[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nightmares\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nightmares":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,43,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100598286","accelerated-treatment-for-co-occurring-insomnia-nightmares-and-ptsd-100598286",false,"NCT07069517","Accelerated Treatment for Co-occurring Insomnia, Nightmares, and PTSD","Accelerated Treatment for Co-occurring Insomnia, Nightmares, and PTSD: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Defense Enrollment Eligibility Reporting System (DEERS) eligible active-duty military personnel or veteran, 18-65 years old.\n2. Ability to speak and read English.\n3. Clinically significant PTSD symptoms (CAPS-5 \\> 25 with at least one Intrusion symptom and at least one Avoidance symptom).\n4. Clinically significant symptoms of insomnia disorder (Structured Clinical Interview for Sleep Disturbance DSM-5 (SCISD) Insomnia Criteria are met and Insomnia Severity Index (ISI) \\> 11).\n5. Nightmares \\> 1 monthly (as reported on the SCISD).\n6. Willing to refrain from new behavioral health or medication treatment for issues pertaining to PTSD, sleep, and nightmares during study participation.\n\nExclusion Criteria:\n\n1. Current suicide or homicide risk meriting crisis intervention.\n2. Inability to comprehend the baseline screening questionnaires.\n3. Unwilling to remain abstinent from alcohol during therapy sessions.\n4. Serious mental health symptoms, such as mania, psychosis, alcohol or substance use disorders warranting immediate clinical attention based on interviewer assessment and clinical judgement.\n5. Currently engaged in evidence-based psychotherapy for PTSD (e.g., Prolonged Exposure Therapy, Cognitive Processing Therapy, Written Exposure Therapy) or insomnia or nightmares (e.g., Cognitive Behavioral Therapy for Insomnia or Nightmares).\n6. Pregnancy, as determined by self-report, because pregnancy can adversely affect sleep outside of PTSD, insomnia, and nightmares.\n7. Working duty shifts ending later than 21:00 or starting before 05:30 more than 2 times per month.","ALL","18 Years","65 Years",{"count":20,"type":21},160,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study is a two-arm individually randomized group treatment clinical trial evaluating behavioral therapies for insomnia, nightmares, and PTSD. The study will compare cognitive-behavioral therapy for insomnia and nightmares to sleep hygiene (Control), both integrated with Written Exposure Therapy for PTSD and delivered in an accelerated (i.e., 5-day) group treatment format, preceded and followed by individual treatment sessions. 160 participants will be randomized into one of two study conditions.",[27,28,29],"Insomnia","PTSD - Post Traumatic Stress Disorder","Nightmares","RECRUITING","2025-12-01",{"date":33,"type":34},"2025-12-03","ACTUAL",{"date":36,"type":21},"2025-12-02",{"date":38,"type":21},"2028-12-01",{"name":40,"class":41},"Palo Alto Veterans Institute for Research","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":42},"100602266","restorative-early-sleep-treatment-after-the-emergency-department-100602266","NCT07121270","Restorative Early Sleep Treatment After the Emergency Department","RESTED","Inclusion criteria:\n\n* Michigan residents treated at Henry Ford Hospital\n* Fluent in English\n* Age 18 years or older\n* Presenting to ED following exposure to Criterion A trauma (exposure to actual or threatened death, serious injury, or sexual violence) characterized by interpersonal violence (defined as any victimization experience that involved being intentionally and directly harmed by another individual\n* i.e., assault with a weapon, physical assault, or sexual assault\n* Qualifying trauma occurred within the past \\~72hr\n* Hospital Mental Health Risk Screen score ≥ 10 (indicating at-risk for developing mental health problems)\n* Patient is not in any other cognitive behavioral treatment with a master's level clinician or above\n* Patient is appropriate for outpatient treatment and level of acuity does not require inpatient treatment\n\nExclusion criteria:\n\n* Presenting to ED for non-interpersonal trauma\n* Defined as any experience that does not involve being intentionally and directly harmed by another individual\n* i.e., falls, motor vehicle collisions, self-injury or suicide attempt\n* Current or past history of schizophrenia or other psychoses based on EMR data\n* Current or past PTSD based on EMR data\n* Unmanaged mania or bipolar disorder based on EMR data\n* Active, untreated substance use disorder based on EMR data other than alcohol use disorder, cannabis use disorder, nicotine use disorder, or tobacco use disorder\n* Active suicidality:\n* Presented to ED with self-inflicted injury or attempted suicide\n* Current suicidal ideation with intent (with or without a specific plan) within past month\n* Suicide attempts during the past three months\n* Current homicidal ideation\n* Active substance withdrawal\n* Pregnant\n* Evidence of a current or past traumatic brain injury or loss of consciousness due to head injury at the time of trauma based on EMR data\n* No cell phone, email address, or stable home address\n* Evidence or risk of ongoing traumatic exposure (e.g., domestic violence)\n* Adults in police custody or Dept of Correction patients\n* Evidence of altered mental status, inability to understand study procedures\u002Frisks, or otherwise unable to give informed consent\n* Admission to an intensive care unit, admission or surgery, medical instability or hemodynamic compromise\n* Currently engaged in cognitive behavioral treatment\n* Currently living in a nursing home\n* Currently working non-standard shifts (outside the hours 7am - 6pm)",{"count":51,"type":21},80,[24],"The goal of this randomized controlled trial is to pilot the virtual delivery of cognitive behavioral therapy for insomnia (CBT-I) and nightmares (CBT-I\\&N) via telehealth as an early intervention for treating posttraumatic sleep disturbance in acute trauma patients exposed to interpersonal violence.\n\nThe main aims are to:\n\n1. Test the acceptability, feasibility, and satisfaction of sleep-focused CBT delivered early after trauma\n2. Evaluate the impact of sleep-focused CBT delivered early after trauma on sleep disturbance\n3. Evaluate the impact of sleep-focused CBT delivered early after trauma on PTSD symptoms\n\nThe investigators will compare CBT-I and CBT-I\\&N to sleep education control.\n\nParticipants will meet with a provider for 6 weekly sessions via telehealth and complete surveys on the participants' symptoms.",[27,55,29,28],"Nightmares Associated With Trauma and Stress",[57,29,27,58,59,60,61,62,63,64,65,66,67,68,69],"CBT-I","Trauma","Sleep Education","PTSD","CBT-I&N","Acute Trauma","RCT","Early intervention","Behavioral sleep medicine","Posttraumatic stress","Trauma-induced insomnia","Cognitive behavioral therapy","Prevention","2025-08-07",{"date":72,"type":34},"2025-08-13",{"date":74,"type":34},"2025-03-17",{"date":76,"type":21},"2027-08",{"name":78,"class":41},"Henry Ford Health System",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":93,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":42},"100227718","brief-treatment-for-trauma-nightmares-in-trauma-exposed-adults-with-bipolar-disorder-100227718","NCT02242110","Brief Treatment for Trauma Nightmares in Trauma-exposed Adults With Bipolar Disorder","Efficacy of a Brief Treatment for Chronic Nightmares Among Trauma-Exposed Persons With Bipolar Disorder","BERRT","Inclusion Criteria:\n\n* Nightmares at least once per week for the past month\n* Formal diagnosis of Bipolar disorder (I or II)\n* Exposure to traumatic event (1+ months ago)\n* Stable on bipolar medication for at least 2 months\n\nExclusion Criteria:\n\n* A traumatic event within the last month\n* Intellectual disability\n* Current or recent mania\u002Fhypomania within the last 3 months\n* Suicide attempt or hospitalization within the last 3 months\n* Current or untreated substance use disorder within the past 6 months",{"count":88,"type":21},20,[24],"Exposure, relaxation, and rescripting therapy (ERRT) is a promising psychological intervention developed to target trauma-related nightmares and sleep disturbances. Though further evidence is needed, ERRT has shown strong support in reducing the number and intensity of nightmares, as well as improving overall sleep quality in both civilian and veteran samples. This study will assess the efficacy in individuals diagnosed with bipolar disorder.",[29,92],"Post-traumatic Stress Disorder",[29,94,60,95],"Sleep","Exposure, Relaxation, and Rescripting Therapy","2024-07-01",{"date":98,"type":34},"2024-07-03",{"date":100,"type":4},"2014-06",{"date":102,"type":21},"2027-05",{"name":104,"class":41},"University of Tulsa"]