[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nsaids\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nsaids":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100600834","phase-4-post-cesarean-analgesia-comparing-effectiveness-of-staggered-v-simultaneous-therapies-100600834",false,"NCT07102641","Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies","PACESS: Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies","PACESS","Inclusion Criteria:\n\n* \\>\u002F= 34 weeks gestation\n* Singleton pregnancy\n* Delivery via cesarean section under regional anesthesia\n\nExclusion Criteria:\n\n* Contraindication to acetaminophen or NSAIDs\n* Current or history of opioid use or misuse\n* Intrauterine fetal demise\n* Major congenital anomaly\n* Conversion to general anesthesia intra-op or planned general anesthesia\n* Mid-line vertical skin incision\n* Receipt of intraoperative local analgesia such as Transversus Abdominis Plan (TAP) block or wound infiltration","FEMALE","16 Years",{"count":20,"type":21},825,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks. Multimodal non-opioid pain medications, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are the preferred first-line therapies. There is no standard practice, however, on best dosing schedules (ie staggered or different time v. simultaneous or same time). This protocol describes a randomized clinical trial aimed to determine whether staggered dosing of acetaminophen and NSAIDs in superior to simultaneous dosing in controlling post-cesarean pain.",[27,28,29,30,31,32],"Cesarean Delivery","Postpartum Comfort","Postpartum Pain","Post-operative Pain","NSAIDs","Acetaminophen (D000082)","RECRUITING","2025-09-02",{"date":36,"type":37},"2025-09-03","ACTUAL",{"date":39,"type":37},"2025-08-26",{"date":41,"type":21},"2027-12",{"name":43,"class":44},"Thomas Jefferson University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":45},"100477999","phase-2-perioperative-analgesia-modes-in-minimally-invasive-esophagectomy-100477999","NCT05504265","Perioperative Analgesia Modes in Minimally Invasive Esophagectomy","Comparison of Efficacy and Safety of Different Analgesic Modes in Minimally Invasive Esophagectomy for Esophageal Cancer","Inclusion Criteria:\n\n* 18-75 years;\n* Patients underwent laparoscopic and thoracoscopic or robotic-assisted minimally invasive esophagectomy ;\n* Informed consent.\n\nExclusion Criteria:\n\n* Has a history of cholecystitis or urolithiasis within 3 months;\n* Has a history of atherothrombosis (peripheral arterial disease), stroke, myocardial infarction;\n* With lung diseases, such as pneumonia, atelectasis, emphysema, pulmonary bullae, etc;\n* Preoperative cardiac function grade ≥ III or coronary artery stenosis;\n* Preoperative indwelling of a thoracic drainage tube;\n* Long-term heavy drinker(heavy drinking was defined as follows: for men, consuming more than 4 drinks on any day or more than 14 drinks per week; For women, consuming more than 3 drinks on any day or more than 7 drinks per week);\n* Opioid-tolerant patients(defined as those who have been taking, for a week or longer, at least 60 mg of morphine daily, or at least 30 mg of oral oxycodone daily, or at least 8 mg of oral hydromorphone daily or an equianalgesic dose of another opioid);\n* With painful skin complications, such as rashes and blisters;\n* Conversion to open surgery;\n* The postoperative ventilation function was limited, or the duration of endotracheal intubation was more than 24h.","ALL","18 Years","75 Years",{"count":57,"type":21},102,[59,60],"PHASE2","PHASE3","This study was designed to compare analgesic efficacy and safety of different perioperative analgesic modes in minimally invasive esophagectomy for esophageal cancer.",[63,64,31,65,66],"Esophageal Cancer","Perioperative Analgesia","Opioid","Patient-controlled Analgesia","2025-03-17",{"date":69,"type":37},"2025-03-20",{"date":71,"type":37},"2022-10-10",{"date":73,"type":21},"2025-12-20",{"name":75,"class":44},"Cancer Institute and Hospital, Chinese Academy of Medical Sciences"]