[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-smoking-healthy-adults\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-smoking-healthy-adults":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":5},"100623243","pharmacokinetic-characterization-of-tartaric-acid-in-humans-100623243",false,"NCT07394101","Pharmacokinetic Characterization of Tartaric Acid in Humans","Pharmacokinetic Characterization of Tartaric Acid in Humans: Effect of the Food Matrix (Wine, Grapes, and Juice) on Its Bioavailability","TARBIO","Inclusion Criteria:\n\n* Healthy non-smoking adults aged 20-40 years.\n* Body mass index (BMI) between 23 and 27 kg\u002Fm².\n* No history of cardiovascular, hepatic, or renal disease.\n* No adherence to any special diet for at least 4 weeks prior to the study.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Current smokers or recent ex-smokers.\n* History of cardiovascular, hepatic, or renal disorders.\n* Current adherence to any special diet or nutritional supplementation that could affect study outcomes.\n* Any condition or medication that could interfere with absorption, metabolism, or excretion of tartaric acid.\n* Participation in another clinical trial within the past 3 months.\n* Pregnancy or lactation.",true,"ALL","20 Years","40 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"NA","The goal of this clinical trial is to characterize the pharmacokinetics (absorption, distribution, metabolism, and excretion; ADME) and oral bioavailability of tartaric acid in humans after its administration through different food matrices (red wine, fresh grapes, and grape juice). The study aims to determine whether the pharmacokinetic behavior of tartaric acid is matrix-dependent and dose-dependent in healthy adult volunteers.\n\nThe main questions it aims to answer are:\n\nDoes the food matrix (wine, grapes, or grape juice) influence the oral bioavailability of tartaric acid?\n\nAre there differences in key pharmacokinetic parameters of tartaric acid, including maximum plasma concentration (Cmax), time to reach maximum concentration (Tmax), total exposure (AUC), half-life (t1\u002F2), and urinary excretion, depending on the matrix of intake?\n\nResearchers will compare the pharmacokinetic profiles of tartaric acid after consumption in red wine, grapes, and grape juice to evaluate differences in absorption, systemic exposure, and elimination attributable to the source of intake.\n\nParticipants will:\n\nFollow a polyphenol-restricted diet prior to the study, including avoidance of grapes, wine, and related products.\n\nConsume a single standardized dose of tartaric acid administered as red wine, fresh grapes, or grape juice after an overnight fast.\n\nProvide blood samples at multiple time points over a 24-hour period to determine plasma tartaric acid concentrations.\n\nCollect urine samples over 24 hours for assessment of tartaric acid excretion.\n\nConsume standardized low-polyphenol meals under controlled conditions during the study day.",[29,30,31],"Healthy Adult Participants","Non-smoking, Healthy Adults","Normal Weight Adults",[33,34,35,36,37,38],"Tartaric acid","Pharmacokinetics","Bioavailability","Food matrix effect","Wine","Healthy volunteers","NOT_YET_RECRUITING","2026-02-02",{"date":42,"type":43},"2026-02-06","ACTUAL",{"date":45,"type":23},"2026-04",{"date":47,"type":23},"2026-05",{"name":49,"class":50},"Fundacion Clinic per a la Recerca Biomédica","OTHER"]