[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-invasive-ventilation-niv\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-invasive-ventilation-niv":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,75,94],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100608232","impact-of-home-non-invasive-ventilation-in-patients-with-chronic-obstructive-pulmonary-disease-discharged-from-assiut-university-hospital-100608232",false,"NCT07198880","Impact of Home Non Invasive Ventilation in Patients With Chronic Obstructive Pulmonary Disease Discharged From Assiut University Hospital","Inclusion Criteria:\n\n* Patients more than 18 year old.\n* Severe COPD (classified as GOLD stage Ⅲ and IV), confirmed by FEV₁\u002FFVC \\\u003C 70% and FEV₁ \\\u003C 50% of the predicted value. (9)\n* Persistent hypercapnia (PaCO₂ ≥ 60 mmHg ≥2 weeks after resolution of acute exacerbation and compliant on optimal medical therapy with or without long term oxygen therapy\n\nExclusion Criteria:\n\n* Other significant respiratory disorders (e.g,history suggestive OSA, Body Mass Index more than 30, pneumothorax, bullous lung disease, advanced interstitial lung diseases , restrictive thoracic wall diseases , neuromuscular disease).\n* Undergone intubation or tracheostomy prior to NIV initiation during the last 2 months.\n* Those using addictive narcotic medications.\n* Comorbidities and diseases that might confound survival outcomes (e.g., malignancy, advanced hepatic or renal diseases).\n* Pregnancy\n* Refusal or Inability to tolerate NIV during initiation and adaptation phase.\n* Expected Poor compliance (patients deemed unlikely to adhere to nightly NIV use such as no family support, severe frailty).\n* Withdrawal criteria: stopping bipap or medical treatment, voluntary withdrawal by the participant, failure to attend scheduled visits, and significant clinical deterioration requiring alternative management during the study period","ALL","18 Years","80 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to evaluate the impact of long-term home non-invasive ventilation (NIV) on patients with COPD",[26,27,28,29,30,31,32],"COPD","COPD (Chronic Obstructive Pulmonary Disease)","Ventilation Therapy","Non Invasive Ventilation (NIV)","BiPAP","Hypercapnia","Long Term Oxygen Therapy","NOT_YET_RECRUITING","2025-09-27",{"date":36,"type":37},"2025-09-30","ACTUAL",{"date":39,"type":20},"2026-01-01",{"date":41,"type":20},"2028-01-01",{"name":43,"class":44},"Assiut University","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100606078","dynamic-impact-of-niv-on-diaphragmatic-ultrasound-in-patients-with-amyotrophic-lateral-sclerosis-100606078","NCT07170865","Dynamic Impact of NIV on Diaphragmatic Ultrasound in Patients With Amyotrophic Lateral Sclerosis","Assessment of the Dynamic Impact of Non-Invasive Ventilation on Diaphragmatic Ultrasound in Patients With Amyotrophic Lateral Sclerosis","EchoDia","Inclusion Criteria:\n\n* Adult patient (≥18 years old)\n* Diagnosis of bulbar or spinal amyotrophic lateral sclerosis (ALS) established by a neurologist\n* Indication for non-invasive ventilation (NIV) confirmed by the referring pulmonologist for daytime and\u002For nocturnal alveolar hypoventilation\n\nExclusion Criteria:\n\n* Continuous (24-hour) non-invasive ventilation\n* Patient refusal to participate\n* Individual under legal guardianship or judicial protection",{"count":54,"type":20},20,"OBSERVATIONAL","The goal of this pilot observational study is to learn about the dynamic impact of the non invasive ventilation on the diaphragm in patient with amyotrophic lateral sclerosis. The main question it aims to answer : can diaphragmatic ultrasound detect differences in diaphragmatic motion (diaphragmactic excursion and diaphragmatic thickening between spontaneous breathing and non-invasive ventilation ?\n\nParticipants will receive diaphragmatic ultrasound assessments both under spontaneous breathing and during non-invasive ventilation on their day hospital evaluation for ventilatory support.",[58,29],"Amyotrophic Lateral Sclerosis (ALS)",[58,60,61,62,63,64],"Non invasive ventilation (NIV)","Diaphragmatic ultrasound","diaphragmatic excursion","ultrasound","diaphragmatic thickening","2025-09-04",{"date":67,"type":37},"2025-09-12",{"date":69,"type":20},"2025-09-01",{"date":71,"type":20},"2026-10-15",{"name":73,"class":44},"University Hospital, Grenoble",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":4},"100598647","value-of-volume-oxygenation-index-to-detect-early-failure-of-non-invasive-ventilation-in-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-100598647","NCT07074210","Value of Volume Oxygenation Index to Detect Early Failure of Non-invasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease","Inclusion Criteria:\n\n* All patients diagnosed with COPD admitted to the respiratory ICU for NIV.\n\nExclusion Criteria:\n\n* Patients indicated for urgent intubation",{"count":82,"type":20},190,"Non-invasive ventilation (NIV) is an evidence-based treatment for patients with acute respiratory failure due to an exacerbation of Chronic Obstructive Pulmonary Disease (COPD). In patients with COPD and acute hypercapnic respiratory failure, NIV improves gas exchange, reduces the work of breathing, and decreases the length of hospital stay and mortality \\[1\\]. Furthermore, when compared to invasive ventilation, NIV leads to fewer complications, such as ventilator-related infections \\[2\\]. These findings have resulted in guideline recommendations for the use of NIV in acute respiratory failure due to an exacerbation of COPD \\[3\\].NIV failure has been defined as the need for endotracheal intubation (ETI) or death. Its rate varies greatly between 5% and 60%, depending on numerous factors \\[4\\].\n\nThe Volume Oxygenation (VOX) index, initially developed to predict treatment failure of high flow nasal cannula therapy, has demonstrated the ability to estimate early increases in respiratory drive. Within the first 2 h, the VOX index exhibits a discriminative potential of 0.88 (95 % CI 0.79-0.97) in predicting HFNC failure \\[5\\]. Based on this premise, we hypothesize that the VOX index could be a predictive tool for NIV treatment failure.",[26,29,85],"VOX Index","2025-07-10",{"date":88,"type":37},"2025-07-20",{"date":90,"type":20},"2025-07-15",{"date":92,"type":20},"2026-07-15",{"name":43,"class":44},{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":21,"phases":104,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":114,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":74},"100581277","music-therapy-during-niv-implantation-in-pediatric-intensive-care-units-100581277","NCT06848218","Music Therapy During NIV Implantation in Pediatric Intensive Care Units","MusiNIV","Target population : Children aged 0 to 17, hospitalized in the pediatric intensive care unit for respiratory failure with indication for NIV.\n\nInclusion Criteria:\n\n* Children aged 0 to 17 inclusive\n* Children hospitalized in pediatric intensive care unit\n* Indication for NIV\n\nExclusion Criteria:\n\n* \\- Severe deafness\n* Clinical condition requiring immediate initiation of NIV\n* Refusal to allow the child to be photographed\n* Child not assessable by FLACC score (paralysis of lower limbs, etc.)\n* Child already receiving NIV respiratory support at home\n* Participation in other ongoing research involving the human person at major risk and constraint (RIPH category 1) or a drug trial according to European regulation 536\u002F2014.\n* Absence of affiliation to a French social security scheme or beneficiary of such a scheme.\n* Subject deprived of liberty (art.L. 1121-6 du CSP)\n* Failure to obtain free and informed written or oral consent and authorization to take photographs from both parents (or from a single parent if the patient is accompanied by only one parent, in accordance with article 1122-2 of the French Public Health Code) or from the legal guardian and\u002For child.","17 Years",{"count":103,"type":20},88,[23],"Non-invasive ventilation makes it possible to avoid intubation and improve patients' quality of life. However, pain is associated with discomfort and could lead to failure of this technique.\n\nThe aim of this study is to measure the effectiveness of music therapy on pain levels during non-invasive ventilation in critically ill children.\n\nTo this end, a pain score (Face Legs Activity Cry Consolability FLACC) will be assessed by raters blinded to the randomization arm during NIV initiation.\n\nThe FLACC score will be compared before and during implementation of NIV between two groups: a control group (without music therapy) and an experimental group (with music therapy).",[107,29],"Acute Respiratory Failure (ARF)",[109,110,111,112,113],"Music Therapy","Non invasive Ventilation","Pediatric intensive care unit","Pain","Comfort","RECRUITING","2025-06-30",{"date":117,"type":37},"2025-07-01",{"date":119,"type":37},"2025-06-18",{"date":121,"type":20},"2027-04-01",{"name":123,"class":44},"University Hospital, Montpellier"]