[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"noninvasive-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:noninvasive-ventilation":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,66,98,132],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100465087","custom-non-invasive-ventilation-masks-in-children-100465087",false,"NCT05336136","Custom Non-invasive Ventilation Masks in Children","Inclusion Criteria:\n\n* Children between 8-12 years of age\n* Followed clinically by the Non-invasive ventilation clinic at the Stollery Children's Hospital\n* Established on non-invasive ventilation as part of their treatment plan.\n\nExclusion Criteria:\n\n* Children with developmental or physical disabilities that would prevent their successful completion of the study protocol (e.g., non-verbal, unable to follow 3-step commands, unalbe to lie still for 20 min).\n* Children whose parent\u002Fguardian are unable to provide consent because of an inability to read the study documents in english.","ALL","8 Years","12 Years",{"count":19,"type":20},15,"ESTIMATED","INTERVENTIONAL",[23],"NA","One significant challenge to non-invasive ventilation (NIV) use in children is finding masks to fit a wide range of growing shapes and sizes. While the technology has improved with development of masks specifically for children, the range of options remains limited. Given the smaller size relative to adults, craniofacial abnormalities and craniofacial differences are more likely to compromise mask fit for children. A poor mask fit is uncomfortable, alters delivery of airway pressure, and, in some children, leads to failure of NIV and the need for surgical insertion of an airway in the neck to deliver positive airway pressure through a tracheostomy. This makes expanding the technology to deliver NIV vital and custom NIV masks an exciting solution.In this study, this study will enroll children who are established on long-term NIV with at least some use within 3 months of starting this therapy but who have non-optimal adherence. After consenting to participate and completing demographic and health questionnaire, participants will undergo a facial scan using stereophotogrammetry. This scan will be imported into a computer-aided design software to create a NIV mask customized to the individual face. The steps of mask testing will include: i) Bench testing to compare the leak and comfort parameters of the current commercial mask used by the participant to the custom mask: ii) Efficacy of treatment as measured by polysomonography iii) NIV compliance from machine downloads; iv) Questionnaires to assess the subjective comfort, fit, and adverse events Finally, participants and their parents\u002Fguardian will be asked which mask they prefer and why.",[26,27,28],"Noninvasive Ventilation","Child, Only","Adherence, Patient","RECRUITING","2026-03-13",{"date":32,"type":33},"2026-03-16","ACTUAL",{"date":35,"type":33},"2023-12-15",{"date":37,"type":20},"2026-06",{"name":39,"class":40},"University of Alberta","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":41},"100615921","high-peep-in-noninvasive-ventilation-patients-with-pneumonia-or-ards-100615921","NCT07298889","High PEEP in Noninvasive Ventilation Patients With Pneumonia or ARDS","Effect of High Versus Low Positive End-Expiratory Pressure on Intubation-Free Survival in Patients With Pneumonia or ARDS Receiving Noninvasive Ventilation: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\>18 years\n* PaO2\u002FFiO2 ≤300 mmHg or SpO2\u002FFiO2 ≤315（SpO2 ≤97%)\n* Anticipated NIV duration \\> 12 h\n* Preserved consciousness (GCS≥13)\n\nExclusion Criteria:\n\n* Use of NIV \\> 24 h before randomization\n* Acute-on-chronic respiratory failure\n* Congestive heart failure\n* Use of NIV after extubation (within 48 hours)\n* Contraindications to NIV (e.g., anatomical malformations, recent pulmonary\u002Fesophageal surgery \\[within 7 days\\])\n* Pneumothorax\n* NIV intolerance\n* Refusal to participate\n* Pregnancy\n* Need for emergency intubation","18 Years",{"count":51,"type":20},706,[23],"Noninvasive ventilation is commonly employed in patients with pneumonia or acute respiratory distress syndrome (ARDS) and has been shown to reduce the need for intubation and invasive mechanical ventilation. However, the rate of noninvasive ventilation failure remains substantial, at approximately 40%. Compared with patients in whom noninvasive ventilation succeeds, those who experience noninvasive ventilation failure have a higher likelihood of mortality during their intensive care unit or hospital stay. Therefore, improving the success rate of noninvasive ventilation is clinically important. In patients with lung consolidation receiving invasive mechanical ventilation, high positive end-expiratory pressure (PEEP) can improve oxygenation. Noninvasive ventilation operates on similar physiological principles and can also deliver high PEEP via a mask interface. Nevertheless, there is limited evidence regarding the use of high PEEP during mask-delivered noninvasive ventilation. This study aimed to evaluate whether high PEEP can increase intubation-free survival in patients with pneumonia or ARDS who are treated with noninvasive ventilation.",[26,55,56],"Pneumonia","ARDS","2026-01-06",{"date":59,"type":33},"2026-01-07",{"date":61,"type":33},"2026-01-04",{"date":63,"type":20},"2029-12-31",{"name":65,"class":40},"Chongqing Medical University",{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":21,"phases":75,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100615362","synchrony-optimized-non-invasive-ventilation-education-program-and-icu-patients-100615362","NCT07291622","Synchrony-Optimized Non-Invasive Ventilation Education Program and ICU Patients","Effect of a Synchrony-Optimized Non-Invasive Ventilation Education Program on Intensive Care Unit Patients' Outcomes: A Randomized Clinical Trial Protocol","Inclusion Criteria:\n\n* Adult patients over 18 years of age\n* Admitted to the ICU for at least 24 hours\n* Anticipated to be hospitalized for more than one week\n* Receiving NIV treatment for any underlying condition\n* Capable of learning\n* Proficient in the Persian language\n\nExclusion Criteria:\n\n* Patients with Richmond Agitation-Sedation Scale (RASS) scores of +4 or -5\n* Patients with cognitive disorders\n* Patients with neurological disorders\n* Patients with anxiety disorders\n* Patients whose condition deteriorates, making continued cooperation impossible\n* Patients unable to participate in educational sessions",{"count":74,"type":20},92,[23],"The aim of this clinical trial is to find out whether a synchrony-optimized education program for non-invasive ventilation (NIV) can help ICU patients use their ventilator more effectively and improve their comfort, symptoms, and psychological well-being.\n\nResearchers want to answer these main questions:\n\nCan a structured two-session NIV education program help patients use their ventilator more regularly and for longer periods?\n\nDoes this type of training reduce anxiety, depression, and respiratory symptoms?\n\nCan synchrony training improve patients' comfort and reduce NIV-related problems such as mask leaks or sleep disturbances?\n\nIs this program more effective than the routine ICU education normally provided?\n\nWhat Will Happen in the Study\n\nAdults (18+) who are receiving NIV in the ICU will participate in this study.\n\nParticipants will be randomly assigned to one of two groups:\n\nIntervention Group: Will receive the SYNC-NIV education program, consisting of:\n\nOne hands-on session (20-40 minutes) teaching patients how to synchronize their breathing with the ventilator\n\nOne supplementary session (45-60 minutes) covering mask management, preventing complications, reducing leaks, breathing exercises, equipment care, and alarm handling\n\nAn educational booklet for continued support\n\nControl Group: Will receive the standard ICU education normally provided about the ICU environment, general care, communication, and monitoring.\n\nAll participants will be evaluated at three times:\n\nbefore the intervention, the day after the program ends, and one week later.",[78,79,80,26],"Ventilator Associated Events","Asynchrony, Patient-Ventilator","Intensive Care (ICU)",[82,83,84,85,86,87],"Non-Invasive Ventilation","Patient-Ventilator Synchrony","Intensive Care Unit (ICU)","Anxiety and Depression","Randomized Clinical Trial","Patient Comfort","NOT_YET_RECRUITING","2025-12-17",{"date":91,"type":33},"2025-12-24",{"date":93,"type":20},"2025-12-19",{"date":95,"type":20},"2026-01-10",{"name":97,"class":40},"Shahid Beheshti University of Medical Sciences",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":15,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":110,"phases":4,"briefSummary":111,"conditions":112,"keywords":116,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":131},"100607084","comparison-of-the-silverman-andersen-score-and-the-downes-score-100607084","NCT07183956","Comparison of the Silverman-Andersen Score and the Downes Score","Comparison of the Silverman-Andersen Score and the Downes Score in Assessing the Severity of Respiratory Distress and Predicting Noninvasive Ventilation Failure in Neonates","CSASDS","Inclusion Criteria:\n\n* Preterm infants born at \\>28 weeks of gestation or term infants born at ≥37 weeks of gestation.\n* Development of respiratory distress within the first 6 hours after birth, defined as the presence of at least two of the following: Respiratory rate ≥60\u002Fmin, Subcostal\u002Fintercostal retractions, Grunting.\n* Persistence of respiratory distress for more than 6 hours.\n* Age within the first 12 hours of life.\n* Silverman-Andersen score ≥3.\n* Receiving NIPPV support.\n\nExclusion Criteria:\n\n* Major congenital malformations.\n* Airway or pulmonary anomalies.\n* Cardiovascular or respiratory instability due to sepsis.\n* Cyanotic congenital heart disease.\n* Severe intraventricular hemorrhage.\n* Contraindications for NIPPV therapy (e.g., congenital nasal anomalies, congenital diaphragmatic hernia, abdominal wall defects).\n* Requirement of intubation or chest compressions in the delivery room.\n* Requirement of intubation within the first hour of life.\n* Death within the first 24 hours of life.\n* Gestational age ≤28 weeks.\n* Diagnosis of air leak syndrome (pneumothorax) prior to initiation of NIPPV therapy.","2 Hours","12 Hours",{"count":109,"type":20},220,"OBSERVATIONAL","This study aimed to compare the Silverman-Andersen score and the Downes score in predicting noninvasive ventilation (NIPPV) failure in preterm and term infants who received NIPPV support due to postnatal respiratory distress, as well as to evaluate the agreement of these scoring systems with other methods used to assess the severity of respiratory distress.\n\nThe present study was designed as a prospective, multicenter, observational study conducted with neonates undergoing noninvasive ventilation.",[113,26,114,115],"Respiratory Distress Neonatal","Intubation","Scoring Systems",[117,118,119,120,121],"Silverman-Andersen score","Downes score","Newborn","Respiratory distress","Noninvasive ventilation","2025-09-13",{"date":124,"type":33},"2025-09-19",{"date":126,"type":20},"2025-09-15",{"date":128,"type":20},"2027-02-15",{"name":130,"class":40},"Muğla Sıtkı Koçman University",4,{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":4,"enrollmentInfo":139,"targetDuration":4,"studyType":21,"phases":141,"briefSummary":142,"conditions":143,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":41},"100577259","effects-of-face-mask-continuous-positive-airway-pressure-vs-noninvasive-ventilation-vs-high-flow-nasal-oxygen-on-intubation-free-survival-in-acute-hypoxemic-respiratory-failure-the-tripod-randomized-clinical-trial-100577259","NCT06795971","Effects of Face Mask Continuous Positive Airway Pressure Vs. Noninvasive Ventilation Vs. High-flow Nasal Oxygen on Intubation-free Survival in Acute Hypoxemic Respiratory Failure: the TRIPOD Randomized Clinical Trial","TRIPOD","Inclusion Criteria:\n\n1. Age≥18 yrs;\n2. A ratio of the partial pressure of arterial oxygen (PaO2) to the FiO2 of 300 mm Hg or less, or a ratio of pulse oximetry oxygen saturation (SpO2) to the FiO2 of 315 or less (SpO2≤97%) and the need for (1) noninvasive positive pressure ventilation with at least 5 cm H2O PEEP, or (2) high-flow nasal cannula at 30L\u002Fmin or higher, or (3) standard oxygen with oxygen flow rate of at least 10 L\u002Fmin;\n3. Sign informed consent.\n\nExclusion Criteria:\n\n1. Patients that have already received Continuous positive airway pressure, Noninvasive ventilation continuously for more than 24 hours before the screening visit.\n2. Previous bout of mechanical ventilation during index hospitalization.\n3. Exacerbation of chronic lung disease, including asthma or chronic obstructive pulmonary disease.\n4. Moderate to severe cardiac insufficiency (New York Heart Association class \\>II or left ventricular ejection fraction\\\u003C50%) or cardiogenic pulmonary edema.\n5. Hemodynamic dysfunction, defined as vasopressor dose \\> 0.3 µg\u002Fkg\u002Fmin of norepinephrine-equivalent to maintain systolic blood pressure \\> 90 mm Hg.\n6. Impaired consciousness with a Glasgow coma score ≤ 12.\n7. Patients with urgent need for intubation, including respiratory or cardiac arrest, respiratory pauses with loss of consciousness or gasping for air, severe hypoxemia defined as SpO2 lower than 90% despite maximal oxygen support.\n8. Patients with contraindication to NIV according to the French consensus conference, patient refusal, cardiorespiratory arrest, coma, non-drained pneumothorax, unresolved vomiting, upper airway obstruction, hematemesis or severe facial trauma, thoracic or abdominal surgery in the previous 7 days.\n9. A do-not-intubate order at time of inclusion.\n10. Pregnancy.",{"count":140,"type":20},1300,[23],"Acute hypoxemic respiratory failure (AHRF) is a common indication for admission to an intensive care unit (ICU), with mortality exceeding 50% in cases where invasive mechanical ventilation is needed. Therefore, assessment of the most adequate oxygen strategy to avoid intubation in patients with AHRF deserves consideration.Previous studies have indicated that non-invasive oxygenation strategies, including high-flow nasal oxygen (HFNO), helmet or face mask noninvasive ventilation (NIV), and continuous positive airway pressure (CPAP), are effective in preventing endotracheal intubation in adult patients with AHRF when compared to the standard oxygen therapy. However, the optimal non-invasive oxygenation strategies remain uncertain. This study aim to determine whether CPAP, compared with HFNC or NIV, increase the intubation-free survival during study period in patients with AHRF.",[144,145,26,146],"Acute Hypoxemic Respiratory Failure","High-Flow Nasal Oxygen Therapy","Continuous Positive Airway Pressure (CPAP)","2025-02-24",{"date":149,"type":33},"2025-02-26",{"date":151,"type":33},"2025-01-23",{"date":153,"type":20},"2027-12-31",{"name":155,"class":40},"Southeast University, China"]