[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"oa-knee\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:oa-knee":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,70,105],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100600177","tissue-engineered-cartilage-to-repairing-articular-cartilage-defects-100600177",false,"NCT07094100","Tissue Engineered Cartilage to Repairing Articular Cartilage Defects","Clinical Study of Cartilage Constructed by Autologous Bone Marrow Mesenchymal Stem Cells in Repairing Articular Cartilage Defects","Inclusion Criteria:\n\n1. The patients' age ranges from 18 to 65 years old, and gender is not restricted;\n2. The imaging results show that the epiphyseal growth is mature;\n3. The defects or localized injuries of joint cartilage caused by trauma or other reasons;\n4. The injured area is the distal weight-bearing surface of the femoral condyle of the knee joint, with no more than 4 lesions, and there is no injury to the cruciate ligaments;\n5. The patients voluntarily sign and provide a written informed consent form and are willing to closely cooperate with the doctor's strict postoperative rehabilitation program.\n\nExclusion Criteria:\n\n1. The patient is extremely overweight, with a body mass index greater than 35;\n2. The lower limb alignment is valgus by more than 10° and varus by more than 5°;\n3. Multiple ligament injuries;\n4. There are numerous bad habits such as heavy smoking, drug abuse, and excessive alcohol consumption;\n5. Has undergone open knee joint surgery within the past six months;\n6. Has severe joint stiffness or fibrosis;\n7. Has an allergic constitution or a history of allergic reactions to collagen;\n8. Has mental abnormalities;\n9. Cannot or is unwilling to undergo rehabilitation training;\n10. Has primary cardiovascular diseases, lung diseases, endocrine and metabolic disorders, or other serious diseases that affect their daily life, such as tumors or AIDS;\n11. Pregnant or lactating women, or those planning to conceive during the trial period;\n12. Other acute or chronic diseases, for which the researchers consider surgery to be inappropriate.","ALL","18 Years","65 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The joint cartilage constructed by combining bone marrow mesenchymal stem cells with three-dimensional materials has achieved the goal of repairing joint cartilage.",[27,28],"Cartilage Injury","OA Knee","RECRUITING","2026-04-28",{"date":32,"type":33},"2026-05-04","ACTUAL",{"date":35,"type":21},"2026-04-20",{"date":37,"type":21},"2028-12",{"name":39,"class":40},"The First Affiliated Hospital of Xinxiang Medical College","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100617256","value-of-adding-t2-mapping-routine-mri-in-assessment-of-knee-articular-cartilage-early-osteoarthritis-100617256","NCT07316257","Value of Adding T2 Mapping Routine MRI in Assessment of Knee Articular Cartilage Early Osteoarthritis","Value of Adding T2mapping Sequence to Routine MRI Protocol in Assessment of Knee Articular Cartilage in Early Osteoarthritis","T2 mapping OS","Inclusion Criteria:\n\n* patients with clinical evidence of osteoarthritis\n\nExclusion Criteria:\n\n* • contraindications for MRI such as claustrophobia, heart pacemaker and ferromagnetic implants\n\n  * patients in which the misaligned images or distortions due to motion artifacts made the interpretation of the MRI unreliable.\n  * Patients with previous knee operation",true,"20 Years","50 Years",{"count":54,"type":21},70,"OBSERVATIONAL","This work aims at elucidating the role of MRI complementary T2 mapping in assessment of the articular knee cartilage for improving sensitivity of detection of early stage of osteoarthritis",[58,59,28],"Osteearthritis","OA","NOT_YET_RECRUITING","2025-12-30",{"date":63,"type":33},"2026-01-05",{"date":65,"type":21},"2026-01-01",{"date":67,"type":21},"2027-02-01",{"name":69,"class":40},"Assiut University",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":104},"100580309","comparison-of-functional-recovery-between-restricted-inverse-kinematic-alignment-and-adjusted-mechanical-alignment-with-robotic-assisted-unilateral-total-knee-arthroplasty-100580309","NCT06835621","Comparison of Functional Recovery Between Restricted Inverse Kinematic Alignment and Adjusted Mechanical Alignment With Robotic-assisted Unilateral Total Knee Arthroplasty.","Comparison of Functional Recovery Between Restricted Inverse Kinematic Alignment and Adjusted Mechanical Alignment With Robotic-assisted Unilateral Total Knee Arthroplasty. A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age 50 - 80 years old\n* Diagnosed with primary OA knee and indicated for unilateral total knee arthroplasty with MAKO robotic-assisted knee replacement system\n* ASA classification I-II\n\nExclusion Criteria:\n\n* Valgus deformity\n* KL grading \\> 3 on contralateral knee\n* Unable or difficulty for walking due to comorbidities\n* BMI \\> 40 kg\u002Fm2\n* Previous knee surgery\n* Infection around the knee","80 Years",{"count":79,"type":21},80,[24],"The goal of this clinical trial is to learn if restricted inverse kinematic alignment total knee arthroplasty (restricted iKA TKA) improves functional recovery compared to adjusted mechanical alignment total knee arthroplasty (aMA TKA) in patients undergoing unilateral robotic-assisted total knee arthroplasty by comparing performance-based outcome, 2-minute walk test (2MWT) as a primary outcome. This trial will also assess other outcomes including satisfaction, patient-reported functional outcomes, range of motion, visual analog scale for pain and complication of both techniques. The main question aims to answer is:\n\nIn unilateral robotic-assisted total knee arthroplasty, dose Restricted iKA technique provide better postoperative performance-based outcome compared to aMA technique?\n\nResearchers will compare restricted iKA and aMA technique to determine which technique offers better acceleration in functional recovery and patient satisfaction.\n\nParticipants will:\n\nAfter randomization, participants will allocate to either restricted iKA or aMA technique for unilateral robotic-assisted total knee arthroplasty.\n\nAttend follow-up visits for assessments of 2-minute walk test (Primary outcome), Time up and go test (TUG), VAS for pain, ROM and complete patient-reported functional outcome questionnaires regarding knee function and satisfaction at regular intervals.",[28,83],"TKA",[85,86,87,88,89,90,91,92,93,94],"Osteoarthritis (OA) of the Knee","OA knee","MAKO","Kinematic alignment","Mechanical alignment","Restricted Kinematic alignment","Inversed Kinematic alignment","Inversed Restricted Kinematic alignment","Robotic assist Total Knee Arthroplasty","Adjusted mechanical alignment","2025-02-14",{"date":97,"type":33},"2025-02-19",{"date":99,"type":21},"2025-03",{"date":101,"type":21},"2028-08",{"name":103,"class":40},"Thammasat University",2,{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":124,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":4},"100570627","kinematic-alignment-in-total-knee-arthroplasty---a-double-blind-randomised-controlled-trial-between-robotic-and-caliper-based-techniques-100570627","NCT06709703","Kinematic Alignment in Total Knee Arthroplasty - a Double-blind Randomised Controlled Trial Between Robotic and Caliper-based Techniques","L'Alignement cinématique Dans Les prothèses de Totales de Genou : un Essai randomisé contrôlé à Double Insu Comparant la Robotique Aux Instruments Traditionnels","Inclusion Criteria:\n\n* Patient aged 18 or above\n* Patient being consented for a primary total knee arthroplasty (TKA)\n* The primary TKA is planned to be done with kinematic alignment\n* All pre-operative alignments are included\n\nExclusion Criteria:\n\n* Revision TKA (including revision of unicompartimental knee arthroplasty into total knee arthroplasty with primary components). TKA being done in the setting of previous femur or tibia fracture or osteotomy are however included.\n* No available adequate pre-operative imaging\n* Patient who does want to be randomized of the two groups\n* At the discretion of the surgeon, if the patient's pathology or particular anatomy precludes the use of kinematic alignment technique, robotic surgery, or traditional instrument TKA.",{"count":113,"type":21},200,[24],"Knee replacement surgery is a surgery designed to treat severe arthritis of the knee. However, as many as 20% of patients are not satisfied with the results of their surgery. To place the knee replacement in correct position, the kinematic alignment method, which tries to reproduce the patient normal anatomy, has shown promise in improving the satisfaction after knee replacement surgery. It is not known if using a robotic arm to assist in surgery is better than the traditional method when trying to recreate kinematic alignment.\n\nThe goal of this study is to learn if robotic assisted surgery is better than traditional method for knee replacement done using kinematic alignment. The main questions the study tries to answer are:\n\n1. Do the radiographs of kinematic knee replacement surgeries done with robotic assistance show better alignment than radiographs of kinematic knee replacements done with the traditional method?\n2. Does robotic assisted kinematic knee replacement give better function to patients than traditional knee replacement done with kinematic alignment?\n3. Does robotic assisted kinematic knee replacement decrease pain, improve knee movement and improve knee stability better than traditional knee replacement done with kinematic alignment?\n4. Are there more complications with robotic assisted kinematic knee replacement in comparison to traditional kinematic knee replacement?\n5. How long long does it take a surgeon to become good a performing a kinematic knee replacement using robotic assistance? Researchers will compare knee replacements done using a robotic to make the bone cuts, and compare it to the usual method using guides and manual instruments. All the knee replacements will be done using the kinematic alignment and with the same type of knee replacement prothesis.\n\nParticipants will:\n\n* Have a knee replacement done with the kinematic alignment technique by an experienced surgeon, with or without robotic assistance during the surgery.\n* Visit the clinic before surgery, six weeks after surgery, three months, six months, twelve months and twenty-four months after the surgery.\n* Fill questionnaire, have their knee examined and have radiographs of their knee done at each visit.",[117,118,119,120,59,28,121,122,123],"Arthritis","Arthritis (Knee)","Osteoarthritis","Osteoarthritis Knee Pain","OA Knee Pain","Osteoarthritis of Knee","Gonarthrosis; Primary",[125,126,127,128,129,130,131,132,133],"osteoarthritis","arthritis","knee osteoarthritis","knee OA","knee arthritis","total knee replacement","robotic","kinematic alignment","patient-specific surgery","2024-11-25",{"date":136,"type":33},"2024-11-29",{"date":138,"type":21},"2025-02",{"date":140,"type":21},"2028-09",{"name":142,"class":40},"Université de Sherbrooke"]