[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"non-surgical-periodontal-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:non-surgical-periodontal-therapy":83},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100628847","minimally-invasive-non-surgical-therapy-of-peri-implantitis-100628847",false,"NCT07466966","Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis","Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis: A Multicenter Randomized Controlled Trial (MINST vs NSPT)","MINST vs NSPT","Inclusion Criteria:\n\n* Age ≥18\n* Peri-implantitis diagnosis (PPD \\>6 mm, BOP+, bone loss ≥3 mm)\n* Accessible implant surface without removing suprastructure\n* FMPS \\\u003C30%, FMBS \\\u003C30-35%\n\nExclusion Criteria:\n\n* Antibiotics in last 3 months\n* Pregnancy\u002Flactation\n* Uncontrolled diabetes (HbA1c ≥7)\n* Long-term SPIC (\\>2 years)\n* Previous implant therapy \\\u003C12 months\n* Smoking\u002Fvaping in last 12 months\n* Hopeless implant\n* Need for adjunctive antibiotics","ALL","18 Years",{"count":20,"type":21},106,"ESTIMATED","INTERVENTIONAL",[24],"NA","This multicenter, single-masked randomized controlled clinical trial evaluates the effectiveness of minimally-invasive non-surgical therapy (MINST) compared with standard non-surgical peri-implant therapy (NSPT) in patients diagnosed with peri-implantitis. The study investigates clinical outcomes, radiographic bone levels, patient-reported outcomes, and treatment time over 12 months.",[27,28,29],"Peri-implantitis","Periodontitis","Non-surgical Periodontal Therapy",[31,32,33,34,35,36],"peri-implantitis","MINST","non-surgical therapy","ultrasonic debridement","implant dentistry","randomised controlled trial","RECRUITING","2026-03-11",{"date":40,"type":41},"2026-03-13","ACTUAL",{"date":43,"type":41},"2026-01-01",{"date":45,"type":21},"2028-04",{"name":47,"class":48},"St. Anne's University Hospital Brno, Czech Republic","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":49},"100599760","natural-bioactive-gel-for-peri-implantitis-100599760","NCT07088679","Natural Bioactive Gel for Peri-Implantitis","Efficacy of a Natural Bioactive Gel as an Adjunct to Standard Therapy in the Treatment of Peri-Implantitis: A Randomized Controlled Split-Mouth Clinical Trial","PERISTER","Inclusion Criteria:\n\n* Patients aged between 18 and 70 years\n* Presence of peri-implantitis involving at least two dental implants located in different quadrants\n* Presence of bleeding and\u002For suppuration on probing\n* Increased probing depth (PD) and radiographic bone loss compared to previous examinations\n* In the absence of previous clinical data: PD ≥ 6 mm and bone loss ≥ 3 mm apically from the coronal portion of the intraosseous implant area (radiographically assessed)\n* Willingness and ability to comply with study protocol and follow-up visits\n* Written informed consent provided\n\nExclusion Criteria:\n\n* Patients with cardiac pacemakers or other implanted electronic devices\n* Neurological or psychiatric disorders that may interfere with study participation\n* Systemic diseases, metabolic disorders, or autoimmune conditions\n* Pregnancy or lactation Current participation in other clinical trials","70 Years",{"count":60,"type":21},20,[24],"This study is a randomized controlled clinical trial using a split-mouth design to evaluate the effectiveness of a natural bioactive gel (Sterify Gel®) as an adjunct to standard non-surgical therapy for peri-implantitis. Peri-implantitis is an inflammatory disease that affects the tissues around dental implants and can lead to bone loss and implant failure. The goal of the study is to determine whether the application of Sterify Gel®, which contains polyvinyl polymers, hydroxytyrosol, magnesium ascorbyl phosphate, and nisin, can improve clinical outcomes when used in addition to conventional mechanical debridement and air-polishing.\n\nThe trial will include 20 patients, each with at least two implants in different quadrants affected by peri-implantitis. One implant will be treated with standard therapy plus the gel (test site), while the other will receive standard therapy alone (control site). Clinical outcomes will be measured over a 9-month period, including plaque levels, bleeding on probing, probing depth, suppuration, and bone loss. The results will help assess whether this gel enhances the effectiveness of routine non-surgical peri-implantitis treatment.",[27,64,29],"Dental Implants",[27,66,67,68,69,70,71,72,73],"Dental implants","Bioactive gel","Sterify Gel","Non-surgical therapy","Split-mouth design","Oral biofilm","Mechanical debridement","Randomized controlled trial","2025-08-17",{"date":76,"type":41},"2025-08-22",{"date":78,"type":41},"2025-07-30",{"date":80,"type":21},"2026-05-30",{"name":82,"class":48},"University of Pavia","Non Surgical Periodontal Therapy"]