[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nocturnal-enuresis-in-children\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nocturnal-enuresis-in-children":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,76,109,143],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100639179","tens-in-nocturnal-enuresis-100639179",false,"NCT07594353","TENS in Nocturnal Enuresis","Maintenance Parasacral Electrical Nerve Stimulation Versus Observation After Initial Response in Children With Primary Nocturnal Enuresis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis of primary monosymptomatic nocturnal enuresis (PMNE) based on International Children's Continence Society (ICCS) criteria.\n* Persistent symptoms after at least 8 weeks of standardized urotherapy, including counseling on timed voiding, evening fluid management, and bowel optimization.\n* Baseline severity of ≥3 wet nights per week on a 14-night diary.\n* Ability of the child and caregiver to complete diaries and comply with home treatment and follow-up.\n\nExclusion Criteria:\n\n* Non-monosymptomatic enuresis, daytime urgency, daytime incontinence, dysfunctional voiding, or significant post-void residual.\n* Neurogenic bladder, spinal dysraphism, cerebral palsy, epilepsy uncontrolled on treatment, or other neurologic diseases affecting lower urinary tract function.\n* Congenital or acquired urinary tract abnormalities.\n* Active urinary tract infection.\n* Untreated or refractory constipation at enrollment.\n* Implanted electrical devices, significant dermatologic lesions at electrode sites, or other contraindications to electrical stimulation.\n* Cognitive, behavioral, or social circumstances preventing adherence.","ALL","5 Years","16 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","Paracascral transcutaneous electrical nerve stimulation (PTENS) is a credible therapeutic option for nocturnal enuresis. The investigators shall investigate whether maintenance PTENS after initial response improves durability of remission compared with observation alone.",[27],"Nocturnal Enuresis in Children",[29],"TENS","NOT_YET_RECRUITING","2026-05-22",{"date":33,"type":34},"2026-05-27","ACTUAL",{"date":36,"type":21},"2026-07-01",{"date":38,"type":21},"2027-02-28",{"name":40,"class":41},"Suez Canal University","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":49,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":60,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100632009","causes-and-types-of-nocturnal-enuresis-in-children-100632009","NCT07508111","Causes and Types of Nocturnal Enuresis in Children","A Descriptive Study on the Causes and Types of Nocturnal Enuresis Among Children Attending Assiut University Children's Hospital","Inclusion Criteria:\n\n* Male and female children aged above 5 years.\n* Presenting with nocturnal enuresis, defined as involuntary voiding during sleep for ≥2 nights\u002Fweek for ≥3 months.\n* Parents or caregivers providing informed consent, including child assent where applicable.\n\nExclusion Criteria:\n\n* Children with known neurological disorders, such as epilepsy or cerebral palsy.\n* Presence of an acute urinary tract infection (indicated by a positive urine culture requiring treatment).\n* Children diagnosed with diabetes mellitus.\n* Structural anomalies of the urinary system requiring immediate surgery, such as severe hypospadias.\n* Families unwilling to participate or complete follow-up data collection.","18 Years",{"count":51,"type":21},80,"OBSERVATIONAL","Nocturnal enuresis, commonly known as bedwetting, is a frequent condition that affects many children and can have a significant impact on their self-esteem, social life, and family stress. The causes of bedwetting can vary widely, ranging from deep sleep patterns and excess nighttime urine production to underlying medical conditions like constipation, urinary tract infections, or enlarged tonsils and adenoids (which can affect breathing during sleep).The main goal of this descriptive study is to understand the different types and the underlying causes of bedwetting among children attending the pediatric outpatient clinics at Assiut University Children's Hospital. By identifying these specific causes in the local population, healthcare providers can offer better, more targeted treatments and help reduce the stigma surrounding this condition.\n\nDuring a single clinic visit, researchers will collect information through a structured interview with the parents and the child. The study involves a routine physical examination, including checking weight, height, and looking for physical signs of constipation or enlarged tonsils. Participants will also undergo standard tests to help pinpoint any medical causes, such as a urine test (urinalysis and culture), a basic ultrasound of the abdomen and pelvis, and potentially plain X-rays if issues like severe constipation or airway blockages are suspected.\n\nThe study aims to include at least 80 male and female children aged 5 years and older who have been experiencing bedwetting at least twice a week for three months or more.",[55,27,56,57,58,59],"Nocturnal Enuresis","Primary Nocturnal Enuresis","Secondary Nocturnal Enuresis","Monosymptomatic Enuresis Nocturna","Polysymptomatic Enuresis",[55,61,62,63,64,65,66],"Bedwetting","Urinary Incontinence","Pediatrics","Primary Enuresis","Secondary Enuresis","Monosymptomatic Enuresis","2026-03-27",{"date":69,"type":34},"2026-04-02",{"date":71,"type":21},"2026-05",{"date":73,"type":21},"2027-06",{"name":75,"class":41},"Assiut University",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":83,"maxAge":49,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100608310","phase-3-omegapres-versus-solifenacin-and-mirabegron-combination-therapy-in-treatment-of-primary-mne-100608310","NCT07199894","Omegapres Versus Solifenacin and Mirabegron Combination Therapy in Treatment of Primary MNE","A Randomized Controlled Trial Comparing Mirabegron and Solifenacin Combination Therapy Versus Desmopressin Monotherapy in Treatment of Children With Primary Mono-Symptomatic Nocturnal Enuresis","Inclusion Criteria:\n\nPrimary mono-symptomatic nocturnal enuresis -\n\nExclusion Criteria:\n\nBowel dysfunction Psychatric illness Respiratory sleep disorders\n\n\\-","6 Years",{"count":85,"type":21},120,[87],"PHASE3","The goal of this clinical trial is to compare combination of Solifenacin and MIrabegron in treatment of primary mono-symptomatic nocturnal enuresis in children. It will also learn about the safety of that combination. The main questions it aims to answer are:\n\nDoes combination of Solifenacin and MIrabegron lower the number of wet nights? What medical problems do participants have when taking combination of Solifenacin and MIrabegron? Researchers will compare the combination to omegapress to see if the combination works better to treat primary mono-symptomatic nocturnal enuresis.\n\nParticipants will:\n\nTake the combination or Omegapress every day for 3 months Visit the clinic once monthly for checkups and tests Keep a diary of their symptoms and the number of wet nights",[27],[91,92,93,94,95,96,97],"nocturnal enuresis","Desmopressin","Mirabegron","Solifenacin","B3 agonist","Anti-cholinergic","Randomised controlled trial","RECRUITING","2025-09-22",{"date":101,"type":34},"2025-09-30",{"date":103,"type":34},"2024-12-01",{"date":105,"type":21},"2026-02-01",{"name":107,"class":41},"Mansoura University",1,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":16,"minAge":116,"maxAge":117,"enrollmentInfo":118,"targetDuration":4,"studyType":22,"phases":120,"briefSummary":121,"conditions":122,"keywords":123,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":138,"leadSponsor":140,"locationsCount":142},"100584016","effectiveness-of-pelvic-floor-muscle-rehabilitation-combined-with-desmopressin-in-children-with-primary-monosymptomatic-nocturnal-enuresis-100584016","NCT06883851","Effectiveness of Pelvic Floor Muscle Rehabilitation Combined With Desmopressin in Children With Primary Monosymptomatic Nocturnal Enuresis","Evaluating the Efficacy of Structured Pelvic Floor Muscle Rehabilitation Combined With Desmopressin in the Management of Primary Monosymptomatic Nocturnal Enuresis in Children","Inclusion Criteria:\n\n* Being between 7 and 13 years old\n* Diagnosed with primary MNE by a pediatric urology department within the last 6 months\n* No urinary tract infection verified by laboratory tests\n* Ability to communicate in Turkish and absence of mental deficit\n* No diagnosed psychiatric problems\n* Willingness to participate in the study (child and family)\n\nExclusion Criteria:\n\n* Presence of orthopedic conditions preventing evaluation\n* Anatomical anomalies in the urinary system\n* History of urinary system surgery\n* Neurological disorders\n* Presence of mental retardation\n* History of orthopedic surgery that could alter pelvic or lower extremity integrity\n* Receiving PFM rehabilitation in the last 6 months\n* Using nighttime alarm therapy in the last 6 months\n* Receiving any treatment for enuresis in the last 6 months","7 Years","13 Years",{"count":119,"type":21},40,[24],"The aim of this randomized controlled trial is to evaluate the effects of Structured Pelvic Floor Muscle Rehabilitation (SPFMR) in children with Primary Monosymptomatic Nocturnal Enuresis (PMNE) who are undergoing desmopressin asetat (DDAVP) treatment prescribed by a pediatric urologist. The study aims to investigate whether SPFMR can reduce the frequency and severity of enuresis episodes and whether it can also reduce relapse rates in the short- and long-term follow-up. The main questions the study seeks to answer are:\n\n* Does SPFMR reduce the frequency and severity of enuresis episodes in children with PMNE?\n* Does SPFMR treatment reduce relapse rates in children with PMNE in the long term? Researchers will compare the group receiving SPFMR in addition to DDAVP treatment with a control group receiving only DDAVP treatment. This comparison will help evaluate the effect of SPFMR on the severity of enuresis episodes and relapse rates.\n\nParticipants will:\n\n* Receive DDAVP treatment (SPFMR group and Control group)\n* Participate in SPFMR sessions ( SPFMR group)\n* Keep a diary of enuresis frequency and severity\n* Assess relapse during short- and long-term follow-up\n\nThe hypotheses of the study are:\n\nH0: Adding SPFMR to desmopressin treatment for children with PMNE has no short-term effect on the severity of enuresis episodes.\n\nH1: Adding SPFMR to desmopressin treatment for children with PMNE has a short-term effect on the severity of enuresis episodes.\n\nH0: Adding SPFMR to desmopressin treatment for children with PMNE has no long-term effect on the severity of enuresis episodes.\n\nH2: Adding SPFMR to desmopressin treatment for children with PMNE has a long-term effect on the severity of enuresis episodes.",[56,27],[124,125,126,127,128,129,130,131,132],"biofeedback","core stabilization","exercise","urinary incontinence","management","treatment","enuresis","pelvic floor rehabilitation","desmopressin","2025-03-16",{"date":135,"type":34},"2025-03-19",{"date":137,"type":34},"2025-03-11",{"date":139,"type":21},"2027-08-30",{"name":141,"class":41},"Bahçeşehir University",2,{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":4,"eligibilityCriteria":149,"healthyVolunteers":150,"sex":16,"minAge":83,"maxAge":49,"enrollmentInfo":151,"targetDuration":4,"studyType":22,"phases":153,"briefSummary":154,"conditions":155,"keywords":156,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":108},"100554327","new-treatment-for-nocturnal-enuresis-in-children-100554327","NCT06497647","New Treatment for Nocturnal Enuresis in Children","Outcome of Treatment of Monosymptomatic Nocturnal Enuresis in Children Using Imipramine Alone Versus Sulbutiamine Alone Versus Imipramine Plus Sulbutiamine : Prospective Comparative Study","Inclusion Criteria:\n\n* Age : 6 - 18 years old.\n* All children diagnosed by Primary monosymptomatic nocturnal enuresis in this age group.\n\nExclusion Criteria:\n\n* Secondary nocturnal enuresis (child who has been continent for at least 6 months before the onset of bedwetting ).\n* congenital anomalies (Posterior urethral valve , ectopic ureter , ectopia vesica ,…)\n* history of previous lower urinary tract surgery (Multiple hypospadias surgeries ,…, )\n* neurogenic bladder (as underactive bladder ).and urge incontinence.\n* presence of post-void residual urine greater than 20% of functional bladder capacity.\n* history or evidence of disorders in other organs such as (cardiovascular system disease), liver , psychological problems , evident allergic reaction to both medication.",true,{"count":152,"type":21},450,[24],"The aim of the study is to evaluate the role of sulbutiamine in treatment of monosymptomatic nocturnal enuresis in children by using it alone or as a combination therapy with tricyclic antidepressants (imipramine+sulbutiamine).",[27],[157],"treatment of monosymptomatic nocturnal enuresis in children using sulbutiamine","2024-07-11",{"date":160,"type":34},"2024-07-12",{"date":162,"type":34},"2024-03-01",{"date":164,"type":21},"2024-11",{"name":166,"class":41},"Sohag University"]