[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nutritional-requirements\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nutritional-requirements":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,79],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":34,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100583027","optimizing-nutrition-and-milk-opti-num-project-100583027",false,"NCT06870981","Optimizing Nutrition and Milk (Opti-NuM) Project","Improving Growth and Neurodevelopment of Very Low Birth Weight Infants Through Precision Nutrition: The Optimizing Nutrition and Milk (Opti-NuM) Project","Opti-NuM","Inclusion Criteria:\n\n• Secondary data and biospecimens from participants of the MaxiMoM Platform RCTs\n\nExclusion Criteria:\n\n• Data and biospecimens from infants who are not enrolled in the three trials are eligible for this project.","ALL","1 Hour","21 Days",{"count":21,"type":22},1100,"ESTIMATED","OBSERVATIONAL","Early nutrition critically influences growth, neurodevelopment and morbidity among infants born of very low birth weight (VLBW), but current one-size-fits-all feeding regimes do not optimally support these vulnerable infants. There is increasing interest in \"precision nutrition\" approaches, but it is unclear which Human Milk (HM) components require personalized adjustment of doses. Previous efforts have focused on macronutrients, but HM also contains essential micronutrients as well as non-nutrient bioactive components that shape the gut microbiome. Further, it is unclear if or how parental factors (e.g. body mass index, diet) and infant factors (e.g. genetics, gut microbiota, sex, acuity) influence relationships between early nutrition and growth, neurodevelopment and morbidity. Understanding these complex relationships is paramount to developing effective personalized HM feeding strategies for VLBW infants. This is the overarching goal of the proposed Optimizing Nutrition and Milk (Opti-NuM) Project.\n\nThe Opti-NuM Project brings together two established research platforms with complementary expertise and resources: 1) the MaxiMoM Program\\* with its clinically embedded translational neonatal feeding trial network in Toronto (Dr. Deborah O'Connor, Dr. Sharon Unger) and 2) the International Milk Composition (IMiC) Consortium, a world-renowned multidisciplinary network of HM researchers and data scientists collaborating to understand how the myriad of HM components contribute \"as a whole\" to infant growth and development, using systems biology and machine learning approaches. Members of the IMiC Corsortium that will work with on this study are located at the University of Manitoba (Dr. Meghan Azad), University of California (Dr. Lars Bode) and Stanford (Dr. Nima Aghaeepour).",[26,27,28,29,30,31,32,33],"Very Low Birth Weight Baby","Early Nutrition and the Preterm Infant","Nutritional Requirements","Human Milk Fortification","Human Milk Microbiome","Human Milk Feeding","Human Milk Nutrition","Growth &Amp; Development",[35,36,37],"Very Low Birth Weight Infants","Early nutrition and the preterm infant","Human milk feeding","RECRUITING","2025-03-06",{"date":41,"type":42},"2025-03-11","ACTUAL",{"date":44,"type":42},"2010-10-01",{"date":46,"type":22},"2027-12",{"name":48,"class":49},"The Hospital for Sick Children","OTHER",6,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100521836","study-on-dietary-intake-levels-of-iodine-for-3-6-years-old-pre-school-children-100521836","NCT06074770","Study on Dietary Intake Levels of Iodine for 3-6 Years Old Pre-school Children","Inclusion Criteria:\n\n* for children with mild malnutrition: hemoglobin \\\u003C110g \u002F L, or weight for age \\\u003CP50 according to the Chinese 2009 child growth and development reference standard, or BMI z score \\\u003C-1 according to the WHO Child Growth Assessment Software (version 3.2.2 ) ; have not been treated for thyroid disease; have not used amiodarone and other drugs (including iodine supplements) during the investigation; have no major diseases ,chronic diseases and family history.\n* for children with good nutritional status: healthy,-1 \\\u003CBMI z score \\\u003C1; have not been treated for thyroid disease; have not used amiodarone and other drugs (including iodine supplements) during the investigation; have no major diseases ,chronic diseases and family history;\n\nExclusion Criteria:\n\nlong-term low-protein; long-term low-heat energy malnutrition",true,"3 Years","6 Years",{"count":61,"type":22},2650,"Iodine as an essential trace element for human, both excessive and insufficient intake would be harmful for human health. As susceptible population, children will be more sensitive to adverse effects caused by inadequate intake of iodine since they are at the peak of growth and development. Meanwhile, there are few direct evidence to establish dietary intakes levels of iodine for 3-6 years old pre-school children.",[28],[65,66,67,68],"nutrient","dietary intake levels","pre-school children","iodine","2023-10-05",{"date":71,"type":42},"2023-10-10",{"date":73,"type":42},"2023-05-05",{"date":75,"type":22},"2026-12-31",{"name":77,"class":49},"Chen Wen",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":57,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":91,"conditions":92,"keywords":93,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":108},"100495408","displacement-of-iodine-balance-value-during-pregnancy-and-the-mechanism-of-breast-iodine-homeostasis-during-lactation-100495408","NCT05730803","Displacement of Iodine Balance Value During Pregnancy and the Mechanism of Breast Iodine Homeostasis During Lactation","Study on the Displacement of Iodine Balance Value During Pregnancy and the Mechanism of Breast Iodine Homeostasis During Lactation Under Different Iodine Exposure","Inclusion Criteria:\n\nPregnant women:\n\n* Aged 18-40, who have lived in the area for ≥5 year;\n* Single pregnancy;\n* Those who have no special dietary habits;\n\nLactating woman:\n\n* Breastfeeding a child;\n* Normal thyroid function during pregnancy;\n* Term delivery (38-42 weeks of gestation);\n\nExclusion Criteria:\n\nPregnant women:\n\n* Smoking or drinking;\n* Iodized drugs or contrast agents have been used in the past year;\n* A history of thyroid disease, autoimmune disease, endocrine disease, heart disease, chronic disease or family hereditary disease, etc\n\nLactating woman:\n\n* A history of thyroid disease, autoimmune disease, endocrine disease, heart disease, chronic disease or family hereditary disease, etc;\n* Iodized drugs or contrast agents have been used;","FEMALE","1 Day","40 Years",{"count":90,"type":22},1200,"In order to solve the bottleneck problems of\"zero balance displacement\"and\"large variation of breastmilk\"in the study of iodine EAR of pregnant women, lactating women and infants, firstly, this study intends to clarify the rate of metabolism and distribution of iodine during pregnancy by 125I tracer, SPECT\u002FCT in vivo small animal imaging and γ counting study. Then, the iodine balance study in rats was conducted to verify the degree of \"zero balance value displacement\"caused by the difference of iodine absorption and store in different organs and tissues under different iodine exposure levels, so as to determine the iodine selection conditions of subjects in the population experiment. To determine the EAR of pregnant women by optimizing the population iodine balance experiment. Secondly, we proposed to study the regulatory mechanism of NIS and Pendrin in the mammary gland of lactating rats under different iodine nutrition levels to clarify the range of breastmilk iodine compensation. Mammary cell experiments intend to clarify the mutual regulations of iodine nutrition, oestrogen, and NIS and Pendrin. Based on the results of animal and cellular experiments, and the effect of genetic, oestrogen and iodine status were considered, a cross-sectional study of lactating women was conducted to determine the normal reference range of breastmilk iodine after screening out the people with abnormal indicators. This study will solve the bottleneck problems and difficulties in the iodine RNI research for pregnant women, lactating women and infants, found the iodine nutritional compensatory mechanism under special physiology, and provide the scientific basis for obtaining the accurate EAR basic data and the revision of iodine DRIs.",[28],[94,65,95,96,97],"nutrition of special population","trace element iodine","zero balance displacement","large variation of breastmilk","NOT_YET_RECRUITING","2023-02-15",{"date":101,"type":42},"2023-02-16",{"date":103,"type":22},"2023-02-17",{"date":105,"type":22},"2027-12-31",{"name":107,"class":49},"Tianjin Medical University",2]