n\nOnly a few studies have analyzed the possible relationship between CA 19.9 and perineural invasion, and their results are inconsistent. Alternatively, some studies have demonstrated the utility of preoperative multidetector computed tomography in detecting extrapancreatic perineural invasion. However, these radiological tests are still not useful for directly detecting microscopic perineural invasion, especially in early stages.\n\nOn the other hand, in recent years, evidence has supported that the systemic inflammatory response may play an important role in the prognosis of different malignancies. Among these inflammatory markers, the neutrophil-to-lymphocyte ratio (NLR) has gained prominence. Regarding pancreatic cancer, many studies suggest that elevated preoperative NLR levels are associated with a worse prognosis. However, no studies have yet been published analyzing a possible relationship between this inflammatory marker and perineural invasion.\n\nThe main objective of this study is to correlate the neutrophil-to-lymphocyte ratio (NLR) and CA 19.9 with histopathologically confirmed perineural invasion and, in this way, investigate these data as potential preoperative markers of perineural invasion in pancreatic cancer. Our working hypothesis is that preoperative NLR and CA 19.9 are potential markers of perineural invasion.\n\nAs secondary objectives, we aim to study the effect of neoadjuvant therapy on inflammatory markers (NLR) and tumor markers (CEA and CA 19.9) in pancreatic cancer.",[80,81,25,82],"Pancreatic Cancer, Adult","Perineural Invasion","CA 19.9",[84,85,25,82],"pancreatic cancer","perineural invasion","RECRUITING","2024-12-20",{"date":89,"type":31},"2024-12-24",{"date":91,"type":31},"2020-01-01",{"date":93,"type":21},"2025-09-30",{"name":95,"class":38},"University of Las Palmas de Gran Canaria",1]