[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"nyhf-class-iii-iv\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:nyhf-class-iii-iv":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":5},"100103452","phase-3-alp-1-continuous-intravenous-infusion-to-maintain-clinical-stability-in-advanced-heart-failure-100103452",false,"NCT00610051","ALP-1 Continuous Intravenous Infusion to Maintain Clinical Stability in Advanced Heart Failure","Phase 3 Study of Alprostadil Continuous Intravenous Infusion to Maintain Clinical Stability in Severe Heart Failure Patients","1. Patients older than 18 years of age, of any gender\u002Fsex and race\u002Fethnicity\n2. Patients with a diagnosis of advanced HFrEF as evidenced by (all must apply):\n\n   1. most recent LVEF( by conventional imaging method\\\u003C30% which was mwasured within 3 months prior randomization.\n   2. Nt-proBNP \\>1500 ng\u002FL or BNP \\>300 ng\u002FL at prior randomization\n   3. New York Heart Association (NYHA) functional class IIIb or IV, i.e., chronic dyspnoea or fatigue at rest or with minimal exertion for at least one month prior to consent.\n   4. Renal dysfunction reflected by a glomerular filtration rate (GFR) \\\u003C60 mL\u002Fmin approximated by the Modification of Diet in Renal Disease formula.\n   5. A total symptom score of KCCQ of \\\u003C70measure within 24 hours of randomization\n   6. Patients on all appropriate recommended HF therapy.\n3. Patient should not be receiving continuous or planned intermittent intravenous infusions with a positive inotropic or vasodilator drug in a non-hospitalized setting\n4. Patients should not be considered as candidates for heart transplantation or LVAD for at least 6 months from randomization according to the opinion of the treating physician.\n5. Women of childbearing potential (i.e., who have not undergone a hysterectomy or who have not been postmenopausal for at least 24 consecutive months) must commit either to abstain continuously from heterosexual sexual contact or to use at least one \"highly effective\" method of birth control (e.g., intrauterine device \\[IUD\\], hormonal contraception, tubal ligation, or partner's vasectomy) or two \"effective\" methods (e.g., latex condom, diaphragm, or cervical cap), beginning 4 weeks prior to screening and throughout study participation.\n\n   Note: As alprostadil is not genotoxic and female sexual partners of male study participants are not likely to have substantial exposure via semen, there are no contraception requirements for men.\n6. Patients must be willing and able to give written informed consent, including local data privacy consents, as required","ALL","18 Years",{"count":19,"type":20},600,"ESTIMATED","INTERVENTIONAL",[23],"PHASE3","This is a global multicenter, doubleblind, placebo-controlled, randomized, parallel-group study that compares ALP-1 given in a continuous infusion ( compared to placebo), 250mcg\u002Fday on majore outcomes up to 6 months after randomization in participants with advanced HF with reduced ejection fraction(HFrEF).",[26,27,28],"End Stage Cardiac Failure","HFrEF - Heart Failure With Reduced Ejection Fraction","NYHF Class III-IV",[30],"advanced HFrEF","NOT_YET_RECRUITING","2025-12-12",{"date":34,"type":35},"2025-12-15","ACTUAL",{"date":37,"type":20},"2026-10",{"date":39,"type":20},"2030-12",{"name":41,"class":42},"Biopeutics Co., Ltd","INDUSTRY"]