[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-cardiac-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-cardiac-surgery":100},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,54,83,115,144,172,205],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100622551","continuous-vital-sign-monitoring-versus-routine-spot-checks-in-patients-after-non-cardiac-surgery-100622551",false,"NCT07385092","Continuous Vital Sign Monitoring Versus Routine Spot-checks in Patients After Non-cardiac Surgery","The Effect of Continuous Monitoring Versus Routine Spot-checks on Altered Vital Signs in Patients Recovering From Non-cardiac Surgery on Normal Wards: the \"COME ON, NOW!\" Trial","COME ON NOW","Inclusion Criteria:\n\nConsenting patients ≥45 years scheduled for elective non-cardiac (abdominal and thoracic) surgery with planned postoperative admission to a normal ward after an overnight stay in an advanced post-anesthesia care unit.\n\nExclusion Criteria:\n\n* Emergency surgery\n* Pregnancy\n* Impossibility to perform continuous monitoring with the Radius VSM sensor (Masimo, Irvine, CA)\n* Atrial fibrillation\n* Patients designated Do Not Resuscitate, or are receiving end-of-life care","ALL","45 Years",{"count":20,"type":21},264,"ESTIMATED","INTERVENTIONAL",[24],"NA","The \"COME ON, NOW!\" trial is a randomized, single-center trial in patients recovering from non-cardiac surgery on normal wards investigating whether continuous vital sign monitoring - compared to routine spot-checks by nurses - reduces the total duration of abnormal vital signs per hour during the first 48 hours after admission to the normal ward.",[27,28,29,30,31],"Vital Sign Monitoring","Post Operative Complications","Non-cardiac Surgery","RCT","Anesthesiology",[33,34,35,36,37,38,39,40],"continuous vital signs","vital signs","vital sign monitoring","post-operative care","anesthesiology","anesthesia","hypotension","post-operative complications","RECRUITING","2026-02-27",{"date":44,"type":45},"2026-03-02","ACTUAL",{"date":47,"type":45},"2026-02-24",{"date":49,"type":21},"2026-12-31",{"name":51,"class":52},"Universitätsklinikum Hamburg-Eppendorf","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":82},"100584125","phase-3-noradrenaline-versus-standard-blood-pressure-management-for-perioperative-hypotension-in-non-cardiac-surgery-100584125","NCT06885268","Noradrenaline Versus Standard Blood Pressure Management for Perioperative Hypotension in Non-cardiac Surgery","The Effect of Noradrenaline Infusion Versus Standard Blood Pressure Management on Perioperative HYPotension in NOn-caRdiac Surgery HYP-NOR Trial","HYP-NOR","Inclusion Criteria:\n\n1. ≥45 years old\n2. Elective or accelerated\\* non-cardiac surgery expected to last ≥1 hour and requiring general, neuraxial, or combined general with neuraxial anesthesia\n3. Expected to stay overnight in the hospital after surgery\n4. Written informed consent to participate in the HYP-NOR Trial provided\n5. American Society of Anesthesiologists (ASA) physical status class II or higher.\n\nExclusion Criteria:\n\n1. Newly diagnosed, untreated, or uncontrolled hypertension -in two measurements on the day before surgery Systolic Blood Pressure (SBP) ≥180 mm Hg or Diastolic Blood Pressure (DBP) ≥110 mm Hg\n2. Persistent difference in recorded SBP between right and left upper limb \\>10 mm Hg\n3. Persistent atrial fibrillation\n4. Have a documented history of dementia\n5. Have language, vision, or hearing impairments that may compromise cognitive assessments\n6. Have a condition that precludes routine blood pressure management such as surgeon request for relative hypotension\n7. Receiving irreversible nonselective monoamine oxidase inhibitors (e.g. tranylcypromine, phenelzine) within 2 weeks preceding study enrolment\n8. The use of tricyclic antidepressants\n9. Have Prinzmetal angina\n10. Have contraindications to noradrenaline per clinician judgement\n11. Noradrenaline infusion started before surgery or plan to use continuous noradrenaline infusion throughout the procedure\n12. Treating physician (surgeon\u002Fanaesthetist) decides on the necessity of extended continuous hemodynamic monitoring during or after surgery\n13. Severe kidney disease (MDRD creatinine clearance \\\u003C15 mL\u002Fmin\u002F1.73m2) or renal replacement therapy\n14. End-stage heart failure: defined as NYHA Class IV - severe limitations in daily activity. Patients experience symptoms even while at rest. Mostly bedbound patients.\n15. Known severe liver disease: defined as the presence of liver cirrhosis or any of the symptoms of severe liver dysfunction: portal hypertension (esophageal varices, ascites), hepatocellular insufficiency (e.g., jaundice, hepatic encephalopathy) and coagulopathy (prolonged INR\u002FAPTT associated with known liver dysfunction).\n16. Emergency and urgent surgery defined as performed within 24 hours of sudden illness\u002Funplanned admission to hospital\n17. Have previously participated in the trial: patient already took a part in the HYP-NOR trial in the past\n18. Pregnant or breastfeeding women.",{"count":63,"type":21},750,[65],"PHASE3","The effect of noradrenaline infusion versus standard blood pressure management on perioperative HYPotension in NOn-caRdiac surgery.\n\nThe study aims to determine whether perioperative noradrenaline infusion is superior to standard blood pressure management for the occurrence of perioperative hypotension.",[68,69,29],"Blood Pressure Management","Intraoperative Hypotension",[39,71,72],"noradrenaline infusion","perioperative care","2026-01-12",{"date":75,"type":45},"2026-01-14",{"date":77,"type":45},"2025-06-25",{"date":79,"type":21},"2027-06-30",{"name":81,"class":52},"Jagiellonian University",5,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":91,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":22,"phases":94,"briefSummary":96,"conditions":97,"keywords":101,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":53},"100611085","phase-4-paracetamol-and-mannitol-injection-and-postoperative-delirium-100611085","NCT07235995","Paracetamol and Mannitol Injection and Postoperative Delirium","Impact of Paracetamol and Mannitol Injection Analgesia on Postoperative Delirium in Elderly Patients After Non-cardical Surgery: A Randomized Controlled Trial","PAPOD-ES","Inclusion Criteria:\n\n* Age ≥ 60 years;\n* Admitted to ICU after a noncardiac surgical procedure\n* Moderate to severe acute pain, with a postoperative pain score ≥ 5 based on the 11-point Numerical Pain Rating Scale (NPRS)\n* Signed informed consent form\n\nExclusion Criteria:\n\n* Preoperative medical history: schizophrenia, epilepsy, Parkinson's disease, or severe myasthenia gravis\n* History of psychiatric disease or significant neurocognitive disorder such as dementia or retardation, making POD assessment impossible\n* Language or communication barrier making POD assessment impossible\n* Intracranial surgery\n* Severe hepatic dysfunction prohibiting the use of acetaminophen per the standard of care\n* Participation in a competing study within 30d\n* Patients experienced intraoperative or postoperative complications, and the investigator determined the subject was unsuitable to continue participation in the study\n* Intolerant to paracetamol or opioid drugs","60 Years",{"count":93,"type":21},1092,[95],"PHASE4","The aim of this multi-center RCT is to investigate the effect of intravenous acetaminophen (paracetamol and mannitol injection) on postoperative delirium, comparing with intravenous sufentanil, in elderly noncardiac surgical patients admitted to ICU.",[98,99,100],"Postoperative Delirium","Elderly","Non Cardiac Surgery",[102,103,99,104],"Postoperative delirium","Intravenous acetaminophen","Noncardiac surgical patients","NOT_YET_RECRUITING","2025-11-17",{"date":108,"type":45},"2025-11-19",{"date":110,"type":21},"2025-12-01",{"date":112,"type":21},"2027-04-30",{"name":114,"class":52},"Xiangya Hospital of Central South University",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":122,"sex":17,"minAge":123,"maxAge":4,"enrollmentInfo":124,"targetDuration":126,"studyType":127,"phases":4,"briefSummary":128,"conditions":129,"keywords":133,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":140,"leadSponsor":142,"locationsCount":53},"100599170","myocardial-injury-after-noncardiac-surgery-mins-in-lumbar-surgery-patients-100599170","NCT07081009","Myocardial Injury After Noncardiac Surgery (MINS) in Lumbar Surgery Patients","Evaluation of the Incidence and Risk Factors of Myocardial Injury After Noncardiac Surgery (MINS) in Lumbar Surgery Patients","Inclusion criteria Age ≥18 years Elective lumbar stabilization surgery\n\nExclusion criteria History of cardiac surgery Recent acute MI (\\\u003C30 days) Chronic elevated troponin levels",true,"18 Years",{"count":125,"type":21},180,"270 Days","OBSERVATIONAL","The aim of this study is to evaluate the incidence of myocardial injury after noncardiac surgery (MINS) in patients undergoing lumbar surgery, and to investigate the associated risk factors.",[130,100,131,132],"MYOCARD INFARCTUS","Lumbar Surgery","Anesthesia",[134,135],"Myocardial injury","noncardiac surgery","2025-10-01",{"date":138,"type":45},"2025-10-06",{"date":136,"type":45},{"date":141,"type":21},"2026-04-24",{"name":143,"class":52},"Ankara City Hospital Bilkent",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":150,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":17,"minAge":123,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":22,"phases":154,"briefSummary":155,"conditions":156,"keywords":159,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":163,"lastUpdatePostDateStruct":164,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":53},"100476268","phase-3-lung-ultrasound-guided-hemodynamic-optimization-100476268","NCT05481723","Lung Ultrasound-guided Hemodynamic Optimization","Lung Ultrasound-guided Hemodynamic Optimization in Major Non-cardiac Surgery: a Randomized Control","POINTBAR","Inclusion Criteria:\n\n* Age\\> 18 years old\n* Abdominal, orthopaedic or vascular surgery with general anaesthesia\n* Patient of legal age ≥ 18 years.\n* ASA score ≥ II\n* Estimated duration of surgery \\> 2 hours\n* At least two of the following comorbidities (age \\> 50 years, hypertension, heart disease, electrocardiogram (ECG) abnormality, acute pulmonary oedema, smoking, stroke, peripheral arterial disease, non-insulin dependent or insulin dependent diabetes, ascites, chronic renal failure)\n* Signed consent.\n* Affiliation to a social security scheme.\n\nExclusion Criteria:\n\n* Severe untreated or unbalanced hypertension on treatment.\n* Preoperative renal failure on dialysis.\n* Acute heart failure.\n* Acute coronary insufficiency.\n* Vascular surgery with renal plasty.\n* Cardiac surgery.\n* Preoperative shock.\n* Refusal of patient participation.\n* Pregnant, parturient or breastfeeding woman.\n* Patient under guardianship or private law.\n* Acute respiratory distress syndrome according to the Berlin definition\n* respiratory distress not fully explained by cardiac failure or increased blood volume,\n* PaO2\u002FFiO2 ratio ≤ 300 mm Hg on mechanical ventilation (invasive or non-invasive)\n* Chronic respiratory failure with home oxygen therapy.\n* Chronic interstitial lung disease\n* Presence of an acoustic barrier (pneumothorax, subcutaneous emphysema, pleural calcifications, chest bandage, gunshot shrapnel...)\n* Participation in other interventional drug research.\n* Surgical fields covering the sites of investigation in lung ultrasound.",{"count":153,"type":21},350,[65],"The formalized expert recommendation of the French Society of Anesthesia and Intensive Care recommends guiding vascular filling by measuring the stroke volume (SV) in surgical patients considered at high risk. Vascular filling should be continued in the event of preload dependence and stopped in the event of the appearance of preload independence. The aim is to avoid vascular overload due to excessive vascular filling. The application of this recommendation has resulted in a reduction in postoperative morbidity, length of hospital stay and time to return to oral feeding. The superiority of this strategy is now being questioned and the predictive indices of response to vascular filling (static and dynamic) have many limitations. In addition, none of the cardiac output monitors are the gold standard for intraoperative use.\n\nThrough the study of artefacts, lung ultrasound has been gaining ground over the last twenty years, particularly in cardiology, nephrology and intensive care. By analogy with radiological B-lines, ultrasound B-lines result from the reverberation of ultrasound on the subpleural inter-lobular septa thickened by oedema. The Fluid Administration Limited by Lung Sonography (FALLS) protocol, described by Lichtenstein et al, is defined as the visualisation of new B lines during a vascular filling test. If a B-line appears in an area where it was not present during vascular filling, the most likely diagnosis is hydrostatic overload of the subpleural interstitial septum. This appearance of B-lines occurs at a sub-clinical stage.\n\nThe use of lung ultrasound could allow real-time assessment of vascular filling and its tolerance during the intraoperative period. The main objective of the study is to demonstrate a decrease in the incidence of postoperative complications (organ failure) (as defined by international guidelines) when using lung ultrasound-guided haemodynamic optimisation compared to standard optimisation.",[157,158,29],"Lung Ultrasound","Goal Directed Therapy",[160,161,162],"lung ultrasound","goal directed therapy","non-cardiac surgery","2025-05-22",{"date":165,"type":45},"2025-05-28",{"date":167,"type":45},"2022-07-28",{"date":169,"type":21},"2027-08",{"name":171,"class":52},"Centre Hospitalier Universitaire, Amiens",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":4,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":17,"minAge":179,"maxAge":180,"enrollmentInfo":181,"targetDuration":4,"studyType":22,"phases":183,"briefSummary":184,"conditions":185,"keywords":191,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":204},"100578895","effect-of-low-dose-esketamine-on-delirium-in-high-risk-elderly-patients-undergoing-elective-surgery-element-100578895","NCT06817239","Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)","Effect of Perioperative Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Major Non-cardiac Surgery: a Multi-center Randomized Trial (ELEMENT Trial)","Inclusion Criteria:\n\n* Age ≥65 years and \\\u003C90 years;\n* Scheduled to undergo major non-cardiac surgery.\n* Fulfill at least one of risk factors as follows: history of stroke; history of delirium; hypertension; congestive heart failure; coronary artery disease; atrial fibrillation; peripheral artery disease; chronic obstructive pulmonary disease; obstructive sleep apnea; diabetes; chronic kidney disease; anemia; malnutrition; hypoalbuminemia; chronic pain; anxiety and depression; poor sleep quality; smoke; alcoholism.\n* Scheduled to receive patient-controlled intravenous analgesia (PCIA).\n\nExclusion Criteria:\n\n* Refuse to participate;\n* Preoperative history of epilepsy, myasthenia gravis, Parkinson's disease, intracranial hypertension, delirium, schizophrenia, or other psychiatric diseases;\n* Inability to communicate in the preoperative period because of coma, profound dementia, or language barrier;\n* Preoperative uncontrolled severe hypertension (baseline SBP\\>180 mmHg or DBP\\>110 mmHg);\n* Preoperative history of hyperthyroidism and pheochromocytoma;\n* Acute cardiovascular event occurring within 30 days before surgery;\n* Severe hepatic dysfunction (Child-Pugh class C), renal dysfunction (required preoperative dialysis), or expected survival ≤24 hours;\n* Scheduled to undergo organ transplantation, vascular surgery, neurosurgery;\n* Receiving treatment with ketamine or esketamine;\n* Contradiction to ketamine or esketamine;\n* Other situations where the investigator or physician considers the patient ineligible for the study.","65 Years","90 Years",{"count":182,"type":21},1670,[24],"Delirium is an acutely occurred neurocognitive disorder characterized by fluctuating symptoms of inattention, altered consciousness and cognitive dysfunction. Delirium is reported to occur in 4% to 65% of postoperative patients depending on the population, and is especially common in older patients. Postoperative delirium is disturbing to patients and their families, and it is a strong predictor of both early and long-term worse outcomes including increased non-delirium complications, increased perioperative mortality, shortened overall survival, declined cognitive function, and lowered quality of life.\n\nAlthough ketamine\u002Fesketamine has anti-inflammatory and neuroprotective effects, evidence on its efficacy in reducing postoperative delirium remains inconsistent and inconclusive. Existing studies are limited by heterogeneity, small sample sizes, single-center designs, and a focus on specific type of surgery. Research on elderly high-risk patients is lacking, and most studies administer the drug intraoperatively, with limited exploration of postoperative use. The optimal dosing and timing for POD prevention are unclear. This study aims to carry out a multicenter, single-blind, placebo-controlled, large-sample randomized controlled trial assessing the effect of low-dose esketamine, given intraoperatively and postoperatively, on delirium in elderly high-risk patients undergoing major non-cardiac surgery.",[186,187,132,188,189,190,29],"Delirium in Old Age","Delirium, Postoperative","Cognitive Dysfunction","Pain, Postoperative","Esketamine",[192,193,190,194],"Delirium","Elderly patients","Non-cardiac surgery","2025-04-23",{"date":197,"type":45},"2025-04-27",{"date":199,"type":45},"2025-02-12",{"date":201,"type":21},"2027-07",{"name":203,"class":52},"Nanfang Hospital, Southern Medical University",6,{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":17,"minAge":212,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":22,"phases":215,"briefSummary":216,"conditions":217,"keywords":220,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":53},"100457884","a-study-of-huperzine-a-injection-in-reducing-postoperative-delirium-in-elderly-patients-undergoing-non-cardiac-surgery-100457884","NCT05242419","A Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery","A Multi-center, Randomized, Double-blinded, Placebo-controlled Study of Huperzine A Injection in Reducing Postoperative Delirium in Elderly Patients Undergoing Non-cardiac Surgery","Inclusion Criteria:\n\n* ≥ 75 years old.\n* Comply with the indication of non-cardiac surgery under general anesthesia.\n* Anesthesia grade of American Society of Anesthesiologist (ASA) as III\\~IV grade.\n* The estimated operation time ≥ 2 hours.\n* Voluntarily sign the informed consent form.\n\nExclusion Criteria:\n\n* Patients with impaired renal function (Cr is 1.5 times higher than the upper limit of the normal value of the central laboratory) or abnormal liver function (Alanine aminotransferase(ALT) and Aspartate aminotransferase(AST) are 2 times higher than the upper limit of the normal value of the central laboratory).\n* Patients who are positive for infectious diseases.\n* Patients accompanied with central nervous system injury.\n* Patients with previous history of delirium and epilepsy, long-term use of psychoactive drugs or preoperative assessment of delirium.\n* Patients who involved diseases with drug taboos, bronchial asthma, mechanical intestinal obstruction and urinary tract obstruction, or serious systemic diseases, especially circulatory diseases: such as myocardial infarction, heart failure, angina pectoris, history of sinus bradycardia.\n* Patients who are known to be allergic to narcotic drugs or Huperzine A Injection, or must use drugs that are not compatible with Huperzine An Injection.\n* patients who participated in other clinical trials within 3 months before this study, for any reason, who could not tolerate the test or cooperate with the examination, or who has any aphasia, audio-visual dysfunction, etc.\n* the investigators think that the patients is not suitable to participate in this study.","75 Years",{"count":214,"type":21},40,[24],"To observe and study the clinical effect of Huperzine A Injection on reducing postoperative delirium in elderly patients undergoing non-cardiac surgery",[218,29,186,219],"Injection","Post Operative Delirium",[221,222,29,223],"Huperzine A Injection","postoperative delirium","Elderly Patients","2025-03-27",{"date":226,"type":45},"2025-04-02",{"date":228,"type":45},"2022-06-10",{"date":230,"type":21},"2025-12-30",{"name":232,"class":52},"Second Affiliated Hospital of Wenzhou Medical University"]