[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"newborn\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:newborn":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,51,80,109,137,165,193,222,248,273,294,322],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100641063","the-effect-of-pre-breastfeeding-breathing-exercises-on-maternal-anxiety-well-being-and-infant-stress-in-mothers-whose-infants-are-in-the-neonatal-intensive-care-unit-100641063",false,"NCT07634445","The Effect of Pre-Breastfeeding Breathing Exercises on Maternal Anxiety, Well-being, and Infant Stress in Mothers Whose Infants Are in the Neonatal Intensive Care Unit","The Effect of Pre-Breastfeeding Breathing Exercises on Maternal Anxiety, Well-being, and Infant Stress in Mothers Whose Infants Are in the Neonatal Intensive Care Unit: A Radicalized Controlled Study","Inclusion Criteria:\n\n* Ability to communicate verbally,\n* Being 18 years of age or older,\n* Having a baby in the neonatal intensive care unit,\n* Breastfeeding.\n\nExclusion Criteria:\n\n* Having a psychiatric diagnosis according to medical records,\n* The mother having a definite health problem in the postpartum period that prevents breastfeeding (heart disease, etc.),\n* The study being terminated due to the newborn being discharged from the hospital,\n* Incomplete data collection.",true,"FEMALE","18 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"NA","Aim: This study was conducted to examine the effects of breathing exercises on maternal anxiety, well-being, and infant stress.\n\nMaterials and Methods: The research was initiated in a hospital in eastern Turkey between November 2024 and November 2026, after obtaining ethical committee and institutional approvals. The study population consisted of mothers whose babies were hospitalized in the neonatal intensive care unit (NICU) of that hospital.The generally available G\\*Power 3.1.9.7 for Windows software was used to calculate the sample size. Similar literature studies were referenced when determining the sample size of the research (Shamsdanesh et al., 2023). Furthermore, after the research is completed, a post-hoc power analysis will be performed on the main dependent variable, maternal anxiety level (MAL), to determine the power of the study (approximately 35 experimental, 35 control). The aim of the research is to ensure that the resulting sample size has sufficient statistical power to reveal the effect being examined. The research data is collected using a Demographic Information Form, prepared by the researcher through a literature review, the State and Trait Anxiety Inventory, the Psychological Well-being Scale, and the Neonatal Stress Scale. Mothers perform this exercise three times a day for two days (days 1 and 2), under the supervision of a researcher. The four-square breathing exercise is a non-pharmacological pain reliever that has been shown to be beneficial in conditions other than pain. Each breathing exercise lasts 5-10 minutes. Mothers in the experimental group are given a questionnaire before the start of the study and after the exercise on days 1 and 2. Mothers in the control group are given only a questionnaire before the start of the study, at the end of day 1, and at the end of day 2. Mothers in the control group do not perform the four-square breathing exercise and receive routine hospital care. At the end of both days, mothers in the control group who wish to practice the breathing exercise are given the opportunity to do so.",[27,28,29,30,31],"Anxiety","Psychological Well-being","Stress","Breath Exercise","Newborn",[33,34,35,36,37],"newborn","anxiety","stress","breathing exercise","psychological well-being","RECRUITING","2026-06-16",{"date":41,"type":42},"2026-06-18","ACTUAL",{"date":44,"type":42},"2024-12-10",{"date":46,"type":21},"2026-11",{"name":48,"class":49},"Inonu University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":67,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":50},"100633372","optimizing-sleep-maternal-offspring-bonding-and-sleep-in-the-maternity-ward-100633372","NCT07525830","Optimizing Sleep Maternal-Offspring Bonding and Sleep in the Maternity Ward","COSMOS","Inclusion Criteria:\n\n* Maternal inclusion criteria:\n* Mother over 18 years of age;\n* Mother for whom vaginal delivery is planned\n* Mother who has chosen to breastfeed exclusively;\n* Mother who has a single pregnancy;\n* Mother with no history of sleep disorders.\n* Mother able to understand, read and speak French or, failing that, who has someone in her immediate circle who can understand, read and speak French;\n* Mother affiliated to the social security system;\n* Having signed the consent to participate in the study\n* Newborn inclusion criteria:\n* Newborns born at term, i.e. ≥ 37+0 weeks of amenorrhea (SA).\n\nExclusion Criteria:\n\n* Non-inclusion criterion relating to the mother:\n* Mother for whom a cesarean section is scheduled\n* Mother under legal protection ;\n* Mother presenting with an acute or chronic non-stabilized condition;\n* Mother with a history of sleep disorders;\n* Mother exposed to substances that can alter sleep (alcohol, sedative drugs).\n\nSecondary exclusion criteria:\n\n* Mother who gave birth by emergency cesarean section\n* Mother with a major post-partum medical complication requiring follow-up in a unit other than the maternity unit;\n* Newborn with a major medical complication requiring follow-up in a unit other than the maternity unit.",{"count":59,"type":21},132,[24],"The quality of sleep in maternity wards is crucial for the mental and physical health of the mother, as well as for the development of secure mother to infant bonding. The introduction of \"co-dodo\" cribs, although scarcely studied, may influence sleep quality in both the mother and the newborn infant. Objective : This study aims at evaluating the impact of a co-dodo crib on the sleep quality of the newborn infant, her mother and the mother-infant bonding, compared to a control group with mother using a standard crib.\n\nThis observational, randomized, controlled, multicenter study will include adult mother, breastfeeding and hospitalized in maternity wards after full-term delivery (≥ 37 weeks of gestation). Participant will be randomly assigned in a 1:1 ratio to receive either a co-dodo crib or a standard crib for their newborn infant during their maternity STAI-Y. Actigraphic data will be used for non-invasive sleep assessment in both the newborn infant and the mother. Validated self-reported questionnaires will evaluate maternal stress, sleep quality, post-partum depression risk and mother-infant bonding. • Hypothesis : We hypothesize that using a co-dodo crib compared to a standard crib may improve the newborn and mother sleep quality, decrease the mother stress and enhance the mother to infant bonding.",[63,64,31,65,66],"Co-spleeping","Spleeping Quality","Breastfeeding Mothers","Bonding",[63,68,33,69,70],"spleeping quality","breastfeeding mothers","bonding","2026-04-07",{"date":73,"type":42},"2026-04-13",{"date":75,"type":42},"2026-02-16",{"date":77,"type":21},"2027-08",{"name":79,"class":49},"Centre Hospitalier Universitaire, Amiens",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":16,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100255235","nirs-monitoring-in-premature-infants-100255235","NCT02601339","NIRS Monitoring in Premature Infants","Beside Monitor of Cerebral Metabolism in Premature Infants With Intraventricular Hemorrhage and Post-Hemorrhagic Hydrocephalus","1. GM-IVH group:\n\n   Inclusion criteria for GM-IVH group: born at gestational age (GA) 24-32 weeks; \\\u003C 3 months old corrected-GA (cGA) at first measure or eligible for measurement within 12 weeks after the infant reaches 40 weeks post-menstrual age (PMA). Grade I-III IVH diagnosed by clinical cranial ultrasound or magnetic resonance imaging (MRI).\n\n   Exclusion criteria for GM-IVH group: chromosomal abnormalities known at the time of enrollment; known or suspected metabolic disorder or neoplasm; critical congenital heart disease; congenital hydrocephalus; brain lesions that affect cerebral brain metabolism, other than GMH-IVH; central nervous system (CNS) infection.\n2. PHH group:\n\n   Inclusion criteria for PHH group: born at gestational age (GA) 24-37 weeks \\\u003C 3 months old cGA at first measure or eligible for measurement within 12 weeks after the infant reaches 40 weeks age (PMA). PHH diagnosed by clinical cranial ultrasound or MRI.\n\n   Exclusion criteria for PHH group: chromosomal abnormalities known at the time of enrollment; known or suspected metabolic disorder or neoplasm; critical congenital heart disease; congenital hydrocephalus; brain lesions that affect cerebral brain metabolism, other than IVH-PHH; CNS infection. Implanted devices or other devices that preclude the use of MRI.\n3. HC group:\n\n   Inclusion criteria for HC group: born at gestational age (GA) 24-32 weeks; \\\u003C 3 months old cGA at first measure or eligible for measurement within 12 weeks after the infant reaches 40 weeks age (PMA); Apgar \\>7 at 5 min.\n\n   Exclusion criteria for HC group: any clinical indication of brain injury or congenital brain malformation; chromosomal abnormality known at the time of enrollment; known or suspected metabolic disorder or neoplasm; critical congenital heart disease; CNS infection.\n4. VC group:\n\nInclusion criteria for VC group: \\\u003C 12 months old cGA at first measure or eligible for measurement within 1 year after the infant reaches 40 weeks age (PMA). Symptomatic hydrocephalus of any etiology or at high risk of developing hydrocephalus of any etiology, except post-hemorrhagic etiology; characterized by abnormal rate of head growth and full anterior fontanelle. Ventricular enlargement diagnosed by ultrasonography or MRI; no signs of IVH.\n\nExclusion criteria for VC group: known or suspected metabolic disorder or neoplasm; critical congenital heart disease; CNS infection. Implanted devices or other devices that preclude the use of MRI.","ALL","0 Months","12 Months",{"count":20,"type":21},"OBSERVATIONAL","This study uses frequency domain near-infrared spectroscopy coupled with diffuse correlation spectroscopy (FDNIRS-DCS) technology for monitoring cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) at the bedside for newborns with germinal matrix-intraventricular hemorrhage (GM-IVH) and\u002For post-hemorrhagic hydrocephalus (PHH) in comparison to newborns with hydrocephalus of a different etiology (VC) and healthy controls (HC). We hypothesize that baseline cerebral metabolic dysfunction is a better biomarker for GM-IVH and PHH severity and response to PHH treatment.\n\nThis is a Boston Children's Hospital (BCH)-institutional review board(IRB) approved, multi-site study that includes collaboration with Brigham and Women's Hospital (BWH) and Beth Israel Deaconess Medical Center (BIDMC). Pei-Yi Lin receives funding from The National Institute of Health (NIH) to support the study and is the overall principal Investigator (PI) overseeing the study.",[94,95,31,96],"Hemorrhage","Premature Infants","Hydrocephalus",[98],"spectroscopy, Near-Infrared","2026-03-16",{"date":101,"type":42},"2026-03-18",{"date":103,"type":42},"2015-04",{"date":105,"type":21},"2026-12",{"name":107,"class":49},"Boston Children's Hospital",3,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":16,"sex":87,"minAge":4,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":119,"conditions":120,"keywords":124,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":50},"100357259","the-china-neonatal-genomes-project-100357259","NCT03931707","The China Neonatal Genomes Project","CNGP","Inclusion Criteria:\n\n* 1\\. Both parents are of Chinese origin;\n* 2\\. Postnatal age less than 28 days;\n* 3\\. Can be retained to at least 1ml venous blood sample;\n* 4\\. Biological parent or guardian's informed consent.\n\nExclusion Criteria:\n\n* 1\\. the nationality of one of the parents is not the Han nationality or other national minorities;\n* 2\\. reluctance of parents to use genetic sequencing data for subsequent research;\n* 3\\. parents under 18 years of age or incapacitated for decision-making;\n* 4\\. subjects older than 28 days.\n* 5\\. multiple pregnancies;\n* 6\\. lack of access to biological samples from which DNA can be extracted;\n* 7\\. failure to sign informed consent","28 Days",{"count":118,"type":21},100000,"The project will carry out the genetic testing of 100000 neonates in the next 5 years. The aim of the project is to construct the Chinese neonatal genome database, establish the genetic testing standard of neonatal genetic diseases, and promote the industrialization of neonatal genetic disease gene testing, improve the training system for genetic counseling.",[31,121,122,123],"Hereditary Disease","Genetic Predisposition to Disease","Defect, Congenital",[31,121,122,123,125,126,127,128],"Genome Sequencing","Exome Sequencing","Newborn Screening","Genetic Diseases, Inborn","2026-03-13",{"date":99,"type":42},{"date":132,"type":42},"2016-08-08",{"date":134,"type":21},"2026-12-30",{"name":136,"class":49},"Children's Hospital of Fudan University",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":146,"conditions":147,"keywords":152,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":50},"100611628","impact-of-prepartum-intravenous-fluid-intake-on-newborn-weight-loss-in-the-first-days-of-life-100611628","NCT07243054","Impact of Prepartum Intravenous Fluid Intake on Newborn Weight Loss in the First Days of Life","PERLE","Inclusion Criteria:\n\n* Full-term delivery (≥37+0 SA)\n* Singleton pregnancy\n* Mother over 18 years of age\n* Infant formula feeding exclusively in the maternity ward for the first 2 days\n\nExclusion Criteria:\n\n* Mother under guardianship\n* Mother who does not understand French\n* Mother objecting to her personal data being reused for research purposes\n* Incomplete or incorrectly completed patient medical record\n* Mixed or exclusive breastfeeding\n* Mother presenting a hemodynamic disorder in the 12 hours preceding delivery, requiring a filling specifically for this reason\n* Child with renal pathology or uropathy\n* Children with cleft lip, palate or labio-palate",{"count":145,"type":21},200,"At birth, the infant's weight was measured daily to assess the adequacy of nutritional intake. This indicator can be influenced by various factors related to the mother, her pregnancy, as well as medical interventions during the pre-delivery phase, such as pre-partum maternal fluid intakes, and the subsequent feeding method chosen for the newborn infant. This study aimed at exploring the association between maternal vascular fluid loading during labor in the pre-partum period and neonatal weight loss in the first two days of life. The study focuses on infants fedded with infant formula.\n\nThis observational, retrospective, single-center study was carried out at the Amiens University Hospital Center. The participants were mothers aged 18 and older, hospitalized in the maternity ward following full-term delivery (\\> 37 weeks of gestation). Data were collected through the medical records of the patient and their newborn.\n\nThe investigators hypothesize that a relationship may exist between maternal pre-partum vascular fluid loading and neonatal weight loss in the first two days of life, in infants fed with infant formula. These results could raise awareness and help adapt medical and parental approaches to neonatal weight loss.",[148,31,149,150,151],"Vascular Filling","Weight Loss","Jaundice","Respiratory Distress",[153,33,154,155,156],"vascular filling","weight loss","jaundice","respiratory distress","2025-11-17",{"date":159,"type":42},"2025-11-21",{"date":161,"type":42},"2025-03-01",{"date":163,"type":21},"2025-11",{"name":79,"class":49},{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":87,"minAge":172,"maxAge":116,"enrollmentInfo":173,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":175,"conditions":176,"keywords":179,"overallStatus":183,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":4},"100608538","validation-of-starz-score-for-early-neonatal-aki-100608538","NCT07202858","Validation of STARZ Score for Early Neonatal AKI","Validation of the STARZ Score for Early Prediction of Neonatal Acute Kidney Injury in Assuit University Children Hospital","* Neonates admitted to the NICU within 48 hours of birth.\n* Gestational age ≥ 28weeks.\n* Birth weight ≥ 1000grams.\n* Neonates with clinical indications necessitating laboratory investigations relevant to kidney function monitoring as part of standard care.\n* Parental or guardian consent obtained for study participation.\n\nExclusion Criteria:\n\n* Neonates with known congenital renal anomalies diagnosed antenatally or postnatally.\n\n  * Neonates with chromosomal abnormalities or genetic syndromes affecting renal function.\n  * Neonates discharged, transferred, or deceased within 24 hours of admission.\n  * Neonates with incomplete medical records or missing key laboratory data","0 Hours",{"count":174,"type":21},140,"Neonatal acute kidney injury (AKI) is a common complication in the NICU, associated with high morbidity and mortality. Prematurity, low birthweight, sepsis, asphyxia, congenital heart disease, and nephrotoxic drugs are major risk factors. Early diagnosis is challenging as serum creatinine lacks sensitivity. The STARZ score, a composite clinical-laboratory tool, has shown high accuracy for predicting early neonatal AKI. This study aims to validate the STARZ score in neonates admitted to Assiut University Children's Hospital for early identification of AKI and improved clinical outcomes.\"",[177,178,31],"Acute Kidney Injury","Kidney Diseases",[180,181,182],"Neonatal Acute Kidney Injury","STARZ Score","NICU","NOT_YET_RECRUITING","2025-09-24",{"date":186,"type":42},"2025-10-02",{"date":188,"type":21},"2025-10-01",{"date":190,"type":21},"2027-11",{"name":192,"class":49},"Assiut University",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":16,"sex":87,"minAge":199,"maxAge":200,"enrollmentInfo":201,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":203,"conditions":204,"keywords":206,"overallStatus":183,"whyStopped":4,"lastUpdateSubmitDate":213,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":220,"locationsCount":4},"100602738","effects-of-music-based-interventions-on-sleep-patterns-and-physiological-responses-in-premature-newborns-a-systematic-review-and-meta-analysis-100602738","NCT07127419","Effects of Music-Based Interventions on Sleep Patterns and Physiological Responses in Premature Newborns: A Systematic Review and Meta-Analysis","Inclusion Criteria:\n\n* Premature infants who are clinically stable and between 26 and 37 weeks' gestational age.\n* Infants monitored in the neonatal intensive care unit (NICU).\n* A music-based intervention\n* Sleep outcomes and\u002For physiological parameters measured.\n* Randomised controlled design Full-text studies are available.\n\nExclusion Criteria:\n\n* Non-neonatal infants (aged over 28 days). Term infants (≥37 weeks).\n\n  * Non-neonatal age groups\n  * Only assessing secondary outcomes, such as parental anxiety or caregiver stress\n  * Case reports, conference abstracts, letters, etc.","26 Weeks","37 Weeks",{"count":202,"type":21},1415,"Sleep in the neonatal period is a fundamental biological requirement for regulating growth, neurodevelopment, and the immune system. However, disruptions in sleep patterns during this period are common among both term and preterm infants. Preterm infants have a more fragile sleep structure due to incomplete neurological maturation, while term infants may also experience sleep difficulties during the postnatal adaptation process. Improving sleep onset and sleep quality in newborns is crucial for the well-being and quality of life of both the infant and the family.",[205,31],"Sleep",[207,208,209,33,210,211,212],"lullaby","music therapy","Sound-Based Interventions","sleep","preterm","term","2025-08-11",{"date":215,"type":42},"2025-08-17",{"date":217,"type":21},"2025-08-10",{"date":219,"type":21},"2025-12-01",{"name":221,"class":49},"Istanbul University - Cerrahpasa",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":16,"sex":87,"minAge":229,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":22,"phases":233,"briefSummary":234,"conditions":235,"keywords":236,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":245,"leadSponsor":246,"locationsCount":50},"100599173","pain-and-comfort-levels-during-heel-stick-blood-sampling-in-newborns-100599173","NCT07081048","Pain and Comfort Levels During Heel Stick Blood Sampling in Newborns","THE EFFECT OF BUZZY® AND SHOTBLOKER® APPLICATION ON THE PAIN AND COMFORT LEVEL OF NEWBORNS DURING HEEL PRICK BLOOD SAMPLING IN NEWBORNS","Inclusion Criteria:\n\n* The baby must be full-term (38-42 weeks),\n* No analgesic administration up to 8 hours prior to the procedure,\n* No pain prior to the procedure,\n* No chronic or metabolic disease,\n* Born at least 24 hours prior,\n* Being in the hospital during the study period\n\nExclusion Criteria:\n\n* The baby is not full-term,\n* Analgesic medication has been administered within 8 hours prior to the procedure,\n* The baby has a chronic or metabolic disease,\n* The baby requires oxygen support,\n* The baby cannot be fed orally,\n* The baby is not in the hospital on the dates the study will be conducted and the parents do not agree to participate in the study.","1 Day","1 Month",{"count":232,"type":21},159,[24],"Aim: The study was designed to determine the effect of Buzzy® and Shotbloker® application on pain and comfort levels in newborns during heel pricking. Method:The study was a randomised controlled trial. The study sample consisted of 159 newborns (Buzzy: 53, Shotbloker: 53, control: 53) who had heel pricks between March 2025 and December 2025 at the Samandağ State Hospital Neonatal Care Unit. The data collection tools used will be the Newborn Information Form, the Newborn Pain Scale, the Newborn Comfort Behaviour Scale, and the Buzzy® and Shotbloker® devices. In the intervention group, the Buzzy® and Shotbloker® devices will be applied before and after heel pricking, while the control group will receive routine care. The infants' pain and comfort levels will be assessed by the nurse before and after the procedure.",[31],[237,238,239,240],"pain","confort","Buzzy","Shotbloker","2025-07-15",{"date":243,"type":42},"2025-07-23",{"date":161,"type":42},{"date":219,"type":21},{"name":247,"class":49},"Tarsus University",{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":87,"minAge":4,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":22,"phases":259,"briefSummary":260,"conditions":261,"keywords":263,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":265,"lastUpdatePostDateStruct":266,"startDateStruct":268,"completionDateStruct":270,"leadSponsor":272,"locationsCount":50},"100536716","infant-sleep-and-exposure-to-mixture-of-chemical-environmental-pollutants-100536716","NCT06268444","Infant Sleep and Exposure to Mixture of Chemical Environmental Pollutants","Infant Sleep and Exposure to Mixture of Environmental Pollutants","SOLANGE","Inclusion Criteria:\n\n* Infant less than 6 months of age still on milk diet (total)\n\nExclusion Criteria:\n\n* Infants with neurological or neurobehavioral disorders\n* Families who wish to relocate within 7 days of inclusion\n* Minor parents deprived of their parental rights, not understanding French, in a state of stress, overwhelmed or vulnerable.\n* Non-affiliation to a social security system","6 Months",{"count":258,"type":21},120,[24],"During their first year of life, children spend more than half their time sleeping, a function essential to their neurodevelopment. This period of maturation and development of the future adult is considered extremely vulnerable to environmental exposure. During this period, the child\\'s diet is mainly provided by breastfeeding, where persistent chemical substances have been found. A cocktail of 19 mostly persistent substances (POPs) present in breast milk has recently been identified as the main contributor to neurodevelopmental risk. However, the reality of their impact on neurophysiological development, in particular on infant sleep, has yet to be assessed.\n\nIn this project, the sleep of children under 6 months of age will be studied using an actimetry watch worn for 7 days by the child, accompanied by a sleep diary. Exposure to environmental pollutants will be assessed by measuring their presence in the infant\\'s milk (breastfeeding) and wearing a silicone bracelet to collect air pollutants. A questionnaire on exposure will complement this evaluation.",[31,262,205],"Chemical Pollutants Exposure",[210,31,264],"chemical pollutants exposure","2025-05-21",{"date":267,"type":42},"2025-05-22",{"date":269,"type":42},"2024-02-07",{"date":271,"type":21},"2026-02",{"name":79,"class":49},{"id":274,"slug":275,"hasResults":11,"nctId":276,"briefTitle":277,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":11,"sex":87,"minAge":4,"maxAge":279,"enrollmentInfo":280,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":282,"conditions":283,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":50},"100432009","study-on-early-genetic-screening-and-precise-strategy-of-neonatal-critical-illness-100432009","NCT04905537","Study on Early Genetic Screening and Precise Strategy of Neonatal Critical Illness","Inclusion Criteria:\n\n* Postnatal age less than 100 days;\n* Perinatal death after 20 weeks of gestation (more than 500 g)\n* Can be retained biological samples for genetic screening;\n* Biological parent or guardian's informed consent.\n\nExclusion Criteria:\n\n* Reluctance of parents to use genetic sequencing data for subsequent research;\n* Parents under 18 years of age or incapacitated for decision-making;\n* subjects older than 100 days;\n* Perinatal death less than 20 weeks of gestation or weight less than 500 g;\n* Inherited metabolic diseases with chromosomal abnormalities;\n* Multiple pregnancies;\n* Lack of access to biological samples from which DNA can be extracted;\n* Failure to sign informed consent.","100 Days",{"count":281,"type":21},4000,"The researchers hope to establish an overall program of early genetic screening for neonatal critical illness in China, and to develop precise intervention strategies to assist clinical diagnosis and treatment of hereditary critical illness.",[284,121,31,285],"Genetic Screening","Stillbirth","2025-02-19",{"date":288,"type":42},"2025-02-20",{"date":290,"type":42},"2021-01-01",{"date":292,"type":21},"2025-12",{"name":136,"class":49},{"id":295,"slug":296,"hasResults":11,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":4,"eligibilityCriteria":300,"healthyVolunteers":11,"sex":87,"minAge":229,"maxAge":116,"enrollmentInfo":301,"targetDuration":4,"studyType":22,"phases":303,"briefSummary":304,"conditions":305,"keywords":308,"overallStatus":183,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":4},"100543768","massage-for-newborns-receiving-nasal-cpap-100543768","NCT06360159","Massage for Newborns Receiving Nasal CPAP","Effect of Massage on Stress, Comfort and Health Parameters of Newborns Receiving Nasal CPAP","Inclusion Criteria:\n\n1. Gestational age greater than 34 weeks\n2. Birth weight of 2000 g and above,\n3. Within the first 24 hours of nasal CPAP application\n4. Fed at least one hour before the procedure,\n5. Having no congenital anomaly,\n6. Not having any disease at birth such as neonatal asphyxia, hemolytic condition, patent ductus arteriosus (PDA),\n7. Those who have not undergone a surgical operation,\n8. The mother does not have alcohol, cigarette or other drug addiction,\n9. These are newborns to whom one of the parents (mother or father) has given verbal and written consent.\n\nExclusion Criteria:\n\n1. Rh and ABO incompatibility,\n2. APGAR score below 6,\n3. Analgesic or anesthetic medication is administered for sedation,\n4. Saliva sample cannot be taken,\n5. NEC developing,\n6. Leaving the hospital before the end of the working period,\n7. Having had maternal obstetric complications,\n8. Receiving blood transfusion during the study,\n9. Newborns whose parents wish to withdraw from the study will not be accepted.",{"count":302,"type":21},36,[24],"One of the most frequently required treatments for respiratory distress in neonatal intensive care is continuous positive airway pressure (NCPAP) support through the nose. NCPAP application has many advantages but also disadvantages and complications.\n\nGastric-abdominal distension, which is a complication of NCPAP application, is caused by gas entering the stomach and gastrointestinal tract. Feeding intolerance may develop in the newborn due to abdominal distension. In recent studies, it has been determined that non-pharmacological methods and supportive developmental care practices used to increase the comfort and reduce pain and stress of babies who experience painful procedures such as NCPAP application and who are exposed to the stressful neonatal intensive care unit environment are effective in increasing comfort and reducing pain and stress. These practices include therapeutic touch, mother's voice, fetal position, white noise, lullaby, wrapping and massage. In the literature, a quasi-experimental study examining the effect of massage (Field massage technique) on the respiration, heart rate and oxygen saturation of 28-34 week old newborns with respiratory distress syndrome who received nasal CPAP showed that massage had no significant effect on oxygen saturation, but respiration and heart rate decreased after the massage. has been determined. There are studies in the literature examining the effects of therapeutic touch, mother's voice, fetal position, white noise, lullaby and wrapping in order to increase the comfort of newborns receiving nasal CPAP, reduce stress and pain, and prolong sleep time. However, no research has been found in the literature examining the effects of massage on the stress, comfort and health parameters of newborns receiving nasal CPAP.",[306,29,31,307],"Massage","Comfort",[309,29,310,311,312],"massage","comfort","salivary cortisol level","nasal CPAP","2024-06-05",{"date":315,"type":42},"2024-06-07",{"date":317,"type":21},"2024-08-15",{"date":319,"type":21},"2026-05-15",{"name":321,"class":49},"Sultan Besiktas",{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":16,"sex":87,"minAge":172,"maxAge":329,"enrollmentInfo":330,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":331,"conditions":332,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":335,"lastUpdatePostDateStruct":336,"startDateStruct":338,"completionDateStruct":340,"leadSponsor":342,"locationsCount":50},"100544382","exosome-micrornas-as-potential-biomarkers-of-metabolic-bone-disease-of-prematurity-100544382","NCT06368154","Exosome microRNAs as Potential Biomarkers of Metabolic Bone Disease of Prematurity","Prospective Cohort Study of Exosomal microRNAs as Biomarkers for Diagnosis and Therapeutic Efficacy Evaluation of Metabolic Bone Diseases in Premature Infants","Inclusion Criteria:\n\n* The gestational age was 37+0-41+6 weeks and the age was less than 28 days\n\nExclusion Criteria:\n\n* There was no blood transfusion, no operation, no congenital malformation, no inherited metabolic diseases, no history of intravenous nutrition, and no intestinal diseases","72 Hours",{"count":145,"type":21},"Metabolic bone disease of prematurity (MBDP) is caused by insufficient content of calcium, phosphorus, and organic protein matrix in preterm infants or bone metabolism disorder, which is one of the complications affecting the quality of life of preterm infants. The early symptoms of MBDP are insidious, and there is no unified and clear diagnostic method. The diagnosis is mostly based on typical clinical manifestations and X-ray findings, but at this time, bone mineral density has decreased significantly, so early detection and diagnosis are difficult. Studies have shown that exosomal micrornas have biological characteristics and targeting specificity, and can be used as new molecular diagnostic markers for diseases. Several studies have reported the use of plasma or serum microRNAs as molecular markers for early prediction of bone diseases. In our previous study, we extracted plasma exosomes from preterm infants for high-throughput sequencing of microRNAs, and identified differentially expressed micrornas related to bone metabolism. In this study, exosomes were used as carriers, and digital PCR was used to verify the specificity and sensitivity of plasma exosomal microRNA as biomarkers of MBDP in a large sample size. The above biomarkers were compared and verified before and after treatment in children with MBDP. Further revealing plasma exosomal microRNA as a biological indicator for evaluating the efficacy of MBDP may improve the diagnostic level of MBDP, improve the outcome and prognosis of very low birth weight preterm infants, thereby improving global health and reducing socioeconomic costs.",[333,31,334],"Exosomes","Bone Diseases, Metabolic","2024-04-15",{"date":337,"type":42},"2024-04-16",{"date":339,"type":42},"2024-01-01",{"date":341,"type":21},"2026-12-31",{"name":343,"class":344},"Hunan Children's Hospital","OTHER_GOV"]