[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-erosive-reflux-disease-nerd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-erosive-reflux-disease-nerd":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100640927","effect-of-inspiratory-muscle-training-on-symptom-severity-and-quality-of-life-in-non-erosive-reflux-disease-100640927",false,"NCT07584096","Effect of Inspiratory Muscle Training on Symptom Severity and Quality of Life in Non-Erosive Reflux Disease","Effect of Inspiratory Muscle Training on Clinical Symptom Severity and Quality of Life in Patients With Non-erosive Reflux Disease: A Randomized Controlled Trial","Inclusion Criteria:\n\n* A clinical diagnosis of NERD,\n* No erosive lesions on endoscopy,\n* Presence of reflux symptoms for at least 3 months.\n\nExclusion Criteria:\n\n* Current use of proton pump inhibitors (PPIs) or failure to complete a minimum 2-week washout period before enrollment.\n* With known gastroduodenal ulcers\n* Diagnosed with erosive esophagitis\n* With hiatal hernia\n* With a history of gastrointestinal malignancy\n* With infectious or inflammatory gastrointestinal diseases\n* With malabsorption syndrome or gastrointestinal obstruction\n* With a history of major gastrointestinal surgery (including anti-reflux, gastric, or duodenal surgery)\n* With systemic sclerosis or other systemic connective tissue diseases\n* With severe cardiovascular, pulmonary, renal, or hepatic disease\n* With chronic respiratory diseases such as asthma or COPD\n* Having had an acute respiratory tract infection within the past 4 weeks\n* With neuromuscular diseases\n* With active tuberculosis\n* Pregnancy","ALL","18 Years","65 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if inspiratory muscle training (IMT) works to treat on clinical symptom severity and quality of life in patients with Non-erosive reflux disease (NERD). The main questions it aims to answer are:\n\nDoes drug IMT lower the clinical symptom severity ? Does drug IMT improve quality of life? Researchers will compare high intensity IMT to a sham-IMT (a IMT device with no resistance) to see if IMT lower the clinical symptom severity and improve improve quality of life.\n\nParticipants will perform the following protocol:\n\nThe IMT protocol will consist of home-based high-intensity training using a Threshold IMT device: two sets of 30 breaths with a 1-minute rest, twice daily for 4 weeks. The study group will train at 60% of baseline maximum inspiratory pressure (MIP), with weekly adjustments based on modified Borg scores (4-6), while the control group will perform sham IMT without resistance.",[27],"Non-erosive Reflux Disease (NERD)","NOT_YET_RECRUITING","2026-06-23",{"date":31,"type":32},"2026-06-24","ACTUAL",{"date":34,"type":21},"2026-07-22",{"date":36,"type":21},"2027-05-15",{"name":38,"class":39},"Izmir University of Economics","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":40},"100636978","transcutaneous-electrical-acustimulation-tea-for-the-treatment-of-non-erosive-gastroesophageal-reflux-disease-nerd-100636978","NCT07572708","Transcutaneous Electrical Acustimulation (TEA) for the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD)","Transcutaneous Electrical Acustimulation (TEA) for the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD): A Multicenter, Randomized, Sham-Controlled Trial","Inclusion Criteria:\n\n* Age 18-75 years, irrespective of gender\n* Typical heartburn symptoms for at least 3 months\n* Heartburn on at least 2 days during the run-in diary period\n* Endoscopically confirmed NERD (no esophageal erosions, Los Angeles grade N or M) within 12 months\n* Willingness and ability to comply with all study procedures and to provide written informed consent\n\nExclusion Criteria:\n\n* Familiarity with acupuncture points and their functions (e.g., previous acupuncture experience or medical training)\n* Any esophageal structural or mucosal disease (e.g., Barrett's esophagus, erosive esophagitis LA grade A-D, eosinophilic esophagitis, esophageal stricture, varices, malignancy, or prior chemical\u002Fthermal\u002Fradiation injury)\n* Presence of gastric or duodenal ulcers\n* History of or suspected diagnosis of functional heartburn or functional dyspepsia by Rome IV criteria\n* Systemic diseases affecting gastrointestinal motility (e.g., systemic sclerosis, dermatomyositis, systemic lupus erythematosus, amyloidosis), uncontrolled diabetes mellitus (fasting glucose ≥11.1 mmol\u002FL or glycated hemoglobin ≥7.0%), severe cardiovascular disease, significant hepatic or renal dysfunction, or severe psychiatric disorders\n* Inability to discontinue prohibited medications (PPIs, P-CABs, H2RAs, prokinetics, or other GERD-directed therapies) except for protocol-defined rescue medication during the study\n* Implanted electronic devices (e.g., pacemaker, defibrillator) or other implants susceptible to electrical stimulation\n* Local skin disease or severe hypersensitivity at stimulation sites\n* Pregnancy, breastfeeding, or planned pregnancy during the study period\n* Participation in other interventional clinical trials within the past 3 months","75 Years",{"count":50,"type":21},204,[24],"This multicenter study aims to evaluate whether Transcutaneous Electrical Acustimulation (TEA) is effective in treating Non-Erosive Gastroesophageal Reflux Disease (NERD). NERD is a common condition where patients experience symptoms like heartburn and regurgitation, but no visible damage can be seen in the esophagus during an endoscopy. TEA is a non-invasive treatment that uses a small device to deliver mild electrical stimulation through the skin on specific acupoints. This study will compare the effects of real TEA treatment with a sham (inactive) control. Participants will be randomly assigned to one of two groups: active TEA treatment or sham stimulation. Neither the participants nor the researchers evaluating the outcomes will know which treatment is being given. The main outcome is the improvement of reflux symptoms after 4 weeks of treatment. The results of this study may provide a new non-drug option for patients suffering from NERD.",[27],[55,56,57,58],"NERD","Transcutaneous electrical Acustimulation","Neuromodulation","Multicenter","2026-05-13",{"date":61,"type":32},"2026-05-15",{"date":63,"type":21},"2026-05-01",{"date":65,"type":21},"2028-03-31",{"name":67,"class":68},"Ningbo Medical Center Lihuili Hospital","OTHER_GOV",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":81,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":91,"locationsCount":40},"100632802","clinical-efficacy-evaluation-of-chaizhi-hewei-decoction-in-the-treatment-of-non-erosive-reflux-disease-with-liver-stomach-disharmony-syndrome-100632802","NCT07518420","Clinical Efficacy Evaluation of Chaizhi Hewei Decoction in the Treatment of Non-Erosive Reflux Disease With Liver-Stomach Disharmony Syndrome","Inclusion Criteria:\n\n1. Meet thediagnosis criteria for NERD;\n2. GERD Q scale score \\>8 points;\n3. Meet the criteria for the liver-stomach disharmony syndrome in traditional Chinese medicine;\n4. Age between 18-70 years old;\n5. Participants are informed and voluntarily sign the informed consent form. -\n\nExclusion Criteria:\n\n1. Patients with active gastric or duodenal ulcers, gastritis with active bleeding, severe dysplasia of the gastric mucosa, or suspected malignancy; patients with achalasia or post-achalasia surgery; and patients with functional heartburn.\n2. Patients with severe primary diseases of the cardiovascular, hepatic, renal, hematological, or respiratory systems, or malignant tumors.\n3. Patients with mental disorders (e.g., schizophrenia, bipolar affective disorder, depression, anxiety, obsessive-compulsive disorder) and those with intellectual or language impairments.\n4. Pregnant or breastfeeding women.\n5. Patients allergic to any components of this preparation.\n6. Patients currently taking medications that may affect the outcome of this study (e.g., proton pump inhibitors, potassium-competitive acid blockers, Tongjiang granules, etc.).\n7. Patients currently participating in or having participated in other drug clinical trials within the past 4 weeks.\n8. Patients with suspected or confirmed history of alcohol or substance abuse, anxiety, or depression; or, according to the investigator's judgment, other conditions that may reduce the likelihood of enrollment or complicate the enrollment process, such as frequent changes in work environment that may lead to loss of follow-up.\n\n   \\-","70 Years",{"count":77,"type":21},66,[24],"This study focuses on patients with NERD (gastroesophageal reflux disease) and liver-gallbladder disharmony syndrome as its research subjects. It conducts a randomized, double-blind, placebo-controlled clinical trial to evaluate the efficacy and safety of the Chai Zhi He Wei formula in terms of symptom improvement, quality of life, and adverse reactions. On one hand, this research aims to enhance the level of evidence-based medicine for TCM syndrome differentiation and treatment of NERD. On the other hand, it seeks to reduce the dosage of PPIs (proton pump inhibitors) or discontinue their use, addressing the side effects caused by PPI overuse, and serving as a leading example for TCM clinical research. Lastly, the study aims to optimize the efficacy of Tongjiang granules and address potential safety concerns, such as diarrhea.",[27],[82,83,84],"Chaizhi Hewei Decoction","Liver-Stomach Disharmony Syndrome","randomized controlled trial","2026-04-06",{"date":87,"type":32},"2026-04-08",{"date":61,"type":21},{"date":90,"type":21},"2028-08-31",{"name":92,"class":39},"Xiyuan Hospital of China Academy of Chinese Medical Sciences"]