[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nutritional-support\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nutritional-support":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,44,78,113,143,172],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100637877","effect-of-protein-dosage-on-persistent-acute-renal-failure-in-critically-ill-patients-100637877",false,"NCT07631221","Effect of Protein Dosage on Persistent Acute Renal Failure in Critically Ill Patients.","Inclusion Criteria:\n\n* Patients aged 18 years or older admitted to the ICU.\n* Patients receiving exclusive enteral or parenteral nutrition\n* Acute kidney injury or exacerbated chronic kidney disease according to KDIGO criteria (increase in creatinine greater than 0.3 mg\u002FdL in less than 48 hours or a 1.5-fold increase in baseline creatinine in 7 days)\n\nExclusion Criteria:\n\n* Patients diagnosed with chronic kidney disease with a creatinine clearance of less than 30 ml\u002Fmin\u002Fm2 or on dialysis at admission.\n* Patients with a history of kidney transplantation\n* Patients with severe liver disease (Child-Pugh score \\>7 points)\n* Patients with acute kidney injury undergoing renal replacement therapy at T0\n* BMI\\> 30","ALL","18 Years",{"count":18,"type":19},344,"ESTIMATED","OBSERVATIONAL","Background:\n\nAcute kidney injury (AKI) is common in critically ill patients and is associated with worse outcomes, including longer ICU stay, need for dialysis, and higher mortality. Patients with AKI often experience significant protein and calorie loss due to their illness and medical treatments. Providing the right amount of protein may help maintain muscle mass and improve recovery; however, consuming too much protein could potentially worsen kidney function. Current international guidelines recommend adequate protein intake, but the best dose remains uncertain, especially for patients with AKI.\n\nStudy Purpose:\n\nThis research will examine whether patients with AKI who receive a higher protein intake (greater than 1.2 g\u002Fkg\u002Fday) have different outcomes compared to those who receive a standard or lower protein intake (≤1.2 g\u002Fkg\u002Fday). The primary outcome is whether a higher protein intake leads to a longer recovery time from AKI or worsens kidney function.\n\nStudy Design:\n\nThis is a retrospective, multicenter study using data from five hospitals in Argentina. It is designed as a \"target trial emulation,\" meaning researchers will analyze existing patient data as if it were a randomized clinical trial. Patients will be included on the fifth day of their ICU stay and classified into two groups based on their protein intake on day 5:\n\n* Group 1 (Standard Protein): ≤1.2 g\u002Fkg\u002Fday\n* Group 2 (High Protein): \\>1.2 g\u002Fkg\u002Fday No additional interventions will be performed; data are collected from medical records.\n\nStudy Population:\n\nThe study will include adult patients (≥18 years) admitted to the ICU who are receiving exclusive enteral or parenteral nutrition and have AKI (or worsening chronic kidney disease) according to KDIGO criteria. Patients with advanced chronic kidney disease (creatinine clearance \\\u003C30 ml\u002Fmin\u002F1.73 m²) or undergoing hemodialysis at T0, previous kidney transplant, severe liver disease, or BMI \\>30 will be excluded.\n\nOutcomes:\n\n* Primary Outcome: Time to recovery of kidney function within 30 days, measured by creatinine returning close to baseline values.\n* Secondary Outcomes: Changes in blood urea levels, duration of renal replacement therapy (hemodialysis), ICU length of stay, and 30-day mortality.\n\nStatistical Approach:\n\nTo minimize bias, the study will use advanced statistical methods, including propensity score weighting, to ensure fair comparison between groups. Competing risks (such as death before kidney recovery) will be taken into account in the analysis.\n\nSignificance:\n\nThis study will provide important information about the safety and effectiveness of higher protein intake in critically ill patients with AKI. The findings may help guide nutritional strategies in the ICU, optimize kidney outcomes, and improve patient care.",[23,24,25,26,27],"Acute Kidney Failure","Critical Illness","Protein Intake","Nutritional Support","Mortality in Intensive Care Units",[29,24,25,30,31,26],"Acute Kidney Injury","Target Trial Emulation","Intensive Care Unit","RECRUITING","2026-06-01",{"date":35,"type":36},"2026-06-05","ACTUAL",{"date":38,"type":36},"2025-09-15",{"date":40,"type":19},"2026-12-01",{"name":42,"class":43},"Hospital Italiano de Buenos Aires","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":15,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100624544","enteral-versus-parenteral-nutrition-during-recovery-after-shock-100624544","NCT07411014","Enteral Versus Parenteral Nutrition During Recovery After Shock","Enteral Versus Parenteral Nutrition During Early Recovery in the Critically Ill After Shock: A Prospective, Multicenter, Open-label, Randomized Controlled Study","Screening Criteria:\n\n* Subjects must be at least 19 years of age at the time of screening.\n* Subjects must be admitted to the intensive care unit (ICU).\n* Subjects must be receiving vasopressor therapy for shock.\n* Subjects must have a documented history of maximum vasopressor requirement with a vasopressor-inotropic score (VIS) of 12 or greater, calculated as follows:\n\nVIS = dopamine dose (µg\u002Fkg\u002Fmin) + dobutamine dose (µg\u002Fkg\u002Fmin) + 10 × milrinone dose (µg\u002Fkg\u002Fmin) + 100 × epinephrine dose (µg\u002Fkg\u002Fmin) + 100 × norepinephrine dose (µg\u002Fkg\u002Fmin) + 10,000 × vasopressin dose (U\u002Fkg\u002Fmin)\n\nInclusion Criteria:\n\n* Subjects must meet all screening criteria.\n* Subjects must have central venous access suitable for the administration of parenteral nutrition (PN).\n* Subjects must demonstrate a decreasing vasopressor requirement, defined as a current VIS of 12 or less at the time of enrollment.\n\nExclusion Criteria:\n\n* Subjects with contraindications to enteral nutrition (EN) or parenteral nutrition (PN) at the time of enrollment will be excluded.\n* Subjects requiring specific nutritional management, including but not limited to long-term home enteral nutrition, long-term parenteral nutrition, or a diagnosis of refeeding syndrome, will be excluded.\n* Subjects who are pregnant or breastfeeding will be excluded.\n* Subjects with severe comorbid conditions associated with an estimated life expectancy of less than three months will be excluded.\n* Subjects with a documented do-not-resuscitate (DNR) order will be excluded.\n* Subjects with active gastrointestinal bleeding will be excluded.\n* Subjects who have undergone gastrointestinal surgery within one month prior to enrollment will be excluded.\n* Subjects currently participating in another randomized controlled trial comparing enteral nutrition and parenteral nutrition will be excluded.","19 Years",{"count":53,"type":19},1150,"INTERVENTIONAL",[56],"NA","This study compares enteral nutrition and parenteral nutrition in critically ill adult patients recovering from shock while receiving decreasing doses of vasopressors in the intensive care unit.\n\nEligible patients will be randomly assigned to receive either enteral or parenteral nutrition during the early recovery phase of shock.\n\nThe study aims to determine whether enteral nutrition improves clinical outcomes, including ICU mortality and ICU-acquired infections, compared with parenteral nutrition.",[59,24,26,60],"Shock","Vasopressor Therapy",[62,63,64,65,66,59],"Enteral Nutrition","Parenteral Nutrition","Critically Ill Patients","Shock Recovery","Vasopressor Weaning","NOT_YET_RECRUITING","2026-02-13",{"date":70,"type":36},"2026-02-18",{"date":72,"type":19},"2026-02-01",{"date":74,"type":19},"2029-12-31",{"name":76,"class":43},"Samsung Medical Center",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":54,"phases":87,"briefSummary":88,"conditions":89,"keywords":95,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":77},"100598506","nutritional-prehabilitation-to-improve-cancer-outcomes-n-pico-100598506","NCT07072377","Nutritional Prehabilitation to Improve Cancer Outcomes (N-PICO)","N-PICO","Inclusion Criteria:\n\n* Diagnosis of invasive cancer with plans to initiate chemo-, immune-, targeted-, or hormonal therapy for treatment of their malignancy, or within one month of starting treatment.\n* Age ≥ 18 years of age.\n* Patients must be able to read, write, and speak English as study material and virtual nutrition consultation calls are only available in English.\n* Patients receiving treatment at a participating ambulatory medical oncology site.\n* Willingness to have a remote nutritional consultation and complete questionnaires\u002Fsurveys.\n* Patients must be informed of the investigational nature of this study and must sign and give written informed consent in accordance with institutional and federal guidelines.\n\nExclusion Criteria:\n\n* Diagnosis of acute leukemia (these patients generally receive predominantly inpatient care).\n* Diagnosis of head \\& neck cancer, esophageal cancer, gastric cancer, patients presenting with recognized cachexia or severe malnutrition, or patients with PEG tubes for enteral feeding.\n\nRationale: These patients would normally be referred for dietary consultation and may need ongoing clinical intervention from an on-site dietitian beyond the period of the proposed study",{"count":86,"type":19},240,[56],"Brief Summary\n\nThe goal of this clinical trial is to evaluate the acceptability and adherence of low- and high-intensity remote nutritional interventions for cancer patients in rural and urban areas, specifically focusing on those with invasive cancer who are about to start treatment. The main question\\[s\\] it aims to answer are:\n\nCan low- and high-intensity remote nutritional interventions improve adherence to cancer treatment and quality of life? What is the impact of nutritional support on treatment delays, unplanned healthcare utilization, and dietary modifications? Researchers will compare the low-intensity arm (initial nutritional consultation plus written materials) to the high-intensity arm (1-hour consultation, monthly follow-ups, and written materials) to see if higher intensity interventions lead to better outcomes in terms of adherence, quality of life, and healthcare utilization.\n\nParticipants will:\n\nReceive either a low- or high-intensity nutritional consultation. Complete surveys assessing quality of life, dietary habits, treatment delays, and unplanned healthcare use.\n\nBe asked to participate in monthly follow-up consultations (for the high-intensity group) to track progress and provide additional support.",[90,91,92,26,93,94],"Malnutrition","Cancer-related Malnutrition","Quality of Life (QOL)","Nutritional Interventions","Rural Health",[96,97,98,99,100,101,102,103],"Cancer Nutrition Intervention","Malnutrition in Cancer Patients","Nutritional Support for Cancer","Prehabilitation Program for Cancer","Rural Cancer Nutrition","Quality of Life and Cancer Nutrition","Remote Nutritional Consultations","Cancer Treatment Outcomes and Nutrition","2026-02-02",{"date":106,"type":36},"2026-02-05",{"date":108,"type":36},"2025-09-10",{"date":110,"type":19},"2028-09",{"name":112,"class":43},"University of Vermont Medical Center",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":121,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":54,"phases":124,"briefSummary":125,"conditions":126,"keywords":131,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":139,"leadSponsor":141,"locationsCount":4},"100598654","training-program-for-peg-caregivers-a-structured-intervention-study-100598654","NCT07074301","Training Program for PEG Caregivers: A Structured Intervention Study","Effectiveness of Education and Mobile Application for Percutaneous Endoscopic Gastrostomy Care","PEG-EDU","Inclusion Criteria:\n\n* Age 18 or older\n* Willingness to participate voluntarily in the study\n* No communication barriers\n* Ability to use a smartphone\n* No diagnosed psychiatric disorder\n* Providing care to a patient aged 18 or older who is scheduled to undergo PEG placement\n\nExclusion Criteria:\n\n* Discharge from hospital or death of the patient during the study period\n* Being under 18 years old\n* Illiteracy of the caregiver",true,{"count":123,"type":19},80,[56],"This study aims to develop and evaluate a structured education program and a mobile application to support caregivers of patients receiving enteral nutrition via percutaneous endoscopic gastrostomy (PEG). The intervention focuses on improving caregivers' knowledge, care practices, and perceived burden. The study will be conducted in three phases: a needs assessment, development of the education and digital support modules, and implementation of the intervention. Quantitative and qualitative data will be collected to evaluate the impact of the intervention. The results are expected to contribute to the improvement of home PEG care quality and the empowerment of caregivers.",[127,128,129,26,130],"Percutaneous Endoscopic Gastrostomy (PEG)","Training","Caregiver Burden","Training Effectiveness",[132,129,133,134],"Percutaneous endoscopic gastrostomy","Structured Training","Home Enteral Nutrition","2025-08-29",{"date":137,"type":36},"2025-09-05",{"date":137,"type":19},{"date":140,"type":19},"2026-03-31",{"name":142,"class":43},"Koç University",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":15,"minAge":151,"maxAge":152,"enrollmentInfo":153,"targetDuration":155,"studyType":20,"phases":4,"briefSummary":156,"conditions":157,"keywords":159,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":171},"100571129","relationship-of-nutritional-support-for-critically-ill-children-with-clinical-outcomes-in-a-pediatric-hospital-in-bolivia-nutpebol-100571129","NCT06716229","Relationship of Nutritional Support for Critically Ill Children With Clinical Outcomes in a Pediatric Hospital in Bolivia (NutPeBol)","Relationship of Nutritional Support for Critically Ill Children With Clinical Outcomes in a Pediatric Hospital in Bolivia in 2025 (NutPeBol)","NutPeBol","Inclusion Criteria:\n\n* Admitted to intensive care or intermediate care in hospital wards\n* Complete clinical and anthropometric data.\n\nExclusion Criteria:\n\n* Congenital or acquired chronic disease affecting growth (secondary malnutrition)\n* On medication (corticosteroids, immunoglobulins, albumin)\n* Burn patients, with prosthetic implants, postoperative of large tumor resections.\n* Unknown history of pre-referral hospital management or hospitalized in other health facilities.","1 Month","15 Years",{"count":154,"type":19},56,"4 Weeks","The aim of this observational study is to learn about the characteristics of nutritional support in critically ill children. The primary question to be answered is Is there an association between nutritional support of the critically ill child and clinical and hospital outcomes in children admitted to a pediatric referral center? Patients will be followed throughout their hospitalization, with a step-by-step evaluation of the nutritional support received through standard care and a review of the results obtained in the patients.",[158,26],"Critically Ill Children",[160,161],"Critically Ill children","Nutritional support","2025-03-11",{"date":164,"type":36},"2025-03-14",{"date":166,"type":19},"2025-04-06",{"date":168,"type":19},"2025-12-19",{"name":170,"class":43},"MPH D Raul Copana-Olmos",2,{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":176,"acronym":177,"eligibilityCriteria":178,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":179,"targetDuration":4,"studyType":54,"phases":181,"briefSummary":182,"conditions":183,"keywords":184,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":77},"100542440","interpretation-and-optimization-of-nutrition-in-the-intensive-care-units-100542440","NCT06342895","Interpretation and Optimization of Nutrition in the Intensive Care Units","IONIC","Inclusion Criteria:\n\n* Age 18 and over.\n* French Social Security system registration.\n* First stay in ICU\n* Admitted to the Lille University Hospital Surgical ICU for at least 3 days.\n* Active enteral and\u002For parenteral nutritional support prescription\n* Patient and\u002For next-of-kin informed about the study and having consented to participation in the study.\n\nExclusion Criteria:\n\n* Age under 18\n* Burn patient\n* Admitted to the ICU with a prior active enteral\u002Fparenteral nutritional support before day 3, except trophic nutrition\n* Dying patient, not-to-be-resuscitated order, or other treatment limitation decision at ICU admission\n* Adult under guardianship\n* Department of corrections inmate",{"count":180,"type":19},144,[56],"Despite recommendations, inadequate nutritional intake in intensive care unit (ICU) patients remains frequent and can lead to complications such as infections, increased length of stay, prolonged weaning from ventilation, increased long-term mortality, and decreased quality of life after intensive care. Studies have shown that patients only receive up to 50-60% of prescribed calories and proteins due to many factors leading to nutritional support interruptions such as ICU procedures, physical therapy, transport for imaging or invasive procedures outside the ICU, and nutrition intolerance.\n\nFurthermore, this discrepancy between prescribed and delivered nutrition may go largely unnoticed, due to issues concerning inadequate manual or automated monitoring of delivered nutrition. A joint \"Call to Action\" by ASPEN, the Academy of Nutrition and Dietetics, and the American Society of Health-System Pharmacists stated that parenteral nutrition errors and their contributing factors could be prevented by improving the functionality of in-house Clinical Decision Support Systems and the interfaces between electronic health records (EHRs), automated preparation devices and pharmacy systems.\n\nNutrow® is a software package designed to support nutritional management based on the calculation of recommended calorie and protein requirements, real-time calculation and monitoring of calorie and protein prescriptions, real-time calculation and monitoring of calories and protein truly delivered to patients, and information feedback to prescribers. Feedim® is a Medical Device Data System (MDDS), designed by Dim3, which transmits information from enteral feeding pumps to third-party software, such as Nutrow®.\n\nThe aim of the study is to assess whether the joint use of Nutrow-Feedim improves the achievement of nutritional objectives in ICU patients prior to oral intake by reducing the discrepancy between prescribed and delivered calories and protein.",[26],[31,185,186,187],"Protein Calorie Malnutrition","Refeeding syndrome","Clinical Decision Support Systems","2024-08-09",{"date":190,"type":36},"2024-08-12",{"date":192,"type":36},"2024-04-10",{"date":194,"type":19},"2025-09",{"name":196,"class":197},"Dim3","INDUSTRY"]