[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-invasive-brain-stimulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-invasive-brain-stimulation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100591412","neural-mechanisms-of-interpersonal-expectations-on-negative-affect-100591412",false,"NCT06980090","Neural Mechanisms of Interpersonal Expectations on Negative Affect","Inclusion Criteria:\n\n'Doctors' are recruited from medical students at the Geisel School of Medicine and resident physicians at Dartmouth Hitchcock Medical Center (DHMC).\n\nExclusion Criteria:\n\n* No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis\n* No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis that can cause cognitive impairment\n* No self-reported current chronic pain, or acute pain within three months of the study period\n* No current migraine disorder (i.e., 15 headache days or more in 1 month)\n* No use of central nervous system-effective medication or other medication for neurological\u002Fpsychiatric treatment\n* No self-reported substance abuse within the last six months\n* No contraindication to MRI or tTIS (e.g., pregnancy, claustrophobia, pacemakers, ear\u002Fcochlear implants, shrapnel injuries, clips, or other ferromagnetic\u002Felectrical objects\u002Fdevices, diagnosed brain abnormality such as tumor, or skin lesions on the scalp.)\n* No contraindications for induced pain (e.g., no heart disease, high blood pressure, heart surgery, heart problems of any kind, severe asthma, respiratory problems of any kind, fibromyalgia, Raynaud's Syndrome or Disease, chronic pain, diabetes)\n* Participants must be capable of performing experimental tasks (e.g., are able to read), are fluent or native speakers of English\n* Participants must be able to tolerate the maximum level of thermal pain stimuli (for thermal stimuli)",true,"ALL","18 Years","55 Years",{"count":20,"type":21},196,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects.\n\nThe main questions this study aims to answer are: (1)Does active tTIS reduce negative affect more effectively than sham (inactive) tTIS? (2)Do positive treatment expectations enhance the effects compared to negative expectations?\n\nParticipants will: (1) Receive either active or sham tTIS. (2) Be provided with positive or negative messaging regarding treatment effectiveness. (3) Interact with care providers and complete assessments measuring negative affect and physiological responses.",[27,28,29,30],"Negative Affectivity","Non-invasive Brain Stimulation","Placebo Effect","Expectations",[32,33,34,35],"Transcranial temporal interference stimulation","Pain","Fear","Cognitive effort","RECRUITING","2026-06-08",{"date":39,"type":40},"2026-06-11","ACTUAL",{"date":42,"type":40},"2025-09-01",{"date":44,"type":21},"2028-03-03",{"name":46,"class":47},"Trustees of Dartmouth College","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":48},"100618480","the-efficacy-of-non-invasive-brain-stimulation-on-cognitive-functions-in-patients-with-chronic-obstructive-pulmonary-disease-double-blinded-randomised-controlled-trial-100618480","NCT07332169","The Efficacy of Non-invasive Brain Stimulation on Cognitive Functions in Patients With Chronic Obstructive Pulmonary Disease: Double-Blinded Randomised Controlled Trial","NIBS COPD","Inclusion Criteria:\n\n* Adult age from eighteen years old and above.\n* Patients with confirmed COPD via pulmonary function test (PFT) according to the classifications of GOLD.\n* All stages of GOLD will be included\n* Stable patients, which means they were not admitted to the hospital in the last 3 months\n* Patients with COPD with confirmed cognitive impairment by MoCA test.\n* All MoCA stages will be included.\n\nExclusion Criteria:\n\n* Patients without COPD\n* Unstable patients with several admission in the last 3 months\n* Patients with COPD but without cognitive impairment.\n* COPD patients who suffered from any neurological problems\n* COPD patients who are contraindicated for using brain stimulation like psychiatric disorders.",{"count":57,"type":21},24,[24],"The goal of this clinical trial is to examine if non-invasive brain stimulation (NIBS) can enhance cognitive function with chronic obstructive pulmonary disease (COPD) population. The main questions it aims to answer are:\n\n* What is the possibility effect of using the NIBS on cognitive functions as well as the cardiopulmonary parameters in COPD population?\n* What is the relation between cognitive function parameters and cardiopulmonary parameters in COPD population who suffer from cognitive impairment (CI)? Researchers will compare NIBS to a sham-NIBS to see if NIBS works to improve cognitive function in COPD population.\n\nParticipants will:\n\nReceive NIBS or a sham-NIBS 5 sessions\u002Fweek for 3 weeks for 20 min each session.\n\nVisit the clinic at the beginning for baseline assessment then after the completion of the 3 weeks to reassess them.\n\nOutcome measures for cognitive parameters and pulmonary parameters will be taken pre and post NIBS intervention",[61,62,63,28],"COPD","COPD (Chronic Obstructive Pulmonary Disease)","Cognitive Impairment (CI)",[61,65,66,67,68],"NIBS","non-invasive brain stimulation","cognitive function","cognitive impairment","NOT_YET_RECRUITING","2025-12-28",{"date":72,"type":40},"2026-01-12",{"date":74,"type":21},"2026-01-20",{"date":76,"type":21},"2028-11-30",{"name":78,"class":79},"Shahad Abdulrahman Alkandari","OTHER_GOV",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":91,"phases":4,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":4},"100562211","closed-loop-non-invasive-brain-stiumlation-100562211","NCT06600217","Closed-loop Non-invasive Brain Stiumlation","Développement De La Stimulation Non-invasive En Boucle Fermée","CLOSEDLOOP","Inclusion Criteria:\n\n* Signed informed consent\n* Having undergone a medical examination prior to participation in research\n* Affiliation with or beneficiary of a social security scheme\n\nExclusion Criteria:\n\n* Contraindications (CI) to MRI, EEG, TMS practice\n* Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,\n* Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,\n* Characterized psychiatric pathology,\n* Suspicion of alcohol ingestion prior to the examination,\n* Participation in other interventional research protocols in progress with exclusion period or in the preceding week.\n* Persons covered by articles L1121-5 to L1121-8 of the CSP (French Public Health Code) (corresponds to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of their liberty by judicial or administrative decision, persons under psychiatric care under articles L.\n\n3212-1 and L. 3213-1 who are not covered by the provisions of article L. 1121-8, persons admitted to a health or social establishment for purposes other than research, minors, persons under legal protection or unable to express their consent).\n\n\\- Personnel with a hierarchical link to the principal investigator","40 Years",{"count":90,"type":21},60,"OBSERVATIONAL","Transcranial magnetic stimulation (TMS) is a widely used tool for exploring brain function in humans (Siebner et al. et al., 2022), which has led to new therapeutics for various psychiatric and neurological disorders (Lefaucheur et al., 2020). However, the open-loop use of this technique has raised questions about its operating principle, due to the high degree of heterogeneity of results and the small to medium observed effect sizes (Zrenner and Ziemann, 2023). To increase the response rate, it has been suggested to individualize stimulation, by adapting the TMS parameters (i.e. delivered dose, target dose, targeting, timing, etc.) to instantaneous estimates of brain brain state. Such an approach, known as closed-loop closed-loop stimulation, is currently one of the main challenges challenges in this field (closed-loop brain state-dependent stimulation). To this end, we are focusing on the combination of robotic TMS and electroencephalography (EEG) (Hernandez-Pavon et al. al., 2023). The closed-loop stimulations using this combination developed to date have two limitations: (i) they are not adaptive and focus focus mainly on calculating the phase of brain oscillations to trigger stimulation and (ii) are limited to central cortical (sensorimotor) areas, where the EEG signal-to-noise ratio is optimal.\n\nThis project aims to develop closed-loop TMS-EEG protocols that overcome these two limitations: (i) by incorporating adaptive decision modeling (AutoHS model, Harquel et al. 2017) to optimize several parameters in parallel (coil location, orientation, intensity) while using a wider range of EEG markers (evoked potentials, oscillatory activity strength, connectivity, etc.), and (ii) by integrating real-time EEG pre-processing to access any cortical target (including frontal, temporal and occipital lobes).",[28,94],"Methodologic Study","2024-09-12",{"date":97,"type":40},"2024-09-19",{"date":99,"type":21},"2024-10",{"date":101,"type":21},"2027-09",{"name":103,"class":47},"University Hospital, Grenoble"]