[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"normal-weight-obesity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:normal-weight-obesity":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100578992","effects-of-body-composition-on-vascular-health-in-females-with-a-healthy-body-weight-100578992",false,"NCT06818500","Effects of Body Composition on Vascular Health in Females With a Healthy Body Weight","Resting Indicators of Vascular Health and Cardiovascular Reactivity in Females With \"Normal-Weight Obesity\"","Inclusion Criteria:\n\n* You are 18-50 years old\n* Your biological sex is female\n* BMI is in \"normal\" category (18.5-24.9 kg\u002Fm2) - this BMI requirement is due to our research aims\n* You are not pregnant or expecting to become pregnant\n* You are not postmenopausal\n* You have not been diagnosed with a cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes)\n* You have not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).\n* You do not regularly take anti-inflammatory drugs (more than 2x week) or are able to temporarily suspend use of anti-inflammatory drugs.\n* You do not use lipid-lowering drugs (e.g., statins), glucose-lowering drugs (e.g., metformin) tobacco products, or any illicit drugs\n* You do not have a pacemaker.\n* You do not have dietary restrictions prohibiting you from eating the provided meal (e.g., vegan\u002Fvegetarian diets, gluten-free diet, relevant food allergies).\n* You are able to stay in the supine position in the dark for at least 10 minutes\n\nExclusion Criteria:\n\n* You are not 18-50 years old\n* Your biological sex is not female\n* Your BMI is not in the \"normal\" category (18.5-24.9 kg\u002Fm2) - this BMI requirement is due to our research aims\n* You are pregnant or expecting to become pregnant (females only)\n* You are postmenopausal\n* You have been diagnosed with a cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes)\n* You have been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease).\n* You regularly take anti-inflammatory drugs (more than 2x week) or are unable to temporarily suspend use of anti-inflammatory drugs.\n* You use lipid-lowering drugs (e.g., statins), glucose-lowering drugs (e.g., metformin) tobacco products, or any illicit drugs\n* You have a pacemaker.\n* You do have dietary restrictions prohibiting you from eating the provided meal (e.g., vegan\u002Fvegetarian diets, gluten-free diet, relevant food allergies).\n* You are unable to stay in the supine position in the dark for at least 10 minutes",true,"FEMALE","18 Years","50 Years",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","Most of the time, body weight is evaluated by looking at the ratio of your weight to your height. This measurement is called body mass index or BMI. However, BMI does not account for what your body is actually made up of (e.g., body fat versus muscle), which may be more important for determining cardiovascular disease risk. The investigators aim to understand vascular health in females with a \"healthy\" BMI with differing amounts of body fat and muscle mass. We will have participants come to the lab for two different study visits. At one visit, participants will eat a meal high in fat, and at the other visit, participants will undergo a stress task.",[28,29,30],"Normal-weight Obesity","BMI","Stress",[29,30,32],"Healthy BMI","RECRUITING","2026-04-22",{"date":36,"type":37},"2026-04-24","ACTUAL",{"date":39,"type":37},"2024-09-01",{"date":41,"type":22},"2027-05-31",{"name":43,"class":44},"Ball State University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":45},"100620508","metabolic-obesity-in-normal-weight-monw-diagnostic-markers-stud-100620508","NCT07358533","Metabolic Obesity in Normal Weight (MONW): Diagnostic Markers Stud","Disorders Hidden Under the Guise of BMI - Metabolic Obesity in People With Normal Body Weight (MONW) - the Search for Diagnostic Markers and Its Consequences for Health","Inclusion Criteria:\n\n* Written, informed consent to participate in the research.\n* Gender: Female.\n* Age 18-35 years.\n* BMI in the range of 18.5-25 kg\u002Fm².\n\nExclusion Criteria:\n\n* Thyroid disease.\n* Pregnancy or breastfeeding.\n* Eating disorders.\n* Polycystic ovary syndrome (PCOS).\n* Hormone therapy and\u002For use of hormonal contraceptives.\n* Smoking.\n* Metal or silicone implants (contraindication for DXA\u002Fbody composition accuracy).\n* Vitamin and\u002For mineral supplementation.\n* Acute and\u002For chronic illnesses.\n* Type I or II diabetes, dyslipidemia, hypertension.\n* Use of hypolipemic, antihypertensive, antiglycemic, or insulin medications.","35 Years",{"count":55,"type":22},176,"OBSERVATIONAL","Metabolically Obese Normal Weight (MONW) represents a phenotype affecting individuals with a normal Body Mass Index (BMI) but characterized by excessive adipose tissue accumulation. This condition is associated with increased cardiovascular risk, insulin resistance, and endothelial dysfunction, yet remains underdiagnosed.\n\nThis observational longitudinal study aims to comprehensively evaluate the relationship between excessive adipose tissue deposition, endothelial dysfunction, and asprosin concentrations in young women. The study will recruit 176 healthy women aged 18-35 years with normal BMI (\\\u003C25 kg\u002Fm²). Participants will be divided into two groups based on body fat percentage (PBF) assessed by dual-energy X-ray absorptiometry (DXA): the MONW group (PBF ≥ 35.78%) and the Control group (PBF \\\u003C 35.78%).\n\nThe specific objectives of the study include:\n\n* Assessment of vascular endothelial function using flow-mediated dilation (FMD) of the brachial artery.\n* Evaluation of asprosin as a novel biomarker in the MONW phenotype.\n* Analysis of biochemical indices including asymmetric dimethylarginine (ADMA) and von Willebrand factor (vWF).\n* Advanced metabolomic profiling to identify metabolic signatures.\n\nParticipants will undergo anthropometric measurements, body composition analysis (DXA), and blood sampling for biochemical and hormonal analyses. The study aims to develop predictive models for early cardiovascular risk detection in normal-weight individuals.",[59,60,61],"Normal Weight Obesity","Metabolically Obese Normal Weight","Metabolic Syndrome",[63,64,65,66,67,68,69],"Endothelial Dysfunction","Metabolic Disorders","Visceral Adiposity","Flow-Mediated Dilation","Metabolomics","Asprosin","Normal Weight","NOT_YET_RECRUITING","2026-01-21",{"date":73,"type":37},"2026-01-23",{"date":75,"type":22},"2026-09",{"date":77,"type":22},"2029-09",{"name":79,"class":44},"Pomeranian Medical University Szczecin",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":16,"sex":87,"minAge":18,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":45},"100590671","the-interaction-of-body-composition-sex-hormones-and-exercise-in-men-100590671","NCT06970457","The Interaction of Body Composition, Sex Hormones and Exercise in Men","AHA-NWO","Inclusion Criteria:\n\n* Biological male\n* BMI 18.5 - 24.9 kg\u002Fm2 or \\>\u002F= 30 kg\u002Fm2\n* Body fat \\\u003C20% or \\>\u002F= 25%\n* Ability and willingness to engage in an exercise training regimen\n\nExclusion Criteria:\n\n* Presence of a chronic health condition, or regular use of associate prescribed medications, that would substantially impact study variables\n* Excessive alcohol use or use of tobacco products, vape products, or illicit drugs\n* Presence of an electrical implant, such as a pacemaker","MALE","79 Years",{"count":90,"type":22},96,[25],"The overall objective of this project is to advance understanding of the causes of normal weight obesity (NWO) in men, namely the hormone profile and related potential mediating mechanisms, and the efficacy of different modes of exercise to restore body composition and cardiometabolic health in this population.",[28],[95,96,97,98],"body composition","sex hormones","exercise","metabolic health","2025-05-09",{"date":101,"type":37},"2025-05-14",{"date":103,"type":37},"2025-04-15",{"date":105,"type":22},"2026-12-31",{"name":107,"class":44},"Oklahoma State University"]