[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-st-segment-elevation-myocardial-infarction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-st-segment-elevation-myocardial-infarction":69},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100603947","early-phase-1-short-term-outcomes-of-early-administration-of-colchicine-in-non-st-segment-elevation-myocardial-infarction-patients-treated-with-drug-eluting-stents-100603947",false,"NCT07143136","Short-Term Outcomes of Early Administration of Colchicine in Non-ST Segment Elevation Myocardial Infarction Patients Treated With Drug-Eluting Stents.","Inclusion Criteria:\n\n* Diagnosed with Non-STEMI\n* Undergoing PCI with drug-eluting stents\n\nExclusion Criteria:\n\n* Severe renal or hepatic dysfunction\n* Colchicine hypersensitivity\n* Active infection and active diarrhea.\n* Gastrointestinal intolerance\n* Pregnancy or breastfeeding.\n* Cardiogenic shock","ALL","18 Years",{"count":18,"type":19},140,"ESTIMATED","INTERVENTIONAL",[22],"EARLY_PHASE1","Inflammation plays a central role in the pathophysiology of atherosclerosis and in the progression of coronary artery. Colchicine, an anti-inflammatory agent traditionally used for gout and pericarditis, has emerged as a potential therapy in cardiovascular disease due to its ability to inhibit microtubule polymerization and suppress interleukin-1β and the NLRP3 inflammasome pathway.\n\nCOLCOT and LoDoCo2 trails have demonstrated the efficacy of colchicine in reducing cardiovascular events in patients with coronary artery disease.\n\nHowever, more recent trials, including OASIS 9 and COVERT-MI trials did not support the use of a short-term colchicine treatment at the acute phase of ST segment elevation myocardial infarction (STEMI) to reduce infarct size and improve outcomes. Limited data exist on the peri-procedural use of colchicine in non-ST elevation myocardial infarction patients undergoing PCI.\n\nThis study proposes to assess whether a loading dose of colchicine before PCI, followed by 3-months maintenance therapy, can improve short-term clinical outcomes and inflammatory markers in non- STEMI patients.",[25],"Non ST-Segment Elevation Myocardial Infarction",[27,28,29],"Colchicine","Inflammation","Non-STEMI","RECRUITING","2025-08-19",{"date":33,"type":34},"2025-08-27","ACTUAL",{"date":36,"type":34},"2025-08-10",{"date":38,"type":19},"2026-09",{"name":40,"class":41},"Assiut University","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":20,"phases":52,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":42},"100532683","treatment-of-acute-coronary-syndromes-with-low-dose-colchicine-100532683","NCT06215989","Treatment of ACuTe Coronary Syndromes With Low-dose colchICine","Treatment of ACuTe Coronary Syndromes With Low-dose colchICine (TACTIC): a Randomised, Double-blinded, Placebo-controlled, Multicentric Trial","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* Definite diagnosis of ACS;\n* Ability and willingness to provide written informed consent\n\nExclusion Criteria:\n\n* Type 2 myocardial infarction (Patients with symptoms or signs of myocardial ischemia and evidence of increased oxygen demand or decreased supply \\[for example, tachyarrhythmia, hypotension, or anaemia\\] secondary to an alternative pathology and myocardial necrosis are defined as suffering type 2 myocardial infarction. The classification of type 2 myocardial infarction also includes patients with coronary vasospasm, embolism or spontaneous dissection without evidence of atherothrombosis related to coronary artery disease);\n* Valvular heart disease that is considered likely to require surgical intervention;\n* History of non-skin cancer in the past 3 years;\n* Inflammatory bowel disease or chronic diarrhea;\n* History of gastric ulcer or previous gastric bleeding;\n* Neuromuscular diseases or non-transient (At least 2 laboratory tests) creatine kinase levels greater than 3 times the upper limit of the normal range (except those associated with myocardial infarction);\n* Clinically significant non-transient (At least 2 laboratory tests) blood abnormalities(Hemoglobin \\\u003C100g\u002FL or hematocrit \\\u003C 30% or \\> 52% or white blood cell count \\\u003C 3×109\u002FL or platelet count \\\u003C 100×109\u002FL);\n* Estimated glomerular filtration rate (eGFR)\\\u003C30mL\u002Fmin\u002F1.73m2 (based on CKD-EPI formula);\n* Serum alanine aminotransferase and\u002For aspartate aminotransferase levels greater than 2 times the upper limit of the normal range accompanied by serum total bilirubin levels greater than 2 times the upper limit of the normal range or severe liver disease with coagulation disorders(INR\\>1.5)(except for elevated glutamic oxalacetic transaminase associated with myocardial infarction);\n* Decline in cognitive function due to inability to perform basic activities of daily living independently;\n* Drug or alcohol abuse;\n* Other immunosuppressive therapies already in existence or planned;\n* Other causes require long-term colchicine treatment;\n* History of clear or suspected colchicine allergy;\n* Strong CYP3A4 or P-glycoprotein inhibitors (such as cyclosporine, antiretrovirals, antifungals, erythromycin and clarithromycin) have been used and no other alternative drugs can be used.",{"count":51,"type":19},6574,[53],"NA","This trial is designed to evaluate whether low-dose colchicine, in addition to standard treatment recommended by guidelines, further reduces the risk of major adverse cardiovascular events in patients with acute coronary syndromes (ACS) through a prospective, randomized, double-blind, placebo-controlled clinical trial.",[56,57,58,59,27],"Acute Coronary Syndrome","Unstable Angina","ST Elevation Myocardial Infarction","Non ST Segment Elevation Myocardial Infarction","2024-10-27",{"date":62,"type":34},"2024-10-30",{"date":64,"type":34},"2024-09-02",{"date":66,"type":19},"2028-06",{"name":68,"class":41},"Beijing Anzhen Hospital","Non-ST Segment Elevation Myocardial Infarction"]