[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nutrition-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nutrition-disorders":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,45,83,109,134,163,199,222],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100641152","the-effect-of-the-distance-of-the-percutaneous-endoscopic-gastrostomy-peg-feeding-tube-to-the-pylorus-on-the-postoperative-outcomes-100641152",false,"NCT07658079","The Effect of the Distance of the Percutaneous Endoscopic Gastrostomy (PEG) Feeding Tube to the Pylorus on the Postoperative Outcomes","PEG","Inclusion Criteria:\n\n* Over 18 years of age\n* No history of major abdominal surgery (appendectomy, hernia, etc.)\n* Patients who started feeding 24 hours after the PEG procedure\n* Patients not using prokinetic agents.\n\nExclusion Criteria:\n\n* History of stomach, small intestine, large intestine surgery or any history of major abdominal surgery\n* Having undergone surgical gastrostomy\n* Expected gastroparesis (hemodynamic instability, inotropic support, electrolyte imbalance, etc.)\n* Intestinal motility disorder\n* Patients who started feeding early","ALL","18 Years",{"count":19,"type":20},200,"ESTIMATED","7 Days","OBSERVATIONAL","Nutrition is the intake of essential nutrients in sufficient quantities and at the appropriate times to maintain and improve health and enhance quality of life.\n\nEnteral nutrition is superior to parenteral nutrition and should be preferred. To protect the gastrointestinal mucosa and maintain normal flora, patients should begin enteral nutrition as soon as possible. In patients who cannot take food orally, enteral nutrition is provided via a nasogastric\u002Fnasojejunal tube or gastrostomy tube.\n\nGastrostomy is the first choice for patients with a functional gastrointestinal system, poor oral intake, and requiring long-term nutritional support. Feeding tubes can be placed percutaneously or surgically. Percutaneous endoscopic gastrostomy (PEG) is a minimally invasive procedure that does not increase morbidity or mortality, is cheaper, and saves time compared to surgical gastrostomy. It was first applied in 1980 as an alternative to surgical gastrostomy. During the procedure, a line was defined between the navel and the middle of the left lower costal margin. A feeding tube was then inserted at the junction of the middle 2\u002F3 and the outer 1\u002F3 under local anesthesia, and feeding was started the following day. Vudayagiri et al. reported that the placement site is generally 2 cm medial to the costal margin and 2 cm below the xiphoid process.\n\nDifferent methods for placing a PEG tube into the stomach (pull technique, push technique, and Russell method) have been described in the literature, with the most common being the \"pull\" technique. The 2005 ESPEN guidelines noted that in the \"pull\" technique, gastroscopic visualization of the anterior gastric wall is performed, followed by determination of the puncture site at the distal corpus level.\n\nThe exact location of the PEG feeding tube, both on the skin and within the gastric lumen, is not fully understood. Its localization on the abdominal skin will be optimally achieved through endoscopic transillumination. However, its level within the gastric lumen is predictable. In our study, we aimed to investigate how measuring the distance of the feeding tube from the pylorus in patients undergoing PEG placement affects post-procedure outcomes and to determine the optimal level within the gastric lumen. Additionally, the placement of the catheter on the skin will be recorded in each patient. Traditionally, tube feeding has been delayed until up to 24 hours after percutaneous endoscopic gastrostomy (PEG) procedure. However, results from various randomized controlled trials suggest that early feeding may be an option. A meta-analysis indicated that early feeding (\\\u003C or = 4 hours) after PEG placement may be a safe alternative to delayed or next-day feeding. However, although there was no difference in overall complications in this meta-analysis, there was a significant increase in gastric residual volume on day 1 in patients who started early feeding. In another meta-analysis conducted by Szary et al., early tube feeding ≤3 hours after PEG placement; Complications, death within ≤72 hours, or significant gastric residual volume on day 1 were found to be significantly different from delayed or next-day feeding. Our study will be the first of its kind in this field. Therefore, to minimize all factors that could negatively affect the results, we will initiate enteral feeding 24 hours after the traditionally used procedure.",[25,26,27,28],"Poor Oral Intake","Requiring Long-term Nutritional Support","Percutaneous Endoscopic Gastrostomy","Nutrition Disorders",[30,31,32],"Percutaneous Endoscopic Gastrostomy (PEG)","Pylorus","Postoperative Outcomes","NOT_YET_RECRUITING","2026-06-14",{"date":36,"type":37},"2026-06-18","ACTUAL",{"date":39,"type":20},"2026-06-01",{"date":41,"type":20},"2027-08-31",{"name":43,"class":44},"Sisli Hamidiye Etfal Training and Research Hospital","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":67,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":82},"100642828","phase-2-a-study-of-pf-08653945-and-pf-08653944-in-adults-with-overweight-or-obesity-solis-1-100642828","NCT07575932","A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)","A PHASE 2B, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND, DOSE RANGING, DOSE-FINDING, UMBRELLA STUDY TO EVALUATE EFFICACY AND SAFETY OF PF-08653945 AND PF-08653944, ALONE OR IN COMBINATION, IN ADULTS WITH OVERWEIGHT OR OBESITY (SOLIS-1)","SOLIS-1","Inclusion Criteria:\n\nEligible participants for this study include:\n\n* adults aged 18 years or older with\n* obesity (BMI of 30.0 kg\u002Fm2 to 50.0 kg\u002Fm2) or with\n* overweight (BMI of 27.0 kg\u002Fm2 to \\\u003C30.0 kg\u002Fm2) who also have at least 1 prespecified weight-related comorbidity (hypertension, dyslipidemia, cardiovascular disease, or obstructive sleep apnea), at the screening visit.\n\nExclusion Criteria:\n\nParticipants who are not eligible include those with diabetes mellitus, a body weight change of \\>5% or use of weight loss medications in the 12 weeks prior to screening, a history of or plan for surgical treatment for obesity, and those who are unable or unwilling to comply with contraceptive requirements or are pregnant or lactating.",{"count":54,"type":20},872,"INTERVENTIONAL",[57],"PHASE2","This study is being done to learn about the safety and effects of the study drugs, PF-08653945 and PF-08653944, when given alone or together for weight loss, compared to a placebo (a dummy drug that has no active ingredient in it).",[60,61,62,63,64,28,65,66],"Overweight","Obesity","Overweight and\u002For Obesity","Overweight or Obesity","Overnutrition","Nutritional and Metabolic Diseases","Body Weight",[64,28,65,66,61,60,68,69,70],"GLP-1RA","Amylin","DACRA","RECRUITING","2026-06-09",{"date":74,"type":37},"2026-06-10",{"date":76,"type":37},"2026-05-11",{"date":78,"type":20},"2028-01-05",{"name":80,"class":81},"Pfizer","INDUSTRY",48,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":55,"phases":94,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100334272","nutritional-course-of-care-after-surgical-treatment-at-the-patients-affected-by-a-cancer-of-the-head-and-by-the-neck-100334272","NCT03632200","Nutritional Course of Care After Surgical Treatment at the Patients Affected by a Cancer of the Head and by the Neck","Improvement of the Nutritional Course of Care After Surgical Treatment at the Patients Affected by a Cancer of the Head and by the Neck","NUTRIMAX","Inclusion Criteria:\n\n* Patients affected by a cancer of the VADS\n* Man or woman of 18 and more years old\n* Patient benefiting from a surgery for its cancer of the VADS\n* Patient having signed a written consent\n* Patient member in a national insurance scheme\n\nExclusion Criteria:\n\n* Patient minor\n* Patient benefiting from a radiotherapy\n* Patient participant in another research interfering on the nutritional state of the patient\n* Patients under guardianship or guardianship","80 Years",{"count":93,"type":20},60,[95],"NA","Whatever are the strategies of coverage, the consideration of the state of bad nutrition is not often the priority. According to the last recommendations (2012) of the French Society Clinical Nutrition and Metabolism (SFNEP), the surgeries of the cancers of the VADS are not listed among surgeries with high morbidity. So the specific recommendations for the patients undernourished with surgery with low morbidity, only a personalized dietary advice and oral nutritional supplements are recommended in preoperative. There is no specific recommendation in post-operative.\n\nTwo groups of cancer patients of the VADS will be compared: a control group benefiting from a nutritional coverage based on the current recommendations of the SFNEP, an experimental group benefiting from an improved nutritional coverage.\n\nIn preoperative, all the patients of experimental group will benefit from dietary advice during a multidisciplinary specific consultation. In post-operative, a dietetic consultation will be set up in 7 days at the exit of hospitalization and call phone at M1, M2, M4 and M5. And for the undernourished patient will benefit a multidisciplinary consultation at the rate of a consultation a month during 6 months.\n\nIn the Group control, the patients will be followed according to the current recommendations of the SFNEP.",[28,98],"Head and Neck Cancer","2026-05-12",{"date":101,"type":37},"2026-05-13",{"date":103,"type":37},"2019-03-21",{"date":105,"type":20},"2027-09",{"name":107,"class":44},"Centre Hospitalier Universitaire, Amiens",1,{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":117,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":118,"targetDuration":4,"studyType":55,"phases":120,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":133},"100399015","replacing-protein-via-enteral-nutrition-in-critically-ill-patients-100399015","NCT04475666","Replacing Protein Via Enteral Nutrition in Critically Ill Patients","Replacing Protein Via Enteral Nutrition in a Stepwise Approach in Critically Ill Patients: An International, Multicenter Randomized Controlled Trial","REPLENISH","Inclusion Criteria(on ICU calendar day 4 or the morning of day 5)\n\n1. Age ≥18-years old\n2. Patient started on enteral nutrition (EN) via nasogastric\u002Forogastric or duodenal or percutaneous endoscopic gastrostomy (PEG) or jejunostomy tubes.\n3. The patient is on invasive mechanical ventilation and unlikely to be discharged from ICU next day.\n\nExclusion Criteria:\n\n1. Lack of commitment to full life support or brain death. Patients with \"Do Not Resuscitate\" order but with commitment to ongoing life support can be enrolled.\n2. Patients on any amount of parenteral nutrition (PN) in ICU at the time of screening, whether PN is used alone or in combination with enteral nutrition. Non-nutritional calories (dextrose, propofol, citrate) not considered as PN.\n3. Patients who received an average protein of more than 0.8g\u002Fkg\u002Fday in the first 4 ICU days.\n4. Patients being fed entirely through oral route - i.e. those who are eating.\n5. Pregnancy.\n6. Burn patients.\n7. Prisoners or those undergoing forced treatment.\n8. Patients with hepatic encephalopathy or Child C liver cirrhosis\n9. Inherited defect of amino acid metabolism.\n10. Allergies to protein supplement",true,{"count":119,"type":20},2502,[95],"The investigator will investigate the effect of supplemental enteral protein (1.2 g\u002Fkg\u002Fday) added to standard formula to achieve high amount of enteral protein (range 2-2.4 g\u002Fkg\u002Fday) given from ICU day 5 until ICU discharge up to ICU day 90 as compared to no supplemental enteral protein to achieve moderate amount enteral protein (0.8-1.2 g\u002Fkg\u002Fday), given in conjunction with similar amounts of stepwise caloric administration in the two groups on all-cause 90-day mortality.",[123,28],"Critical Illness","2025-08-31",{"date":126,"type":37},"2025-09-08",{"date":128,"type":37},"2020-09-21",{"date":130,"type":20},"2026-04-30",{"name":132,"class":44},"King Abdullah International Medical Research Center",2,{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":142,"enrollmentInfo":143,"targetDuration":4,"studyType":55,"phases":145,"briefSummary":146,"conditions":147,"keywords":150,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":108},"100561209","semi-elemental-versus-polymeric-een-in-the-preoperative-optimization-for-patients-with-cd-100561209","NCT06587178","Semi-elemental Versus Polymeric EEN in the Preoperative Optimization for Patients with CD","Semi-elemental Versus Polymeric Exclusive Enteral Nutrition in the Preoperative Optimization for Patients with Crohn's Disease: a Randomized Controlled Trial","SEPEN-CD","Inclusion Criteria:\n\n1. elective bowel resection for Crohn's disease;\n2. preoperative diagnosis of Crohn's disease;\n3. age between 18 to 65 years old;\n4. malnutrition;\n5. the Crohn's disease activity index over 150;\n6. nasal feeding.\n\nExclusion Criteria:\n\n1. emergency surgery;\n2. preoperative exclusive enteral nutrition before three months;\n3. can not tolerate enteral nutrition;\n4. less than 6 weeks of exclusive enteral nutrition;\n5. preoperative corticosteroids within 3 months;\n6. history of gastrointestinal surgery;\n7. isolated colon disease;\n8. metabolic disease (diabetes, hyperthyroidism).","65 Years",{"count":144,"type":20},304,[95],"Growing evidence has shown that exclusive enteral nutrition (EEN) plays an important role in the preoperative optimization for patients with Crohn's disease (CD). However, the efficacy and safety of different types of enteral feeds including semi-elemental and polymeric enteral nutrition on CD have not been investigated. The aim of this study was to compare the role of semi-elemental and polymeric enteral nutrition on CD.",[148,28,149],"Crohn Disease","Surgery",[151,152,153],"Crohn's disease","Exclusive enteral nutrition","surgery","2024-09-05",{"date":156,"type":37},"2024-09-19",{"date":158,"type":20},"2024-10-01",{"date":160,"type":20},"2025-12-30",{"name":162,"class":44},"Wei Zhou",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":171,"minAge":172,"maxAge":17,"enrollmentInfo":173,"targetDuration":4,"studyType":55,"phases":174,"briefSummary":175,"conditions":176,"keywords":185,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":108},"100558914","in-person-lifestyle-program-for-black-adolescent-girls-at-risk-for-type-2-diabetes-100558914","NCT06557317","In-Person Lifestyle Program for Black Adolescent Girls at Risk for Type 2 Diabetes","Examining the Preliminary Efficacy of an In-Person Lifestyle Intervention for Black Female Adolescent\u002FCaregiver Dyads at Risk for Type 2 Diabetes Mellitus","BGW In-Person","Inclusion Criteria for adolescent participants:\n\n* 12-18 years of age\n* self-identify as Black or African American\n* have obesity (\\>=95th percentile BMI)\n\nExclusion Criteria for adolescent participants:\n\n* pregnant or within 3 months postpartum.\n* participated in a formal weight management program within 6 months prior to study.\n* currently taking medications or diagnosed with a condition known to influence metabolism, physical activity ability, or cognitive function.\n* have previously undergone bariatric surgery.\n* have type 2 diabetes.\n* unable to speak English or have developmental conditions that interfere with ability to communicate.\n\nInclusion Criteria for caregiver participants:\n\n* 18 years or older.\n* proficiency in speaking English.\n* live in the same household as the adolescent who will also be enrolled.\n* prepares the majority (\\>50%) of meals in the household.\n\nExclusion Criteria for caregiver participants:\n\n* pregnant or within 3 months postpartum.\n* unable to speak English or have developmental conditions that interfere with ability to communicate.","FEMALE","12 Years",{"count":93,"type":20},[95],"The aim of this study is to look at changes in diabetes-related risk factors in Black adolescent girls who are at risk for type 2 diabetes and their primary female caregiver after both participating in a 12-week in-person lifestyle program.",[177,178,179,180,181,182,183,60,64,28,66,184],"Behavior, Adolescent","Childhood Obesity","Diabetes Mellitus, Type 2","Pediatric Obesity","Glucose Metabolism Disorders","Metabolic Disease","Endocrine System Diseases","Diabetes Mellitus",[186,187,188,189,61],"Adolescents","In-Person Lifestyle Program","Diabetes prevention","Black girls","2024-08-14",{"date":192,"type":37},"2024-08-16",{"date":194,"type":20},"2024-08",{"date":196,"type":20},"2024-12-31",{"name":198,"class":44},"Cornell University",{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":142,"enrollmentInfo":206,"targetDuration":4,"studyType":55,"phases":208,"briefSummary":209,"conditions":210,"keywords":211,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":216,"completionDateStruct":217,"leadSponsor":219,"locationsCount":108},"100558604","phase-2-effect-of-nutritional-intervention-based-on-prediction-model-on-adult-umbilical-cord-blood-transplantation-patients-100558604","NCT06553274","Effect of Nutritional Intervention Based on Prediction Model on Adult Umbilical Cord Blood Transplantation Patients","Effect of Nutritional Intervention Based on Predictive Model of Nutritional Factors on Survival of Adult Umbilical Cord Blood Transplantation Patients","Inclusion Criteria:\n\n* Age 18-65 years old, conscious, with language communication skills;\n* UCBT patients to be performed;\n* Major organs without serious dysfunction;\n* The participants agreed to participate in the study and signed the informed consent form.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years old or \\> 65 years old or with cognitive impairment can not complete this survey;\n* Failure or recurrence of transplantation;\n* Combined with severe other organ system diseases (such as severe cardiac insufficiency, autoimmune disease, active infection, severe trauma) ;\n* Patients who have difficulty collecting data to complete the nutritional intervention;\n* Patients who asked to withdraw from the study.",{"count":207,"type":20},67,[57],"Based on the nutritional factor prediction model, the individualized nutritional management of patients with umbilical cord blood transplantation (UCBT) was carried out to observe the impact on the survival efficacy of patients.",[28],[212,213],"umbilical cord blood transplantation","nutrition intervention","2024-08-11",{"date":190,"type":37},{"date":194,"type":20},{"date":218,"type":20},"2025-12",{"name":220,"class":221},"Anhui Provincial Hospital","OTHER_GOV",{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":91,"enrollmentInfo":229,"targetDuration":4,"studyType":55,"phases":231,"briefSummary":233,"conditions":234,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":238,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":108},"100554526","phase-3-nutrition-impact-on-immunotherapy-of-cancer-100554526","NCT06500234","Nutrition Impact on Immunotherapy of Cancer","Phase III Study on the Relation of Nutrition and Immunotherapy of Cancer Patients","Inclusion Criteria:\n\n* Diagnosis of cancer, malnutrition Age \\>18 years Performance status ECOG of 0 or 2. Life expectancy ≥ 6 months. At least one lesion measurable as defined by standard imaging criteria for the patient's tumor type (RECIST v1.1) Patients must have normal organ and bone marrow function measured within 28 days prior to administration of study treatment Postmenopausal or evidence of non-childbearing status for women of childbearing potential Patient is willing and able to comply with the protocol for the duration of the study.\n\nFor all oral medications patients must be able to comfortably swallow capsules;\n\nExclusion Criteria:\n\n* Patients unable to swallow orally administered medication and patients with Impairment of gastrointestinal (GI) function or GI disease that may significantly alter drug absorption of oral drugs History of allogenic organ, bone marrow or double umbilical cord blood transplantation.\n\nActive or prior documented autoimmune or inflammatory disorders Uncontrolled intercurrent illness or patient considered a poor medical risk due to a serious, uncontrolled medical disorder, including but not limited to, ongoing or active infection, symptomatic congestive heart failure Currently taking medications with known risk of prolonging the QT interval or inducing Torsades de Pointes.",{"count":230,"type":20},300,[232],"PHASE3","This study investigates nutritional status and outcomes of immuntherapy in cancer patients.",[28,235,236,237],"Immunotherapy","Cancer","Survival, Prosthesis","2024-07-12",{"date":240,"type":37},"2024-07-15",{"date":242,"type":37},"2024-06-01",{"date":244,"type":20},"2027-05-31",{"name":246,"class":44},"Qingdao Central Hospital"]