[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nktcl\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nktcl":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,65],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100640296","phase-1-adebrelimab-combined-with-shr2554-in-relapsedrefractory-ptcl-and-nkt-cell-lymphoma-100640296",false,"NCT07615283","Adebrelimab Combined With SHR2554 in Relapsed\u002FRefractory PTCL and NK\u002FT-Cell Lymphoma","A Single-Arm, Multicenter, Phase Ib\u002FII Exploratory Study to Evaluate Adebrelimab in Combination With EZH2 Inhibitor SHR2554 for the Treatment of Relapsed or Refractory Peripheral T-Cell Lymphoma and NK\u002FT-Cell Lymphoma","Inclusion Criteria:\n\n1. Age ≥18 years old,regardless of gender;\n2. Centrally confirmed histopathological\u002Fcytologic diagnosis of PTCL with the following subtypes:\n\n   1. Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS);\n   2. Systemic anaplastic large cell lymphoma (ALK+ and ALK-);\n   3. Follicular helper T (TFH) cell lymphoma of lymph nodes, including angioimmunoblastic, follicular, NOS;\n   4. NKTCL\n   5. and any other PTCL subtypes deemed by the investigator to be eligible for inclusion.\n3. Met the criteria of relapsed\u002Frefractory lymphoma: Relapsed lymphoma was defined as relapsed lymphoma after achieving complete response (CR) or partial response(PR)after initial therapy. Refractory is defined as having an evaluation of progressive disease (PD) after 2 cycles, or stable disease (SD) after 4 cycles of a previous systemic therapy regimen.\n4. There must be at least one measurable or evaluable lesion that meets the Lugano 2014 criteria for lymphoma: Measurable lesion: Nodal lesions with major diameter greater than 1.5cm and minor diameter greater than 1.0cm as assessed by PET\u002FCT or Computed Tomography (CT) and\u002For Magnetic Resonance Imaging (MRI); Or the length of extranodal lesions \\>1.0cm; 2)Evaluable lesions: PET-CT showed increased uptake in lymph nodes or extranodal regions (higher than liver) and imaging features consistent with lymphoma;\n5. ECOG performance status score: 0-2;\n6. Expected survival time ≥3 months;\n7. Have adequate organ and bone marrow function, defined as follows(The patients had not received granulocyte growth factor, platelet transfusion, or red blood cell transfusion within 14 days before the examination):\n\n   1. Blood routine: absolute neutrophil count (ANC) ≥ 1.0×109\u002FL;\n   2. platelet count (PLT) ≥ 60×109\u002FL;\n   3. hemoglobin (HGB) ≥ 8.0 g\u002FdL;\n   4. white blood cell (WBC) ≥ 3.5×109\u002FL;\n   5. Renal function: serum creatinine (Cr) ≤1.5×ULN.or creatinine clearance (CrCl) ≥ 40 mL\u002Fmin (calculated using the Cockcroft-Gault formula);\n   6. serum total bilirubin (TBIL) ≤1.5× upper limit of normal value ;\n   7. alanine aminotransferase (ALT) and aspartate transferase (AST) ≤2.5×ULN ;\n   8. Coagulation function: International Normalized Ratio (INR) ≤1.5 × ULN; Prothrombin Time (PT), Activated PartialThromboplastin Time (APTT) ≤1.5×ULN (unless the subject is receiving anticoagulant therapy, And PT and APTT at screening were within the expected range for anticoagulant therapy).\n   9. Thyroid stimulating hormone (TSH) or free thyroxine (FT4) or free triiodothyronine (FT3) within the normal range ±10% (Note: non-autoimmune causes of abnormal TSH, FT3 and FT4 can be maintained in the normal range after replacement treatment of hypothyroidism can be enrolled).\n8. Capable of understanding the study procedures and voluntarily signing a written informed consent form (ICF).;\n9. Women of childbearing potential must have a negative serum pregnancy test within 7 days before the first dose of medication; Effective contraception should be used from the time of informed consent until 6 months after the last dose of study drug.\n\nExclusion Criteria:\n\n1. Pregnant or lactating women;\n2. Patients with hemophagocytic lymphohistiocytosis;\n3. Primary central nervous system (CNS) lymphoma or secondary CNS involvement.\n4. History of allogeneic organ transplantation;\n5. Received allogeneic hematopoietic stem cell transplantation (allo-HSCT) within 3 years prior to the first dose of study drug (patients who received allo-HSCT \\> 3 years prior to the first dose of study drug and currently have no active graft-versus-host disease \\[GVHD\\] are eligible to enroll);\n6. Known allergy or hypersensitivity to the study drugs or their related metabolites;\n7. Uncontrolled active infection;\n8. Currently participating in another clinical study, or less than 4 weeks elapsed from the end of treatment in a previous clinical study to the planned start of study treatment;\n9. Planned autologous hematopoietic stem cell transplantation (auto-HSCT);\n10. Less than 3 months elapsed since the last dose of prior treatment with any immune checkpoint inhibitors (e.g., anti-PD-1, anti-PD-L1, anti-CTLA-4).\n11. Active autoimmune disease that required systemic treatment within the past 2 years (hormone replacement therapy is not considered systemic treatment, e.g., type 1 diabetes mellitus, hypothyroidism requiring only thyroxine replacement therapy, or adrenal\u002Fpituitary insufficiency requiring only physiologic doses of corticosteroids). Patients with an autoimmune disease that did not require systemic treatment within the past 2 years are eligible to enroll;\n12. Required systemic treatment with corticosteroids or other immunosuppressive agents for any condition within 14 days prior to the start of study treatment (except for topical or short-term use of corticosteroids, or corticosteroids used for non-autoimmune conditions such as delayed-type hypersensitivity caused by contact allergens);\n13. Diagnosis of another malignancy within the past 5 years, except for malignancies treated with curative intent, including basal cell carcinoma of the skin, squamous cell carcinoma of the skin, carcinoma in situ of the breast, or carcinoma in situ of the cervix.\n14. Received systemic anti-tumor therapy within 28 days prior to the start of study treatment, including chemotherapy, immunotherapy, and biological therapy (tumor vaccines, cytokines, or growth factors to control cancer);\n15. Underwent major surgery within 28 days, or received radiotherapy within 90 days prior to the start of study treatment;\n16. Received live vaccines within 28 days prior to the start of study treatment (excluding attenuated influenza vaccines);\n17. Patients with a known history of Human Immunodeficiency Virus (HIV) infection and\u002For acquired immunodeficiency syndrome;\n18. Patients with active chronic hepatitis B or active hepatitis C. Hepatitis B SurfaceAntigen (HBsAg) or hepatitis B core Antibody (HBcAb) or Hepatitis C Virus (HCV) during the screening period HCV) antibody positive patients must be further tested for Hepatitis B Virus (HBV) DNA (no more than 2500 copies \u002FmL or 500 IU\u002FmL) and HCV RNA (no more than the lower limit of detection of the assay), Enrollment in the trial occurred after the exclusion of patients with active hepatitis B or hepatitis C infection requiring treatment. Hepatitis B virus (HBV) carriers, medically stable hepatitis B (DNA \\> 2500 copies \u002FmL or 500IU\u002FmL) and cured hepatitis C patients are eligible for enrollment.\n19. Active tuberculosis (TB);\n20. Uncontrolled fungal or bacterial infections;\n21. Known history of alcohol or substance abuse;\n22. Uncontrolled comorbidities, including but not limited to symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, active peptic ulcer, or bleeding disorders;\n23. History of interstitial lung disease or non-infectious pneumonitis (subjects with a history of asymptomatic drug-induced or radiation-induced non-infectious pneumonitis are eligible for enrollment);\n24. QTcF interval \\> 450 msec, unless secondary to bundle branch block;\n25. History of psychiatric disorders;\n26. Severe concomitant diseases that, in the judgment of the investigator, would compromise patient safety or interfere with the patient's ability to complete the study;\n27. Any other condition that, in the opinion of the investigator, makes the patient unsuitable for inclusion in this study.","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23,24],"PHASE1","PHASE2","To evaluate the safety of adebrelimab combined with SHR2554 in the treatment of relapsed or refractory peripheral T-cell lymphoma (PTCL) and NK\u002FT-cell lymphoma (NKTCL), to determine the recommended Phase 2 dose (RP2D) of the combination regimen, and to assess preliminary efficacy.",[27,28],"Relapsed or Refractory Peripheral T Cell Lymphoma","NKTCL",[30,31,32],"SHR2554","adebrelimab","EZH2 inhibitor","NOT_YET_RECRUITING","2026-05-22",{"date":36,"type":37},"2026-05-29","ACTUAL",{"date":36,"type":20},{"date":40,"type":20},"2030-10-29",{"name":42,"class":43},"Sun Yat-sen University","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":44},"100638190","phase-2-a-phase-ii-study-of-sintilimab-pegaspargase-and-selinexor-followed-by-radiotherapy-in-newly-diagnosed-stage-iii-extranodal-nkt-cell-lymphoma-100638190","NCT07574528","A Phase II Study of Sintilimab, Pegaspargase and Selinexor Followed by Radiotherapy in Newly Diagnosed Stage I\u002FII Extranodal NK\u002FT-Cell Lymphoma","A Multicenter, Single-Arm, Phase II Study of Sintilimab, Pegaspargase and Selinexor Followed by Radiotherapy in Newly Diagnosed Stage I\u002FII Extranodal NK\u002FT-Cell Lymphoma","Inclusion Criteria:\n\n* Age 18 years or older.\n* No prior systemic treatment for lymphoma, except short-term corticosteroids for symptom control.\n* Life expectancy of more than 3 months.\n* Eastern Cooperative Oncology Group performance status of 0 to 2.\n* Histologically confirmed extranodal natural killer\u002FT-cell lymphoma.\n* Primary lesion located in the nasal cavity or upper aerodigestive tract.\n* Stage I to II disease.\n* At least one measurable or evaluable lesion according to Lugano 2014 criteria.\n* Adequate organ and bone marrow function.\n\nExclusion Criteria:\n\n* Aggressive NK-cell leukemia.\n* Significant dysfunction of major organs.\n* Known hypersensitivity to any study drug or its components, or contraindication to any study treatment.\n* Pregnant or breastfeeding women, or participants of childbearing potential unwilling to use effective contraception.\n* Known history of human immunodeficiency virus infection or acquired immunodeficiency syndrome.",{"count":53,"type":20},47,[24],"This is a single-arm, open-label, multicenter phase II study evaluating sintilimab, pegaspargase, and selinexor followed by radiotherapy as first-line treatment for patients with newly diagnosed stage I\u002FII extranodal natural killer\u002FT-cell lymphoma (ENKTL).",[28],"2026-05-02",{"date":59,"type":37},"2026-05-08",{"date":61,"type":20},"2026-05-06",{"date":63,"type":20},"2031-05-06",{"name":42,"class":43},{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":21,"phases":76,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":44},"100559086","phase-1-selinexorpegaspargasedexamethasonein--nktcl-100559086","NCT06559553","\"Selinexor+Pegaspargase+Dexamethasone\"in Ⅰ\u002FⅡ NKTCL","A Prospective Clinical Study of \"Selinexor+Pegaspargase+Dexamethasone\" in the Treatment of Stage Ⅰ\u002FⅡ NK\u002F T-Cell Lymphoma","Selinexor","Inclusion Criteria:\n\n1. Age 18-70 years old, ECOG score 0-2; (including those aged 18 and 70);\n2. Pre-survival time \\> 6 months;\n3. The pathological tissue was confirmed as NK\u002FT cell lymphoma (the pathological report of the first three months of enrollment could be accepted) (Note: If there is any doubt about the pathological diagnosis, domestic third-party consultation could be organized);\n4. Clinical stage Ⅰ to Ⅱ (CA stage) with at least one measurable lesion;\n5. Acceptable hematological indicators, no contraindications to chemotherapy; Neutrophil absolute value ≥1.0×10\\^9 \u002FL, platelet ≥75×10\\^9 \u002FL, hemoglobin ≥80g\u002FL (except patients with lymphoma bone marrow infiltration);\n6. Liver function: direct bilirubin ≤1.5× upper limit reference value; Glutamic pyruvic transaminase or glutamic oxalacetic transaminase ≤2.5× upper limit reference value; Alkaline phosphatase ≤3×ULN in non-bone invaded patients;\n7. Renal function: serum creatinine ≤1.5×ULN;\n8. Female and male patients of reproductive age and their spouses are willing to use adequate contraception throughout the study period, and female patients of reproductive age must have a negative serum pregnancy test within 7 days before the first dose;\n9. The newly treated patient had not received other tumor-related treatment in the past;\n10. Subjects voluntarily participate in the clinical trial, sign informed consent, and cooperate with follow-up;\n\nExclusion Criteria:\n\n1. Refuse to collect blood samples;\n2. Previous allergy to any of the drugs in the program;\n3. Pregnant and lactating women;\n4. Major diseases that the investigator believes can cause interference with the test;\n5. Combined with other tumors;\n6. There are contraindications related to therapeutic drugs in the program;\n7. Persons with serious mental illness;\n8. Participating in other clinical trials;\n9. Previous anti-tumor therapy (such as radiotherapy, chemotherapy, hormone therapy, biotherapy, immunotherapy);\n10. Other serious medical conditions that may limit participants\\' participation in the trial, such as uncontrolled diabetes; Severe cardiac insufficiency (NYHA grade II or above); Acute coronary syndrome within the last 6 months; Coronary revascularization such as stenting, coronary artery bypass surgery, and other heart and large vessel related procedures within the last 6 months; Severe arrhythmias include frequent ventricular early, ventricular tachycardia, rapid atrial fibrillation\u002Fflutter, and severe bradycardia. Uncontrolled hypertension: systolic blood pressure \\>150mmHg, diastolic blood pressure \\>100mmHg. Gastric ulcers (stomach ulcers that researchers have determined are at risk of perforation); Active autoimmune diseases (e.g. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, Sjogren\\'s syndrome, autoimmune thrombocytopenia, etc.); Severe respiratory disease (such as obstructive pulmonary disease and a history of bronchospasm);\n11. Hemophagic cell syndrome;\n12. Researchers do not consider it suitable for inclusion;\n13. Hepatitis B core antibody (HBcAb) positive and peripheral blood hepatitis B virus (HBV) DNA titer detection is not within the normal reference value range; Hepatitis C virus (HCV) antibody positive and peripheral blood hepatitis C virus (HCV) RNA positive; Human immunodeficiency virus (HIV) antibody positive; Syphilis test positive.","70 Years",{"count":75,"type":20},50,[23,24],"evaluate the efficacy and safety of \"Selinexor+pegaspargase+dexamethasone\" in early stage NK\u002F T-cell lymphoma",[28,71],[28,71],"RECRUITING","2025-07-10",{"date":83,"type":37},"2025-07-14",{"date":85,"type":37},"2024-09-01",{"date":87,"type":20},"2026-12-31",{"name":89,"class":43},"Mingzhi Zhang"]