[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nicotine-withdrawal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nicotine-withdrawal":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,73,106],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100375023","the-initiate-study-initiating-nicotine-dependence-treatment-for-smokers-admitted-to-emergency-departments-100375023",false,"NCT04163081","The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments","INITIATE","Inclusion Criteria:\n\n* Current daily smoker (smokes ≥ 5 cigarettes per day);\n* ≥ 18 years of age (the age of majority in Ontario);\n* For ED sites only, assigned a CTAS level of 2-5 (emergent to non-urgent);\n* Able to read and understand English or French;\n* Resides in Ontario and eligible for Ontario Health Insurance Plan (to permit linkage with administrative data housed at the Institute for Clinical Evaluative Sciences \\[ICES\\]);\n* Available and willing to participate in follow-up assessments over the next 12 months;\n* Has access to a telephone or computer;\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Currently participating in this or another smoking cessation study;\n* For ED sites only, assigned a CTAS level of 1 (resuscitation - the most seriously ill patients with highest likelihood of hospital admission) or in psychiatric emergency unit;\n* Pregnant, planning to become pregnant over the next year, or breastfeeding;\n* Has morbid illness which will prevent completion of 26-week follow-up (e.g., receiving palliative care);\n* In the opinion of the attending physician, manifests acute physical and\u002For psychiatric illness or has cognitive impairment that would preclude participation in\u002Fbenefit from the intervention.\n* Scheduled for a known elected surgery, procedure, or future hospitalization during the study period.","ALL","18 Years",{"count":19,"type":20},1208,"ESTIMATED","INTERVENTIONAL",[23],"NA","The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term abstinence among tobacco smokers seen in emergency departments (ED) and other high-volume hospital and community ambulatory care settings. The intervention includes a behavioural incentive and tailored follow-up support on long-term smoking abstinence, health, healthcare utilization, and cost. Tobacco-related illnesses cost the healthcare system millions each year. Quitting smoking improves smoking-related outcomes, like the onset or management of heart disease, stroke, lung diseases, and several cancers. There are approximately 16 million visits to Canadian EDs each year; an estimated 3-4 million of these involve smokers. Effective quit smoking interventions exist, but are underutilized. Few hospital EDs, community healthcare centers, and other inpatient and outpatient clinics in Canada offer tobacco-use interventions. In order for clinicians to offer quit smoking support, interventions need to be simple given the realities of these high-volume environments. Considering that stopping smoking improves health outcomes, that tobacco-use is an important cause of preventable ED use, and the volume of smokers, Canadian EDs and other high-volume hospital and community ambulatory care settings are a missed opportunity in the initiation of quit smoking support. Our intervention has been designed to optimize uptake and smoking abstinence by including the most effective evidence-based behavioural and drug-related approaches, removing specific barriers and challenges that smokers face when trying to quit (e.g., affordability, low confidence and motivation), while packaging the intervention in a quick-to-initiate manner, making it ideal for fast-paced, complex environments.",[26,27],"Nicotine Dependence, Cigarettes","Nicotine Withdrawal",[29,30,31,32,33,34],"Nicotine Replacement Therapy","Emergency Department","Nicotine Dependence","Tobacco Abstinence","Tobacco Treatment","Cigarette","RECRUITING","2026-04-29",{"date":38,"type":39},"2026-05-06","ACTUAL",{"date":41,"type":39},"2022-04-19",{"date":43,"type":20},"2027-03",{"name":45,"class":46},"Ottawa Heart Institute Research Corporation","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":72},"100628840","auricular-stimulation-for-nicotine-withdrawal-in-psychiatric-inpatients-100628840","NCT07466875","Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients","The Efficacy of Auricular Acupressure Combined With Nicotine Replacement Therapy on Nicotine Craving, Withdrawal Symptoms and Anxiety Levels in Psychiatric Inpatients: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Psychiatric inpatients aged 18 to 65 years.\n* Diagnosed with a mental disorder according to ICD-10-CM criteria.\n* History of daily smoking within the past six months (Fagerström Test for Nicotine Dependence \\[FTND\\] score ≥ 2).\n* Experiencing nicotine withdrawal symptoms due to mandatory smoking cessation upon admission (Minnesota Tobacco Withdrawal Scale \\[MNWS\\] baseline score ≥ 5).\n* Agree to and comply with the standard-of-care Nicotine Replacement Therapy (NRT) provided by the hospital.\n* Capable of understanding the study procedures and providing written informed consent\n\nExclusion Criteria:\n\n* Presence of severe skin infection, open wounds, or lesions on the auricle (outer ear).\n* Severe coagulation disorders or currently taking high-dose anticoagulants (due to potential risk of bleeding or irritation).\n* Pregnant or breastfeeding women.\n* Significant language barriers or cognitive impairment that prevents completion of assessment scales or adherence to study protocols.\n* History of receiving auricular therapy for smoking cessation within the past three months.","65 Years",{"count":56,"type":20},60,[23],"The goal of this clinical trial is to evaluate the feasibility and preliminary effectiveness of auricular acupressure (ear seeds) combined with nicotine replacement therapy (NRT) in psychiatric inpatients (both male and female, aged 18-65) who are forced to abstain from smoking due to the smoke-free environment of the inpatient ward. The main questions it aims to answer are:\n\n* Does auricular acupressure significantly reduce the severity of nicotine withdrawal symptoms compared to standard care?\n* Can auricular acupressure effectively lower nicotine craving and anxiety levels in patients during their mandatory abstinence? Researchers will compare the experimental group (NRT plus active auricular acupressure) to a control group (NRT plus sham auricular acupressure) to see if the addition of ear point stimulation provides better relief for withdrawal distress.\n\nParticipants will:\n\n* Receive standard nicotine replacement therapy (NRT) as prescribed by their physician.\n* Be randomly assigned to receive either Vaccaria segetalis seeds or sham materials on specific ear acupuncture points.\n* Be instructed to press the beads 3 times daily to stimulate the points for a period of 4 weeks.\n* Complete standardized assessments (MNWS, HAMA, and craving scales) at baseline and multiple time points during the intervention.",[31,27,60,61,62],"Tobacco Use Disorder","Anxiety","Mental Disorders","2026-04-06",{"date":65,"type":39},"2026-04-13",{"date":67,"type":39},"2026-03-23",{"date":69,"type":20},"2027-12-31",{"name":71,"class":46},"Chiao-Chiao Liao",1,{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":21,"phases":83,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":72},"100478738","phase-1-overcoming-nicotine-dependence-to-enable-quitting-100478738","NCT05513872","Overcoming Nicotine Dependence to Enable Quitting","A Mechanistic Test of Treatment Strategies to Foster Practice Quitting","ON-DEQ","Inclusion Criteria:\n\nEligible participants will be males and females who:\n\n1. are 18 years or older\n2. report current daily cigarette smoking (≥ 5 cigarettes per day)\n3. are not planning to quit in the next 30 days\n4. are not currently engaged in smoking cessation treatment\n5. are motivated to quit or engage in a non-cessation goal (i.e., reduce smoking, learn more about treatment options, and\u002F or try out skills to change smoking) in the next 6 months\n6. are English speaking\n7. reside in the continental United States\n8. have access to a smartphone that can be used to complete study procedures\n\nExclusion Criteria:\n\nParticipants will be excluded for daily vaping\u002F electronic cigarettes use (i.e., use for ≥ 25 days within past 30 days) and any FDA contraindications for NRT use if they:\n\n1. are pregnant\u002Fbreastfeeding\n2. had recent cardiovascular trauma such as myocardial infarction\n3. had a stroke within the past 3 months",{"count":82,"type":20},780,[84,85],"PHASE1","PHASE2","Tobacco use disorder is a chronic, relapsing health condition that necessitates a chronic care approach. However, traditional smoking cessation treatment programs allocate nearly all their resources only to those smokers who are willing to set a quit date. This is problematic because few smokers are ready to set a quit date at any given time, and a smoker's stated intention to quit can change rapidly.\n\nOne novel potential treatment strategy is to foster practice quitting (PQ), defined as attempting to not smoke for a few hours or days, without pressure or expectation to permanently quit. Although a growing body of evidence supports the role of practice quitting in fostering permanent quit attempts and cessation, there is a significant knowledge gap regarding which treatment strategies should be used to engage smokers in practice quitting. The proposed study will test the role of PQ counseling vs. Motivational Interviewing (MI) counseling, and NRT sampling (four-week supply of nicotine lozenges and patches) vs. none.",[88,89,90,31,27],"Tobacco Use","Smoking Cessation","Smoking Behaviors",[92,93,94,95,96],"tobacco","smoking cessation","nicotine dependence","nicotine replacement therapy","behavioral treatment","2025-08-13",{"date":99,"type":39},"2025-08-17",{"date":101,"type":39},"2023-03-24",{"date":103,"type":20},"2027-08-30",{"name":105,"class":46},"Rush University Medical Center",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":21,"phases":115,"briefSummary":117,"conditions":118,"keywords":122,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":72},"100535605","phase-4-effectiveness-of-combined-tobacco-treatment-in-hospitalized-subjects-100535605","NCT06254001","Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects","Effectiveness of Combined Treatment of Bupropion and Nicotine Replacement Therapy in Hospitalized Subjects With Active Smoking in a Reference Center","Inclusion Criteria:\n\n\\>18 years Active smokers (consumption of more than 100 cigarettes in their entire life, and who have consumed cigarettes in the last 30 days) Hospitalized subjects Informed consent\n\nExclusion Criteria:\n\n* Subjects who have had pharmacological treatment to stop smoking in the last month\n* Subjects with contraindications for medications.\n\nSample size calculation, 80% power, unilateral, due to difference in proportions, estimated loss of 25%.",{"count":114,"type":20},134,[116],"PHASE4","In the 20th century, tobacco caused the death of 100 million people worldwide and it is estimated that it will be responsible for 1 billion deaths in the 21st century. Currently 8 million people die each year from smoking, 7 million are associated with active smoking, thus being the main risk factor for loss of disability-adjusted life years for men and the ninth most important risk factor for women. In previous studies it has been reported that approximately 21% (14%-30%) of subjects who have required hospitalization are active smokers, being higher in men than in women (28% vs 14%). The initiation of treatment for smoking cessation in this group of subjects has shown an effectiveness rate of up to 65% to maintain abstinence 6 to 12 months after discharge. The effectiveness has been analyzed in scenarios with only brief advice, in some others with the use of medications such as varenicline, bupropion and nicotine replacement therapy, however, the interventions have not been standardized for adequate analysis, which could contribute to the different results.",[119,120,121,27,29],"Tobacco Smoking","Tobacco Withdrawal","Nicotine Addiction",[92,123,95,124],"bupropion","abstinence","2024-02-21",{"date":127,"type":39},"2024-02-23",{"date":129,"type":39},"2024-01-15",{"date":131,"type":20},"2026-06-15",{"name":133,"class":134},"National Institute of Respiratory Diseases, Mexico","OTHER_GOV"]