[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nitrate-supplementation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nitrate-supplementation":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100529089","early-phase-1-effect-of-nitrate-supplementation-on-blood-pressure-and-microvascular-function-of-resistant-hypertensive-patients-100529089",false,"NCT06169241","Effect of Nitrate Supplementation on Blood Pressure and Microvascular Function of Resistant Hypertensive Patients","Effect of Nitrate Supplementation on Blood Pressure and Systemic Microvascular Function of Resistant Hypertensive Patients","Inclusion Criteria:\n\n* Resistant hypertension, with a diagnosis described in the medical record, without changing medications or increasing doses in the last 30 days.\n\nExclusion Criteria:\n\n* neoplasms\n* heart failure\n* use of medications with nitrate in their formula\n* patients undergoing renal denervation","ALL","18 Years","75 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","Arterial hypertension (AH) has been identified as an important public health problem and considered a new epidemic with high mortality and morbidity. High blood pressure (BP) levels increase the chances of coronary artery disease (CAD), heart failure (HF), stroke, chronic renal failure (CRF) and death. Beetroot powder may be an easier way to increase the availability of nitric oxide and consequently vasodilation in these patients. However, studies are needed to evaluate its benefits in patients with AH.",[27,28,29,30],"Arterial Hypertension","Resistant Hypertension","Microvascular Function","Nitrate Supplementation",[32,33,34,35],"microcirculation","capillary density","microvascular reactivity","systemic resistant hypertension","RECRUITING","2026-04-07",{"date":39,"type":40},"2026-04-13","ACTUAL",{"date":42,"type":40},"2023-11-01",{"date":44,"type":21},"2026-12",{"name":46,"class":47},"National Institute of Cardiology, Laranjeiras, Brazil","OTHER_GOV",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":17,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100629324","beetroot-beverage-and-repeated-sprint-power-output-during-rast-100629324","NCT07473193","Beetroot Beverage and Repeated Sprint Power Output During RAST","\"Effects of a Beetroot-Based Functional Beverage on Repeated Sprint Performance: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial\"","Inclusion Criteria:\n\n* Healthy trained athletes\n\nAge between 18-35 years\n\nRegular training ≥3 times\u002Fweek\n\nNo cardiovascular or metabolic disease\n\nExclusion Criteria:Healthy trained athletes\n\nAge between 18-35 years\n\nRegular training ≥3 times\u002Fweek\n\nNo cardiovascular or metabolic disease\n\n\\-",true,"MALE","35 Years",{"count":60,"type":21},10,[62],"NA","This randomized, double-blind, placebo-controlled crossover trial aims to evaluate the acute effects of a nitrate-rich beetroot-based beverage on repeated sprint performance in trained athletes.\n\nTen athletes will complete two experimental conditions in randomized order: beetroot beverage (BET) and placebo (PLA), separated by a 7-day washout period. The beetroot beverage consists of 200 mL of a mixture containing beetroot, cocoa, and green tea, providing approximately 6.4 mmol of nitrate.\n\nIn each condition, participants will perform a Running Anaerobic Sprint Test (RAST), consisting of six maximal 35-meter sprints with 10 seconds of passive recovery between sprints. The primary outcome is mean power output across the six sprints.\n\nSecondary outcomes include fatigue index, sprint-by-sprint power output, heart rate, rating of perceived exertion (Borg 6-20 scale), maximal oxygen uptake (VO₂max), and sleep quality assessed using the Insomnia Severity Index (ISI).",[65,66,30],"Repeated Sprint Performance in Trained Athletes","Exercise Performance",[68],"Beetroot juice","NOT_YET_RECRUITING","2026-03-10",{"date":72,"type":40},"2026-03-16",{"date":74,"type":21},"2026-03-12",{"date":76,"type":21},"2026-04-30",{"name":78,"class":79},"Universidad Autonoma de Chihuahua","OTHER",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":56,"sex":16,"minAge":17,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":48},"100609605","effects-of-breathing-training-and-nitrate-on-exercise-at-simulated-altitude-100609605","NCT07216755","Effects of Breathing Training and Nitrate on Exercise at Simulated Altitude","Impact of Respiratory Muscle Training and Nitrate Therapy on Exercise Tolerance in Simulated Altitude","Inclusion Criteria:\n\n* Healthy adults between 18 and 40 years old.\n\nRecreationally active (performing ≥3 hours of structured physical activity per week).\n\nNon-smokers for at least the past 6 months.\n\nFree from any known cardiovascular, pulmonary, metabolic, or neuromuscular disease as determined by health screening questionnaire and medical history.\n\nAble to perform cycle ergometer exercise to volitional fatigue.\n\nWilling to abstain from high-nitrate foods and supplements (e.g., beets, spinach, arugula) for 48 hours prior to each testing session.\n\nAble and willing to provide written informed consent and comply with all study procedures.\n\nExclusion Criteria:\n\n* Diagnosis of or history of heart disease, hypertension, diabetes, or chronic respiratory disorders (e.g., asthma, COPD).\n\nCurrent use of medications or supplements known to affect cardiovascular, metabolic, or respiratory function (e.g., beta-blockers, nitrates, stimulants).\n\nSmoking, vaping, or tobacco use within the past 6 months.\n\nKnown allergy or intolerance to beetroot products or nitrates.\n\nParticipation in another interventional research study within the past 30 days.\n\nPregnant or breastfeeding women.\n\nAny orthopedic or musculoskeletal limitation preventing safe exercise testing.\n\nFailure to meet inclusion criteria or inability to complete familiarization and baseline testing.","40 Years",{"count":89,"type":21},80,[62],"This study investigates whether respiratory muscle training (RMT) and dietary nitrate supplementation can improve exercise tolerance under simulated moderate altitude conditions. Exposure to reduced oxygen availability at altitude places additional strain on the cardiovascular and respiratory systems, which may limit endurance performance. By combining RMT-designed to strengthen the muscles involved in breathing-with nitrate therapy, which enhances nitric oxide availability and vascular function, this study aims to determine whether these interventions independently or synergistically improve oxygen delivery, reduce physiological strain, and enhance exercise performance. The findings will help identify non-pharmacological strategies to improve physical performance and tolerance to hypoxia in both clinical and operational environments.",[93,94,95,96,97,98,30,99],"Healthy Adults","Mechanical Ventilation Dependence","Hypoxia","Exercise Training","Exercise Intolerance","Dietary Supplement","Inspiratory Muscle Training","2025-10-13",{"date":102,"type":40},"2025-10-15",{"date":104,"type":40},"2025-09-01",{"date":106,"type":21},"2028-08-31",{"name":108,"class":79},"Embry-Riddle Aeronautical University"]