[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nicotine-dependence-cigarettes\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nicotine-dependence-cigarettes":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,78,102,128],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100590275","ai-enhanced-app-based-intervention-for-adolescent-e-cigarette-cessation-100590275",false,"NCT06965296","AI-Enhanced App-based Intervention for Adolescent E-cigarette Cessation","Inclusion Criteria\n\n* Adolescents who are 14 to 20 years old\n* Currently use nicotine-containing e-cigarettes (those responding \"Yes\" to: Have you used an electronic vaping product such as PuffBar, ElfBar, Lost Mary, JUUL, Vuse, e-cigarettes, vapes, vape pens, e-cigars, e-hookahs, hookah pens, or mods at least 1 day in the last 30 days? \\[CDC, 2020\\])\n* Interested in participating in an e-cigarette use cessation program\n* Owners of an iPhone or Android smartphone who use their phone daily\n* Able to read English\n\nExclusion Criteria\n\n* Individuals who fall outside the age range of 14 to 20 years\n* Those who have not used a nicotine-containing e-cigarette in the past 30 days\n* Individuals not interested in participating in an e-cigarette cessation program\n* Adolescents who do not own or regularly use an iPhone or Android smartphone\n* Non-English speakers","ALL","14 Years","20 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this quasi-experimental study is to test if a smartphone app can help adolescents aged 14-20 quit e-cigarettes. The main questions it aims to answer are:\n\n* Can the app help adolescents manage cravings and increase their readiness to quit?\n* Does the personalized and real-time support provided by the app improve their success in quitting e-cigarettes?\n\nResearchers will compare two groups: an immediate-intervention group that starts using the app right away and a delayed-intervention group that begins after three months, to see if the timing of app access influences outcomes in e-cigarette cessation.\n\nParticipants will:\n\n* Set personal goals and track their daily progress within the app.\n* Use a real-time \"urge\" feature that provides immediate support during cravings.\n* Engage with a chatbot for quick answers and motivational support around quitting.\n\nThis study aims to create an accessible, personalized tool to help adolescents reduce or quit e-cigarette use, exploring its feasibility as a broader intervention model.",[26],"Nicotine Dependence, Cigarettes",[28,29,30,31,32],"Adolescent e-cigarette use","E-cigarette cessation","Smartphone app","Digital health intervention","Personalized health support","NOT_YET_RECRUITING","2026-06-30",{"date":36,"type":37},"2026-07-02","ACTUAL",{"date":39,"type":20},"2026-08-01",{"date":41,"type":20},"2027-06-30",{"name":43,"class":44},"State University of New York at Buffalo","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100375023","the-initiate-study-initiating-nicotine-dependence-treatment-for-smokers-admitted-to-emergency-departments-100375023","NCT04163081","The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments","INITIATE","Inclusion Criteria:\n\n* Current daily smoker (smokes ≥ 5 cigarettes per day);\n* ≥ 18 years of age (the age of majority in Ontario);\n* For ED sites only, assigned a CTAS level of 2-5 (emergent to non-urgent);\n* Able to read and understand English or French;\n* Resides in Ontario and eligible for Ontario Health Insurance Plan (to permit linkage with administrative data housed at the Institute for Clinical Evaluative Sciences \\[ICES\\]);\n* Available and willing to participate in follow-up assessments over the next 12 months;\n* Has access to a telephone or computer;\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Currently participating in this or another smoking cessation study;\n* For ED sites only, assigned a CTAS level of 1 (resuscitation - the most seriously ill patients with highest likelihood of hospital admission) or in psychiatric emergency unit;\n* Pregnant, planning to become pregnant over the next year, or breastfeeding;\n* Has morbid illness which will prevent completion of 26-week follow-up (e.g., receiving palliative care);\n* In the opinion of the attending physician, manifests acute physical and\u002For psychiatric illness or has cognitive impairment that would preclude participation in\u002Fbenefit from the intervention.\n* Scheduled for a known elected surgery, procedure, or future hospitalization during the study period.","18 Years",{"count":55,"type":20},1208,[23],"The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term abstinence among tobacco smokers seen in emergency departments (ED) and other high-volume hospital and community ambulatory care settings. The intervention includes a behavioural incentive and tailored follow-up support on long-term smoking abstinence, health, healthcare utilization, and cost. Tobacco-related illnesses cost the healthcare system millions each year. Quitting smoking improves smoking-related outcomes, like the onset or management of heart disease, stroke, lung diseases, and several cancers. There are approximately 16 million visits to Canadian EDs each year; an estimated 3-4 million of these involve smokers. Effective quit smoking interventions exist, but are underutilized. Few hospital EDs, community healthcare centers, and other inpatient and outpatient clinics in Canada offer tobacco-use interventions. In order for clinicians to offer quit smoking support, interventions need to be simple given the realities of these high-volume environments. Considering that stopping smoking improves health outcomes, that tobacco-use is an important cause of preventable ED use, and the volume of smokers, Canadian EDs and other high-volume hospital and community ambulatory care settings are a missed opportunity in the initiation of quit smoking support. Our intervention has been designed to optimize uptake and smoking abstinence by including the most effective evidence-based behavioural and drug-related approaches, removing specific barriers and challenges that smokers face when trying to quit (e.g., affordability, low confidence and motivation), while packaging the intervention in a quick-to-initiate manner, making it ideal for fast-paced, complex environments.",[26,59],"Nicotine Withdrawal",[61,62,63,64,65,66],"Nicotine Replacement Therapy","Emergency Department","Nicotine Dependence","Tobacco Abstinence","Tobacco Treatment","Cigarette","RECRUITING","2026-04-29",{"date":70,"type":37},"2026-05-06",{"date":72,"type":37},"2022-04-19",{"date":74,"type":20},"2027-03",{"name":76,"class":44},"Ottawa Heart Institute Research Corporation",4,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":15,"minAge":53,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":21,"phases":88,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":45},"100490387","early-phase-1-neurobehavioral-mechanisms-linking-childhood-adversity-to-increased-risk-for-smoking-100490387","NCT05665465","Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking","Inclusion Criteria:\n\n1. generally healthy\n2. 18-21 years of age\n3. never smoked a full cigarette or used an equivalent amount of other nicotine or tobacco products\n4. no tobacco exposure in the past 3 years\n5. expired air CO level ≤ 3 ppm\n6. corroboration of non-smoking status from 2 collateral reporters\n7. breath alcohol value = 0.000\n\nExclusion Criteria:\n\n1. use of illegal drugs as measured by urine drug screen\n2. reported history of illicit drug use \\> 10 times lifetime\n3. lifetime history of alcohol use disorder\n4. binge drinking \\> 5 times per month over the past 3 months\n5. history of serious mental illness including bipolar or psychotic disorders\n6. significant medical or unstable psychiatric disorders\n7. systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg\n8. heart rate ≥ 100 bpm\n9. use of psychoactive medications (e.g., antidepressants, opioid analgesics, etc.) in the past 6 months\n10. presence of conditions that would make fMRI unsafe (e.g., pacemaker)\n11. brain abnormality (including but not limited to stroke, brain tumor, and seizure disorder)\n12. history of serious traumatic brain injury\n13. claustrophobia\n14. lack of firm resolve to refrain from cigarette, e-cigarette or other tobacco use in the coming year\n15. pregnant, trying to become pregnant, or breastfeeding\n16. inability to understand written and\u002For spoken English language\n17. inability to attend all experimental sessions",true,"21 Years",{"count":87,"type":20},150,[89],"EARLY_PHASE1","The purpose of this study is to evaluate how certain childhood experiences influences brain function and responses to nicotine exposure in a group of nonsmoking young adults. The investigators assess responses to nicotine exposure by giving participants a small amount of nicotine or placebo, and then asking them to answer questionnaires. The investigational drugs used in this study are a nicotine nasal spray (i.e., Nicotrol) and\u002For a nasal spray placebo (made of common kitchen ingredients, including a very tiny amount of pepper extract also called capsaicin). The investigators assess brain function through function magnetic resonance imaging (fMRI), which is a noninvasive procedure that uses a magnetic field to take pictures of your brain while you are performing certain tasks. This study will help us to learn more about why some childhood experiences (adverse childhood experiences, or ACEs) contribute to increased risk for smoking and other substance use.",[92,26],"Adverse Childhood Experiences","2026-04-01",{"date":95,"type":37},"2026-04-02",{"date":97,"type":37},"2024-01-19",{"date":99,"type":20},"2027-05-31",{"name":101,"class":44},"Duke University",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":84,"sex":15,"minAge":53,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":21,"phases":112,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":45},"100629434","effects-of-nicotine-dependence-on-multidimensional-health-outcomes-100629434","NCT07474623","Effects of Nicotine Dependence on Multidimensional Health Outcomes","The Relationship Between Nicotine Addiction Level and Respiratory Muscle Strength, Functional Capacity, Cognitive Functions, Pain, Quality of Life, Physical Activity Level, and Sleep Quality","Inclusion Criteria:\n\n* Regular cigarette use for at least the past 6 months\n* No history of respiratory, cardiovascular, or neurological\u002Fpsychiatric disease\n* No recent history of surgery or trauma that could affect respiratory muscles\n* No current acute infection (especially upper or lower respiratory tract infections)\n\nExclusion Criteria:\n\n* Presence of chronic respiratory diseases such as COPD or\n* History of cardiovascular disease\n* Diagnosed neurological or psychiatric disorders\n* history of surgery or trauma affecting the respiratory muscles within the last 3 months\n* Pregnancy or suspected pregnancy","65 Years",{"count":111,"type":20},212,[23],"Nicotine, a major toxic component of cigarette smoke, together with carbon monoxide (CO), constitutes a significant environmental exposure with systemic effects. Beyond its addictive potential, chronic nicotine exposure may induce inflammation, oxidative stress, tissue hypoxia, and autonomic imbalance, potentially impairing respiratory muscle strength, functional capacity, and overall physical performance. Additionally, nicotine dependence has been associated with sleep disturbances, cognitive dysfunction, altered pain perception, and reduced quality of life.\n\nAlthough previous studies have examined individual effects of smoking on specific health outcomes, research addressing these multidimensional impacts within a comprehensive framework remains limited. Therefore, this study aims to investigate the relationship between nicotine dependence level and respiratory muscle strength, functional capacity, cognitive functions, pain, quality of life, physical activity level, and sleep quality, in order to provide a more holistic understanding of the clinical consequences of nicotine dependence.",[115,26],"Tobacco Use Disorder",[63,117,118],"Respiratory Muscle Strength","Quality of Life","2026-03-11",{"date":121,"type":37},"2026-03-16",{"date":123,"type":20},"2026-04-15",{"date":125,"type":20},"2027-07-15",{"name":127,"class":44},"Izmir Democracy University",{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":84,"sex":15,"minAge":53,"maxAge":4,"enrollmentInfo":135,"targetDuration":4,"studyType":21,"phases":137,"briefSummary":138,"conditions":139,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":45},"100456481","re-connect-application-for-smoking-cessation-100456481","NCT05224154","Re-Connect Application for Smoking Cessation","Re-Connect Usability, Feasibility, Acceptability, and Preliminary Efficacy Testing","Inclusion Criteria:\n\n* individuals who report smoking at least 10 cigarettes per day for at least 2 years, -18 years of age or older\n* do not have any health complications that might interfere with the study or require more intensive treatment (e.g., emphysema, chronic obstructive pulmonary disorder, asthma, lactose intolerance)\n* report a strong desire to quit smoking (8 or higher on a 10-point Likert scale)\n* has prior experience using a smartphone, speak English, and are literate, will be eligible for the study.\n\nExclusion Criteria:\n\n* Individuals with mental health complications that are either un-managed or that have been managed for less than 6-months",{"count":136,"type":20},82,[23],"This series of studies will explore the acceptability, feasibility, and preliminary efficacy of making access to smartphone applications contingent on objective evidence of smoking abstinence.",[140,141,26],"Smoking Cessation","Acceptability of Health Care","2025-02-26",{"date":144,"type":37},"2025-02-28",{"date":146,"type":37},"2021-12-14",{"date":148,"type":20},"2026-03-31",{"name":150,"class":44},"Rowan University"]