[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nicotine-vaping\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nicotine-vaping":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,78,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100513189","phase-1-comparative-pharmacokinetics-and-pharmacodynamics-of-synthetic-nicotine-100513189",false,"NCT05962229","Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine","Inclusion Criteria:\n\n* Healthy on the basis of medical history and limited physical examination.\n* Current regular user of E-Cigarettes (≥ 15 days in the past 30 days)\n\nExclusion Criteria:\n\n* • Medications\n\n  * Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rifampicin, carbamazepine, phenobarbital, and other anticonvulsant drugs).\n  * Use of sympatholytic medications for cardiovascular conditions including hypertension (Example: beta and alpha-blockers).\n  * Concurrent use of nicotine-containing medications (Example: nicotine patch, lozenge, gum).\n  * Any stimulant medications (example: Adderall) generally given for ADHD treatment.\n\n    • Pregnancy\n  * Pregnancy (self-reported and urine pregnancy test)\n  * Breastfeeding (determined by self-report)\n  * Women of childbearing potential must be using an acceptable method of contraception\n\n    * Inability to read and write in English\n    * A known propylene glycol\u002Fvegetable glycerin allergy\n    * Uncomfortable with getting blood drawn",true,"ALL","21 Years","65 Years",{"count":20,"type":21},18,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving\u002Fwithdrawal and enjoyment.",[27,28],"Nicotine Dependence","Nicotine Vaping",[30,31,32,33],"Nicotine Pharmacokinetics","Nicotine Pharmacodynamics","Vaping","E-cigarettes","RECRUITING","2026-05-12",{"date":37,"type":38},"2026-05-14","ACTUAL",{"date":40,"type":38},"2024-12-06",{"date":42,"type":21},"2027-05",{"name":44,"class":45},"University of California, San Francisco","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":46},"100515646","phase-1-testing-the-feasibility-and-acceptability-of-social-media-and-digital-therapeutics-to-decrease-vaping-behaviors-100515646","NCT05994209","Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping Behaviors","Inclusion Criteria:\n\n* US Resident\n* English Speaking\n* Have daily access to a smartphone\n* Current vaping product user (P30D)\n* Identified as socially networking about a desire to quit vaping and\u002For experiencing negative health outcomes due to vaping\n* Vaping product user only (i.e., not using vaping as a means to support combustible smoking cessation)","15 Years","25 Years",{"count":56,"type":21},189,[24],"Use of vaping products (e.g., electronic nicotine delivery systems, e-cigarettes) has been increasing rapidly, particularly among teens and young adults. With limited information on the long-term effects of vaping products, health information about vaping has been somewhat unclear in regards to associated health risks. Teens and young adults may be reluctant to disclose their use of vaping products to parents or health providers and instead turn to social media to share and seek out information regarding vaping risks and cessation supports. Thus, our current proposal outlines the use of social media to identify teens and young adults socially networking about vaping, the use of an online chatbot screen to evaluate individual cessation support needs, and the use of a digital intervention system to support vaping cessation. The mobile intervention used in this study is based on a widely-used evidence-based mobile intervention for combustible smoking (i.e., quitSTART) and has been adapted for vaping and young adults to include an in-app chatbot to guide users to tailored content and to motivate and encourage their cessation efforts. We aim to integrate our social media recruitment and online screening approach to connect individuals with this mobile app intervention, and will conduct a randomized controlled trial to evaluate user engagement with and preliminary efficacy of the digital intervention on reducing vaping behaviors among teens and young adults.",[28,60],"Nicotine Use Disorder",[62,63,64,65,66,67,68],"vaping","mobile app intervention","youth","young adults","chatbot","nicotine","social media","2026-04-07",{"date":71,"type":38},"2026-04-13",{"date":73,"type":38},"2025-06-04",{"date":75,"type":21},"2027-03",{"name":77,"class":45},"Washington University School of Medicine",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":15,"sex":16,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":46},"100566986","phase-2-kick-nic-youth-quit-vaping-app-100566986","NCT06662305","Kick-Nic! Youth Quit Vaping App","Vaping Cessation Among Youth: Evaluating the Kick-Nic! App","Inclusion Criteria:\n\n1. high school aged youth (13-19 years old),\n2. regular current (past month) e-cig users using nicotine-containing e-cigs at least 1 day\u002Fweek.\n3. want to quit using e-cigarettes.\n4. have a smartphone with data\u002FWIFI plan in order to access and utilize the KickNic! app\n\nExclusion Criteria:\n\n* Those who have non-stable (\\\u003C2 months) use of anxiolytics, antidepressants, and other psychostimulants or have a history of psychosis or any significant current psychiatric\u002Fmedical condition that would increase risk will be excluded.","13 Years","19 Years",{"count":88,"type":21},306,[90],"PHASE2","High school students who want to quit vaping will be randomized to receive the Kick-Nic! app or a control NCI website to determine the efficacy of the app for vaping cessation. Participants will be screened for eligibility, then go through an 8 week treatment period where they will be given access to use the Kick-Nic! app or referred to the NCI Quit Vaping website. This will be followed by 1, 2, 3, and 6 month follow up visits. Qualitative interviews with participants and school staff will also be conducted to obtain feedback on the app and best ways to implement\u002Fdisseminate the app.\n\nAbstinence rates will be assessed biweekly during treatment including at end of treatment (EOT), and then at 1, 2, 3 and 6 month follow ups (FU). Biochemical verification (salivary cotinine \\\u003C 30 ng.ml) of self-reports of abstinence will be conducted at EOT and 6-month FU.",[28],"2026-01-26",{"date":95,"type":38},"2026-01-28",{"date":97,"type":38},"2025-01-16",{"date":99,"type":21},"2029-08-31",{"name":101,"class":45},"Yale University",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":15,"sex":16,"minAge":110,"maxAge":4,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":46},"100593674","pilot-study-of-the-yes-can-program-to-prevent-youth-nicotine-vaping-100593674","NCT07009509","Pilot Study of the YES-CAN! Program to Prevent Youth Nicotine Vaping","Pilot and Feasibility Testing of a Peer-led Program to Prevent Youth Nicotine Vaping: The YES-CAN! Program","YES-CAN!","Inclusion Criteria:\n\n* Children enrolled in middle school grades 6-8 and high school grades 9-12 (age approximately 10-13 and 14-17); adults (over age 18) involved in educational system\n\nExclusion Criteria:\n\n* Not able to read and write in English or Spanish","9 Years",{"count":112,"type":21},1166,[114],"NA","The goal of this pilot study is to determine the feasibility of a randomized trial of the YES-CAN! (Youth Engaged Strategies to Change Adolescent Norms) program to prevent nicotine vaping among adolescents. The program integrates the following evidence-based strategies: youth-adult collaboration; youth-developed narrative videos to convey health messages; peer leaders as change agents; and sustained implementation to change the normative environment. Two middle\u002Fhigh school communities will receive the YES-CAN! intervention. In each school community, a trained teacher will deliver a credit-earning middle or high school class to 25-30 middle or high school students, who will produce 6-8 short videos intended to increase refusal skills; promote stress management and positive coping; change social norms; prevent vaping initiation; and promote vaping cessation among current users. Videos will use a narrative approach and integrate known determinants of vaping. Middle or high school students will collaborate with the teacher and researchers to develop discussion guides and skills-building activities based on best practices for substance use prevention. In 6-8 sessions, middle or high school students will deliver their videos to all students in the associated middle school. A text messaging or other media component will reinforce and boost the effectiveness of the classroom sessions.\n\nAims for this pilot\u002Ffeasibility study are:\n\n1. To determine the feasibility and acceptability of implementing the YES-CAN! program\n2. To determine the feasibility and acceptability of the research protocols that will be used in a future efficacy trial",[28],[28,118,119,120,121,122],"Adolescents","School","Behavior change","Social norms","Electronic cigarettes","2025-07-14",{"date":125,"type":38},"2025-07-15",{"date":127,"type":38},"2024-08-15",{"date":129,"type":21},"2026-10-30",{"name":131,"class":45},"University of Colorado, Denver"]