[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nociception\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nociception":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,78,104,130],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100639599","pain-assessment-during-rapid-sequence-induction-100639599",false,"NCT07588165","Pain Assessment During Rapid Sequence Induction","Nociception Assessment During Rapid Sequence Induction: A Prospective Observational Study of Practices and Complications - The NARSI Study","NARSI","Inclusion Criteria:\n\n* Age \\>= 18 years\n* Patient requiring tracheal intubation after rapid sequence induction in the visceral surgery operating room\n* Pain monitoring by Analgesia Nociception Index (ANI) as part of general anesthesia\n\nExclusion Criteria:\n\n* Patient with atrial fibrillation at the time of intubation following rapid sequence induction\n* Patient on long-term beta-blocker therapy","ALL","18 Years",{"count":20,"type":21},150,"ESTIMATED","OBSERVATIONAL","Rapid sequence induction (RSI) is a standard anesthesia technique used in patients at risk of aspiration. Although tracheal intubation following RSI is a frequent and painful procedure, no study has yet evaluated nociception using the Analgesia Nociception Index (ANI) during this procedure.\n\nThis monocentric prospective observational study aims to describe the impact of RSI on pain measured by ANI, and to explore early complications (desaturation, hypotension, regurgitation) and factors associated with pain and complications. 150 patients undergoing RSI in the visceral surgery operating room at CHPG Monaco will be analyzed.",[25,26,27,28],"Rapide Sequence Induction","Tracheal Intubation","Nociception","General Anesthesia",[30,31,32,33,34,35],"Analgesia Nociception Index (ANI)","Rapid Sequence Induction (RSI)","Pain monitoring","Tracheal intubation","Hemodynamic response","General anesthesia","RECRUITING","2026-05-22",{"date":39,"type":40},"2026-05-27","ACTUAL",{"date":42,"type":40},"2026-05-21",{"date":44,"type":21},"2028-05",{"name":46,"class":47},"Centre Hospitalier Princesse Grace","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":57,"targetDuration":58,"studyType":22,"phases":4,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100612394","ai-assisted-analgesia-copilot-system-100612394","NCT07253012","AI-Assisted Analgesia Copilot System","AI-assisted Analgesia Copilot System for Proper Management of Nociception","SEASCAPE","Inclusion Criteria:\n\n* Patients scheduled for elective surgery with general anesthesia.\n* Surgeries scheduled to last at least two hours.\n\nExclusion Criteria:\n\n* Patients undergoing emergency surgery.\n* Pregnant women.\n* Presence of a mental or intellectual disability before the hospitalization.\n* Drug dependence.\n* Surgeries scheduled for more than 4 hours.\n* Intraoperative complications requiring changes in routine behavior.",{"count":20,"type":21},"5 Weeks","The primary objective of the SEASCAPE project is to design, develop, and to apply a clinical implementation tool of a machine learning (ML) and artificial intelligence (AI)-based co-pilot system for the real-time monitoring and control of nociception during general anesthesia (GA).\n\nThe ultimate clinical purpose is to optimize individualized pain management by achieving precise titration of intravenous opioids (specifically remifentanil), thereby minimizing the incidence of over- and under-dosing. This optimization is projected to enhance patient outcomes, reduce opioid-related complications, and improve overall cost-effectiveness of anesthetic procedures.\n\nThe main scientific question guiding this work is: Can a novel algorithm be generated and validated to provide superior analytical precision for analgesic management by reliably differentiating genuine nociceptive responses from confounding physiological variables-such as inadequate neuromuscular blockade or changes in depth of anesthesia-thereby significantly improving the clinical decision-making framework for intraoperative nociception control? This project addresses the recognized challenge in anesthesiology: defining an objective measure to quantify nociception and antinociception during GA.\n\nStudy Population: Patients scheduled for elective surgical procedures requiring general anesthesia (GA).\n\nExisting Intervention: The standard anesthetic regimen includes continuous intravenous infusion of the remifentanil for intraoperative analgesia, typically governed by a Target Controlled Infusion (TCI) system utilizing a pharmacokinetic\u002Fpharmacodynamic (PK\u002FPD) model (Eleveld TCI model).\n\nProject Focus: The research seeks to improve the accuracy and efficacy of this existing analgesic strategy by integrating a multivariate patient data stream with the newly developed SEASCAPE co-pilot AI. This aims to refine the remifentanil dose predictions beyond the current TCI model's capabilities, personalized system.",[27,61,62,63],"Artificial Intelligence (AI)","Target Controlled Infusion (TCI)","Remifentanil Consumption",[27,65,66,67],"Target Controlled Infusion","Remifentanil","Artificial Intelligence","2026-03-06",{"date":70,"type":40},"2026-03-09",{"date":72,"type":40},"2026-01-29",{"date":74,"type":21},"2027-10-27",{"name":76,"class":47},"Pontificia Universidad Catolica de Chile",2,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":48},"100578877","nociception-monitoring-during-cardiac-surgery-100578877","NCT06817005","Nociception Monitoring During Cardiac Surgery","Feasibility Study of the Nociception Level (NOL) Index for Intraoperative Assessment of Nociception During Cardiac Surgery","MoNOLcard","Inclusion criteria:\n\n* adult patients\n* patients undergoing on-pump cardiac surgery\n* specific cardiac procedure : coronary artery bypass grafting\n\nExclusion criteria:\n\n* patients with preoperative cardiac arrhythmia\n* patients with a cardiac pacemaker\n* emergency cardiac surgical procedure\n* peripheral artery disease stage 2\n* patients in shock prior to the cardiac surgery : mean arterial pressure 65mmHg with vasopressors\n* persons participating in another interventional research\n* patient refusal",{"count":87,"type":21},50,"INTERVENTIONAL",[90],"NA","Cardiac surgery is frequently a source of acute or chronic pain. According to the International Association for the Study of Pain (IASP), nociception is defined as \"the neural mechanisms of encoding and processing harmful stimuli,\" while pain is defined as \"an undesirable sensory and emotional experience associated with real tissue damage\". When patients are under general anesthesia (GA) during surgery, a lack of intraoperative analgesia can expose them to high levels of pain sensitization associated with surgical nociceptive stimuli. The response to the surgical nociceptive stress (via activation of the autonomic nervous system) can lead to alterations in hemodynamic or metabolic status, coagulation or the immune system. In addition, it is now well established that acute intra- and post-operative pain is directly related to the onset of chronic pain, particularly in the post-sternotomy period. On the contrary, excessive administration of opioid analgesics causes moderate to severe side effects (nausea, vomiting, bradypnea, delayed awakening, prolongation of recovery time, hyperalgesia syndrome, postoperative tolerance to opioids leading to misuse or occurrence of DCPO), which will result in postoperative morbidity for the patient independent of the surgery. Indeed, in cardiac surgery, there is a dose-dependent relationship between the intraoperative use of opioid analgesics such as remifentanil and the occurrence of postoperative hyperalgesia. The interest in intraoperative monitoring of nociception has therefore clearly increased in order to improve patient care from the point of view of intra- and postoperative pain management: administering a sufficient and personalized dose of analgesics, neither too high nor too low.\n\nStrategies to prevent perioperative pain must therefore be developed to avoid sensitizing the patient to pain and thus limiting the onset of CD, or conversely, to avoid the onset of side effects from excessive analgesic treatment. These strategies include intra-operative pain monitoring. Numerous medical devices are available on the market to measure the level of nociception in patients undergoing GA. The vast majority of these monitors analyse clinical parameters that assess the balance between the sympathetic and parasympathetic nervous systems. Of all the monitors available, there is currently only one multiparametric monitor, the PMD200® which provides the Nociception Level Index or NOL Index (Medasense, Ramat Gan, Israel). In fact, the latter incorporates 5 parameters in its assessment of nociception: heart rate, RR segment variability, pulse wave amplitude, skin conductance level and skin temperature with the number of variations of these last two parameters. New devices for monitoring nociception used in the administration of intraoperative intravenous opioid agents could help to adjust the analgesia\u002Fnociception balance. In non-cardiac surgery, the NOL index has shown better sensitivity and specificity than variations in heart rate and blood pressure in detecting and helping to manage a surgical nociceptive stimulus during GA. This monitor has also enabled a dramatic reduction in the doses of intraoperative opioids administered.\n\nIn this study we hypothesized that monitoring of nociception using the NOL index is feasible during coronary artery surgery despite extracorporeal circulation.",[27,93,94],"NOL Index","Cardiac Surgery","2025-08-01",{"date":97,"type":40},"2025-08-06",{"date":99,"type":40},"2025-03-18",{"date":101,"type":21},"2026-03-01",{"name":103,"class":47},"University Hospital, Strasbourg, France",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":111,"sex":17,"minAge":18,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":88,"phases":115,"briefSummary":116,"conditions":117,"keywords":118,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":48},"100575846","quantitative-consciousness-index-monitoring-qnox-of-sedation-during-endoscopy-100575846","NCT06777589","Quantitative Consciousness Index Monitoring (qNOX) of Sedation During Endoscopy","Exploration of the Range of the Quantitative Nociception Index (qNOX) During Gastrointestinal Endoscopy Under Intravenous Sedation: a Multicenter Clinical Study","Inclusion Criteria\n\n1. Age between 18 and 60 years old;\n2. ASA-PS (American Society of Anesthesiologists Physical Status) classification of I to II;\n3. Body Mass Index (BMI): 18 to 28 kg\u002Fm²;\n4. Patients undergoing diagnostic and therapeutic procedures under sedation for lower gastrointestinal endoscopy;\n5. Clear understanding and voluntary participation in this study, with informed consent signed.\n\nExclusion Criteria\n\n1. Patients requiring complex endoscopic techniques for diagnosis and treatment;\n2. Patients who have participated in other clinical trials in the past three months;\n3. Pregnant and lactating patients;\n4. Patients with allergies to sedatives\u002Fanesthetics and other severe anesthesia risks;\n5. Patients with preoperative chronic pain or a history of substance abuse;\n6. Patients with severe neurological diseases such as stroke, hemiplegia, convulsions, epilepsy, etc.;\n7. Patients with known difficult airways such as limited mouth opening, restricted neck and jaw movement, rheumatoid spondylitis, temporomandibular joint arthritis, etc.;\n8. Patients with potentially life-threatening circulatory and respiratory diseases that are not adequately controlled, such as uncontrolled severe hypertension, severe arrhythmias, unstable angina pectoris, acute respiratory infections, asthma exacerbations, etc.;\n9. Patients with liver dysfunction (Child-Pugh Class C or higher), acute upper gastrointestinal bleeding with shock, severe anemia, gastrointestinal obstruction with gastric retention.",true,"60 Years",{"count":114,"type":21},900,[90],"Nociception is the encoding and processing of noxious stimulation and is considered an objective indicator for monitoring pain. Currently, a new clinically-applied medical-engineering integrated monitoring device for noxious stimulation response has emerged. Its fundamental principle is based on the monitoring of electroencephalographic (EEG) activity, incorporating two monitoring parameters: the quantitative consciousness (qCON) index and the quantitative nociceptive (qNOX) index. This device enables more precise monitoring of anesthesia depth, quantification of patients' anesthesia analgesia and stress levels, and reliable monitoring of responses to noxious stimulation. During tracheal intubation for general anesthesia, when the qCON value falls within the range of 40 to 60 and the qNOX value is between 30 and 50, it indicates that the patient is in an appropriate state of sedation and analgesia. However, there is currently no universally acknowledged standard for the optimal qNOX reference range during conscious sedation endoscopy. Therefore, this study utilizes the noxious stimulation response index (qNOX) to monitor noxious stimulation during the procedure, aiming to identify the best timing for inserting the endoscope during conscious sedation endoscopy and explore the appropriate range of qNOX for this purpose.",[27],[27,119,120],"endoscopy","Depth of anesthesia","2025-05-28",{"date":123,"type":40},"2025-06-02",{"date":125,"type":21},"2025-06-01",{"date":127,"type":21},"2025-08-31",{"name":129,"class":47},"Min Su",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":112,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":139,"conditions":140,"keywords":143,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":48},"100562514","anesthesia-induction-scheme-for-painless-gastrointestinal-endoscopy-patients-based-on-nociceptive-stimulation-monitoring-100562514","NCT06604156","Anesthesia Induction Scheme for Painless Gastrointestinal Endoscopy Patients Based on Nociceptive Stimulation Monitoring","The Effect of the Nociception Index (qNOX) in Painless Gastrointestinal Endoscopy :a Clinical Study","Inclusion Criteria:\n\n1. Aged 18-60 years old;\n2. American Society of Anesthesiologists (ASA) Class I-III;\n3. Body mass index (BMI): 18-30 kg\u002Fm\\^2;\n4. Individuals scheduled for elective gastroscopy and colonoscopy examinations;\n5. Willing to comply with the experimental procedures and voluntarily sign the informed consent form\n\nExclusion Criteria:\n\n1. Pregnant or breastfeeding women;\n2. Individuals with allergies to sedatives\u002Fanesthetic drugs or other severe anesthetic risks;\n3. Patients with chronic preoperative pain or a history of substance abuse;\n4. Individuals with severe neurological diseases, such as stroke, hemiplegia, seizures, epilepsy, etc.;\n5. Patients with clearly difficult airways, such as those with limited mouth opening, neck or jaw mobility restrictions, rheumatoid arthritis, or temporomandibular joint disorders;\n6. Individuals with respiratory diseases, such as bronchitis, asthma, chronic obstructive pulmonary disease, or acute respiratory infections, which may lead to increased airway sensitivity;\n7. Patients with chronic pharyngitis, laryngitis, laryngeal edema, or recurrent laryngeal nerve paralysis that may affect normal throat function;\n8. Individuals with esophagitis, esophageal strictures, or esophageal motility disorders that may cause difficulty swallowing or reflux;\n9. Patients with poorly controlled life-threatening cardiovascular diseases, such as uncontrolled severe hypertension, severe arrhythmias, or unstable angina; 10.10.Patients with liver dysfunction (Child-Pugh grade C or above), acute upper gastrointestinal bleeding with shock, severe anemia, or gastrointestinal obstruction with retained gastric contents.",{"count":138,"type":21},220,"Nociception is the encoding and processing of noxious stimulation and is considered an objective indicator for monitoring pain. Currently, a new clinically-applied medical-engineering integrated monitoring device for noxious stimulation response has emerged. Its fundamental principle is based on the monitoring of electroencephalographic (EEG) activity, incorporating two monitoring parameters: the quantitative consciousness (qCON) index and the quantitative nociceptive (qNOX) index. However, in the context of sedation for gastrointestinal endoscopy, how the dynamic changes of the quantitative consciousness index (qCON) and the quantitative nociception index (qNOX) reflect the depth of sedation and nociceptive response remains unclear. Safe and effective sedation monitoring includes both direct visual monitoring and physiological monitoring, that is, monitoring the patient's hemodynamics and depth of sedation. This study utilizes qCON and qNOX monitoring to assess the sedation and analgesic states of patients undergoing painless gastroenterological endoscopy. By combining visual assessment (cough reflex, respiratory depression, and limb movement) with clinical physiological monitoring (vital signs monitoring and pulse oximetry), the aim is to explore the optimal sedation range for gastrointestinal endoscopy under sedation, providing new anesthesia monitoring tools for clinical use.",[141,27,142],"Depth of Anesthesia","Painless Gastrointestinal Endoscopy",[144,145,146],"Painless Gastrointestinal endoscopy","depth of anesthesia","nociception","2025-03-04",{"date":149,"type":40},"2025-03-06",{"date":151,"type":40},"2024-09-01",{"date":153,"type":21},"2025-10-31",{"name":129,"class":47}]