[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"obese-children-and-adolescents\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:obese-children-and-adolescents":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,77],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100639827","phase-2-akk-study-in-improving-obesity-and-metabolic-status-in-children-and-adolescents-100639827",false,"NCT07593170","AKK Study in Improving Obesity and Metabolic Status in Children and Adolescents","A Randomized, Double-blind, Placebo-controlled Study of Akkermansia Muciniphila AKK PROBIO in Improving Obesity and Metabolic Abnormalities in Children and Adolescents Aged 7-18 Years","Inclusion Criteria:\n\n* Age range: 7 years old to 18 years old (inclusive of boundary values), gender not restricted.\n* Primary obesity: According to the WS\u002FT 586-2018 standard issued by the National Health Commission of China, or the internationally recognized CDC\u002FWHO standard, diagnosed as obesity (if BMI ≥ the 95th percentile of children of the same age and gender).\n* The subjects and their legal guardians understand the research content, voluntarily participate and sign the written informed consent form (for guardians), and the informed consent form (for children aged 8 years and above).\n* Able to comply with the research protocol, complete all visits and sample collection.\n\nExclusion Criteria:\n\n* Have a definite endocrine disorder causing obesity (such as Cushing's syndrome, hypothyroidism), a genetic syndrome (such as Prader-Willi syndrome), or other known organic diseases.\n* Have a severe primary disease of the liver, kidney, cardiovascular system, respiratory system or hematopoietic system, etc.\n* Have used antibiotics, probiotics, prebiotics or synbiotic products within 3 months prior to screening.\n* Have a history of systemic use of glucocorticoids or other drugs that may affect weight and metabolism (such as metformin, systemic glucocorticoids, diuretics, etc.) within 1 month prior to screening.\n* Subjects are allergic to any component of the study product (AKK probiotic capsules or placebo).\n* Subjects are participating in other clinical trials.\n* Have a history of severe gastrointestinal diseases, such as inflammatory bowel disease (IBD).\n* Other conditions as determined by the researcher to be unsuitable for participation in this study.","ALL","7 Years","18 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The problem of obesity among children and adolescents is becoming increasingly serious and may affect their health in adulthood. Researches have found that a type of probiotic in the intestinal tract - \"Akkermansia muciniphila\" (referred to as AKK), may help regulate metabolism and weight. Although it has shown effects in adults, its safety and efficacy in children and adolescents still need further verification.\n\nThis study aims to evaluate the effects of supplementing Akkermansia Muciniphila AKK PROBIO on weight, metabolic health and intestinal flora of obese children and adolescents aged 7 to 18.",[27,28,29,30],"Obesity","Obese Adolescents","Obese Children and Adolescents","Akkermansia Muciniphila",[32,33],"obesity","Akkermansia muciniphila","NOT_YET_RECRUITING","2026-06-01",{"date":37,"type":38},"2026-06-03","ACTUAL",{"date":40,"type":21},"2026-06-06",{"date":42,"type":21},"2027-02-12",{"name":44,"class":45},"Central South University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":46},"100599693","digital-wellness-nurse---fit-families-virtual-family-intervention-for-adolescent-obesity-100599693","NCT07087808","Digital Wellness Nurse - FIT Families: Virtual Family Intervention for Adolescent Obesity","DWN-FIT","Inclusion Criteria:\n\n1. Adolescents (ages 12-17)\n2. Adolescent BMI ≥ 90th percentile for age and gender\n3. Primary caregiver either overweight (BMI 25.0 to 29.9) or obese (BMI ≥ 30) and willing to participate in treatment\n4. Adolescent residing primarily with the primary caregiver in a rural community (RUCA Codes 4-10)\n5. Both caregiver and adolescent must have (separate) Android or Apple (iOS) smartphone with mobile internet connection\n6. Adolescent and caregiver are English proficient\n7. Supporters must be 18 years of age or older\n\nExclusion Criteria:\n\n* Exclusion criteria for youth only:\n\n  1. Obesity secondary to medication use for another medical condition (e.g., steroids, antipsychotics)\n  2. Obesity secondary to a chronic condition (e.g., Down syndrome, Prader-Willi syndrome, Cushing's syndrome)\n\nExclusion criteria that apply to both adolescents and caregivers:\n\n1. Pregnancy (e.g., caregivers and youth will be asked each week if they expect if they are pregnant)\n2. Mental\u002Femotional disorder (e.g., schizophrenia or other psychosis), suicidal, or homicidal\n3. Serious cognitive impairment (e.g., inability to complete questionnaires)\n4. Medical condition where weight loss is contraindicated\n5. Receiving or planned to receive other obesity treatments (e.g., pharmacologic treatment, bariatric surgery) within the next 6 months","12 Years","17 Years",{"count":57,"type":21},32,[59],"NA","The purpose of the research is to evaluate the digital wellness nurse (DWN) app to find out if it is helpful in delivering the FIT Families intervention. The study is sponsored by the National Institutes of Health (NIH).",[29],[32,63,64,65],"digital health","nutrition","Cognitive Behavioral Skills Testing","RECRUITING","2025-07-23",{"date":69,"type":38},"2025-07-28",{"date":71,"type":38},"2025-06-20",{"date":73,"type":21},"2025-12-31",{"name":75,"class":76},"Machine and Human Interaction","INDUSTRY",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":4},"100531881","the-therapeutic-effect-of-different-exercise-intensities-on-weight-loss-in-obese-children-100531881","NCT06205563","The Therapeutic Effect of Different Exercise Intensities on Weight Loss in Obese Children","The Effects of Short-term Supervised High-intensity Interval Training and Moderate Intensity Continuous Training on Weight Loss and Metabolic Indicators in Obese Children Under Energy Limited Balanced Diet","Inclusion Criteria:\n\n1. The guardian understands and signs the informed consent. If the subject is at least 8 years old, the informed consent must be signed.\n2. Age 6\\~16 years old, male and female;\n3. BMI≥ \\"sex-age BMI reference point for obesity screening of school-age children aged 6-18 years\\";\n4. no disability;\n5. Joint cardiopulmonary function assessment showed that participation was safe;\n6. At least one year of follow-up is expected.\n\nExclusion Criteria:\n\n1. Have high blood pressure (defined as systolic or diastolic blood pressure values above the 95th percentile), any history or evidence of heart disease and\u002For abnormal resting or stress echocardiography or a combined cardiopulmonary function assessment indicating that participation is not safe;\n2. have any chronic disease, such as chronic asthma, kidney disease, type 1 diabetes, epilepsy, etc.;\n3. suffering from organic diseases, such as ovarian tumors, hamartoma, etc.;\n4. A smoking habit or orthopedic\u002Fneurological condition that may limit exercise ability;\n5. Confirmed attention deficit hyperactivity disorder and steroid use.","6 Years","16 Years",{"count":87,"type":21},388,[59],"The incidence of childhood obesity is increasing, followed by metabolic diseases related to overweight and obesity in children. High intensity interval training (HIIT) has recently been shown to improve the body composition and cardiovascular health of obese children. Currently, there is little evidence on the impact of exercise intensity on endocrine and metabolic indicators and quality of life in obese children.\n\nThe main purpose of this study is to compare the effects of short-term supervised high-intensity interval training and moderate intensity continuous training (MICT) on metabolic indicators in obese children under an energy limited balanced diet. A multicenter prospective randomized controlled trial was conducted on 388 obese children in South China. The experimental group will be randomly assigned to (1) HIIT and energy limited balanced diet, and (2) MICT and energy limited balanced diet. The experimental group will participate in a 3-month (supervised) exercise training. The measurement of the study endpoint will be followed up at baseline, 3 months (after supervised intervention), 9 months, and 1 year. The primary endpoint is the percentage of weight loss (△ Wt%). Secondary endpoints include waist to height ratio, body mass index (BMI), body fat percentage, insulin resistance index (HOMA-IR), insulin secretion index (ISI), and Δ HtSDSBA. The results of this study will generate a wealth of information on the impact of exercise intensity on weight loss and endocrine metabolism in obese children, and develop more effective evidence-based exercise prescription guidelines in this population.",[91,29],"Weight Loss","2024-01-03",{"date":94,"type":38},"2024-01-16",{"date":96,"type":21},"2024-05-01",{"date":98,"type":21},"2026-12-30",{"name":100,"class":45},"Third Affiliated Hospital, Sun Yat-Sen University"]