[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"no-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:no-disease":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100620102","fibrescope-vs-videolaryngoscope-for-nasotracheal-intubation-100620102",false,"NCT07353255","Fibrescope vs Videolaryngoscope for Nasotracheal Intubation","Flexible Fibrescope Versus Video Laryngoscope for Nasotracheal Intubation - A Randomised Comparison","Inclusion Criteria:\n\nPatients aged 18 and above, presenting for elective surgical procedures and requiring general anaesthesia and nasal intubation will be invited to take part in the study.\n\nExclusion Criteria:\n\n* Patients who do not want to take part or do not give consent\n* Patients unable to give written consent.\n* Patient physical status of ASA 4 and 5,\n* Patients deemed to require awake intubation.","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"NA","Patients having surgery under general anaesthesia require insertion of a breathing tube to keep the airway open. The technique of inserting a breathing tube through the nose into the trachea (airway) is known as nasotracheal intubation. This is the ideal airway for surgical procedures performed inside the mouth, such as complex teeth extractions and operations on the jaw.\n\nTraditionally, the breathing tube is initially inserted blindly into the nasal cavity. Then, a video laryngoscope (a camera device) or a direct laryngoscope is used to visualise and guide the passage of tube into the trachea. This approach can be associated with difficulty passing the tube and has a high incidence of nasal trauma and nosebleed.\n\nAlternatively, a flexible fibrescope ( flexible camera device) with pre-loaded tracheal tube is passed through the nostril first under vision, gently advanced through the nasal passage and then to the trachea. Once it is correctly placed in the trachea, the breathing tube is railroaded over it. This procedure allows the clinician to visualise the nasal passage and to choose most patent nostril and hence is likely to reduce risk of nosebleed as compared blind passage of tube through the nose. A videolaryngoscope has a camera on the blade that projects the image onto a monitor screen. As this is a rigid device, it can only be inserted through the oral cavity and allows the advancement of tube into the trachea. Both these techniques are currently used in the clinical practice. However, there are no studies to inform anaesthetists whether there are any differences in the incidence of nosebleed.\n\nThe investigators therefore wish to do a randomised comparison between flexible fibrescope and videolaryngocope to assess if use of the former is associated with any reduced risk or severity of nosebleed.",[26],"No Disease","RECRUITING","2026-06-11",{"date":30,"type":31},"2026-06-15","ACTUAL",{"date":33,"type":31},"2026-02-01",{"date":35,"type":20},"2027-01-31",{"name":37,"class":38},"University Hospitals Coventry and Warwickshire NHS Trust","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":59,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100617729","kaempferol-absorption-and-pharmacokinetics-evaluation-100617729","NCT07322406","Kaempferol Absorption and Pharmacokinetics Evaluation","Kaempferol Absorption and Pharmacokinetics Evaluation (K.A.P.E.)","KAPE","Inclusion Criteria:\n\nAdults aged 18 to 70 years\n\n* Healthy volunteers as determined by medical history and screening assessment\n* Ability to understand the study procedures and provide informed consent\n* Willingness and ability to comply with all study procedures, including dietary restrictions, clinic visits, blood draws, urine collection, and follow-up assessments\n* Willingness to abstain from restricted foods, beverages, and supplements as specified in the study protocol during the study period\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to Kaempferol or related flavonoids\n* Pregnancy or breastfeeding\n* Presence of significant acute or chronic medical conditions that could increase risk or interfere with study outcomes, including but not limited to:\n* Active or chronic infections\n* Cancer\n* Cardiovascular disease\n* Neurological or neurodegenerative disorders\n* Metabolic or systemic inflammatory conditions\n* Use of prescription medications or supplements known to interfere with Kaempferol metabolism or pharmacokinetic assessment\n* Blood donation within 8 weeks prior to study enrollment\n* Participation in another interventional clinical study within a timeframe that could interfere with study results or participant safety\n* Any condition or circumstance that, in the judgment of the study investigator, would make participation unsafe or compromise data integrity",true,"70 Years",{"count":51,"type":20},120,[23],"This study is a multi-site clinical trial designed to evaluate how the body absorbs and processes Kaempferol, a naturally occurring compound found in many plant-based foods. The primary purpose of the study is to measure the pharmacokinetics and biological absorption of Kaempferol in healthy adults.\n\nParticipants will receive Kaempferol and undergo scheduled blood and urine collections over a short study period. These samples will be used to measure Kaempferol levels in the body and to assess safety and tolerability. In addition, selected biological samples will be analyzed to explore molecular changes associated with Kaempferol exposure using advanced laboratory methods.\n\nThe study will be conducted at multiple research centers in the United States using a standardized protocol to ensure consistency across sites. The information collected will help improve understanding of how Kaempferol is absorbed and metabolized in humans and will support future research and regulatory evaluation.",[26,55,56,57,58],"Mitochondria Health","Longevity","Pharmacokinetics and Biological Absorption of Kaempferol in Healthy Adult","Healthy Volunteers",[60,61,62,63,64,65,66,67,68],"Mitochondria","Kaempferol","KMP","Pharmacokinetics","Bioavailability","Absorption","Dietary supplement","Healthy volunteers","Multi-omics","2026-03-19",{"date":71,"type":31},"2026-03-23",{"date":73,"type":31},"2025-12-09",{"date":75,"type":20},"2027-12-22",{"name":77,"class":38},"University of Pittsburgh",3]