[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obese-adolescents\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obese-adolescents":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,47,78,103,125,155,183],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100639827","phase-2-akk-study-in-improving-obesity-and-metabolic-status-in-children-and-adolescents-100639827",false,"NCT07593170","AKK Study in Improving Obesity and Metabolic Status in Children and Adolescents","A Randomized, Double-blind, Placebo-controlled Study of Akkermansia Muciniphila AKK PROBIO in Improving Obesity and Metabolic Abnormalities in Children and Adolescents Aged 7-18 Years","Inclusion Criteria:\n\n* Age range: 7 years old to 18 years old (inclusive of boundary values), gender not restricted.\n* Primary obesity: According to the WS\u002FT 586-2018 standard issued by the National Health Commission of China, or the internationally recognized CDC\u002FWHO standard, diagnosed as obesity (if BMI ≥ the 95th percentile of children of the same age and gender).\n* The subjects and their legal guardians understand the research content, voluntarily participate and sign the written informed consent form (for guardians), and the informed consent form (for children aged 8 years and above).\n* Able to comply with the research protocol, complete all visits and sample collection.\n\nExclusion Criteria:\n\n* Have a definite endocrine disorder causing obesity (such as Cushing's syndrome, hypothyroidism), a genetic syndrome (such as Prader-Willi syndrome), or other known organic diseases.\n* Have a severe primary disease of the liver, kidney, cardiovascular system, respiratory system or hematopoietic system, etc.\n* Have used antibiotics, probiotics, prebiotics or synbiotic products within 3 months prior to screening.\n* Have a history of systemic use of glucocorticoids or other drugs that may affect weight and metabolism (such as metformin, systemic glucocorticoids, diuretics, etc.) within 1 month prior to screening.\n* Subjects are allergic to any component of the study product (AKK probiotic capsules or placebo).\n* Subjects are participating in other clinical trials.\n* Have a history of severe gastrointestinal diseases, such as inflammatory bowel disease (IBD).\n* Other conditions as determined by the researcher to be unsuitable for participation in this study.","ALL","7 Years","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The problem of obesity among children and adolescents is becoming increasingly serious and may affect their health in adulthood. Researches have found that a type of probiotic in the intestinal tract - \"Akkermansia muciniphila\" (referred to as AKK), may help regulate metabolism and weight. Although it has shown effects in adults, its safety and efficacy in children and adolescents still need further verification.\n\nThis study aims to evaluate the effects of supplementing Akkermansia Muciniphila AKK PROBIO on weight, metabolic health and intestinal flora of obese children and adolescents aged 7 to 18.",[27,28,29,30],"Obesity","Obese Adolescents","Obese Children and Adolescents","Akkermansia Muciniphila",[32,33],"obesity","Akkermansia muciniphila","NOT_YET_RECRUITING","2026-06-01",{"date":37,"type":38},"2026-06-03","ACTUAL",{"date":40,"type":21},"2026-06-06",{"date":42,"type":21},"2027-02-12",{"name":44,"class":45},"Central South University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":46},"100574172","phase-1-pilot-testing-a-novel-approach-to-pediatric-obesity-treatment-100574172","NCT06755827","Pilot Testing a Novel Approach to Pediatric Obesity Treatment","Emotion Regulation Intervention to Improve Neural Responsiveness and Health","Inclusion Criteria:\n\n* Being English-proficient\n* Ages 11-14\n* At or above the 85th BMI percentile based on age and sex norms\n* Having access to WIFI or cellular data to attend the telehealth groups\n* Living in a home in Lubbock County (TX) or surrounding areas.\n\nExclusion Criteria:\n\n* Having a psychiatric or medical diagnosis that interferes with participation (e.g., significant developmental delay; pregnancy)\n* Current enrollment in overweight\u002Fobesity treatment.\n* Because the study will include entering an MRI scanner, additional standard exclusion criteria will be considered (e.g., having immovable medical devices with batteries, body piercings on the head\u002Fface, and having substantial visual impairment that cannot be corrected with staff-provided glasses)","11 Years","14 Years",{"count":57,"type":21},30,[59,24],"PHASE1","The goal of this clinical trial is to learn if an emotion regulation and self-monitoring intervention can help treat overweight and obesity in teens. The main question it aims to answer is:\n\n* Does emotion regulation and self-monitoring help reduce biases in teens with overweight and obesity?\n* Do changes in biases relate to changes in health functioning and health behavior?\n\nResearchers will compare the intervention to the provision of educational handouts about overweight and obesity to see if the intervention is more effective.\n\nParticipants will:\n\n* Complete self-report questionnaires, an fMRI scan, and have their blood drawn\n* Received educational handouts or attend weekly telehealth group sessions weekly for four weeks and be asked to self-monitor their mood and behavior between sessions\n* Return to complete the same questionnaires, fMRI and blood draw procedures",[62,28],"Overweight Adolescents",[64,32,65,66,67],"overweight","adolescents","neuronal responsiveness","emotion regulation","RECRUITING","2026-05-13",{"date":71,"type":38},"2026-05-15",{"date":73,"type":38},"2026-03-24",{"date":75,"type":21},"2026-12-31",{"name":77,"class":45},"Texas Tech University",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":18,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":46},"100586502","study-of-the-effect-of-capsinoid-supplementation-on-brown-adipose-tissue-in-obese-adolescents-100586502","NCT06916208","Study of the Effect of Capsinoid Supplementation on Brown Adipose Tissue in Obese Adolescents","ADOBAT","Inclusion Criteria:\n\n* member or beneficiary of a health insurance scheme\n* aged between 11 and 18\n* Body Mass Index Z score corresponding to stage 2 obesity according to the curves of Rolland-Cachera et al., 1991 and an absence of weight loss of more than 5% of the total weight over the last 3 months.\n* effective contraception (in pubescent females)\n\nExclusion Criteria:\n\n* known allergy to capsinoids and\u002For soya\n* inflammatory digestive pathology and\u002For history of digestive tract surgery\n* participation in another study or in a period of exclusion determined by a previous study\n* pregnant, parturient or breastfeeding\n* The holder(s) of parental authority or the adolescent refuse(s) to sign the authorisation or acceptance form, respectively.\n* It proves impossible to provide the adolescent or parental guardian(s) with informed information.",{"count":86,"type":21},38,[88],"NA","Among the new strategies being considered for the treatment of obesity and its metabolic complications, the activation of brown adipose tissue (BAT) from white adipose tissue looks promising. Interest in the study of BAT has increased over the last 5-10 years in response to the discovery of functional BAT in humans. The BAT is a tissue specialized in regulating energy expenditure by producing heat through the oxidation of fatty acids contained in the multiple lipid droplets of brown adipocytes. This adipose tissue does not play a storage role, but rather an anti-obesogenic one, thanks to its high metabolic and energetic activity.\n\nIn addition to exposure to cold, which is the major physiological inducer of brown adipocytes, it seems that exercise and the intake of \"adrenergic\" foods can activate the TAB and potentially induce a change from white to brown tissue via the production of adrenalin and myokines. Acute and\u002For chronic effects of thermogenic food supplements have been reported on BAT activation and energy metabolism. The most conclusive of these involve the capsinoids found in sweet peppers and chillies. Weight loss also improves BAT activation.\n\nThe BAT has already been identified in children. A decrease in its volume and activity from childhood to adolescence and during puberty has been reported.\n\nThe main objective of this randomized controlled double-blind study is to investigate the effects of capsinoid dietary supplementation on BAT activity in obese adolescents.\n\nOur general working hypothesis is that capsinoid supplementation, combined with dietary management, leads to an increase in BAT activity.",[28,91,92,93],"Exercise","Diet Modification","Dietary Supplement","2026-04-29",{"date":96,"type":38},"2026-04-30",{"date":98,"type":38},"2025-03-03",{"date":100,"type":21},"2027-03",{"name":102,"class":45},"University of Avignon",{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":18,"enrollmentInfo":111,"targetDuration":4,"studyType":22,"phases":113,"briefSummary":114,"conditions":115,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},"100564216","exercise-snacks-for-breaking-the-sedentary-lifestyle-and-improving-the-physical-fitness-of-obese-adolescents-100564216","NCT06626295","Exercise-snacks for Breaking the Sedentary Lifestyle and Improving the Physical Fitness of Obese Adolescents?","Exercise-snacks: an Effective Solution for Breaking the Sedentary Lifestyle and Improving the Physical Fitness of Obese Adolescents?","SNACKEX","Inclusion Criteria:\n\n* Body mass index Z-score corresponding to stage 2 obesity,\n* no weight loss of more than 5% of total body weight in the past 3 months,\n* parental consent\n* minor\\'s acceptance\n\nExclusion Criteria:\n\n* Contraindication to physical activity\n* current participation in a clinical trial",{"count":112,"type":21},48,[88],"The management of a person with obesity involves long-term behavioral changes with a balanced diet in both quantity and quality, along with the adoption of a more active lifestyle: increasing physical activities and reducing sedentary behaviors. The school setting has been identified as a favorable environment for interventions aimed at reducing and interrupting the time adolescents spend sitting and preventing the associated negative health consequences.\n\nRecently, very short (\\< 1 minute) and intense exercises, called 'exercise-snacks,' have been reported to be effective in adults for 1) improving physical fitness over 6 weeks, and 2) improving vascular function and lowering blood glucose levels over a single day. Additionally, in adolescents with diabetes, they have been shown to reduce body fat. This raises the question of whether adding \\'exercise-snack\\' sessions to a multidimensional care program for hospitalized obese adolescents could further improve their physical fitness in the short and medium term.\n\nThe objective of this project is to compare the effects of a traditional multidimensional care program with the addition of 'exercise-snacks' to the same care program without \\'exercise-snacks\\' on the physical fitness, body composition, vascular function, and physical activity and sedentary behaviors of obese children in the short and medium term. Forty-eight obese adolescents will be included. The \\'exercise-snack\\' group will perform six exercise sessions per day for three weeks in addition to the standard care. The control group will receive only the standard care. Assessments of physical fitness, body composition, vascular health, and questionnaires on physical activity, sedentary behavior, and cognitive restraint will be conducted at the beginning and end of the three-week program, as well as 1 and 3 months after the end of the program.",[28,116,91],"Sedentary Time",{"date":118,"type":38},"2026-05-05",{"date":120,"type":38},"2024-09-09",{"date":122,"type":21},"2026-06",{"name":102,"class":45},2,{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":131,"sex":16,"minAge":54,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":139,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":124},"100618519","building-healthy-food-environment-in-schools-evaluating-co-created-interventions-in-low-resource-settings-betternutrition4adolescent-100618519","NCT07332676","Building Healthy Food Environment in Schools: Evaluating Co-created Interventions in Low Resource Settings. #BetterNutrition4Adolescent","Inclusion Criteria:\n\n* Adolescents studying in grade 7 to 9 (aged 11-15 years) Exclusion criteria:\n\nExclusion Criteria:\n\n* Adolescents with siblings enrolled in schools assigned to a different trial arm to avoid clustering, with underlying medical conditions and those who plan to change school within one year of enrollment (during follow up period) will be excluded.",true,"15 Years",{"count":134,"type":21},2600,[88],"The goal of this clinical trial is to learn if a multicomponent nutrition program developed together with the students, parents, teachers and canteen operators will improve nutrition status of adolescents. It will also learn about the acceptability and feasibility of implementing the program in the school settings. The main questions it aims to answer are:\n\nWhat is the effect of co-created multicomponent intervention promoting healthy food behavior and environment in schools on the proportion of normal weight adolescents? What proportion of the target adolescents and teachers does the intervention reach? What proportion of the schools are willing to implement the intervention? What was the level of fidelity of implementation of all components of the intervention and the barriers and facilitators to implementation? What is the cost for maintenance, and facilitators and barriers of sustainment? School going adolescents studying in grades 7 to 9 from 26 schools in India and 26 schools in Nepal will be enrolled in the trial and their height, weight, dietary behavior, mental well-being and physical activity will be measured at baseline and at 12 months follow up. After the baseline assessment the school community (students, school environment, parents, teachers, canteen operators) will receive the intervention.",[62,138,28],"Underweight",[140,141,142,143,144,145],"nutrition","multicomponent nutrition intervention","co-creation","adolescent","low resource settings","Poor nutrition","2025-12-30",{"date":148,"type":38},"2026-01-12",{"date":150,"type":21},"2026-10",{"date":152,"type":21},"2027-12",{"name":154,"class":45},"Norwegian University of Science and Technology",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":131,"sex":16,"minAge":162,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":167,"conditions":168,"keywords":170,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":46},"100602208","co-creating-school-community-intervention-program-on-physical-activity-to-increase-health-equity-in-children-and-adolescents-100602208","NCT07120516","Co-creating School Community Intervention Program on Physical Activity to Increase Health Equity in Children and Adolescents","Connection","Inclusion Criteria:\n\n* Children aged 12-16 years\n* Attending VDU Atžalynas Progymnasium (Kaunas, Lithuania)\n* Written informed consent from parents\u002Flegal guardians and assent from the child\n* Willingness to participate in questionnaires, physical measurements, and (if selected) wearable device monitoring\n\nExclusion Criteria:\n\n* Younger than 12 or older than 16 years\n* No signed informed consent from parents\u002Flegal guardians or refusal by the child\n* Medical or psychological conditions that may interfere with participation (e.g., severe cardiovascular disease, mobility impairments, skin allergies preventing wearable use)","12 Years","16 Years",{"count":165,"type":21},200,"OBSERVATIONAL","The goal of this observational and interventional study is to understand whether environmental and behavioral interventions can improve physical activity and health outcomes in children aged 12-16 years attending VDU Atžalynas Progymnasium, Lithuania.\n\nThe main questions it aims to answer are:\n\n1. Does higher physical activity and improved lifestyle reduce health disparities among children living in disadvantaged social and economic conditions?\n2. What is the relationship between environmental pollution, physical activity, and children's health indicators? Researchers will compare data from the cross-sectional group (baseline measurements only) and the intervention group (7-day activity tracking and follow-up after 3 months) to see if targeted environmental interventions improve children's physical activity, sleep quality, and health outcomes.\n\nParticipants will:\n\n* Fill in questionnaires about health behaviors, well-being, and living environment (children and parents).\n* Undergo physical measurements (blood pressure, height, weight, body composition).\n* Wear a smart wristband for 7 days to monitor activity, sleep, and heart rate (only for selected participants).\n* Attend a follow-up visit after 3 months (intervention group only).",[28,169],"Mental Health",[171,172,173],"Child Health Inequalities","Physical Activity","Health Behavior in Adolescents","2025-08-06",{"date":176,"type":38},"2025-08-13",{"date":178,"type":38},"2025-06-01",{"date":180,"type":21},"2027-04",{"name":182,"class":45},"Sandra Andrusaityte",{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":16,"minAge":162,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":166,"phases":4,"briefSummary":194,"conditions":195,"keywords":200,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":46},"100590436","mitigation-of-cardiovascular-disease-risks-in-children-with-extreme-obesity-100590436","NCT06967389","Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity","Mitigation of Cardiovascular Disease Risks in Children With Extreme Obesity (MODERN)","MODERN","Inclusion Criteria:\n\n* Patient seen at University of Kentucky Pediatric High BMI Clinic\n* Diagnosis of Obesity Class 2 or 3\n* Meeting the clinical criteria for the medical intervention with semaglutide for weight loss\n\nExclusion Criteria:\n\n* Any current prescribed anti-obesity medications (AOM) such as Orlistat, Phentermine, Qsymia (Phentermine\u002FTopiramate), Liraglutide, Semaglutide, and Setmelanotide\n* Any current prescribed anti-hypertensive medications\n* Any specific end-organ acute concerns (kidney disease, liver disease, congenital disease).\n* Any active infections at enrollment.\n* Any systemic steroid use longer than 3 month use or within the last month before enrollment (not including inhaled, ophthalmic, intranasal, and topical).\n* Any limitations that would make exercise testing not possible.\n* Any congenital abnormality or genetic syndrome known to be associated with obesity\n* Pregnancy\n* Inability to receive an MRI\n* Personal or family history of medullary thyroid carcinoma (per product insert)\n* Patients with Multiple Endocrine Neoplasia syndrome type 2 (per product insert)","17 Years",{"count":193,"type":21},50,"The goal of this clinical trial is to learn if the drug semaglutide changes markers of disease risk as it relates to weight in children ages 12-15 years old who are obese (class 2 or 3). The main questions it aims to answer are:\n\n* How do the rate of weight loss, body mass index (BMI), body composition, heart structure and function, and exercise ability interact with one another in the study population at enrollment?\n* How do risk markers of disease change over the study in the study participants who are given semaglutides to help with weight loss?\n* Are there differences in the above factors between males and females and are there key factors to help improve the outcomes?\n\nParticipants will be given semaglutide for this study. During the course of the study, participants will:\n\n* have two cardiac MRI scans OR two cardiac echocardiograms (one before starting semaglutide and one around 12 months after taking the drug)\n* have body composition and fitness levels assessed twice (before semaglutide and around 12 months after taking it) and have urine specific gravity (USG) measured\n* have extra blood drawn when labs their doctor orders are already being drawn (once at the beginning of the study, once around 6 months after enrollment, and once at the end of the study)\n* have follow up visits with the study doctor\n* be asked to take a pregnancy test if they are female and have started menstruation",[196,28,197,198,199],"Obesity and Overweight","Weight Management","Weight Loss","Cardiovascular Disease Risk Factor",[201,202,203,32,64,143,204,205],"semaglutide","Wegovy","Ozempic","weight management","weight loss","2025-07-01",{"date":208,"type":38},"2025-07-04",{"date":210,"type":38},"2025-06-12",{"date":212,"type":21},"2027-07",{"name":214,"class":45},"John Bauer"]