[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-obstructive-coronary-atherosclerosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-obstructive-coronary-atherosclerosis":32},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,59,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":37,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100414271","icormica---stratified-medicine-in-angina-100414271",false,"NCT04674449","iCorMicA - Stratified Medicine in Angina","International Study of Coronary Microvascular Angina (iCorMicA): a Randomised, Controlled, Multicentre Trial and Registry","iCorMicA","Inclusion Criteria:\n\n1. Age ≥18 years.\n2. A clinical plan for invasive coronary angiography.\n3. Symptoms of angina (typical or atypical) according to the Rose- and\u002For Seattle Angina questionnaires.\n4. Able to comply with study procedures.\n5. Able to provide informed consent.\n\nExclusion Criteria:\n\n1. A non-coronary primary indication for invasive angiography (e.g. valve disease, heart failure).\n2. History of coronary artery bypass surgery.\n3. Presence of obstructive disease evident in a main coronary artery (diameter \\>2.5 mm), i.e. a coronary stenosis \\>50% and\u002For a fractional flow reserve (FFR) ≤0.80\\*.\n4. Logistical reason\\*. \\*These patients will enter a follow-up registry.","ALL","18 Years",{"count":20,"type":21},1500,"ESTIMATED","INTERVENTIONAL",[24],"NA","The iCorMicA study is a multicentre, prospective, randomised, double-blind, sham-controlled, parallel-group, end-point trial and registry. The investigators seek to determine whether stratified medical therapy guided by an adjunctive interventional diagnostic procedure (IDP) during the invasive management of patients with known or suspected angina but no obstructive coronary artery disease improves symptoms, wellbeing, cardiovascular risk and clinical outcomes.",[27,28,29,30,31,32,33,34,35,36],"Microvascular Angina","Angina, Stable","Ischemia With No Obstructive Coronary Arteries (INOCA)","Coronary Microvascular Dysfunction (CMD)","Ischaemic Heart Disease","Non-Obstructive Coronary Atherosclerosis","Coronary Artery Disease","Vasospastic Angina","Coronary; Ischemic","Angina Attacks",[38,39,40,41,42,43,44,45],"angina","microvascular angina","ischaemia with no obstructive coronary artery disease (INOCA)","stratified medicine","clinical trial","outcomes research","prognosis","health economics","RECRUITING","2026-04-03",{"date":49,"type":50},"2026-04-09","ACTUAL",{"date":52,"type":50},"2020-12-30",{"date":54,"type":21},"2030-12-31",{"name":56,"class":57},"NHS Greater Glasgow and Clyde","OTHER",39,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":67,"targetDuration":69,"studyType":70,"phases":4,"briefSummary":71,"conditions":72,"keywords":75,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100561290","inoca-na-a-local-prospective-registry-100561290","NCT06588244","INOCA-NA a Local Prospective Registry","Ischemia in Patients with Non- Obstructive Disease (INOCA) - a Local Prospective Registry (INOCA-Naples)","INOCA-NA","Inclusion Criteria:\n\n* Clinical presentation of chronic ischemic heart dis- ease (IHD), requiring coronary angiography for the diagnosis;\n* Absence of obstructive coronary artery disease (CAD) at coronary angiography;\n* Age \\> 18 years.\n* Ability to provide a valid informed consent to the study procedure at the time of baseline evaluation;\n\nExclusion Criteria:\n\nClinical presentation of acute coronary syndrome (ACS) or cardiogenic shock;\n\n* Presence of obstructive CAD with at least 1 significant coronary artery stenosis, defined as diameterstenosis \\>50% and FFR ≤0.80 (or iFR\u002FRFR ≤0.89);\n* Previous coronary artery bypass grafting (CABG);\n* Left ventricular systolic dysfunction, defined as ejection fraction (EF) \\<40%;\n* Severe valvular heart disease;\n* Pregnant or breastfeeding women\n* Known hypersensitivity or contraindication to any of the drugs used for coronary physiology testing (adenosine, nitrates, acetylcholine)\n* Inability or unwillingness to provide a valid in- formed consent to the study procedure at the time of baseline evaluation.",{"count":68,"type":21},250,"1 Year","OBSERVATIONAL","The present study has the following objectives:\n\n1. To investigate the prevalence of INOCA in patients referring for a clinically indicated coronary angiography (CA) c\u002Fo Division of Cardiology - Federico II University Hospital;\n2. To stratify in INOCA endotypes patients according to the presence or absence of alternative (i.e. non obstructive CAD) causes of myocardial ischemia detected during CA clinically indicated through physiology tests;\n3. to implement a stratified therapy in these patients considering the different INOCA endotypes and evaluate the impact on angina class and quality of life as well as cardiac hospitalization and coronary revascularization during 5 year follow up",[73,32,74,30],"Ischemia, Myocardial","Microcirculatory Status",[76,77,78],"INOCA","CMD","VSA","2025-03-12",{"date":81,"type":50},"2025-03-17",{"date":83,"type":50},"2024-09-19",{"date":85,"type":21},"2027-09-01",{"name":87,"class":57},"Federico II University",1,{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":70,"phases":4,"briefSummary":98,"conditions":99,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":109,"locationsCount":88},"100426016","myocardial-ischemia-without-obstructive-coronary-stenoses-100426016","NCT04827498","Myocardial Ischemia Without Obstructive Coronary Stenoses","Myocardial Ischemia Without Obstructive Coronary Stenoses: A Prospective Observational Study With Invasive Coronary Pressure and Flow Measurements and Endothelial Function Test","Inclusion Criteria:\n\n* Written informed consent available.\n* Age ≥ 18 years.\n* Patient eligible for invasive physiological assessment with adenosine and \u002F or acetylcholine.\n\nExclusion Criteria:\n\n* Hemodynamic instability.\n* Anticipated technical issues for physiology wire measurements.\n* Culprit vessel of acute coronary syndrome\n* Contraindications for adenosine administration.\n* Contraindications for acetylcholine test.\n* Reduced life expectancy (less than 1 year).",{"count":97,"type":21},600,"Coronary-related myocardial ischemia can result from obstructive epicardial stenosis or non-obstructive causes including coronary microcirculatory dysfunction and vasomotor disorders. This prospective study has been created in order to provide knowledge in the field of non-obstructive coronary artery disease.",[100,32,101,34,102],"Myocardial Ischemia","Microvascular Coronary Artery Disease","Myocardial Bridging","2021-04-23",{"date":105,"type":50},"2021-04-26",{"date":107,"type":50},"2017-11-08",{"date":54,"type":21},{"name":110,"class":57},"Hospital San Carlos, Madrid"]