[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nocturnal-enuresis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nocturnal-enuresis":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,79,101],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100632009","causes-and-types-of-nocturnal-enuresis-in-children-100632009",false,"NCT07508111","Causes and Types of Nocturnal Enuresis in Children","A Descriptive Study on the Causes and Types of Nocturnal Enuresis Among Children Attending Assiut University Children's Hospital","Inclusion Criteria:\n\n* Male and female children aged above 5 years.\n* Presenting with nocturnal enuresis, defined as involuntary voiding during sleep for ≥2 nights\u002Fweek for ≥3 months.\n* Parents or caregivers providing informed consent, including child assent where applicable.\n\nExclusion Criteria:\n\n* Children with known neurological disorders, such as epilepsy or cerebral palsy.\n* Presence of an acute urinary tract infection (indicated by a positive urine culture requiring treatment).\n* Children diagnosed with diabetes mellitus.\n* Structural anomalies of the urinary system requiring immediate surgery, such as severe hypospadias.\n* Families unwilling to participate or complete follow-up data collection.","ALL","5 Years","18 Years",{"count":20,"type":21},80,"ESTIMATED","OBSERVATIONAL","Nocturnal enuresis, commonly known as bedwetting, is a frequent condition that affects many children and can have a significant impact on their self-esteem, social life, and family stress. The causes of bedwetting can vary widely, ranging from deep sleep patterns and excess nighttime urine production to underlying medical conditions like constipation, urinary tract infections, or enlarged tonsils and adenoids (which can affect breathing during sleep).The main goal of this descriptive study is to understand the different types and the underlying causes of bedwetting among children attending the pediatric outpatient clinics at Assiut University Children's Hospital. By identifying these specific causes in the local population, healthcare providers can offer better, more targeted treatments and help reduce the stigma surrounding this condition.\n\nDuring a single clinic visit, researchers will collect information through a structured interview with the parents and the child. The study involves a routine physical examination, including checking weight, height, and looking for physical signs of constipation or enlarged tonsils. Participants will also undergo standard tests to help pinpoint any medical causes, such as a urine test (urinalysis and culture), a basic ultrasound of the abdomen and pelvis, and potentially plain X-rays if issues like severe constipation or airway blockages are suspected.\n\nThe study aims to include at least 80 male and female children aged 5 years and older who have been experiencing bedwetting at least twice a week for three months or more.",[25,26,27,28,29,30],"Nocturnal Enuresis","Nocturnal Enuresis in Children","Primary Nocturnal Enuresis","Secondary Nocturnal Enuresis","Monosymptomatic Enuresis Nocturna","Polysymptomatic Enuresis",[25,32,33,34,35,36,37],"Bedwetting","Urinary Incontinence","Pediatrics","Primary Enuresis","Secondary Enuresis","Monosymptomatic Enuresis","NOT_YET_RECRUITING","2026-03-27",{"date":41,"type":42},"2026-04-02","ACTUAL",{"date":44,"type":21},"2026-05",{"date":46,"type":21},"2027-06",{"name":48,"class":49},"Assiut University","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":65,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100526482","optimal-pulse-width-used-in-transcutaneous-electrical-nerve-stimulation-for-treating-nocturnal-enuresis-in-children-100526482","NCT06135311","Optimal Pulse Width Used in Transcutaneous Electrical Nerve Stimulation for Treating Nocturnal Enuresis in Children","Optimal Pulse Width Used in Transcutaneous Electrical Nerve Stimulation (TENS) for Treating Nocturnal Enuresis in Children","Inclusion Criteria:\n\n1. Presenting with nocturnal enuresis (more than 1x a week)\n2. Failed Behavioral modification treatment (limiting evening drinking, double voiding prior to bedtime, bowel habits, social anxiety factors) during the 30 day period prior to randomization\n3. Ability to provide informed consent and assent and complete study requirements\n\nExclusion Criteria:\n\n1. Patients who have previously tried pharmacologic treatment for nocturnal enuresis, neuromodulation or other alternative therapy for urologic disorders within the past 30 days\n2. Daytime incontinence symptoms\n3. Known \"high volume\" voiders (determined from history)\n4. Bedwetting episodes on the average of less than two times per week,\n5. Medications predisposing to incontinence (eg, Lithium for bipolar disorder)\n6. Other known voiding or neurologic disorders (eg, overactive bladder, myelomeningocele, interstitial cystitis, etc)\n7. Secondary etiologies for nocturnal enuresis (eg, cystitis, obstructive sleep apnea, urinary fistulae, heart disease)\n8. Any contraindications to usage of a TENS unit (pacemaker or other implantable device, lymphedema, pregnancy, malignancy, bleeding or clotting disorders, unhealthy tissue, seizure disorders, impaired cognition)\n9. Any history of heart disease or complications","17 Years",{"count":59,"type":21},70,"INTERVENTIONAL",[62],"NA","Children referred to pediatric urology clinic for primary nocturnal enuresis will be screened for enrollment. Patients who fail will next be offered therapy with a bedwetting alarm device or a TENS unit as an alternative, and those who chose TENS therapy will be included in the study.The patients will be randomized into two groups of 35 patients each.Group 1 will be the high pulse width set at 260us. Group 2 will be the low pulse width set at 50us. The patients will be provided with a TENS unit and electrode pads and caretakers instructed on how to use the apparatus. The child's TENS unit will be set at a pulse width determined by randomization, frequency of 10Hz, and an intensity to be determined in the office based upon when the child feels sensitive to the TENS unit. The child will be randomized and will place the electrodes along the posterior tibial nerve on the medial ankle each night before bed time for 30 minutes for a total of 30 days. Diaries including nighttime incontinence episodes and a \"wet sheet\" scale (dry, damp, wet, soaked) will be recorded, along with any adverse reactions to the TENS unit. Patients will be followed up after one month of TENS with evaluation including the Bowel \\& Bladder Questionnaire (BBQ), a validated tool for measuring symptoms in children with voiding dysfunction \\[6\\]; this questionnaire will be filled out prior to starting TENS treatment in order to compare the effect of treatment. The data will be collected at different time points (baseline and after 1 month of treatment) for each group by itself and the groups compared against each other using statistical analysis.",[25,32],[66,32,67],"Noctural Eneuresis","TENS","RECRUITING","2025-09-29",{"date":71,"type":42},"2025-10-02",{"date":73,"type":42},"2023-10-24",{"date":75,"type":21},"2026-12-31",{"name":77,"class":49},"Albany Medical College",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":60,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":4},"100581674","aromatherapy-versus-diet-100581674","NCT06853379","Aromatherapy Versus Diet","Aromatherapy Versus Diet Management on Children with Primary Nocturnal Enuresis","Inclusion Criteria:\n\n* The participants age will be ranged from 5to 10 years.\n* primary Nocturnal enuresis(NE) number of wet nights\u002Fweek is more than 4\\\\7\n\nExclusion Criteria:\n\n* secondary nocturnal enuresis to any neurological disorders , musculoskeletal problems, or congenital abnormalities\n* the child receives any Pharmacological treatment to NE","10 Years",{"count":88,"type":21},30,[62],"Eligible children were randomly divided into 2 groups assigned to receive dietary recommendations (group A) or to receive herbal compounds (group B). Children were treated for a period of one week , then cross over the two groups is done",[25],"2025-02-27",{"date":94,"type":42},"2025-03-03",{"date":96,"type":21},"2025-03-05",{"date":98,"type":21},"2025-05-10",{"name":100,"class":49},"Cairo University",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":108,"maxAge":57,"enrollmentInfo":109,"targetDuration":4,"studyType":60,"phases":111,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":78},"100561155","the-role-of-timed-awakening-in-treatment-of-enuresis-100561155","NCT06586476","The Role of Timed Awakening in Treatment of Enuresis","A Randomized Clinical Trial to Investigate the Efficacy and Feasibility of Timed Awakening in the Treatment of Enuresis","Inclusion Criteria:\n\n* Our inclusion criteria are new and recently evaluated (within past 6 months) patients who are English-speaking\n* aged 6-17\n* referred to the urology clinic for enuresis (Enuresis in our study is defined as nocturnal or diurnal enuresis (more than 1 bedwetting episode\u002Fweek) for greater than 3 months)\n\nExclusion Criteria:\n\n* Diagnosis of enuresis with comorbid diagnosis of diabetes mellitus (type 1 and 2), diabetes insipidus, chronic kidney disease, polyuria and\u002For polydipsia\n* Structural urologic disease (evaluated via baseline imaging)\n* Diagnosis of neurodevelopmental delays or conditions (i.e. celebral palsy, autism spectrum disorder) that hinders inability to follow age-appropriate instructions\n* Not potty trained\n* Improved or resolved enuresis for patients recently evaluated (within the past 6 months)\n* Non-English speaking\n* Patients currently on any over-active-bladder (OAB) medications (b3- agonists, antichloingerics) or alpha blockers for urinary symptoms (i.e. alfuzosin, tamsulosion, etc) or anti-diurectic medications for urinary symptoms (i.e.: desmopression (DDAVP))\n* Patients currently using bed-wetting alarms\n* Patients and families who are actively seeing Pediatric Clinical Urologic Psychologist.\n* Inability or unwillingness of individual or legal guardian\u002Frepresentative to give written informed consent or participate in the study","6 Years",{"count":110,"type":21},40,[62],"The goal of this clinical trial is to evaluate the effectiveness of nightly timed awakening in the treatment of nocturnal enuresis in children aged 6-17. The main questions it aims to:\n\n* Determine feasibility of nightly timed awakenings\n* Determine the role, if any, of comorbidities on resolution of enuresis\n* Determine incidence of daytime accidents\n* Obtain patient and parental satisfaction scores\n\nResearchers will compare a control group to treatment groups to see if there is any impact on nocturnal enuresis.\n\nParticipants will be woken up by parents in the middle of the night to use the restroom. In addition, participants will receive 30 minute psychotherapy sessions using telehealth.",[25,114],"Voiding Dysfunction",[116,117,32],"Lifting","Incontinence","2024-09-05",{"date":120,"type":42},"2024-09-19",{"date":122,"type":21},"2024-10-01",{"date":124,"type":21},"2026-12-01",{"name":126,"class":49},"Children's Hospital Los Angeles"]