[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-obstructive-azoospermia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-obstructive-azoospermia":66},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100258322","phase-1-intra-testicular-transplantation-of-autologous-stem-cells-for-treatment-of-non-obstructive-azoospermia-male-infertility-100258322",false,"NCT02641769","Intra-Testicular Transplantation of Autologous Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility.","Intra-Testicular Transplantation of Purified Autologous None Marrow-Derived, Highly Specialized Cellular Populations, and Mesenchymal Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility. Patients Diagnosed With Any of the Following Might Benefit: Sertoli Cell Only Syndrome (SCOS), Maturation Arrest, Post- Chemotherapy, Small Testes, Cystic Fibrosis Obstructive Azoospermia, Post-hormonal Therapy,","Inclusion Criteria:\n\n* Infertile males with confirmed diagnosis of non-obstructive azoospermia (NOA)\n\nExclusion Criteria:\n\n* Patients with Obstructive Azoospermia (OA)\n* Previous surgical history in Testis\n* Patients with infectious genital diseases\n* Patients with anatomical abnormalities of the genital tract\n* Patients with major medical problems as malignancies\n* Chromosomal aberration (e.g. Y microdeletion, trisomy….)","MALE","21 Years","50 Years",{"count":20,"type":21},600,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","This is an open label, single arm, single center investigation to assess the safety and efficacy of purified adult autologous, bone marrow derived, highly specialized, differentiation specific into spermatogonial lineages, and mesenchymal stem cells injected into the seminiferous tubules and testis, through a 24-month follow-up period. The investigators' selected model of research is based on maximizing the efficiency of the approach by choosing an autologous pattern which preserves the genetic make-up of an individual that is vital in infertility conditions. Additionally, the approach involves injecting a combination of different but purified cell types which all aid in the re-establishment of spermatogenesis, and the generation of mature spermatozoa. Expected outcomes of this study are defined in general improvements in infertile patients with regards to testicular morphology, sexual function, semen quality, development of primary or secondary spermatocytes, spermatids, or mature spermatozoa in the testis, seminiferous tubules, or semen.",[28],"Non-obstructive Azoospermia","RECRUITING","2026-06-27",{"date":32,"type":33},"2026-07-01","ACTUAL",{"date":35,"type":33},"2014-01",{"date":37,"type":21},"2031-01",{"name":39,"class":40},"Stem Cells Arabia","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":41},"100593596","testicular-sperm-retrieval-rate-after-varicocele-ligation-in-men-with-non-obstructive-azoospermia-100593596","NCT07008495","Testicular Sperm Retrieval Rate After Varicocele Ligation in Men With Non Obstructive Azoospermia","Testicular Sperm Retrieval Rate After Varicocele Ligation in Men With Non Obstructive Azoospermia.","Inclusion Criteria:\n\n* Men with non obstructive azoospermia.\n* Clinically palpable varicocele ( unilateral or bilateral ).\n\nExclusion Criteria:\n\n* Known cases of obstructive azoospermia.\n* Non palpable varicocele.\n* Uncorrectable female causes of infertility.\n* genetic abnormalities like klinefelter syndrome.","20 Years","60 Years",{"count":52,"type":21},50,[54],"NA","A varicocele is an abnormal dilatation and tortuosity of the veins of the spermatic cord. Although varicoceles are common in the general population and are frequently found on routine physical examinations, they represent the most common correctable cause of male factor infertility.\n\nMale factor infertility affects up to half of all couples struggling to conceive, and 10-20% of men evaluated for infertility are found to be azoospermic.",[28],"2025-06-10",{"date":59,"type":33},"2025-06-13",{"date":61,"type":33},"2024-09-01",{"date":63,"type":21},"2025-08-31",{"name":65,"class":40},"South Valley University","Non-Obstructive Azoospermia"]