[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-dystrophic-myotonia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-dystrophic-myotonia":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100607015","a-single-center-prospective-study-in-an-estimated-570-patients-who-underwent-genetic-screening-at-uz-brussel-in-the-context-of-a-primary-cardiac-arrhythmia-patients-showing-a-variant-class-34-or-5-in-scn4a-or-clcn1-will-undergo-a-clinical-and-electrophysiological-review-after-ic-100607015",false,"NCT07183059","A Single Center Prospective Study in an Estimated 570 Patients Who Underwent Genetic Screening at UZ Brussel in the Context of a Primary Cardiac Arrhythmia. Patients Showing a Variant Class 3,4 or 5 in SCN4A or CLCN1 Will Undergo a Clinical and Electrophysiological Review After IC.","Exploring Overlap Between Primary Cardiac Arrhythmias and Non-dystrophic Myotonia: a Single Center Prospective Study.","Inclusion Criteria:\n\n* Patients with PCA who underwent a genetic analysis with a PCA gene panel since 2021 (since the panel involves 112 genes including SCN4A).\n* Male and female gender.\n\nExclusion Criteria:\n\n* Genetic analysis before 2021\n* Patients without cardiac screening in UZ Brussel","ALL","18 Years","100 Years",{"count":20,"type":21},570,"ESTIMATED","INTERVENTIONAL",[24],"NA","A prospective interventional single-center study will be conducted. The study includes clinically diagnosed Intramuros PCA-patients who underwent a PCA gene panel of 113 genes (see Appendix 1) in the UZ-Brussel since 2021. In a retrospective part of the study, we will assess cardiac history, cardiac family history, cardiac exams and medical treatment and genetic data and family history. The prevalence of a class 3, 4 or 5 variant in the SCN4A and CLCN1 gene in the PCA-group will be compared to controls who underwent genetic screening for different causes, in which no association with muscular channelopathies is expected, without access to their medical file. In a prospective part of the study, patients with PCA carrying a variant class 3,4 or 5 in the SCN4A gene or a variant class 3, 4 or 5 in the CLCN1 gene will be invited for a one day visit for an interview, clinical neurological assessment and EMG. The aim of this second phase is to describe the clinical presentation of patients with concomitant PCA and non-dystrophic myotonia .",[27,28],"Non Dystrophic Myotonia","Arrythmia, Cardiac","NOT_YET_RECRUITING","2025-11-27",{"date":32,"type":33},"2025-12-01","ACTUAL",{"date":35,"type":21},"2025-12-15",{"date":37,"type":21},"2027-09-30",{"name":39,"class":40},"Universitair Ziekenhuis Brussel","OTHER","Non-Dystrophic Myotonia"]