[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nosocomial-pneumonia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nosocomial-pneumonia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100529176","high-dose-inhalations-of-nitric-oxide-in-the-treatment-of-pneumonia-100529176",false,"NCT06170372","High-dose Inhalations of Nitric Oxide in the Treatment of Pneumonia","The Effectiveness of Adding Multiple Intermittent High-dose Inhalations of Nitric Oxide to Standard Antibacterial Therapy in the Treatment of Pneumonia","Inclusion Criteria:\n\n1. An established diagnosis of Nosocomial Pneumonia (NP) after cardiac surgery under cardiopulmonary bypass (CPB) or hospitalization for Community-acquired pneumonia (CAP).\n2. Spontaneous breathing.\n3. Age \\> 18 years.\n4. Signed informed consent.\n5. Negative result of immunochromatographic Severe acute respiratory syndrome-related coronavirus 2 rapid antigen test on the day of diagnosis of pneumonia.\n\nDiagnostic criteria for NP The diagnosis of NP is considered established when the number of points on the\n\nClinical Pulmonary Infection Score (CPIS) is greater than 6:\n\nDiagnostic criteria for CAP:\n\nRadiologically confirmed focal pulmonary opacity and at least 2 clinical symptoms and signs of the following:\n\n1. acute fever at the onset of the disease (t° \\> 38.0°C);\n2. cough with sputum;\n3. physical signs (crepitus\u002Ffine rales, bronchial breathing, shortening of percussion sound);\n4. leukocytosis \\> 10x109\u002Fl and\u002For left shift (\\> 10%)\n\nExclusion Criteria:\n\n1. Diagnosed infectious process of another localization (surgical site infection (SSI), acute and chronic urinary tract infection (active), catheter-related bloodstream infection, peritonitis, infective endocarditis etc.).\n2. Mechanical ventilation\n3. Presence of tracheostomy\n4. Patient's participation in another clinical trial at the time of screening or within the previous 3 months.\n5. Concomitant pulmonary disease with the need for respiratory support before the development of pneumonia.\n6. History of malignancy or other irreversible diseases\u002Fconditions with a life expectancy of less than 1 year.\n7. Presence of HIV infection","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a multicenter, prospective randomized controlled trial. At least 2 but no more than 5 centers are expected to participate in the study.\n\nThe primary objective is to test the hypothesis that the addition of high-dose inhaled nitric oxide therapy to standard treatment has a positive effect on the clinical course of pneumonia and the structure and function of cardiopulmonary system.\n\nNumber of participants: 200, including the subproject NO-PNEUMONIA-CAP - 100 CAP participants, the subproject NO-PNEUMONIA-NP - 100 NP participants.\n\nNumber of groups: 4 Inhalation of iNO at a dose of 200 ppm for 30 minutes under the control of methemoglobin level (no more than 5%) three times a day if the patient is allocated to the main group. The general course of iNO therapy will last until the pneumonia resolves, but no more than 7 days. Recording of vital signs and safety assessment will be carried out immediately before the initiation of NO therapy and every 15 minutes after its start (pulse, blood pressure, respiratory rate, SpO2, temperature, MetHb level).",[26,27],"Nosocomial Pneumonia","Community-acquired Pneumonia","RECRUITING","2025-04-07",{"date":31,"type":32},"2025-04-10","ACTUAL",{"date":34,"type":32},"2024-01-15",{"date":36,"type":20},"2027-01-15",{"name":38,"class":39},"Tomsk National Research Medical Center of the Russian Academy of Sciences","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":52,"conditions":53,"keywords":58,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100539984","mechanical-insufflation-exsufflation-and-hypertonic-saline-in-nosocomial-bacterial-respiratory-tract-infection-100539984","NCT06310941","Mechanical Insufflation-exsufflation and Hypertonic Saline in Nosocomial Bacterial Respiratory Tract Infection","Aspiration of Bronchial Secretions With Mechanical Insufflation-Exsufflation and Hypertonic Saline in Bacterial Nosocomial Tracheobronchitis and Pneumonia in Intubated Patients.","ABSENTA","Inclusion Criteria:\n\n* Signed informed consent\n* Nosocomial pneumonia (vHAP or VAP) or nosocomial tracheobronchitis\n* Intubated with a cuffed endotracheal tube or tracheostomy cannula.\n\nExclusion Criteria:\n\n* Ominous prognosis\n* Frank hemoptisis\n* Barotrauma (pneumothorax or pneumomediastinum)\n* Bronchospasm (patients on bronchodilators for previous bronchospasm may be included\n* Unstable thoracic cage\n* Suspected unmonitored intracraneal hypertension",{"count":50,"type":20},100,[23],"Multicenter, randomized open label clinical trial to evaluate IEM and HS as concomitant therapy for respiratory tract infection in patients under artificial ventilation in the ICU.\n\nLung infection is a serious complication that may occur during hospital stay and may need artificial respiration or even develop during artificial ventilation for other causes.\n\nCurrent specific treatment consists of intravenous antibiotics. The current study evaluated whether aspiration and drainage of infected sputum helps curing this severe complication and whether nebulized HS has additional benefits, like loosening of secretions, eradicating bacteria or reducing inflammation.",[54,26,55,56,57],"Nosocomial Infection","Tracheobronchitis","Mechanical Ventilation Complication","Endotracheal Intubation",[59,60,61,62,63,64,65,66],"mechanical insufflation-exsufflation","cough assist device","hypertonic saline","nosocomial respiratory tract infection","hospital-acquired pneumonia","tracheobronchitis","ventilator-associated pneumonia","nebulization","NOT_YET_RECRUITING","2025-03-21",{"date":70,"type":32},"2025-03-26",{"date":72,"type":20},"2026-01-01",{"date":74,"type":20},"2027-12-30",{"name":76,"class":39},"Hospital San Carlos, Madrid",8,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":21,"phases":87,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":40},"100569219","role-of-oral-care-in-prevention-of-nosocomial-pneumonia-among-copd-patients-100569219","NCT06691399","Role of Oral Care in Prevention of Nosocomial Pneumonia Among COPD Patients","Routine Oral Care Versus Chlorhexidine Oral Care on Incidence of Nosocomial Pneumonia and Oral Health Among Critically Ill Non-intubated Patients With COPD","Inclusion Criteria:\n\n* Patients diagnosed as COPD\n* admitted to ICU with acute exacerbation\n* need for noninvasive ventilatory support including noninvasive ventilation anf high flow nasal cannula\n\nExclusion Criteria:\n\n* patients refusing to participate\n* End stage organ failure (Heart Failure, Liver cell failure and\u002For Renal failure",{"count":86,"type":20},60,[23],"Poor dental hygiene has been linked to respiratory pathogen colonization in ICU patients. Therefore, respiratory pathogens tend to colonize dental plaque and oral mucosa in these populations. Therefore, strategies to eliminate respiratory pathogens from the oral cavity may improve oral hygiene and decrease the development of nosocomial pneumonia.",[26,90],"COPD Exacerbation",[92,93,94,95],"COPD","Oral care","Nosocomial pneumonia","Chlorhexidine","2024-11-14",{"date":98,"type":32},"2024-11-15",{"date":100,"type":32},"2024-10-01",{"date":102,"type":20},"2025-06-01",{"name":104,"class":39},"Assiut University"]