[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"normobaric-hypoxia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:normobaric-hypoxia":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,52,87,106,135],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100626126","effect-of-acute-hypoxia-on-right-ventricular-function-in-asthma-100626126",false,"NCT07431580","Effect of Acute Hypoxia on RIght VEntRicular Function in Asthma.","Effect of Acute Hypoxia on RIght VEntRicular Function. A Single-Center, Double-Blind, Randomized Controlled Cross-Over Trial.","RIVER-Asthma","Inclusion Criteria:\n\n* Signed informed consent\n* Diagnosed and well controlled asthma bronchiale\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders\n* Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old\n* Any other diagnosed cardiopulmonary condition including past HAPE\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women\n* Participation in other study with active treatment","ALL","18 Years","80 Years",{"count":21,"type":22},18,"ESTIMATED","INTERVENTIONAL",[25],"NA","More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with asthma responds to this stress is still not well understood.\n\nTherefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with asthma. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability.\n\nIn addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random.\n\nThe aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[28,29,30,31],"Hypoxia, Altitude","Hypoxia","Normobaric Hypoxia","Right Ventricular Function",[33,34,35,36,37,38,39],"right ventricular free wall strain","RVFWS","right ventricular function","tissue oxygenation","breathing difficulty","blood gas","heart rate","RECRUITING","2026-05-26",{"date":43,"type":44},"2026-05-29","ACTUAL",{"date":41,"type":44},{"date":47,"type":22},"2030-01",{"name":49,"class":50},"Mona Lichtblau","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":64,"briefSummary":65,"conditions":66,"keywords":73,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":51},"100638153","study-of-the-effects-of-acute-exposure-to-moderate-altitude-hypoxia-on-prospective-memory-100638153","NCT07585227","Study of the Effects of Acute Exposure to Moderate Altitude Hypoxia on Prospective Memory.","Etude Des Effets d'Une Exposition aiguë à l'Hypoxie d'Altitude modérée Sur la mémoire Prospective (HYPRO)","HYPRO","Inclusion Criteria:\n\n* Healthy volunteer\n* Has provided informed consent\n\nExclusion Criteria:\n\n* Individuals who do not understand French\n* Pregnant or breastfeeding women\n* Cardiovascular risk factor\n* Infectious disease within the last 4 weeks\n* Chronic cardiovascular, respiratory, hematological, neurological, psychiatric, or metabolic disease\n* History of epileptic seizures, convulsions, or loss of consciousness\n* Individuals with migraines\n* History of a bleeding disorder\n* History of high blood pressure\n* Current medication use (excluding contraception)\n* History of episodes of altitude intolerance\n* Stay at high altitude (\\> 3,500 m) within the last 3 months\n* Anxiety score on the Hospital Anxiety and Depression (HAD) scale \\> 7\n* Depression score on the HAD scale \\> 7\n* Uncontrollable claustrophobia or a history of panic attacks",true,"45 Years",{"count":63,"type":22},50,[25],"The goal of this study is to investigate whether prospective memory, i.e., memory for delayed intentions, is impaired at moderate altitude (4,000m).\n\nIt will also allow to study the effect of air and oxygen administration during hypoxia exposure.\n\nThe main questions it aims to answer are:\n\n* Does moderate acute hypoxia impair prospective memory ?\n* If so, does air or oxygen adminsitration induce a restoration of prospective memory? Researchers will compare cognitive performance during normobaric hypoxia exposure to cognitive performance during normoxia (control situation).\n\nParticipants will:\n\n* Session S0. Perform a battery of neuropsychological tests and questionnaires). EEG will be recorded during tests. A cheek swab will be performed.\n* Sessions S1 and S2. Perform several cognitive tasks while exposed to hypoxia and to normoxia (2 different sessions, randomized order) in a normobaric chamber. These are standardized cognitive tests administered on a computer and cognitive tests embedded in a flight simulator scenario. Various questionnaires will be performed on a regular basis. Several physiological measurements will be performed continuously: EEG, ECG, SpO2 and breathing rate. Blood pressure will be measured at the beginning and at the end of hypoxia\u002Fnormoxia exposure. A blood sample will also be performed. At last, participants will inhale air or oxygen through a mask while making a cognitive task in the chamber.",[29,67,68,69,28,70,71,72,30],"Hypoxia Brain","Hypoxia Altitude Simulation Test","Hypoxia in Healthy Individuals","Hypoxia, Brain","Altitude","Altitude Hypoxia",[74,75,76],"prospective memory","working memory","flight simulator","NOT_YET_RECRUITING","2026-05-09",{"date":80,"type":44},"2026-05-13",{"date":82,"type":22},"2026-05-06",{"date":84,"type":22},"2026-12-31",{"name":86,"class":50},"Direction Centrale du Service de Santé des Armées",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":14,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":105,"locationsCount":51},"100626124","effect-of-acute-hypoxia-on-right-ventricular-function-in-hape-100626124","NCT07431554","Effect of Acute Hypoxia on RIght VEntRicular Function in HAPE.","RIVER-HAPE","Inclusion Criteria:\n\n* Signed informed consent\n* Diagnosed or suspicion of past HAPE\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders\n* Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old\n* Any other diagnosed cardiopulmonary condition\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women\n* Participation in other study with active treatment",{"count":21,"type":22},[25],"More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with past HAPE responds to this stress is still not well understood. Therefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with past HAPE. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability. In addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random. The aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[72,29,30,31],[33,34,35,36,37,38,39],"2026-04-28",{"date":101,"type":44},"2026-05-01",{"date":103,"type":44},"2026-03-17",{"date":47,"type":22},{"name":49,"class":50},{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":51},"100598579","effects-of-normobaric-hypoxic-training-in-metabolic-dysfunction-associated-steatotic-liver-disease-masld-100598579","NCT07073326","Effects of Normobaric Hypoxic Training in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)","Effects of Normobaric Hypoxia Aerobic Training in People With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)","HYPOMASLD","Inclusion Criteria:\n\n* Being diagnosed with MASLD from at the least 3 years\n* BMI \\> 26 kg\u002Fm2\n* Being sedentary\n\nExclusion Criteria:\n\n* Cardiovascular, respiratory, renal complications\n* Hypertension\n* COPD\n* Previous history of acute mountain sickness or altitude-associated symptoms\n* Females only: pregnancy or breastfeeding","50 Years",{"count":116,"type":22},20,[25],"Altitude training has been suggested to be of potential support to improve some chronic clinical conditions, especially metabolic conditions. Normobaric hypoxia represents a promising system to simulate altitude training, and its efficacy and safety have been suggested in different conditions, including diabetes, obesity and hypertension. Metabolic dysfunction-associated steatotic liver disease (MASLD) can characterized by metabolic alterations (including altered body composition, lipid and glycemic profile, etc.), and might benefit from aerobic training performed in simulated altitude training (i.e., normobaric hypoxia). Mild altitude training will be proposed (equal to about 2'500 m, 15% FiO2) and compared to a sham normobaric normoxia condition, during an 8-week 3 or 2 times per week 1-h aerobic training (walking) at 60-65% of maximum heart rate (HRmax). Cardiorespiratory fitness, body composition, and metabolic profile will be investigated.",[120,30],"MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease",[29,71,122,123,124,125],"Exercise","Liver","Metabolism","Fat","2026-04-27",{"date":128,"type":44},"2026-05-04",{"date":130,"type":44},"2025-09-01",{"date":132,"type":22},"2026-07",{"name":134,"class":50},"University of Trieste",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":14,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":142,"targetDuration":4,"studyType":23,"phases":143,"briefSummary":144,"conditions":145,"keywords":147,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":153,"locationsCount":154},"100626125","effect-of-acute-hypoxia-on-right-ventricular-function-in-healthy-adults-100626125","NCT07431567","Effect of Acute Hypoxia on RIght VEntRicular Function in Healthy Adults.","RIVER-H","Inclusion Criteria:\n\n* Signed informed consent\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders -Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old -Any diagnosed cardiopulmonary condition including past HAPE\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women -Participation in other study with active treatment",{"count":21,"type":22},[25],"More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the healthy heart, especially the right ventricle, responds to this stress is still not well understood. Therefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity. The present investigation focuses on healthy individuals in order to establish a reference for future comparisons with patients suffering from cardiopulmonary diseases. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability. In addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Healthy participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random. The aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[29,30,72,146],"Right Heart Function",[33,34,35,36,37,38,39],"2026-03-13",{"date":103,"type":44},{"date":151,"type":44},"2026-03-11",{"date":47,"type":22},{"name":49,"class":50},2]